Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q13VU2 (ACDH2_BURXL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 2

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene names
Name:amnH
Ordered Locus Names:Bxeno_A3259
ORF Names:Bxe_A1151
OrganismBurkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]
Taxonomic identifier266265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Acetaldehyde dehydrogenase 2 HAMAP-Rule MF_01657
PRO_0000387645

Regions

Nucleotide binding12 – 154NAD By similarity
Nucleotide binding163 – 1719NAD By similarity

Sites

Active site1321Acyl-thioester intermediate By similarity
Binding site2871NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q13VU2 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 18902D4982DDABD3

FASTA31332,856
        10         20         30         40         50         60 
MTRKFKAAII GSGNIGTDLM IKIMRHGRHI EVGAMVGIDP ASDGLARASR LGVGTTHEGV 

        70         80         90        100        110        120 
EGLTRLPIFE EIDFVFDATS AGAHVHNDAL LRKYKPGIRV IDLTPAAIGP YCIPVVNGKQ 

       130        140        150        160        170        180 
NLDALNVNMV TCGGQATVPM VAAVSRVTQV HYGEIVASIA SKSAGPGTRA NIDEFTETTS 

       190        200        210        220        230        240 
KAIEVVGGAS KGKAIIVLNP ADPPLIMRDT VYTLSDVADE AAIADSVARM AADVQSYVPG 

       250        260        270        280        290        300 
YRLKQTVQFD RVENLNVPGV GRISGLKTSI FLEVEGAAHY LPAYAGNLDI MTSAGLRTAE 

       310 
QMAARMTAGT VAA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000270 Genomic DNA. Translation: ABE31797.1.
RefSeqYP_559849.1. NC_007951.1.

3D structure databases

ProteinModelPortalQ13VU2.
SMRQ13VU2. Positions 1-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266265.Bxe_A1151.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE31797; ABE31797; Bxe_A1151.
GeneID4002974.
KEGGbxe:Bxe_A1151.
PATRIC19332244. VBIBurXen52548_3426.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMASIYLEIE.
OrthoDBEOG6H1PXH.

Enzyme and pathway databases

BioCycBXEN266265:GJII-3391-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH2_BURXL
AccessionPrimary (citable) accession number: Q13VU2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: August 22, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families