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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Paraburkholderia xenovorans (strain LB400)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei246ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBXEN266265:BXE_RS13790-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Bxeno_A2775
ORF Names:Bxe_A1642
OrganismiParaburkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeParaburkholderia
Proteomesi
  • UP000001817 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000018851 – 469Glutamate--tRNA ligaseAdd BLAST469

Proteomic databases

PRIDEiQ13X76

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi266265.Bxe_A1642

Structurei

3D structure databases

ProteinModelPortaliQ13X76
SMRiQ13X76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi243 – 247"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
1.10.8.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020752 aa-tRNA-synth_I_codon-bd_sub1
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q13X76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSVRTRFA PSPTGFIHLG NIRSALYPWA FARKMKGTFV LRIEDTDVER
60 70 80 90 100
STSESVDAIL EGMAWLGLDF DEGPFYQMQR MDRYREVLKQ MQDEGLVYLC
110 120 130 140 150
YMSTEELDAL RERQREAGEK PRYDGTWRPE PGKVLPEPPA GVQPVLRFRN
160 170 180 190 200
PLNGVVAWDD AVKGRIEISN EELDDLVIAR PDGTPTYNFC VVVDDLDMRI
210 220 230 240 250
THVIRGDDHV NNTPRQINIL RALGGEPPVY AHLPTVLNEQ GEKMSKRHGA
260 270 280 290 300
MSVMGYRDAG YLPEAVVNYL ARLGWSHGDA EIFSREQFVE WFDLEHLGKS
310 320 330 340 350
PAQYDHDKLN WLNAHYIKEA GNVRLAELAR PFFAGLGIDE AMLAQGADLT
360 370 380 390 400
AVVGLLKDRA STVKEIAENA AMFYRAPAPD AESLTQHVTD AVRPALADLA
410 420 430 440 450
AALKAVEWTR EAIAAALKAT LGAHKLKMPQ LAMPVRLLVA GTTHTPSIDS
460
VLMLFGRDVV VSRIEKALA
Length:469
Mass (Da):52,305
Last modified:August 22, 2006 - v1
Checksum:iF58E9DCED4286AFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA Translation: ABE31313.1
RefSeqiWP_011488902.1, NZ_CP008760.1

Genome annotation databases

EnsemblBacteriaiABE31313; ABE31313; Bxe_A1642
GeneIDi4004638
KEGGibxb:DR64_3802
bxe:Bxe_A1642
PATRICifig|266265.5.peg.2910

Similar proteinsi

Entry informationi

Entry nameiSYE_PARXL
AccessioniPrimary (citable) accession number: Q13X76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: June 20, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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