Q13V13 (UPPP1_BURXL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 1
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1

Gene names

Name:	uppP1
Ordered Locus Names:	Bxeno_A3538
ORF Names:	Bxe_A0858

Organism

Burkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]

Taxonomic identifier

266265 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia xenovorans

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Undecaprenyl-diphosphatase 1 HAMAP-Rule MF_01006		PRO_0000250230
Regions
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	108 – 128	21	Helical; Potential
	Transmembrane	188 – 208	21	Helical; Potential
	Transmembrane	218 – 238	21	Helical; Potential
	Transmembrane	254 – 274	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q13V13 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 93B4746F9C759F40	FASTA	278	30,134
	10 20 30 40 50 60 MDWLLACKAL ILGVVEGLTE FLPVSSTGHL IVAGSLLNFT DEHAKTFDVV IQLGAILAVC 70 80 90 100 110 120 WEYRRRIGSV VSGLPSRPDA RRFTLNVIIA TIPAIVLGLL FEKTIKAALF SPVPVAFALV 130 140 150 160 170 180 AGGVVILWAE SRQRTRGETV ARVQNVDDLG ALDALKVGLA QCFALIPGMS RSGSTIIGGM 190 200 210 220 230 240 LFGLDRRVAT EFSFFLAIPI IFGATAYELH KDWHLLSVDA LGTFALGFVA AFVSAFACVR 250 260 270 WLLRYIAAHD FTAFAWYRIG FGLLILLVGY SGALNWTE

References

[1]

"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility." Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L., Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J., Parnell J.J. , Ramette A., Richardson P., Seeger M., Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M. Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LB400.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000270 Genomic DNA. Translation: ABE32076.1.
RefSeq	YP_560128.1. NC_007951.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	266265.Bxe_A0858.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE32076; ABE32076; Bxe_A0858.
GeneID	4002875.
KEGG	bxe:Bxe_A0858.
PATRIC	19332857. VBIBurXen52548_3724.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	RWLLRYI.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	BXEN266265:GJII-3690-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP1_BURXL

Accession

Primary (citable) accession number: Q13V13

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	August 22, 2006
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program