Reviewed, UniProtKB/Swiss-Prot Q13V49 (KGUA_BURXL)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	Bxeno_A3502
ORF Names:	Bxe_A0905

Organism

Burkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]

Taxonomic identifier

266265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Guanylate kinase HAMAP MF_00328		PRO_0000266299
Regions
	Domain	20 – 198	179	Guanylate kinase-like
	Nucleotide binding	27 – 34	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q13V49-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: ADEC71F0CD51F1F2	FASTA	225	25,306
	10 20 30 40 50 60 MTDHHTRETP RNPYAGAYPG NLFMVVAPSG AGKSTLVNAL LAGDDAIRLS ISYTTRPPRP 70 80 90 100 110 120 KELDGEHYHF TTVDDFMKRH DAGEFLESAE VHGNYYGTSR VWIEDQMKSG HDVLLEIDWQ 130 140 150 160 170 180 GAQQVKKQFH NAVEIFILPP SLEALEERLK KRGQDEPNVI TRRLLAAGSE MAHAAEAEYV 190 200 210 220 VINENFDRAL SELQCLVAAT RSRFASQYAR HTQLFVQLGI HLPHA

References

[1]

"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility." Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L., Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J., Parnell J.J. , Ramette A., Richardson P., Seeger M., Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M. Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006) [PubMed: 17030797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000270 Genomic DNA. Translation: ABE32040.1.
RefSeq	YP_560092.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4002827.
GenomeReviews	Gene locus Bxeno_A3502 in contig CP000270_GR.
KEGG	bxe:Bxe_A0905.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q13V49.
OMA	EWAEFAG.
Family and domain databases
HAMAP	MF_00328. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_BURXL

Accession

Primary (citable) accession number: Q13V49

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	August 22, 2006
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)