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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBXEN266265:GJII-4512-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Bxeno_A4335
ORF Names:Bxe_A0054
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 978978Glycine dehydrogenase (decarboxylating)PRO_1000045578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei726 – 7261N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi266265.Bxe_A0054.

Structurei

3D structure databases

ProteinModelPortaliQ13SR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13SR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLEHPDRLM NRTPLSLAAL EVHDAFAERH IGPDSADQQA MLEALGFASR
60 70 80 90 100
AALIDAVIPK TIRRTEPLPL GPFAQPKSEA EALATLRELA DRNQVFRSYI
110 120 130 140 150
GQGYYNAHTP TVILRNVLEN PAWYTAYTPY QPEISQGRLE ALLNFQQMIV
160 170 180 190 200
DLTGLAISNA SLLDEATAAA EAMTLLQRIG KPKSNVFYVA DDVLPQTIEV
210 220 230 240 250
VKTRATPVGI EVKVGPAADA ANANAFGVLL QYPGVNGDVR DYRALAEAIH
260 270 280 290 300
AAGGHVVVAA DLLALTVLTP PGEWGADVAV GNTQRFGVPV GFGGPHAAYL
310 320 330 340 350
AVRDEFKRQM PGRLVGVTVD AQGNPALRLA LQTREQHIRR EKATSNVCTA
360 370 380 390 400
QALLAIMASM YAVYHGPHGL KTIALRVNRI AALLAEGAKQ LGYTLVNETF
410 420 430 440 450
FDTLTFETGA RTQALHDAAL AKRINLRRVS DTQVGLSVDE TTTRRDLADL
460 470 480 490 500
LEVFAQAAGA KIVPQVDALD STIAASDTAS VPPALERTSA YLTHHVFNRH
510 520 530 540 550
HSETEMLRYL RSLSDKDLAL DRSMIPLGSC TMKLNATSEM LPVTWPEFGQ
560 570 580 590 600
IHPFAPAEQT VGYREMIDQL EAMLVAATGY AAVSLQPNAG SQGEYAGLLI
610 620 630 640 650
IHAYHASRGE AHRNVCLIPA SAHGTNPASA HMAGMQVIVV ACDAQGNVDI
660 670 680 690 700
EDLKKKAEQH ADKLAAIMIT YPSTHGVFEQ NVREICEIVH AHGGQVYVDG
710 720 730 740 750
ANMNAMVGLT APGQFGGDVS HLNLHKTFCI PHGGGGPGVG PVAVGAHLAQ
760 770 780 790 800
FLPNQISSGY ERAPNGIGAV SGAPYGSASI LPISWMYIAM MGAKNLTAAT
810 820 830 840 850
ETAILNANYV AKKLAPHYPV LYSGPGGLVA HECILDLRPI KETSGITVDD
860 870 880 890 900
VAKRLADYGF HAPTMSFPVP GTLMVEPTES ESKEELDRFI EAMIAIREEI
910 920 930 940 950
RAVEEGRSDR EDNPLKHAPH TAAVVIANDW KHAYARETAA YPLPTLIAKK
960 970
YWPPVGRADN VYGDRNLFCS CVPIADYE
Length:978
Mass (Da):105,253
Last modified:August 22, 2006 - v1
Checksum:i7B74B5CD79035C11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE32873.1.
RefSeqiWP_011490275.1. NC_007951.1.
YP_560925.1. NC_007951.1.

Genome annotation databases

EnsemblBacteriaiABE32873; ABE32873; Bxe_A0054.
GeneIDi4006373.
KEGGibxe:Bxe_A0054.
PATRICi19334562. VBIBurXen52548_4557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE32873.1.
RefSeqiWP_011490275.1. NC_007951.1.
YP_560925.1. NC_007951.1.

3D structure databases

ProteinModelPortaliQ13SR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266265.Bxe_A0054.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE32873; ABE32873; Bxe_A0054.
GeneIDi4006373.
KEGGibxe:Bxe_A0054.
PATRICi19334562. VBIBurXen52548_4557.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciBXEN266265:GJII-4512-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiGCSP_BURXL
AccessioniPrimary (citable) accession number: Q13SR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: May 27, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.