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Protein

Catalase-peroxidase

Gene

katG

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei88 – 881Transition state stabilizerUniRule annotation
Active sitei92 – 921Proton acceptorUniRule annotation
Metal bindingi284 – 2841Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBXEN266265:GJII-3777-MONOMER.

Protein family/group databases

PeroxiBasei2290. BxCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Bxeno_A3624
ORF Names:Bxe_A0772
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeParaburkholderia
Proteomesi
  • UP000001817 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 753753Catalase-peroxidasePRO_0000354753Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki91 ↔ 243Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-269)UniRule annotation
Cross-linki243 ↔ 269Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ13US7.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi266265.Bxe_A0772.

Structurei

3D structure databases

ProteinModelPortaliQ13US7.
SMRiQ13US7. Positions 16-753.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 3 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13US7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEAKCPFN HAAGGGTTNR DWWPKQLRLD LLSQHSGKSN PLDGGFNYAE
60 70 80 90 100
AFRSLDLAAV KKDLAALMTD SQDWWPADFG HYGPLFIRMA WHSAGTYRIG
110 120 130 140 150
DGRGGAGRGQ QRFAPLNSWP DNVSLDKARR LLWPIKQKYG QKISWADLLI
160 170 180 190 200
LTGNVALETM GFKTFGFAGG REDTWEPDLD VYWGNEKTWL GGDVRYGKGA
210 220 230 240 250
AGDNDDGGVI VADEEKHGEE VSRDNSGRNL ENPLGAVQMG LIYVNPEGPD
260 270 280 290 300
GNPDPLAAAH DIRETFARMA MNDEETVALI AGGHTFGKTH GAGPADNVGP
310 320 330 340 350
EPEAADLENQ GLGWKNSFGT GKGADTITSG LEVTWTTTPT KWGNGFFENL
360 370 380 390 400
FKYEWELTKS PAGAHQWVAR DAGETIPHAH DPSKKLRPTM LTTDLSLRFD
410 420 430 440 450
PVYEKISRRF LENPDQLADA FARAWFKLTH RDMGPRARYL GPEVPAEELN
460 470 480 490 500
WQDPIPALDH PLVNEQDIAS LKQKILASGL SVSQLVSTAW ASASTFRGSD
510 520 530 540 550
KRGGANGARI RLAPQKDWPV NQPEQLAKVL KVLEGIQSEF NGVQSGGKKI
560 570 580 590 600
SLADLIVLGG AAAIEQAAKS AGQQVSVPFS PGRMDASQEQ TDVQSVAALE
610 620 630 640 650
PLADGFRNYL KGKYRAPAEA LLIDKAQLLT LTAPEMTVLL GGLRALNVHA
660 670 680 690 700
GQDSHGVFTH RPQTLSNDFF RNLLDMGTEW KPLSPARDVF EGRDRKTGEL
710 720 730 740 750
KWTGTRVDLV FGSHAQLRAL CEVYASEDAQ EKFVRDFVAA WAKVMDLDRF

EIA
Length:753
Mass (Da):82,467
Last modified:August 22, 2006 - v1
Checksum:i22250FE21A9D110F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE32162.1.
RefSeqiWP_011489662.1. NZ_CP008760.1.

Genome annotation databases

EnsemblBacteriaiABE32162; ABE32162; Bxe_A0772.
GeneIDi4005619.
KEGGibxb:DR64_2939.
bxe:Bxe_A0772.
PATRICi19333049. VBIBurXen52548_3819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE32162.1.
RefSeqiWP_011489662.1. NZ_CP008760.1.

3D structure databases

ProteinModelPortaliQ13US7.
SMRiQ13US7. Positions 16-753.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266265.Bxe_A0772.

Protein family/group databases

PeroxiBasei2290. BxCP01.

Proteomic databases

PRIDEiQ13US7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE32162; ABE32162; Bxe_A0772.
GeneIDi4005619.
KEGGibxb:DR64_2939.
bxe:Bxe_A0772.
PATRICi19333049. VBIBurXen52548_3819.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciBXEN266265:GJII-3777-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 3 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_BURXL
AccessioniPrimary (citable) accession number: Q13US7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: August 22, 2006
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.