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Q13U82

- SYL_BURXL

UniProt

Q13U82 - SYL_BURXL

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei626 – 6261ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBXEN266265:GJII-3974-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Bxeno_A3819
ORF Names:Bxe_A0576
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Leucine--tRNA ligasePRO_1000009314Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_A0576.

Structurei

3D structure databases

ProteinModelPortaliQ13U82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi623 – 6275"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13U82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHEKYVPSDV ESAAQGQWRA IDAYKTTEVT DKPKFYCVSM LPYPSGKLHM
60 70 80 90 100
GHVRNYTIND VMYRYLRMNG YNVLMPMGWD AFGMPAENAA MANNVPPAKW
110 120 130 140 150
TYDNIAYMKK QMQSMGLAID WSREVATCSP DYYKWNQWLF LKMLEKGIAY
160 170 180 190 200
KKTGTVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKREIPM YYMRITQYAD
210 220 230 240 250
ELLNDLEGLG WPERVKIMQQ NWIGKSFGVN FGFPYEIDGE QKLLRVFTTR
260 270 280 290 300
ADTIMGVTFC AIAAEHPLAT RLAKDKPELQ AFIEECKRGG VAEADVATME
310 320 330 340 350
KKGMATGFTV THPLTQEQVE VWIGNYVLMS YGEGAVMGVP AHDERDFAFV
360 370 380 390 400
KKYGLPVRQV VAVEGKEFST EAWQEWYGEK TGTLINSGKY DGLNYEQAVD
410 420 430 440 450
RIAADLKELG LGDKQITWRL RDWGVSRQRY WGTPIPIIHC PTCGDVPVPE
460 470 480 490 500
KDLPVVLPED LVPDGTGNPL ARSEAFVNCT CPTCGGAAKR ETDTMDTFVD
510 520 530 540 550
SSWYFYRYAS PGAKTMVDER TDYWAPMDQY IGGIEHAILH LLYSRFWAKV
560 570 580 590 600
MRDLGLIRFG EPAKNLLTQG MVLNETYYRE NEAGKKTWYN PAEVTVSFDD
610 620 630 640 650
KGRPVGAILN EDGQPVVLGG VEKMSKSKNN GVDPQLLIDQ HGADTARLFV
660 670 680 690 700
MFAAPPEQSL EWSGSGVEGA SRFLRRVWSF SQANEAALRQ GGTFDAAQLS
710 720 730 740 750
DVEKVLRREI YSVLKQADFD YQRLQYNTVV SAAMKMLNAL DSAKGARPAV
760 770 780 790 800
LRETCSVMLR VLYPVVPHLT FQLWQELGYA DELGSLLDAP WPKVDEKALE
810 820 830 840 850
QSEIELVLQV NGKVRGAITV AKDASREAIE QLAAAHEMVA KFSEGKAPKK
860
IVVVPGRLVN VVV
Length:863
Mass (Da):96,985
Last modified:August 22, 2006 - v1
Checksum:iC4CA8F1BAC7F1069
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000270 Genomic DNA. Translation: ABE32357.1.
RefSeqiYP_560409.1. NC_007951.1.

Genome annotation databases

EnsemblBacteriaiABE32357; ABE32357; Bxe_A0576.
GeneIDi4005835.
KEGGibxe:Bxe_A0576.
PATRICi19333483. VBIBurXen52548_4035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000270 Genomic DNA. Translation: ABE32357.1 .
RefSeqi YP_560409.1. NC_007951.1.

3D structure databases

ProteinModelPortali Q13U82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266265.Bxe_A0576.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE32357 ; ABE32357 ; Bxe_A0576 .
GeneIDi 4005835.
KEGGi bxe:Bxe_A0576.
PATRICi 19333483. VBIBurXen52548_4035.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BXEN266265:GJII-3974-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiSYL_BURXL
AccessioniPrimary (citable) accession number: Q13U82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3