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Q13SR6

- GCSP_BURXL

UniProt

Q13SR6 - GCSP_BURXL

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBXEN266265:GJII-4512-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Bxeno_A4335
    ORF Names:Bxe_A0054
    OrganismiBurkholderia xenovorans (strain LB400)
    Taxonomic identifieri266265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001817: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 978978Glycine dehydrogenase (decarboxylating)PRO_1000045578Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei726 – 7261N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi266265.Bxe_A0054.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13SR6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q13SR6-1 [UniParc]FASTAAdd to Basket

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    MKLEHPDRLM NRTPLSLAAL EVHDAFAERH IGPDSADQQA MLEALGFASR    50
    AALIDAVIPK TIRRTEPLPL GPFAQPKSEA EALATLRELA DRNQVFRSYI 100
    GQGYYNAHTP TVILRNVLEN PAWYTAYTPY QPEISQGRLE ALLNFQQMIV 150
    DLTGLAISNA SLLDEATAAA EAMTLLQRIG KPKSNVFYVA DDVLPQTIEV 200
    VKTRATPVGI EVKVGPAADA ANANAFGVLL QYPGVNGDVR DYRALAEAIH 250
    AAGGHVVVAA DLLALTVLTP PGEWGADVAV GNTQRFGVPV GFGGPHAAYL 300
    AVRDEFKRQM PGRLVGVTVD AQGNPALRLA LQTREQHIRR EKATSNVCTA 350
    QALLAIMASM YAVYHGPHGL KTIALRVNRI AALLAEGAKQ LGYTLVNETF 400
    FDTLTFETGA RTQALHDAAL AKRINLRRVS DTQVGLSVDE TTTRRDLADL 450
    LEVFAQAAGA KIVPQVDALD STIAASDTAS VPPALERTSA YLTHHVFNRH 500
    HSETEMLRYL RSLSDKDLAL DRSMIPLGSC TMKLNATSEM LPVTWPEFGQ 550
    IHPFAPAEQT VGYREMIDQL EAMLVAATGY AAVSLQPNAG SQGEYAGLLI 600
    IHAYHASRGE AHRNVCLIPA SAHGTNPASA HMAGMQVIVV ACDAQGNVDI 650
    EDLKKKAEQH ADKLAAIMIT YPSTHGVFEQ NVREICEIVH AHGGQVYVDG 700
    ANMNAMVGLT APGQFGGDVS HLNLHKTFCI PHGGGGPGVG PVAVGAHLAQ 750
    FLPNQISSGY ERAPNGIGAV SGAPYGSASI LPISWMYIAM MGAKNLTAAT 800
    ETAILNANYV AKKLAPHYPV LYSGPGGLVA HECILDLRPI KETSGITVDD 850
    VAKRLADYGF HAPTMSFPVP GTLMVEPTES ESKEELDRFI EAMIAIREEI 900
    RAVEEGRSDR EDNPLKHAPH TAAVVIANDW KHAYARETAA YPLPTLIAKK 950
    YWPPVGRADN VYGDRNLFCS CVPIADYE 978
    Length:978
    Mass (Da):105,253
    Last modified:August 22, 2006 - v1
    Checksum:i7B74B5CD79035C11
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000270 Genomic DNA. Translation: ABE32873.1.
    RefSeqiWP_011490275.1. NC_007951.1.
    YP_560925.1. NC_007951.1.

    Genome annotation databases

    EnsemblBacteriaiABE32873; ABE32873; Bxe_A0054.
    GeneIDi4006373.
    KEGGibxe:Bxe_A0054.
    PATRICi19334562. VBIBurXen52548_4557.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000270 Genomic DNA. Translation: ABE32873.1 .
    RefSeqi WP_011490275.1. NC_007951.1.
    YP_560925.1. NC_007951.1.

    3D structure databases

    ProteinModelPortali Q13SR6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266265.Bxe_A0054.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE32873 ; ABE32873 ; Bxe_A0054 .
    GeneIDi 4006373.
    KEGGi bxe:Bxe_A0054.
    PATRICi 19334562. VBIBurXen52548_4557.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BXEN266265:GJII-4512-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LB400.

    Entry informationi

    Entry nameiGCSP_BURXL
    AccessioniPrimary (citable) accession number: Q13SR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3