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Protein
Submitted name:

3,4-dehydroadipyl-CoA semialdehyde dehydrogenase

Gene

Bxe_A1420

Organism
Burkholderia xenovorans (strain LB400)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei296 – 2961NADPCombined sources
Binding sitei346 – 3461NADPCombined sources
Binding sitei485 – 4851NADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi156 – 1583NADPCombined sources
Nucleotide bindingi182 – 1854NADPCombined sources
Nucleotide bindingi214 – 2163NADPCombined sources
Nucleotide bindingi232 – 2376NADPCombined sources
Nucleotide bindingi257 – 2593NADPCombined sources
Nucleotide bindingi400 – 4023NADPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

NADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciBXEN266265:GJII-3116-MONOMER.
BRENDAi1.2.1.5. 7691.
1.2.1.77. 7691.

Names & Taxonomyi

Protein namesi
Submitted name:
3,4-dehydroadipyl-CoA semialdehyde dehydrogenaseImported (EC:1.2.1.-Imported)
Gene namesi
ORF Names:Bxe_A1420Imported
OrganismiBurkholderia xenovorans (strain LB400)Imported
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
Proteomesi
  • UP000001817 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_A1420.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VROX-ray1.60A/B1-531[»]
2Y51X-ray1.60A/B1-531[»]
2Y52X-ray1.65A/B1-531[»]
2Y53X-ray1.40A/B1-531[»]
2Y5DX-ray1.40A/B1-531[»]
ProteinModelPortaliQ13WK4.
SMRiQ13WK4. Positions 1-522.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13WK4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 469457AldedhInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4105DXM. Bacteria.
COG2030. LUCA.
HOGENOMiHOG000249929.
KOiK15514.
OMAiFYHRRSA.
OrthoDBiEOG6Z0QB6.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011966. PaaN-DH.
[Graphical view]
PANTHERiPTHR11699:SF12. PTHR11699:SF12. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR02278. PaaN-DH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13WK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELLKNHVA GQWIAGTGAG ITLTDPVTGV ALVRVSSEGL DLARAFSFAR
60 70 80 90 100
EDGGAALRAL TYAQRAARLA DIVKLLQAKR GDYYAIATAN SGTTRNDSAV
110 120 130 140 150
DIDGGIFTLS YYAKLGASLG EVHALRDGSA ESLSKDRSFS AQHVLSPTRG
160 170 180 190 200
VALFINAFNF PSWGLWEKAA PALLSGVPVI VKPATATAWL TQRMVADVVD
210 220 230 240 250
AGILPPGALS IICGSSAGLL DQIRSFDVVS FTGSADTAAT LRAHPAFVQR
260 270 280 290 300
GARLNVEADS LNSAILCADA TPDTPAFDLF IKEVVREMTV KSGQKCTAIR
310 320 330 340 350
RAFVPEAALE PVLEALKAKL AKITVGNPRN DAVRMGSLVS REQYENVLAG
360 370 380 390 400
IAALREEAVL AYDSSAVPLI DADANIAACV APHLFVVNDP DNATLLHDVE
410 420 430 440 450
VFGPVASVAP YRVTTDTNAL PEAHAVALAR RGQGSLVASI YSNDDAHLGR
460 470 480 490 500
LALELADSHG RVHAISPSVQ HSQTGHGNVM PMSLHGGPGR AGGGEELGGL
510 520 530
RALAFYHRRS AIQAASAAIG TLTQATHWPA A
Length:531
Mass (Da):55,496
Last modified:August 22, 2006 - v1
Checksum:i4363176C8F426FCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE31535.1.
RefSeqiWP_011489106.1. NZ_CP008760.1.

Genome annotation databases

EnsemblBacteriaiABE31535; ABE31535; Bxe_A1420.
GeneIDi4004406.
KEGGibxb:DR64_3583.
bxe:Bxe_A1420.
PATRICi19331676. VBIBurXen52548_3150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE31535.1.
RefSeqiWP_011489106.1. NZ_CP008760.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VROX-ray1.60A/B1-531[»]
2Y51X-ray1.60A/B1-531[»]
2Y52X-ray1.65A/B1-531[»]
2Y53X-ray1.40A/B1-531[»]
2Y5DX-ray1.40A/B1-531[»]
ProteinModelPortaliQ13WK4.
SMRiQ13WK4. Positions 1-522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266265.Bxe_A1420.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE31535; ABE31535; Bxe_A1420.
GeneIDi4004406.
KEGGibxb:DR64_3583.
bxe:Bxe_A1420.
PATRICi19331676. VBIBurXen52548_3150.

Phylogenomic databases

eggNOGiENOG4105DXM. Bacteria.
COG2030. LUCA.
HOGENOMiHOG000249929.
KOiK15514.
OMAiFYHRRSA.
OrthoDBiEOG6Z0QB6.

Enzyme and pathway databases

BioCyciBXEN266265:GJII-3116-MONOMER.
BRENDAi1.2.1.5. 7691.
1.2.1.77. 7691.

Miscellaneous databases

EvolutionaryTraceiQ13WK4.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011966. PaaN-DH.
[Graphical view]
PANTHERiPTHR11699:SF12. PTHR11699:SF12. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR02278. PaaN-DH. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400Imported.
  2. "Structural and biochemical characterization of a novel aldehyde dehydrogenase encoded by the benzoate oxidation pathway in Burkholderia xenovorans LB400."
    Bains J., Boulanger M.J.
    J. Mol. Biol. 379:597-608(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH NADP.
  3. "Elucidating the reaction mechanism of the benzoate oxidation pathway encoded aldehyde dehydrogenase from Burkholderia xenovorans LB400."
    Bains J., Leon R., Temke K.G., Boulanger M.J.
    Protein Sci. 20:1048-1059(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN COMPLEX WITH NADP.

Entry informationi

Entry nameiQ13WK4_BURXL
AccessioniPrimary (citable) accession number: Q13WK4
Entry historyi
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: May 11, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.