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Q13UA8 (Q13UA8_BURXL) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase HAMAP-Rule MF_00219
Short name=DHOase HAMAP-Rule MF_00219
EC=3.5.2.3 HAMAP-Rule MF_00219
Gene names
Name:pyrC HAMAP-Rule MF_00219
Ordered Locus Names:Bxeno_A3793
ORF Names:Bxe_A0602 EMBL ABE32331.1
OrganismBurkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]
Taxonomic identifier266265 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia ›

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP-Rule MF_00219 RuleBase RU003440 SAAS SAAS002195

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP-Rule MF_00219 RuleBase RU003440 SAAS SAAS002195

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP-Rule MF_00219 RuleBase RU003440 SAAS SAAS002195

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00219 SAAS SAAS002195

Sequence similarities

Belongs to the DHOase family. Type 1 subfamily. HAMAP-Rule MF_00219 RuleBase RU003440

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding201Zinc 1 By similarity HAMAP-Rule MF_00219
Metal binding221Zinc 1 By similarity HAMAP-Rule MF_00219
Metal binding1061Zinc 1; via carbamate group By similarity HAMAP-Rule MF_00219
Metal binding1061Zinc 2; via carbamate group By similarity HAMAP-Rule MF_00219
Metal binding1431Zinc 2 By similarity HAMAP-Rule MF_00219
Metal binding1811Zinc 2 By similarity HAMAP-Rule MF_00219
Metal binding2571Zinc 1 By similarity HAMAP-Rule MF_00219

Amino acid modifications

Modified residue1061N6-carboxylysine By similarity HAMAP-Rule MF_00219

Sequences

Sequence LengthMass (Da)Tools
Q13UA8 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: FE7699FCB8B93A68

FASTA35338,807
        10         20         30         40         50         60 
MTASNASLDS ITLARPDDWH LHVRDGAMLA AVLPDTARQF GRAIIMPNLK PPVTTTAMAQ 

        70         80         90        100        110        120 
AYRERIVTAI PEGAKFEPLM TLYLTDNTPP DEIRRARESG FVHGVKLYPA GATTNSDAGV 

       130        140        150        160        170        180 
TDIMKCAKTL EVMQELGMPL LVHGEVTDAS IDLFDREKVF IDRVMTPLRR AFPALKVVFE 

       190        200        210        220        230        240 
HITTKDAVDY IREAGVAPEV LGATITAHHL LYNRNAIFQG GIRPHYYCLP VLKRETHRVA 

       250        260        270        280        290        300 
LVEAATSGNP RFFLGTDSAP HPKGLKEHAC GCAGCYTALH ALELYTEAFD KAGALDKLEG 

       310        320        330        340        350 
FASFFGADFY GLPRNEEKVT LRREEWTLPA ELPVGDTPVV PLRGGESIGW RLV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000270 Genomic DNA. Translation: ABE32331.1.
RefSeqYP_560383.1. NC_007951.1.

3D structure databases

ProteinModelPortalQ13UA8.
SMRQ13UA8. Positions 9-352.
ModBaseSearch...

Protein-protein interaction databases

STRING266265.Bxe_A0602.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE32331; ABE32331; Bxe_A0602.
GeneID4005809.
KEGGbxe:Bxe_A0602.
PATRIC19333435. VBIBurXen52548_4011.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0418.
HOGENOMHOG000256259.
KOK01465.
OMAMTLYLTE.
ProtClustDBPRK05451.

Enzyme and pathway databases

BioCycBXEN266265:GJII-3948-MONOMER.
UniPathwayUPA00070; UER00117.

Family and domain databases

HAMAPMF_00219. PyrC_type1.
InterProIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsTIGR00856. pyrC_dimer. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ13UA8_BURXL
AccessionPrimary (citable) accession number: Q13UA8
Entry history
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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