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Q13XC9

- LPXB_BURXL

UniProt

Q13XC9 - LPXB_BURXL

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBXEN266265:GJII-2832-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Bxeno_A2722
ORF Names:Bxe_A1695
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Lipid-A-disaccharide synthasePRO_0000255169Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_A1695.

Structurei

3D structure databases

ProteinModelPortaliQ13XC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13XC9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALQPSPLRV AMVAGEPSGD LLAASLLDGL ASRLPAGTQY YGIGGPRMIA
60 70 80 90 100
TGFDAHFPME KLTVRGYVEA LKHIPEILGI RTELKRQLLA EPPSVFVGVD
110 120 130 140 150
APDFNFGLEH PLRDAGIPTV HFVCPSIWAW RGGRIKKIAK AVDHMLCVFP
160 170 180 190 200
FETALLEKAG VAASYVGHPL ADEIPLVPDT LGARRALGLA EEGPIIAVLP
210 220 230 240 250
GSRRSEIDLI GPTFFAAIEM MQHQEPALRF VMPAATPALR EMLRPLVDSH
260 270 280 290 300
PGLALTITDG QSQLAMTAAD AILVKSGTVT LEAALLKKPM VISYKVPWLT
310 320 330 340 350
GQIMRRQGYL PYVGLPNILA GRFVVPEILQ HFATPQALAE ATLKQLRDEN
360 370 380
NRRTLTEIFT EMHHVLKQNT AQRAAEVVAS VIEKRKARP
Length:389
Mass (Da):42,315
Last modified:August 22, 2006 - v1
Checksum:i407E4FD6BC473528
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000270 Genomic DNA. Translation: ABE31260.1.
RefSeqiYP_559312.1. NC_007951.1.

Genome annotation databases

EnsemblBacteriaiABE31260; ABE31260; Bxe_A1695.
GeneIDi4005004.
KEGGibxe:Bxe_A1695.
PATRICi19331064. VBIBurXen52548_2852.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000270 Genomic DNA. Translation: ABE31260.1 .
RefSeqi YP_559312.1. NC_007951.1.

3D structure databases

ProteinModelPortali Q13XC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266265.Bxe_A1695.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE31260 ; ABE31260 ; Bxe_A1695 .
GeneIDi 4005004.
KEGGi bxe:Bxe_A1695.
PATRICi 19331064. VBIBurXen52548_2852.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci BXEN266265:GJII-2832-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiLPXB_BURXL
AccessioniPrimary (citable) accession number: Q13XC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 22, 2006
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3