Q13QH7 (ACDH3_BURXL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase 3
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3

Gene names

Ordered Locus Names:	Bxeno_B0694
ORF Names:	Bxe_B2326

Organism

Burkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]

Taxonomic identifier

266265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Acetaldehyde dehydrogenase 3 HAMAP MF_01657		PRO_0000337977
Regions
	Nucleotide binding	13 – 16	4	NAD By similarity
	Nucleotide binding	164 – 172	9	NAD By similarity
Sites
	Binding site	291	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q13QH7 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: F0A85325E5E6BAD5	FASTA	313	32,763
	10 20 30 40 50 60 MASEKLKAAI IGSGNIGTDL MIKIMRHSEH LEMAAMVGID AASDGLARAA RLGVATTHEG 70 80 90 100 110 120 VEGLTRLPVF DDIDFVFDAT SAGAHVKNDA FLRALKPGIR LIDLTPAAIG PYCVPVVNLD 130 140 150 160 170 180 AHLDSRNVNM VTCGGQATIP MVAAVSRVAK VHYAEIVASI SSKSAGPGTR ANIDEFTETT 190 200 210 220 230 240 SKAIEAVGGA AKGKAIIVLN PAEPPVMMRD TVYVLSDLAD RAQVEASIEA MAAAVHAYVP 250 260 270 280 290 300 GYRLKQKVQF DEIAADVPLN IPGLGRFSGL KTSVFIEVEG AAHYLPAYAG NLDIMTSAAL 310 ATAERMAQSL VQA

References

[1]

"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility." Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L., Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J., Parnell J.J. , Ramette A., Richardson P., Seeger M., Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M. Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006) [PubMed: 17030797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LB400.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000271 Genomic DNA. Translation: ABE33662.1.
RefSeq	YP_553012.1. NC_007952.1.
3D structure databases
ProteinModelPortal	Q13QH7.
SMR	Q13QH7. Positions 3-313.
ModBase	Search...
Protein-protein interaction databases
STRING	Q13QH7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4007178.
GenomeReviews	Gene locus Bxeno_B0694 in contig CP000271_GR.
KEGG	bxe:Bxe_B2326.
PATRIC	19336234. VBIBurXen52548_5386.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG300125.
OMA	HVKNDAF.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	BXEN266265:BXE_B2326-MONOMER.
Family and domain databases
HAMAP	MF_01657. Ac_ald_DH_ac. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K04073.
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH3_BURXL

Accession

Primary (citable) accession number: Q13QH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program