Q13RX0 (GCH4_BURXL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
Ordered Locus Names:	Bxeno_B0201
ORF Names:	Bxe_B2826

Organism

Burkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]

Taxonomic identifier

266265 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia xenovorans

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_0000289484
Sites
	Site	154	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q13RX0 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: DCFBF57639836259	FASTA	268	30,006
	10 20 30 40 50 60 MNQMNPAFVM PDVQSTPDTR QIPIQRVGVK AVRHPLTVRT QGGEVQPTVG TWNLDVHLPA 70 80 90 100 110 120 DQKGTHMSRF VALLEENKAP LEPATFRTML AAMLEKLEAE AGRIEVSFPY FVNKTAPVSG 130 140 150 160 170 180 VQSLLDYEVT LTGETRNGAT RLFLRVRVPV TSLCPCSKKI SQYGAHNQRS HVTINAELAG 190 200 210 220 230 240 DVAVEELIRI AEEEASCELW GLLKRPDEKF VTERAYENPK FVEDLVRDVA QRLNADERIV 250 260 AYVLEAENFE SIHNHSAYAV IERDKRAG

References

[1]

"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility." Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L., Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J., Parnell J.J. , Ramette A., Richardson P., Seeger M., Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M. Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LB400.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000271 Genomic DNA. Translation: ABE33169.1.
RefSeq	YP_552519.1. NC_007952.1.
3D structure databases
ProteinModelPortal	Q13RX0.
SMR	Q13RX0. Positions 21-265.
ModBase	Search...
Protein-protein interaction databases
STRING	266265.Bxe_B2826.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE33169; ABE33169; Bxe_B2826.
GeneID	4006575.
KEGG	bxe:Bxe_B2826.
PATRIC	19335184. VBIBurXen52548_4867.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000280679.
KO	K09007.
OMA	INMYVDL.
ProtClustDB	PRK13674.
Enzyme and pathway databases
BioCyc	BXEN266265:GJII-4811-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 1 hit.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH4_BURXL

Accession

Primary (citable) accession number: Q13RX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	August 22, 2006
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program