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Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBXEN266265:GJII-3239-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 2UniRule annotation
Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
Gene namesi
Name:uppP2UniRule annotation
Ordered Locus Names:Bxeno_A3116
ORF Names:Bxe_A1299
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 1

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2723HelicalUniRule annotationAdd
BLAST
Transmembranei44 – 6421HelicalUniRule annotationAdd
BLAST
Transmembranei87 – 10721HelicalUniRule annotationAdd
BLAST
Transmembranei114 – 13421HelicalUniRule annotationAdd
BLAST
Transmembranei150 – 17021HelicalUniRule annotationAdd
BLAST
Transmembranei190 – 21021HelicalUniRule annotationAdd
BLAST
Transmembranei218 – 23821HelicalUniRule annotationAdd
BLAST
Transmembranei251 – 27121HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Undecaprenyl-diphosphatase 2PRO_0000250231Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_A1299.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiHMMWALI.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13W85-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLSFLIFLS VLQGVTELFP VSSLGHTLLV PALFGMHIDK HAPQLLPFLV
60 70 80 90 100
ALHLGTAFAL LWYFRKRWCA LVRGFFASFG GRRNDDAHMM WALIIGTIPA
110 120 130 140 150
GLVGLLLEKR LERIFHDLRI VAIALIVNGV LLWFGDRLQR TRAHQAPEKL
160 170 180 190 200
TFRQAFFVGL AQIGALIPGF SRSGLTMIAG NAAGLTAEKA AEFSFLLGTP
210 220 230 240 250
IIFAAGVLEL PKLFHAPGQL ADALLGGVLT AIAAYLSVRF LMRYFEGRGR
260 270
LASFGVYCVI AGIVFLGWFL LHPQPV
Length:276
Mass (Da):30,268
Last modified:August 22, 2006 - v1
Checksum:iA81481C5549D5610
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE31654.1.
RefSeqiYP_559706.1. NC_007951.1.

Genome annotation databases

EnsemblBacteriaiABE31654; ABE31654; Bxe_A1299.
GeneIDi4005068.
KEGGibxe:Bxe_A1299.
PATRICi19331934. VBIBurXen52548_3276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE31654.1.
RefSeqiYP_559706.1. NC_007951.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266265.Bxe_A1299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE31654; ABE31654; Bxe_A1299.
GeneIDi4005068.
KEGGibxe:Bxe_A1299.
PATRICi19331934. VBIBurXen52548_3276.

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiHMMWALI.
OrthoDBiEOG6QP13M.

Enzyme and pathway databases

BioCyciBXEN266265:GJII-3239-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiUPPP2_BURXL
AccessioniPrimary (citable) accession number: Q13W85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: August 22, 2006
Last modified: January 7, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.