ID   BETA_BURXL              Reviewed;         561 AA.
AC   Q13NG7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Choline dehydrogenase;
DE            Short=CHD;
DE            Short=CDH;
DE            EC=1.1.99.1;
GN   Name=betA; OrderedLocusNames=Bxeno_B1404; ORFNames=Bxe_B1592;
OS   Burkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
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DR   EMBL; CP000271; ABE34372.1; -; Genomic_DNA.
DR   RefSeq; YP_553722.1; -.
DR   GeneID; 4007919; -.
DR   GenomeReviews; CP000271_GR; Bxeno_B1404.
DR   KEGG; bxe:Bxe_B1592; -.
DR   HOGENOM; Q13NG7; -.
DR   OMA; Q13NG7; PNLQYHF.
DR   BioCyc; BXEN266265:BXE_B1592-MON; -.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00750; -; 1.
DR   InterPro; IPR011533; Choline_dehydrogenase.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    561       Choline dehydrogenase.
FT                                /FTId=PRO_0000258923.
FT   NP_BIND       7     36       FAD (Probable).
FT   ACT_SITE    474    474       By similarity.
SQ   SEQUENCE   561 AA;  62136 MW;  1C0CDF3540761AD6 CRC64;
     MAANEYDYII VGAGSAGNVL ASRLAEDADV TVLLLEAGGP DYRFDFRTQM PAALAYPLQG
     RRYNWAYETD PEPHMNNRRM ECGRGKGLGG SSLINGMCYI RGNALDYDGW AAHAGLENWT
     YLDCLPYFRK AETRDIGANA YHGGDGPVHV TTSKPGNNPL FAAMVEAGVQ AGFPRTDDLN
     GYQQEGFGPM DRTVTANGRR ASTARGYLDR AKARPNLTIV THAVTDRVLF SGKRAVGVSY
     LHHGNVLNAQ ARREVLVCSG AIASPQLLQR SGVGRSTWLR ELDVPLVHDL PGVGENLQDH
     LEMYIQYECK EPVSLYPALQ WWNQPAIGLE WMLNGTGIGA SNQFEAGGFI RTRDDDPWPN
     IQYHFLPVAI NYNGSNAIRM HGFQAHVGSM RSPSRGRVKL TSRDPNAHPG ILFNYMADPL
     DWREFRDGIR ITREIMRQPA LDRYRGRELN PGAELTTDEQ LDSFVRMRAE TAFHPSCSCK
     MGYDDMAVVD NEGRVHGMQG LRVVDASIMP RITTGNLNAP TIMLAEKIAD RIRGREALAR
     VDTPYFVANG VASRKRESAT V
//