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Q13RX0

- GCH4_BURXL

UniProt

Q13RX0 - GCH4_BURXL

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, Bxeno_B0201, Bxe_B2826
Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBXEN266265:GJII-4811-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Bxeno_B0201
ORF Names:Bxe_B2826
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268GTP cyclohydrolase FolE2UniRule annotation
PRO_0000289484Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_B2826.

Structurei

3D structure databases

ProteinModelPortaliQ13RX0.
SMRiQ13RX0. Positions 21-265.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13RX0-1 [UniParc]FASTAAdd to Basket

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MNQMNPAFVM PDVQSTPDTR QIPIQRVGVK AVRHPLTVRT QGGEVQPTVG    50
TWNLDVHLPA DQKGTHMSRF VALLEENKAP LEPATFRTML AAMLEKLEAE 100
AGRIEVSFPY FVNKTAPVSG VQSLLDYEVT LTGETRNGAT RLFLRVRVPV 150
TSLCPCSKKI SQYGAHNQRS HVTINAELAG DVAVEELIRI AEEEASCELW 200
GLLKRPDEKF VTERAYENPK FVEDLVRDVA QRLNADERIV AYVLEAENFE 250
SIHNHSAYAV IERDKRAG 268
Length:268
Mass (Da):30,006
Last modified:August 22, 2006 - v1
Checksum:iDCFBF57639836259
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000271 Genomic DNA. Translation: ABE33169.1.
RefSeqiWP_011490545.1. NC_007952.1.
YP_552519.1. NC_007952.1.

Genome annotation databases

EnsemblBacteriaiABE33169; ABE33169; Bxe_B2826.
GeneIDi4006575.
KEGGibxe:Bxe_B2826.
PATRICi19335184. VBIBurXen52548_4867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000271 Genomic DNA. Translation: ABE33169.1 .
RefSeqi WP_011490545.1. NC_007952.1.
YP_552519.1. NC_007952.1.

3D structure databases

ProteinModelPortali Q13RX0.
SMRi Q13RX0. Positions 21-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266265.Bxe_B2826.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE33169 ; ABE33169 ; Bxe_B2826 .
GeneIDi 4006575.
KEGGi bxe:Bxe_B2826.
PATRICi 19335184. VBIBurXen52548_4867.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BXEN266265:GJII-4811-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiGCH4_BURXL
AccessioniPrimary (citable) accession number: Q13RX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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