Q13SQ6 (DCUP_BURXL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Bxeno_A4345
ORF Names:	Bxe_A0044

Organism

Burkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]

Taxonomic identifier

266265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm By similarity HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_1000023886
Regions
	Region	28 – 32	5	Substrate binding By similarity
Sites
	Binding site	78	1	Substrate By similarity
	Binding site	160	1	Substrate By similarity
	Binding site	215	1	Substrate By similarity
	Binding site	333	1	Substrate By similarity
	Site	78	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q13SQ6 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 96ACA571C723CCB7	FASTA	366	40,018
	10 20 30 40 50 60 MAHKLLNDTF LRALLRQPTD YTPIWLMRQA GRYLPEYNAT RARAGSFLGL AKNPAFATEV 70 80 90 100 110 120 TLQPLERYPL DAAILFSDIL TVPDAMGLGL EFVTGEGPKF ARPVRTEDDV ARLAVPDIDA 130 140 150 160 170 180 TLRYVTDAVR EIRTALTDAQ GRQRVPLIGF SGSPWTLACY MVEGGGSADF RTVKSMLYAR 190 200 210 220 230 240 PDLMHRILDV NARAVAAYLN AQIEAGAQAV MIFDTWGGAL ADGVYQRFSL HYIQQVVSQL 250 260 270 280 290 300 KRDHDGEKVP VITFTKGGGL WLDEIAETGV DAVGLDWTVN LSKARERVGG KVALQGNIDP 310 320 330 340 350 360 SVLFAPPAAI RMEARAVLDS FGNHPGHVFN LGHGISQFTP PEHVAELVDE VHRHSRAIRS GAHAPA

References

[1]

"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility." Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L., Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J., Parnell J.J. , Ramette A., Richardson P., Seeger M., Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M. Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006) [PubMed: 17030797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LB400.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000270 Genomic DNA. Translation: ABE32883.1.
RefSeq	YP_560935.1. NC_007951.1.
3D structure databases
ProteinModelPortal	Q13SQ6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q13SQ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4006383.
GenomeReviews	Gene locus Bxeno_A4345 in contig CP000270_GR.
KEGG	bxe:Bxe_A0044.
PATRIC	19334586. VBIBurXen52548_4569.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG628392.
OMA	PRIHFGV.
PhylomeDB	Q13SQ6.
ProtClustDB	PRK00115.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
KO	K01599.
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. HemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_BURXL

Accession

Primary (citable) accession number: Q13SQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program