Q13U45 (Q13U45_BURXL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase 1 HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE1 HAMAP MF_00222
Ordered Locus Names:	Bxeno_A3856
ORF Names:	Bxe_A0539 EMBL ABE32394.1

Organism

Burkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]

Taxonomic identifier

266265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222 SAAS SAAS011342
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222 SAAS SAAS011342
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222 SAAS SAAS011342
Ligand	NADP HAMAP MF_00222 SAAS SAAS011342
Molecular function	Oxidoreductase HAMAP MF_00222 RuleBase RU004037 SAAS SAAS011342 EMBL ABE32394.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	132 – 136	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	71	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	Q13U45 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: B9ED24DA6AE97335	FASTA	287	29,845
	10 20 30 40 50 60 MSAGDSLDRY AVIGNPVGHS KSPFIHGRFA EQTGEAIEYG RLLAPVDAFV PTVRAFIEAG 70 80 90 100 110 120 GRGLNVTVPF KLEACTFADT LSPRAAAAGA VNTLRVDANG IYGDNTDGFG LVRDIEVNLG 130 140 150 160 170 180 VSLKGARILL LGAGGAARGV VLPILERAPH TLTIINRTAQ KAEALVDQFA QAARDAACRL 190 200 210 220 230 240 GGGSARAIEA GAYDVIVNAT AGSLDASLPE CDDRAFGSGT LAYDMMYGAH PTVFMEHARK 250 260 270 280 LGARGADGLG MLVEQAAESF YVWRGVRPDG APVLAELRAL LTAPSHA

References

[1]

"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility." Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L., Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J., Parnell J.J. , Ramette A., Richardson P., Seeger M., Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M. Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006) [PubMed: 17030797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000270 Genomic DNA. Translation: ABE32394.1.
RefSeq	YP_560446.1. NC_007951.1.
3D structure databases
ProteinModelPortal	Q13U45.
ModBase	Search...
Protein-protein interaction databases
STRING	Q13U45.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4005872.
GenomeReviews	Gene locus Bxeno_A3856 in contig CP000270_GR.
KEGG	bxe:Bxe_A0539.
PATRIC	19333563. VBIBurXen52548_4075.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	VVFGNPI.
PhylomeDB	Q13U45.
ProtClustDB	PRK00258.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q13U45_BURXL

Accession

Primary (citable) accession number: Q13U45

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)