ID   MHPE_BURXL              Reviewed;         338 AA.
AC   Q13QH6;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=4-hydroxy-2-oxovalerate aldolase;
DE            Short=HOA;
DE            EC=4.1.3.39;
DE   AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase;
GN   Name=mhpE; OrderedLocusNames=Bxeno_B0695; ORFNames=Bxe_B2325;
OS   Burkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Catalyzes the fission of 4-hydroxy-2-ketovalerate to
CC       yield pyruvate and acetaldehyde (By similarity).
CC   -!- CATALYTIC ACTIVITY: 4-hydroxy-2-oxopentanoate = acetaldehyde +
CC       pyruvate.
CC   -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropionic acid
CC       degradation.
CC   -!- SIMILARITY: Belongs to the mhpE aldolase family.
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DR   EMBL; CP000271; ABE33663.1; -; Genomic_DNA.
DR   RefSeq; YP_553013.1; -.
DR   SMR; Q13QH6; 3-335.
DR   GeneID; 4007179; -.
DR   GenomeReviews; CP000271_GR; Bxeno_B0695.
DR   KEGG; bxe:Bxe_B2325; -.
DR   HOGENOM; Q13QH6; -.
DR   OMA; Q13QH6; AGFLMMS.
DR   BioCyc; BXEN266265:BXE_B2325-MON; -.
DR   GO; GO:0008701; F:4-hydroxy-2-oxovalerate aldolase activity; IEA:HAMAP.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:HAMAP.
DR   HAMAP; MF_01656; -; 1.
DR   InterPro; IPR017629; 4OH_2_O-val_aldolase.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR012425; DmpG_comm.
DR   InterPro; IPR000891; PYR_CT.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF07836; DmpG_comm; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   TIGRFAMs; TIGR03217; 4OH_2_O_val_ald; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; Complete proteome; Lyase.
FT   CHAIN         1    338       4-hydroxy-2-oxovalerate aldolase.
FT                                /FTId=PRO_0000337802.
SQ   SEQUENCE   338 AA;  36450 MW;  81AF29BB8BDD02EB CRC64;
     MDRKLYISDV TLRDGSHAIR HQYSIDNVQQ IARALDSAKV DSIEVAHGDG LQGSSFNYGF
     GAHSDLEWIE AVADVVGHAQ IATLLLPGIG TIHDLKAAYQ AGARIVRVAT HCTEADISKQ
     HIEYARELGM DTVGFLMMSH MTTPENLAVE AKKMESYGAT CIYVVDSGGA MNMNDVRARF
     RALKAVLKPE TKTGMHAHHN LSLGVANSLV AVEEGCDRID ASLAGMGAGA GNAPLEVFIA
     AAERAGWHHG TDLYTLMDAA DDIVRPLQDR PVRVDRETLA LGYAGVYSSF LRHSEVAAKK
     YGLKAVDILV ELGKRRMVGG QEDMIVDVAL DLKRAAGV
//