Reviewed, UniProtKB/Swiss-Prot Q13V90 (ADD_BURXL)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	Bxeno_A3461
ORF Names:	Bxe_A0947

Organism

Burkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]

Taxonomic identifier

266265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Adenosine deaminase HAMAP MF_00540		PRO_1000081921
Sites
	Active site	207	1	Potential
	Active site	255	1	Potential
	Active site	288	1	Potential
	Active site	289	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q13V90-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: BD35A6AA4A624641	FASTA	350	38,712
	10 20 30 40 50 60 MTTTTVTSTP LAEKTVLAPK AELHIHIEGS LEPELIFALA ERNGVKLAYD SIDALRAAYA 70 80 90 100 110 120 FTDLQSFLDI YYAGASVLLH EQDFYDMTMA YVERCLADNV VHSEIFFDPQ THTERGVPIA 130 140 150 160 170 180 TVVAGIERAL ADAEQRGMSS KLILCFLRHL SEEDALATFE EARPLFEQYR HRLIGVGLDS 190 200 210 220 230 240 SERGHPPSKF ERVFAKARSL GLKLVAHAGE EGPPSYIYEA LDLLKVDRVD HGVRSIEDPA 250 260 270 280 290 300 LVTRLADSRV ALTVCPLSNL KLCVFDDLTK HTLKDLLDRG VAVTVNSDDP AYFGGYVNAN 310 320 330 340 350 YLATIDALKL NDAEVYTIIR NSFEASFVTP GQRSELIAKL DAHWHPGGPH

References

[1]

"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility." Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L., Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J., Parnell J.J. , Ramette A., Richardson P., Seeger M., Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M. Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006) [PubMed: 17030797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000270 Genomic DNA. Translation: ABE31999.1.
RefSeq	YP_560051.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4003067.
GenomeReviews	Gene locus Bxeno_A3461 in contig CP000270_GR.
KEGG	bxe:Bxe_A0947.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q13V90.
OMA	LAQNSLD.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_BURXL

Accession

Primary (citable) accession number: Q13V90

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	August 22, 2006
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)