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Q13U82

- SYL_BURXL

UniProt

Q13U82 - SYL_BURXL

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei626 – 6261ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBXEN266265:GJII-3974-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Bxeno_A3819
    ORF Names:Bxe_A0576
    OrganismiBurkholderia xenovorans (strain LB400)
    Taxonomic identifieri266265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001817: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 863863Leucine--tRNA ligasePRO_1000009314Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266265.Bxe_A0576.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13U82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi623 – 6275"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13U82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHEKYVPSDV ESAAQGQWRA IDAYKTTEVT DKPKFYCVSM LPYPSGKLHM    50
    GHVRNYTIND VMYRYLRMNG YNVLMPMGWD AFGMPAENAA MANNVPPAKW 100
    TYDNIAYMKK QMQSMGLAID WSREVATCSP DYYKWNQWLF LKMLEKGIAY 150
    KKTGTVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKREIPM YYMRITQYAD 200
    ELLNDLEGLG WPERVKIMQQ NWIGKSFGVN FGFPYEIDGE QKLLRVFTTR 250
    ADTIMGVTFC AIAAEHPLAT RLAKDKPELQ AFIEECKRGG VAEADVATME 300
    KKGMATGFTV THPLTQEQVE VWIGNYVLMS YGEGAVMGVP AHDERDFAFV 350
    KKYGLPVRQV VAVEGKEFST EAWQEWYGEK TGTLINSGKY DGLNYEQAVD 400
    RIAADLKELG LGDKQITWRL RDWGVSRQRY WGTPIPIIHC PTCGDVPVPE 450
    KDLPVVLPED LVPDGTGNPL ARSEAFVNCT CPTCGGAAKR ETDTMDTFVD 500
    SSWYFYRYAS PGAKTMVDER TDYWAPMDQY IGGIEHAILH LLYSRFWAKV 550
    MRDLGLIRFG EPAKNLLTQG MVLNETYYRE NEAGKKTWYN PAEVTVSFDD 600
    KGRPVGAILN EDGQPVVLGG VEKMSKSKNN GVDPQLLIDQ HGADTARLFV 650
    MFAAPPEQSL EWSGSGVEGA SRFLRRVWSF SQANEAALRQ GGTFDAAQLS 700
    DVEKVLRREI YSVLKQADFD YQRLQYNTVV SAAMKMLNAL DSAKGARPAV 750
    LRETCSVMLR VLYPVVPHLT FQLWQELGYA DELGSLLDAP WPKVDEKALE 800
    QSEIELVLQV NGKVRGAITV AKDASREAIE QLAAAHEMVA KFSEGKAPKK 850
    IVVVPGRLVN VVV 863
    Length:863
    Mass (Da):96,985
    Last modified:August 22, 2006 - v1
    Checksum:iC4CA8F1BAC7F1069
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000270 Genomic DNA. Translation: ABE32357.1.
    RefSeqiYP_560409.1. NC_007951.1.

    Genome annotation databases

    EnsemblBacteriaiABE32357; ABE32357; Bxe_A0576.
    GeneIDi4005835.
    KEGGibxe:Bxe_A0576.
    PATRICi19333483. VBIBurXen52548_4035.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000270 Genomic DNA. Translation: ABE32357.1 .
    RefSeqi YP_560409.1. NC_007951.1.

    3D structure databases

    ProteinModelPortali Q13U82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266265.Bxe_A0576.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE32357 ; ABE32357 ; Bxe_A0576 .
    GeneIDi 4005835.
    KEGGi bxe:Bxe_A0576.
    PATRICi 19333483. VBIBurXen52548_4035.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BXEN266265:GJII-3974-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LB400.

    Entry informationi

    Entry nameiSYL_BURXL
    AccessioniPrimary (citable) accession number: Q13U82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3