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Q13SR6

- GCSP_BURXL

UniProt

Q13SR6 - GCSP_BURXL

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Bxeno_A4335, Bxe_A0054
Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBXEN266265:GJII-4512-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Bxeno_A4335
ORF Names:Bxe_A0054
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 978978Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei726 – 7261N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi266265.Bxe_A0054.

Structurei

3D structure databases

ProteinModelPortaliQ13SR6.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13SR6-1 [UniParc]FASTAAdd to Basket

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MKLEHPDRLM NRTPLSLAAL EVHDAFAERH IGPDSADQQA MLEALGFASR    50
AALIDAVIPK TIRRTEPLPL GPFAQPKSEA EALATLRELA DRNQVFRSYI 100
GQGYYNAHTP TVILRNVLEN PAWYTAYTPY QPEISQGRLE ALLNFQQMIV 150
DLTGLAISNA SLLDEATAAA EAMTLLQRIG KPKSNVFYVA DDVLPQTIEV 200
VKTRATPVGI EVKVGPAADA ANANAFGVLL QYPGVNGDVR DYRALAEAIH 250
AAGGHVVVAA DLLALTVLTP PGEWGADVAV GNTQRFGVPV GFGGPHAAYL 300
AVRDEFKRQM PGRLVGVTVD AQGNPALRLA LQTREQHIRR EKATSNVCTA 350
QALLAIMASM YAVYHGPHGL KTIALRVNRI AALLAEGAKQ LGYTLVNETF 400
FDTLTFETGA RTQALHDAAL AKRINLRRVS DTQVGLSVDE TTTRRDLADL 450
LEVFAQAAGA KIVPQVDALD STIAASDTAS VPPALERTSA YLTHHVFNRH 500
HSETEMLRYL RSLSDKDLAL DRSMIPLGSC TMKLNATSEM LPVTWPEFGQ 550
IHPFAPAEQT VGYREMIDQL EAMLVAATGY AAVSLQPNAG SQGEYAGLLI 600
IHAYHASRGE AHRNVCLIPA SAHGTNPASA HMAGMQVIVV ACDAQGNVDI 650
EDLKKKAEQH ADKLAAIMIT YPSTHGVFEQ NVREICEIVH AHGGQVYVDG 700
ANMNAMVGLT APGQFGGDVS HLNLHKTFCI PHGGGGPGVG PVAVGAHLAQ 750
FLPNQISSGY ERAPNGIGAV SGAPYGSASI LPISWMYIAM MGAKNLTAAT 800
ETAILNANYV AKKLAPHYPV LYSGPGGLVA HECILDLRPI KETSGITVDD 850
VAKRLADYGF HAPTMSFPVP GTLMVEPTES ESKEELDRFI EAMIAIREEI 900
RAVEEGRSDR EDNPLKHAPH TAAVVIANDW KHAYARETAA YPLPTLIAKK 950
YWPPVGRADN VYGDRNLFCS CVPIADYE 978
Length:978
Mass (Da):105,253
Last modified:August 22, 2006 - v1
Checksum:i7B74B5CD79035C11
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000270 Genomic DNA. Translation: ABE32873.1.
RefSeqiWP_011490275.1. NC_007951.1.
YP_560925.1. NC_007951.1.

Genome annotation databases

EnsemblBacteriaiABE32873; ABE32873; Bxe_A0054.
GeneIDi4006373.
KEGGibxe:Bxe_A0054.
PATRICi19334562. VBIBurXen52548_4557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000270 Genomic DNA. Translation: ABE32873.1 .
RefSeqi WP_011490275.1. NC_007951.1.
YP_560925.1. NC_007951.1.

3D structure databases

ProteinModelPortali Q13SR6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 266265.Bxe_A0054.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE32873 ; ABE32873 ; Bxe_A0054 .
GeneIDi 4006373.
KEGGi bxe:Bxe_A0054.
PATRICi 19334562. VBIBurXen52548_4557.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BXEN266265:GJII-4512-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiGCSP_BURXL
AccessioniPrimary (citable) accession number: Q13SR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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