Reviewed, UniProtKB/Swiss-Prot Q13NG6 (BETB_BURXL)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	Bxeno_B1405
ORF Names:	Bxe_B1591

Organism

Burkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]

Taxonomic identifier

266265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Betaine aldehyde dehydrogenase		PRO_1000047042
Regions
	Nucleotide binding	228 – 233	6	NAD By similarity
Sites
	Active site	251	1	By similarity
	Active site	285	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q13NG6-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 01A05941F3834FFC	FASTA	489	52,414
	10 20 30 40 50 60 MAVFAIQRLY IGGAYVDATS GETFDTLDPA TGETLASVQQ ASAADVERAV QSAREGQREW 70 80 90 100 110 120 AALTAMQRSR VLRRAVEILR ERNDELAALE TRDTGKPIAE TLAVDIATGA DVIEYYAGLA 130 140 150 160 170 180 TAIEGQQIPL RPTSFVYTRR EPLGVCAGIG AWNYPIQIAC WKSAPALAAG NAMIFKPSEI 190 200 210 220 230 240 TPLSALKLAE IYTEAGVPAG VFNVVQGDGR VGAMLAAHPD IEKISFTGGV ETGKKVMSLA 250 260 270 280 290 300 GASSLKEVTM ELGGKSPLLV FDDADLERAA DIAMSANFFS SGQVCTNGTR VFVQRGVLER 310 320 330 340 350 360 FEALVLERVK RIRVGAPTNA ATNFGPLASA AQLQKVLGYI ESGKQEGARL MAGGKRLTEG 370 380 390 400 410 420 HFGNGQYVEP TVFTGCHDDM RIVREEIFGP VMSILVFDDE DEAIARANRT AYGLAAGVVT 430 440 450 460 470 480 GNLARAHRVI HRLEAGICWI NTWGESPAEM PVGGYKQSGV GRENGLTTLE HYTRIKSVQV ELGPYQPVF

References

[1]

"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility." Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L., Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J., Parnell J.J. , Ramette A., Richardson P., Seeger M., Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M. Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006) [PubMed: 17030797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000271 Genomic DNA. Translation: ABE34373.1.
RefSeq	YP_553723.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4007920.
GenomeReviews	Gene locus Bxeno_B1405 in contig CP000271_GR.
KEGG	bxe:Bxe_B1591.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q13NG6.
Enzyme and pathway databases
BioCyc	BXEN266265:BXE_B1591-MON.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR011264. Betaine_Ald_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_BURXL

Accession

Primary (citable) accession number: Q13NG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	November 4, 2008
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)