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Q13NG7 (BETA_BURXL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:Bxeno_B1404
ORF Names:Bxe_B1592
OrganismBurkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]
Taxonomic identifier266265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_0000258923

Regions

Nucleotide binding7 – 3630FAD By similarity

Sites

Active site4741 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q13NG7 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 1C0CDF3540761AD6

FASTA56162,136
        10         20         30         40         50         60 
MAANEYDYII VGAGSAGNVL ASRLAEDADV TVLLLEAGGP DYRFDFRTQM PAALAYPLQG 

        70         80         90        100        110        120 
RRYNWAYETD PEPHMNNRRM ECGRGKGLGG SSLINGMCYI RGNALDYDGW AAHAGLENWT 

       130        140        150        160        170        180 
YLDCLPYFRK AETRDIGANA YHGGDGPVHV TTSKPGNNPL FAAMVEAGVQ AGFPRTDDLN 

       190        200        210        220        230        240 
GYQQEGFGPM DRTVTANGRR ASTARGYLDR AKARPNLTIV THAVTDRVLF SGKRAVGVSY 

       250        260        270        280        290        300 
LHHGNVLNAQ ARREVLVCSG AIASPQLLQR SGVGRSTWLR ELDVPLVHDL PGVGENLQDH 

       310        320        330        340        350        360 
LEMYIQYECK EPVSLYPALQ WWNQPAIGLE WMLNGTGIGA SNQFEAGGFI RTRDDDPWPN 

       370        380        390        400        410        420 
IQYHFLPVAI NYNGSNAIRM HGFQAHVGSM RSPSRGRVKL TSRDPNAHPG ILFNYMADPL 

       430        440        450        460        470        480 
DWREFRDGIR ITREIMRQPA LDRYRGRELN PGAELTTDEQ LDSFVRMRAE TAFHPSCSCK 

       490        500        510        520        530        540 
MGYDDMAVVD NEGRVHGMQG LRVVDASIMP RITTGNLNAP TIMLAEKIAD RIRGREALAR 

       550        560 
VDTPYFVANG VASRKRESAT V 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000271 Genomic DNA. Translation: ABE34372.1.
RefSeqYP_553722.1. NC_007952.1.

3D structure databases

ProteinModelPortalQ13NG7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266265.Bxe_B1592.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE34372; ABE34372; Bxe_B1592.
GeneID4007919.
KEGGbxe:Bxe_B1592.
PATRIC19337789. VBIBurXen52548_6153.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMALTDDYNG.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycBXEN266265:GJII-6059-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_BURXL
AccessionPrimary (citable) accession number: Q13NG7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 22, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways