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Q13SR6 (GCSP_BURXL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Bxeno_A4335
ORF Names:Bxe_A0054
OrganismBurkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]
Taxonomic identifier266265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia

Protein attributes

Sequence length978 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 978978Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045578

Amino acid modifications

Modified residue7261N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q13SR6 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 7B74B5CD79035C11

FASTA978105,253
        10         20         30         40         50         60 
MKLEHPDRLM NRTPLSLAAL EVHDAFAERH IGPDSADQQA MLEALGFASR AALIDAVIPK 

        70         80         90        100        110        120 
TIRRTEPLPL GPFAQPKSEA EALATLRELA DRNQVFRSYI GQGYYNAHTP TVILRNVLEN 

       130        140        150        160        170        180 
PAWYTAYTPY QPEISQGRLE ALLNFQQMIV DLTGLAISNA SLLDEATAAA EAMTLLQRIG 

       190        200        210        220        230        240 
KPKSNVFYVA DDVLPQTIEV VKTRATPVGI EVKVGPAADA ANANAFGVLL QYPGVNGDVR 

       250        260        270        280        290        300 
DYRALAEAIH AAGGHVVVAA DLLALTVLTP PGEWGADVAV GNTQRFGVPV GFGGPHAAYL 

       310        320        330        340        350        360 
AVRDEFKRQM PGRLVGVTVD AQGNPALRLA LQTREQHIRR EKATSNVCTA QALLAIMASM 

       370        380        390        400        410        420 
YAVYHGPHGL KTIALRVNRI AALLAEGAKQ LGYTLVNETF FDTLTFETGA RTQALHDAAL 

       430        440        450        460        470        480 
AKRINLRRVS DTQVGLSVDE TTTRRDLADL LEVFAQAAGA KIVPQVDALD STIAASDTAS 

       490        500        510        520        530        540 
VPPALERTSA YLTHHVFNRH HSETEMLRYL RSLSDKDLAL DRSMIPLGSC TMKLNATSEM 

       550        560        570        580        590        600 
LPVTWPEFGQ IHPFAPAEQT VGYREMIDQL EAMLVAATGY AAVSLQPNAG SQGEYAGLLI 

       610        620        630        640        650        660 
IHAYHASRGE AHRNVCLIPA SAHGTNPASA HMAGMQVIVV ACDAQGNVDI EDLKKKAEQH 

       670        680        690        700        710        720 
ADKLAAIMIT YPSTHGVFEQ NVREICEIVH AHGGQVYVDG ANMNAMVGLT APGQFGGDVS 

       730        740        750        760        770        780 
HLNLHKTFCI PHGGGGPGVG PVAVGAHLAQ FLPNQISSGY ERAPNGIGAV SGAPYGSASI 

       790        800        810        820        830        840 
LPISWMYIAM MGAKNLTAAT ETAILNANYV AKKLAPHYPV LYSGPGGLVA HECILDLRPI 

       850        860        870        880        890        900 
KETSGITVDD VAKRLADYGF HAPTMSFPVP GTLMVEPTES ESKEELDRFI EAMIAIREEI 

       910        920        930        940        950        960 
RAVEEGRSDR EDNPLKHAPH TAAVVIANDW KHAYARETAA YPLPTLIAKK YWPPVGRADN 

       970 
VYGDRNLFCS CVPIADYE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000270 Genomic DNA. Translation: ABE32873.1.
RefSeqYP_560925.1. NC_007951.1.

3D structure databases

ProteinModelPortalQ13SR6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266265.Bxe_A0054.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE32873; ABE32873; Bxe_A0054.
GeneID4006373.
KEGGbxe:Bxe_A0054.
PATRIC19334562. VBIBurXen52548_4557.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycBXEN266265:GJII-4512-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_BURXL
AccessionPrimary (citable) accession number: Q13SR6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families