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Q13RX0

- GCH4_BURXL

UniProt

Q13RX0 - GCH4_BURXL

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei154 – 1541May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciBXEN266265:GJII-4811-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Bxeno_B0201
    ORF Names:Bxe_B2826
    OrganismiBurkholderia xenovorans (strain LB400)
    Taxonomic identifieri266265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001817: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268GTP cyclohydrolase FolE2PRO_0000289484Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266265.Bxe_B2826.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13RX0.
    SMRiQ13RX0. Positions 21-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13RX0-1 [UniParc]FASTAAdd to Basket

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    MNQMNPAFVM PDVQSTPDTR QIPIQRVGVK AVRHPLTVRT QGGEVQPTVG    50
    TWNLDVHLPA DQKGTHMSRF VALLEENKAP LEPATFRTML AAMLEKLEAE 100
    AGRIEVSFPY FVNKTAPVSG VQSLLDYEVT LTGETRNGAT RLFLRVRVPV 150
    TSLCPCSKKI SQYGAHNQRS HVTINAELAG DVAVEELIRI AEEEASCELW 200
    GLLKRPDEKF VTERAYENPK FVEDLVRDVA QRLNADERIV AYVLEAENFE 250
    SIHNHSAYAV IERDKRAG 268
    Length:268
    Mass (Da):30,006
    Last modified:August 22, 2006 - v1
    Checksum:iDCFBF57639836259
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000271 Genomic DNA. Translation: ABE33169.1.
    RefSeqiWP_011490545.1. NC_007952.1.
    YP_552519.1. NC_007952.1.

    Genome annotation databases

    EnsemblBacteriaiABE33169; ABE33169; Bxe_B2826.
    GeneIDi4006575.
    KEGGibxe:Bxe_B2826.
    PATRICi19335184. VBIBurXen52548_4867.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000271 Genomic DNA. Translation: ABE33169.1 .
    RefSeqi WP_011490545.1. NC_007952.1.
    YP_552519.1. NC_007952.1.

    3D structure databases

    ProteinModelPortali Q13RX0.
    SMRi Q13RX0. Positions 21-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266265.Bxe_B2826.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE33169 ; ABE33169 ; Bxe_B2826 .
    GeneIDi 4006575.
    KEGGi bxe:Bxe_B2826.
    PATRICi 19335184. VBIBurXen52548_4867.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci BXEN266265:GJII-4811-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LB400.

    Entry informationi

    Entry nameiGCH4_BURXL
    AccessioniPrimary (citable) accession number: Q13RX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3