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Protein

Alanine racemase

Gene

Bxe_B0373

Organism
Burkholderia xenovorans (strain LB400)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei146 – 1461SubstrateUniRule annotation
Active sitei275 – 2751Proton acceptor; specific for L-alanineUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBXEN266265:GJII-7278-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:Bxe_B0373Imported
OrganismiBurkholderia xenovorans (strain LB400)Imported
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 2

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_B0373.

Structurei

3D structure databases

ProteinModelPortaliQ13K16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000118797.
KOiK01775.
OMAiKIYFVCK.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13K16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVPIIEPAA DAQGVRLLRP SWAELDYGAV AANLAVAREQ VGRATKIYFV
60 70 80 90 100
CKGDGFGFGA AKVARLAAQA GVDGFCVGSP EEGVTIRRAG IDRDILLFAS
110 120 130 140 150
TLPEDAAQVA ALGLTVTIQS RESLHAFINA GVAVDAFLEI DPGFGRFGFL
160 170 180 190 200
PSQWQAAFAA LRDQSTVRLK GVYTHLSSPE SEDVTRQQAG VFDAALADAR
210 220 230 240 250
AAGFDNLTTM LASSRVMLAH PHLAYQAVDP GRLLYGALDA DWMARAPLRP
260 270 280 290 300
MLRAVRGRII HVQEHPAGAT LGIGYAEPIR LERGVRIGVV PIGFWDGLNH
310 320 330 340 350
VPPLGRVLVH GQPARILGRR SFQHTVIDIT EIAAARTGSV VTLLGQDGDQ
360 370 380 390
SITIDEMAET LRLPVMELIP RLARSLPHVE VKTADPAGNN
Length:390
Mass (Da):41,663
Last modified:August 22, 2006 - v1
Checksum:i6DE8B221C58DDFDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000271 Genomic DNA. Translation: ABE35573.1.
RefSeqiWP_011492848.1. NC_007952.1.
YP_554923.1. NC_007952.1.

Genome annotation databases

EnsemblBacteriaiABE35573; ABE35573; Bxe_B0373.
GeneIDi4009138.
KEGGibxe:Bxe_B0373.
PATRICi19340324. VBIBurXen52548_7420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000271 Genomic DNA. Translation: ABE35573.1.
RefSeqiWP_011492848.1. NC_007952.1.
YP_554923.1. NC_007952.1.

3D structure databases

ProteinModelPortaliQ13K16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266265.Bxe_B0373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE35573; ABE35573; Bxe_B0373.
GeneIDi4009138.
KEGGibxe:Bxe_B0373.
PATRICi19340324. VBIBurXen52548_7420.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000118797.
KOiK01775.
OMAiKIYFVCK.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciBXEN266265:GJII-7278-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400Imported.

Entry informationi

Entry nameiQ13K16_BURXL
AccessioniPrimary (citable) accession number: Q13K16
Entry historyi
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: March 4, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.