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Q13V14

- TRMB_BURXL

UniProt

Q13V14 - TRMB_BURXL

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei90 – 901S-adenosyl-L-methionineUniRule annotation
    Binding sitei115 – 1151S-adenosyl-L-methionineUniRule annotation
    Binding sitei142 – 1421S-adenosyl-L-methionineUniRule annotation
    Active sitei165 – 1651By similarity
    Binding sitei165 – 1651S-adenosyl-L-methionineUniRule annotation
    Binding sitei169 – 1691SubstrateUniRule annotation
    Binding sitei201 – 2011SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciBXEN266265:GJII-3689-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Bxeno_A3537
    ORF Names:Bxe_A0859
    OrganismiBurkholderia xenovorans (strain LB400)
    Taxonomic identifieri266265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001817: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260tRNA (guanine-N(7)-)-methyltransferasePRO_0000288131Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266265.Bxe_A0859.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13V14.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni236 – 2394Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiQDNFLCC.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13V14-1 [UniParc]FASTAAdd to Basket

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    MIHDPNDAGL PDQLPTPSSE AENSPAGDTT PPEEALHRRR IRSFVTRAGR    50
    VSTGQRRAMD ELGPRFVVPF APQQPDWNSV FGREAPRVLE IGFGMGATTA 100
    EIASHRPDED FLGVEVHEPG VGALLKLMGE QNLSNIRIIQ HDAVEVLEQM 150
    IAPDSLDGVH IFFPDPWHKA RHHKRRLIQP KFVALLVSRL KPGAYLHCAT 200
    DWQNYAEQML EVLGAEPSLK NTADGYAPRP EYRPVTKFER RGLRLGHGVW 250
    DLVFRKRGAG 260
    Length:260
    Mass (Da):29,078
    Last modified:May 29, 2007 - v2
    Checksum:i433D83F9E3C279D8
    GO

    Sequence cautioni

    The sequence ABE32075.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000270 Genomic DNA. Translation: ABE32075.1. Different initiation.
    RefSeqiYP_560127.1. NC_007951.1.

    Genome annotation databases

    EnsemblBacteriaiABE32075; ABE32075; Bxe_A0859.
    GeneIDi4002874.
    KEGGibxe:Bxe_A0859.
    PATRICi19332855. VBIBurXen52548_3723.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000270 Genomic DNA. Translation: ABE32075.1 . Different initiation.
    RefSeqi YP_560127.1. NC_007951.1.

    3D structure databases

    ProteinModelPortali Q13V14.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266265.Bxe_A0859.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE32075 ; ABE32075 ; Bxe_A0859 .
    GeneIDi 4002874.
    KEGGi bxe:Bxe_A0859.
    PATRICi 19332855. VBIBurXen52548_3723.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi QDNFLCC.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci BXEN266265:GJII-3689-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LB400.

    Entry informationi

    Entry nameiTRMB_BURXL
    AccessioniPrimary (citable) accession number: Q13V14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3