Reviewed, UniProtKB/Swiss-Prot Q13QH6 (MHPE_BURXL)

Names and origin

Protein names

Recommended name:
    4-hydroxy-2-oxovalerate aldolase
      Short name=HOA
    EC=4.1.3.39
Alternative name(s):
    4-hydroxy-2-keto-pentanoic acid aldolase

Gene names

Name:	mhpE
Ordered Locus Names:	Bxeno_B0695
ORF Names:	Bxe_B2325

Organism

Burkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]

Taxonomic identifier

266265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the fission of 4-hydroxy-2-ketovalerate to yield pyruvate and acetaldehyde By similarity.
Catalytic activity	4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate. HAMAP MF_01656
Pathway	Aromatic compound metabolism; 3-phenylpropionic acid degradation. HAMAP MF_01656
Sequence similarities	Belongs to the mhpE aldolase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	4-hydroxy-2-oxovalerate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	4-hydroxy-2-oxovalerate aldolase HAMAP MF_01656		PRO_0000337802

Sequences

	Sequence		Length	Mass (Da)
	Q13QH6-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 81AF29BB8BDD02EB	FASTA	338	36,450
	10 20 30 40 50 60 MDRKLYISDV TLRDGSHAIR HQYSIDNVQQ IARALDSAKV DSIEVAHGDG LQGSSFNYGF 70 80 90 100 110 120 GAHSDLEWIE AVADVVGHAQ IATLLLPGIG TIHDLKAAYQ AGARIVRVAT HCTEADISKQ 130 140 150 160 170 180 HIEYARELGM DTVGFLMMSH MTTPENLAVE AKKMESYGAT CIYVVDSGGA MNMNDVRARF 190 200 210 220 230 240 RALKAVLKPE TKTGMHAHHN LSLGVANSLV AVEEGCDRID ASLAGMGAGA GNAPLEVFIA 250 260 270 280 290 300 AAERAGWHHG TDLYTLMDAA DDIVRPLQDR PVRVDRETLA LGYAGVYSSF LRHSEVAAKK 310 320 330 YGLKAVDILV ELGKRRMVGG QEDMIVDVAL DLKRAAGV

References

[1]

"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility." Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L., Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J., Parnell J.J. , Ramette A., Richardson P., Seeger M., Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M. Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006) [PubMed: 17030797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000271 Genomic DNA. Translation: ABE33663.1.
RefSeq	YP_553013.1.
3D structure databases
SMR	Q13QH6. Positions 3-335.
ModBase	Search...
Genome annotation databases
GeneID	4007179.
GenomeReviews	Gene locus Bxeno_B0695 in contig CP000271_GR.
KEGG	bxe:Bxe_B2325.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q13QH6.
OMA	Q13QH6. AGFLMMS.
Enzyme and pathway databases
BioCyc	BXEN266265:BXE_B2325-MON.
Family and domain databases
HAMAP	MF_01656. [Tree]
InterPro	IPR017629. 4OH_2_O-val_aldolase. IPR013785. Aldolase_TIM. IPR012425. DmpG_comm. IPR000891. PYR_CT. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF07836. DmpG_comm. 1 hit. PF00682. HMGL-like. 1 hit. [Graphical view]
TIGRFAMs	TIGR03217. 4OH_2_O_val_ald. 1 hit.
PROSITE	PS50991. PYR_CT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MHPE_BURXL

Accession

Primary (citable) accession number: Q13QH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	August 22, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)