Reviewed, UniProtKB/Swiss-Prot Q13QH7 (MHPF_BURXL)

Names and origin

Protein names

Recommended name:
    Acetaldehyde dehydrogenase
    EC=1.2.1.10
Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]

Gene names

Name:	mhpF
Ordered Locus Names:	Bxeno_B0694
ORF Names:	Bxe_B2326

Organism

Burkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]

Taxonomic identifier

266265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the terminal reaction in meta-cleavage pathways, that is, the transformation of acetaldehyde into acetyl coenzyme A By similarity.
Catalytic activity	Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH.
Pathway	Aromatic compound metabolism; 3-phenylpropionic acid degradation.
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family. MhpF subfamily.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	amino acid metabolic process Inferred from electronic annotation. Source: InterPro aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Acetaldehyde dehydrogenase		PRO_0000337977

Sequences

	Sequence		Length	Mass (Da)
	Q13QH7-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: F0A85325E5E6BAD5	FASTA	313	32,763
	10 20 30 40 50 60 MASEKLKAAI IGSGNIGTDL MIKIMRHSEH LEMAAMVGID AASDGLARAA RLGVATTHEG 70 80 90 100 110 120 VEGLTRLPVF DDIDFVFDAT SAGAHVKNDA FLRALKPGIR LIDLTPAAIG PYCVPVVNLD 130 140 150 160 170 180 AHLDSRNVNM VTCGGQATIP MVAAVSRVAK VHYAEIVASI SSKSAGPGTR ANIDEFTETT 190 200 210 220 230 240 SKAIEAVGGA AKGKAIIVLN PAEPPVMMRD TVYVLSDLAD RAQVEASIEA MAAAVHAYVP 250 260 270 280 290 300 GYRLKQKVQF DEIAADVPLN IPGLGRFSGL KTSVFIEVEG AAHYLPAYAG NLDIMTSAAL 310 ATAERMAQSL VQA

References

[1]

"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility." Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L., Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J., Parnell J.J. , Ramette A., Richardson P., Seeger M., Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M. Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006) [PubMed: 17030797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000271 Genomic DNA. Translation: ABE33662.1.
RefSeq	YP_553012.1.
3D structure databases
SMR	Q13QH7. Positions 3-313.
ModBase	Search...
Genome annotation databases
GeneID	4007178.
GenomeReviews	Gene locus Bxeno_B0694 in contig CP000271_GR.
KEGG	bxe:Bxe_B2326.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q13QH7.
Enzyme and pathway databases
BioCyc	BXEN266265:BXE_B2326-MON.
Family and domain databases
HAMAP	MF_01657. [Tree]
InterPro	IPR003361. Acetylald_dehydrogenase. IPR015426. Acetylald_DHase_C. IPR000534. Semialdehyde_DHase_NAD-bd. IPR006035. Ureohydrolase. [Graphical view]
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MHPF_BURXL

Accession

Primary (citable) accession number: Q13QH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	August 22, 2006
Last modified:	November 25, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)