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Q13NG7

- BETA_BURXL

UniProt

Q13NG7 - BETA_BURXL

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei474 – 4741UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 3630FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciBXEN266265:GJII-6059-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:Bxeno_B1404
    ORF Names:Bxe_B1592
    OrganismiBurkholderia xenovorans (strain LB400)
    Taxonomic identifieri266265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001817: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 561561Oxygen-dependent choline dehydrogenasePRO_0000258923Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266265.Bxe_B1592.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13NG7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiLTDDYNG.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13NG7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAANEYDYII VGAGSAGNVL ASRLAEDADV TVLLLEAGGP DYRFDFRTQM    50
    PAALAYPLQG RRYNWAYETD PEPHMNNRRM ECGRGKGLGG SSLINGMCYI 100
    RGNALDYDGW AAHAGLENWT YLDCLPYFRK AETRDIGANA YHGGDGPVHV 150
    TTSKPGNNPL FAAMVEAGVQ AGFPRTDDLN GYQQEGFGPM DRTVTANGRR 200
    ASTARGYLDR AKARPNLTIV THAVTDRVLF SGKRAVGVSY LHHGNVLNAQ 250
    ARREVLVCSG AIASPQLLQR SGVGRSTWLR ELDVPLVHDL PGVGENLQDH 300
    LEMYIQYECK EPVSLYPALQ WWNQPAIGLE WMLNGTGIGA SNQFEAGGFI 350
    RTRDDDPWPN IQYHFLPVAI NYNGSNAIRM HGFQAHVGSM RSPSRGRVKL 400
    TSRDPNAHPG ILFNYMADPL DWREFRDGIR ITREIMRQPA LDRYRGRELN 450
    PGAELTTDEQ LDSFVRMRAE TAFHPSCSCK MGYDDMAVVD NEGRVHGMQG 500
    LRVVDASIMP RITTGNLNAP TIMLAEKIAD RIRGREALAR VDTPYFVANG 550
    VASRKRESAT V 561
    Length:561
    Mass (Da):62,136
    Last modified:August 22, 2006 - v1
    Checksum:i1C0CDF3540761AD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000271 Genomic DNA. Translation: ABE34372.1.
    RefSeqiYP_553722.1. NC_007952.1.

    Genome annotation databases

    EnsemblBacteriaiABE34372; ABE34372; Bxe_B1592.
    GeneIDi4007919.
    KEGGibxe:Bxe_B1592.
    PATRICi19337789. VBIBurXen52548_6153.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000271 Genomic DNA. Translation: ABE34372.1 .
    RefSeqi YP_553722.1. NC_007952.1.

    3D structure databases

    ProteinModelPortali Q13NG7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266265.Bxe_B1592.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE34372 ; ABE34372 ; Bxe_B1592 .
    GeneIDi 4007919.
    KEGGi bxe:Bxe_B1592.
    PATRICi 19337789. VBIBurXen52548_6153.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi LTDDYNG.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci BXEN266265:GJII-6059-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LB400.

    Entry informationi

    Entry nameiBETA_BURXL
    AccessioniPrimary (citable) accession number: Q13NG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3