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Protein

Adenylosuccinate lyase

Gene

Bxe_A0593

Organism
Paraburkholderia xenovorans (strain LB400)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi: AMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes AMP from IMP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Adenylosuccinate synthetase (purA)
  2. Adenylosuccinate lyase (Bxe_A0593)
This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (Bxe_A0593)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processPurine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
ORF Names:Bxe_A0593Imported
OrganismiParaburkholderia xenovorans (strain LB400)Imported
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeParaburkholderia
Proteomesi
  • UP000001817 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_A0593.

Structurei

3D structure databases

ProteinModelPortaliQ13U99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 318Lyase_1InterPro annotationAdd BLAST299
Domaini337 – 451ASL_CInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QTF. Bacteria.
COG0015. LUCA.
HOGENOMiHOG000252916.
KOiK01756.
OMAiTQVNPCD.
OrthoDBiPOG091H01RB.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiView protein in InterPro
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
IPR013539. PurB_C.
PfamiView protein in Pfam
PF08328. ASL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiView protein in PROSITE
PS00163. FUMARATE_LYASES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13U99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTRPDTLF ALNALSPLDG RYASKTEALR DWLSEAAFMR NRVTVEIHWL
60 70 80 90 100
IALSHAGFAE VPRFSEAAEQ FLLQLAERFT AHDAARIKEI ERVTNHDVKA
110 120 130 140 150
VEYWLKESVK GQEELERASE FIHFACTSED INNTSHGLML AGAREHVILP
160 170 180 190 200
ALRSVHQRLV ALAHTLADQS MLSRTHGQPA SPTTLGKEIA NVAARLERAI
210 220 230 240 250
DRIAKVELLG KMNGAVGNFN AHLSAYPEFD WEAFSREVVE QRLKLTFNPY
260 270 280 290 300
TIQIEPHDYM AELFDAMSRA NTILLDLDRD VWGYISVGYF KQRTKAGEIG
310 320 330 340 350
SSTMPHKVNP IDFENSEGNL GLANATLRHL ADKLPVSRWQ RDLTDSTVLR
360 370 380 390 400
NIGVAFGYSL LAYDSLIRGL DKLEVNAQRL HEDLDNCWEV LAEPVQTVMR
410 420 430 440 450
RYGIENPYEQ LKELTRGKGI TREALQTFVS GLAIPQDAKD RLLAMTPASY
460
VGKAAELARR IA
Length:462
Mass (Da):51,921
Last modified:August 22, 2006 - v1
Checksum:i77E8F7F87DB424C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE32340.1.
RefSeqiWP_011489822.1. NZ_CP008760.1.

Genome annotation databases

EnsemblBacteriaiABE32340; ABE32340; Bxe_A0593.
GeneIDi4005818.
KEGGibxb:DR64_2763.
bxe:Bxe_A0593.
PATRICifig|266265.5.peg.4021.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ13U99_PARXL
AccessioniPrimary (citable) accession number: Q13U99
Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: June 7, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported