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Q13QH7

- ACDH3_BURXL

UniProt

Q13QH7 - ACDH3_BURXL

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Protein

Acetaldehyde dehydrogenase 3

Gene

Bxeno_B0694

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331Acyl-thioester intermediateUniRule annotation
Binding sitei291 – 2911NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 164NADUniRule annotation
Nucleotide bindingi164 – 1729NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBXEN266265:GJII-5318-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 3UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3UniRule annotation
Gene namesi
Ordered Locus Names:Bxeno_B0694
ORF Names:Bxe_B2326
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Acetaldehyde dehydrogenase 3PRO_0000337977Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_B2326.

Structurei

3D structure databases

ProteinModelPortaliQ13QH7.
SMRiQ13QH7. Positions 3-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiFTETTAH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13QH7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASEKLKAAI IGSGNIGTDL MIKIMRHSEH LEMAAMVGID AASDGLARAA
60 70 80 90 100
RLGVATTHEG VEGLTRLPVF DDIDFVFDAT SAGAHVKNDA FLRALKPGIR
110 120 130 140 150
LIDLTPAAIG PYCVPVVNLD AHLDSRNVNM VTCGGQATIP MVAAVSRVAK
160 170 180 190 200
VHYAEIVASI SSKSAGPGTR ANIDEFTETT SKAIEAVGGA AKGKAIIVLN
210 220 230 240 250
PAEPPVMMRD TVYVLSDLAD RAQVEASIEA MAAAVHAYVP GYRLKQKVQF
260 270 280 290 300
DEIAADVPLN IPGLGRFSGL KTSVFIEVEG AAHYLPAYAG NLDIMTSAAL
310
ATAERMAQSL VQA
Length:313
Mass (Da):32,763
Last modified:August 22, 2006 - v1
Checksum:iF0A85325E5E6BAD5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000271 Genomic DNA. Translation: ABE33662.1.
RefSeqiWP_011491022.1. NC_007952.1.
YP_553012.1. NC_007952.1.

Genome annotation databases

EnsemblBacteriaiABE33662; ABE33662; Bxe_B2326.
GeneIDi4007178.
KEGGibxe:Bxe_B2326.
PATRICi19336234. VBIBurXen52548_5386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000271 Genomic DNA. Translation: ABE33662.1 .
RefSeqi WP_011491022.1. NC_007952.1.
YP_553012.1. NC_007952.1.

3D structure databases

ProteinModelPortali Q13QH7.
SMRi Q13QH7. Positions 3-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266265.Bxe_B2326.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE33662 ; ABE33662 ; Bxe_B2326 .
GeneIDi 4007178.
KEGGi bxe:Bxe_B2326.
PATRICi 19336234. VBIBurXen52548_5386.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi FTETTAH.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci BXEN266265:GJII-5318-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiACDH3_BURXL
AccessioniPrimary (citable) accession number: Q13QH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 22, 2006
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3