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Q13RX0

- GCH4_BURXL

UniProt

Q13RX0 - GCH4_BURXL

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBXEN266265:GJII-4811-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Bxeno_B0201
ORF Names:Bxe_B2826
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268GTP cyclohydrolase FolE2PRO_0000289484Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_B2826.

Structurei

3D structure databases

ProteinModelPortaliQ13RX0.
SMRiQ13RX0. Positions 21-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13RX0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQMNPAFVM PDVQSTPDTR QIPIQRVGVK AVRHPLTVRT QGGEVQPTVG
60 70 80 90 100
TWNLDVHLPA DQKGTHMSRF VALLEENKAP LEPATFRTML AAMLEKLEAE
110 120 130 140 150
AGRIEVSFPY FVNKTAPVSG VQSLLDYEVT LTGETRNGAT RLFLRVRVPV
160 170 180 190 200
TSLCPCSKKI SQYGAHNQRS HVTINAELAG DVAVEELIRI AEEEASCELW
210 220 230 240 250
GLLKRPDEKF VTERAYENPK FVEDLVRDVA QRLNADERIV AYVLEAENFE
260
SIHNHSAYAV IERDKRAG
Length:268
Mass (Da):30,006
Last modified:August 22, 2006 - v1
Checksum:iDCFBF57639836259
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000271 Genomic DNA. Translation: ABE33169.1.
RefSeqiYP_552519.1. NC_007952.1.

Genome annotation databases

EnsemblBacteriaiABE33169; ABE33169; Bxe_B2826.
GeneIDi4006575.
KEGGibxe:Bxe_B2826.
PATRICi19335184. VBIBurXen52548_4867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000271 Genomic DNA. Translation: ABE33169.1 .
RefSeqi YP_552519.1. NC_007952.1.

3D structure databases

ProteinModelPortali Q13RX0.
SMRi Q13RX0. Positions 21-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266265.Bxe_B2826.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE33169 ; ABE33169 ; Bxe_B2826 .
GeneIDi 4006575.
KEGGi bxe:Bxe_B2826.
PATRICi 19335184. VBIBurXen52548_4867.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BXEN266265:GJII-4811-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiGCH4_BURXL
AccessioniPrimary (citable) accession number: Q13RX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 22, 2006
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3