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Q13V14

- TRMB_BURXL

UniProt

Q13V14 - TRMB_BURXL

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901S-adenosyl-L-methionineUniRule annotation
Binding sitei115 – 1151S-adenosyl-L-methionineUniRule annotation
Binding sitei142 – 1421S-adenosyl-L-methionineUniRule annotation
Active sitei165 – 1651By similarity
Binding sitei165 – 1651S-adenosyl-L-methionineUniRule annotation
Binding sitei169 – 1691SubstrateUniRule annotation
Binding sitei201 – 2011SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBXEN266265:GJII-3689-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Bxeno_A3537
ORF Names:Bxe_A0859
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260tRNA (guanine-N(7)-)-methyltransferasePRO_0000288131Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_A0859.

Structurei

3D structure databases

ProteinModelPortaliQ13V14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni236 – 2394Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiQDNFLCC.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13V14-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIHDPNDAGL PDQLPTPSSE AENSPAGDTT PPEEALHRRR IRSFVTRAGR
60 70 80 90 100
VSTGQRRAMD ELGPRFVVPF APQQPDWNSV FGREAPRVLE IGFGMGATTA
110 120 130 140 150
EIASHRPDED FLGVEVHEPG VGALLKLMGE QNLSNIRIIQ HDAVEVLEQM
160 170 180 190 200
IAPDSLDGVH IFFPDPWHKA RHHKRRLIQP KFVALLVSRL KPGAYLHCAT
210 220 230 240 250
DWQNYAEQML EVLGAEPSLK NTADGYAPRP EYRPVTKFER RGLRLGHGVW
260
DLVFRKRGAG
Length:260
Mass (Da):29,078
Last modified:May 29, 2007 - v2
Checksum:i433D83F9E3C279D8
GO

Sequence cautioni

The sequence ABE32075.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000270 Genomic DNA. Translation: ABE32075.1. Different initiation.
RefSeqiYP_560127.1. NC_007951.1.

Genome annotation databases

EnsemblBacteriaiABE32075; ABE32075; Bxe_A0859.
GeneIDi4002874.
KEGGibxe:Bxe_A0859.
PATRICi19332855. VBIBurXen52548_3723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000270 Genomic DNA. Translation: ABE32075.1 . Different initiation.
RefSeqi YP_560127.1. NC_007951.1.

3D structure databases

ProteinModelPortali Q13V14.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266265.Bxe_A0859.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE32075 ; ABE32075 ; Bxe_A0859 .
GeneIDi 4002874.
KEGGi bxe:Bxe_A0859.
PATRICi 19332855. VBIBurXen52548_3723.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi QDNFLCC.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci BXEN266265:GJII-3689-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiTRMB_BURXL
AccessioniPrimary (citable) accession number: Q13V14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: October 1, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3