Reviewed, UniProtKB/Swiss-Prot Q13RY4 (KHSE_BURXL)

Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Bxeno_B0187
ORF Names:	Bxe_B2840

Organism

Burkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]

Taxonomic identifier

266265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Homoserine kinase HAMAP MF_00301		PRO_0000300791

Sequences

	Sequence		Length	Mass (Da)
	Q13RY4-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 48C1A92E324F2777	FASTA	331	37,328
	10 20 30 40 50 60 MAVFTAVTEP QLAEWMRHYD LGDVVEFRGI SSGIENSNFF LTTTRGEYVL TIFEKLTAEQ 70 80 90 100 110 120 LPFYLDLMRH LAAHRVPVPD PMPREDGALF GLLQGKPAAI VTRLEGAPEL APGVEHCIEV 130 140 150 160 170 180 GQMLARMHLA GRDYPAYQPN LRSLPWWKET VPTILPFLEG GQRELLSSEL AYQEAFFASA 190 200 210 220 230 240 DYAALPEGPC HADLFRDNAM FAHAEPGTGH EVRLGGFFDF YFAGCDKWLF DVAVTVNDWC 250 260 270 280 290 300 VDLATGKLDA ARTEAMLRAY QTVRPFTAEE NRHWGDMLRA GAYRFWVSRL YDFHLPRAAE 310 320 330 LLKPHDPGHF ERILRERLSG VALPGIHTSC N

References

[1]

"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility." Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L., Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J., Parnell J.J. , Ramette A., Richardson P., Seeger M., Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M. Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006) [PubMed: 17030797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000271 Genomic DNA. Translation: ABE33155.1.
RefSeq	YP_552505.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4006561.
GenomeReviews	Gene locus Bxeno_B0187 in contig CP000271_GR.
KEGG	bxe:Bxe_B2840.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q13RY4.
OMA	ADLFRDN.
Enzyme and pathway databases
BioCyc	BXEN266265:BXE_B2840-MON.
Family and domain databases
HAMAP	MF_00301. [Tree]
InterPro	IPR002575. APH_trans. IPR005280. Homoserine_Kinase_ThrB. [Graphical view]
Pfam	PF01636. APH. 1 hit. [Graphical view]
TIGRFAMs	TIGR00938. thrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BURXL

Accession

Primary (citable) accession number: Q13RY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	August 22, 2006
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)