Q13UP0 (KYNB_BURXL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
Short name=KFase
EC=3.5.1.9

Alternative name(s):
Arylformamidase
N-formylkynurenine formamidase
Short name=FKF

Gene names

Name:	kynB
Ordered Locus Names:	Bxeno_A3661
ORF Names:	Bxe_A0735

Organism

Burkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]

Taxonomic identifier

266265 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia xenovorans

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation By similarity. HAMAP-Rule MF_01969
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine. HAMAP-Rule MF_01969
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. HAMAP-Rule MF_01969
Sequence similarities	Belongs to the KynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Kynurenine formamidase HAMAP-Rule MF_01969		PRO_0000362119

Sequences

	Sequence		Length	Mass (Da)
	Q13UP0 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 8EB926EC71A801C8	FASTA	212	22,887
	10 20 30 40 50 60 MRTLWDITPA VDTATPVWPG DTPVGIERVW RMEAGSPVNV ARLTLSPHTG AHTDAPLHYD 70 80 90 100 110 120 AEGAAIGDVP LDAYLGRCRV IHCIGASPVV TPQHLTGSLD DLPPRVLLRT YRNAPTNVWD 130 140 150 160 170 180 SAFCAVAPDT IDLLASRGVK LIGIDTPSLD PQESKTMDAH HRIRAHRMAI LEGIVLDEVA 190 200 210 AGDYELIALP LKLTTLDASP VRAILRALPE SH

References

[1]

"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility." Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L., Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J., Parnell J.J. , Ramette A., Richardson P., Seeger M., Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M. Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LB400.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000270 Genomic DNA. Translation: ABE32199.1.
RefSeq	YP_560251.1. NC_007951.1.
3D structure databases
ProteinModelPortal	Q13UP0.
ModBase	Search...
Protein-protein interaction databases
STRING	266265.Bxe_A0735.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE32199; ABE32199; Bxe_A0735.
GeneID	4005675.
KEGG	bxe:Bxe_A0735.
PATRIC	19333129. VBIBurXen52548_3859.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1878.
HOGENOM	HOG000219455.
KO	K07130.
OMA	HTSKWPL.
ProtClustDB	CLSK930430.
Enzyme and pathway databases
BioCyc	BXEN266265:GJII-3814-MONOMER.
UniPathway	UPA00333; UER00454.
Family and domain databases
HAMAP	MF_01969. KynB.
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BURXL

Accession

Primary (citable) accession number: Q13UP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	August 22, 2006
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program