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Q13VU2

- ACDH2_BURXL

UniProt

Q13VU2 - ACDH2_BURXL

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Protein

Acetaldehyde dehydrogenase 2

Gene

amnH

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321Acyl-thioester intermediateUniRule annotation
Binding sitei287 – 2871NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 154NADUniRule annotation
Nucleotide bindingi163 – 1719NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBXEN266265:GJII-3391-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Name:amnH
Ordered Locus Names:Bxeno_A3259
ORF Names:Bxe_A1151
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Acetaldehyde dehydrogenase 2PRO_0000387645Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_A1151.

Structurei

3D structure databases

ProteinModelPortaliQ13VU2.
SMRiQ13VU2. Positions 1-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiSIYLEIE.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13VU2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRKFKAAII GSGNIGTDLM IKIMRHGRHI EVGAMVGIDP ASDGLARASR
60 70 80 90 100
LGVGTTHEGV EGLTRLPIFE EIDFVFDATS AGAHVHNDAL LRKYKPGIRV
110 120 130 140 150
IDLTPAAIGP YCIPVVNGKQ NLDALNVNMV TCGGQATVPM VAAVSRVTQV
160 170 180 190 200
HYGEIVASIA SKSAGPGTRA NIDEFTETTS KAIEVVGGAS KGKAIIVLNP
210 220 230 240 250
ADPPLIMRDT VYTLSDVADE AAIADSVARM AADVQSYVPG YRLKQTVQFD
260 270 280 290 300
RVENLNVPGV GRISGLKTSI FLEVEGAAHY LPAYAGNLDI MTSAGLRTAE
310
QMAARMTAGT VAA
Length:313
Mass (Da):32,856
Last modified:August 22, 2006 - v1
Checksum:i18902D4982DDABD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE31797.1.
RefSeqiYP_559849.1. NC_007951.1.

Genome annotation databases

EnsemblBacteriaiABE31797; ABE31797; Bxe_A1151.
GeneIDi4002974.
KEGGibxe:Bxe_A1151.
PATRICi19332244. VBIBurXen52548_3426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE31797.1 .
RefSeqi YP_559849.1. NC_007951.1.

3D structure databases

ProteinModelPortali Q13VU2.
SMRi Q13VU2. Positions 1-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266265.Bxe_A1151.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE31797 ; ABE31797 ; Bxe_A1151 .
GeneIDi 4002974.
KEGGi bxe:Bxe_A1151.
PATRICi 19332244. VBIBurXen52548_3426.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi SIYLEIE.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci BXEN266265:GJII-3391-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiACDH2_BURXL
AccessioniPrimary (citable) accession number: Q13VU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: August 22, 2006
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3