Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q13UC4

- PUR9_BURXL

UniProt

Q13UC4 - PUR9_BURXL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciBXEN266265:GJII-3931-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Bxeno_A3777
ORF Names:Bxe_A0619
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Bifunctional purine biosynthesis protein PurHPRO_1000018865Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_A0619.

Structurei

3D structure databases

ProteinModelPortaliQ13UC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13UC4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKQALISVS DKSGIVDFAK SLSDLGVRIL STGGTAKLLA DAGLSVTEVA
60 70 80 90 100
DYTGFPEMLD GRVKTLHPKV HGGILARRDL PEHMAALEKH DIPTIDLLVV
110 120 130 140 150
NLYPFVQTVS KEECSLEDAI ENIDIGGPTM LRSAAKNHRD VTVVVDPADY
160 170 180 190 200
AVVLDEMRAN SNAVSYKTNF RLATKVFAHT AQYDGAITNY LTSLTDELQH
210 220 230 240 250
SSRNAYPATF NLAFNKAQDL RYGENPHQSA AFYRDLSVPA GALANYNQLQ
260 270 280 290 300
GKELSYNNIA DSDAAWECVK TFDVPACVIV KHANPCGVAV GADANEAYAK
310 320 330 340 350
AFQTDPTSAF GGIIAFNREV DEAAAQAVAR QFVEVLIAPS FSAAARQVFA
360 370 380 390 400
AKQNVRLLEI ALGDGHNAFD LKRVGGGLLV QSLDSKNVQP RELRVVTKRH
410 420 430 440 450
PTPKEMDDLL FAWRVAKYVK SNAIVFCGNG MTLGVGAGQM SRVDSARIAS
460 470 480 490 500
IKAQNAGLTL AGSAVASDAF FPFRDGLDVV VAAGATCVIQ PGGSMRDEEV
510 520
VSAADEHNIA MVLTGVRHFR H
Length:521
Mass (Da):55,935
Last modified:August 22, 2006 - v1
Checksum:i70D3AA5DFB633A4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE32315.1.
RefSeqiWP_011489803.1. NC_007951.1.
YP_560367.1. NC_007951.1.

Genome annotation databases

EnsemblBacteriaiABE32315; ABE32315; Bxe_A0619.
GeneIDi4005792.
KEGGibxe:Bxe_A0619.
PATRICi19333401. VBIBurXen52548_3994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE32315.1 .
RefSeqi WP_011489803.1. NC_007951.1.
YP_560367.1. NC_007951.1.

3D structure databases

ProteinModelPortali Q13UC4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266265.Bxe_A0619.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE32315 ; ABE32315 ; Bxe_A0619 .
GeneIDi 4005792.
KEGGi bxe:Bxe_A0619.
PATRICi 19333401. VBIBurXen52548_3994.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci BXEN266265:GJII-3931-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiPUR9_BURXL
AccessioniPrimary (citable) accession number: Q13UC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3