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Q13ES7

- UPPP_RHOPS

UniProt

Q13ES7 - UPPP_RHOPS

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Rhodopseudomonas palustris (strain BisB5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciRPAL316057:GHDC-174-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:RPD_0172
    OrganismiRhodopseudomonas palustris (strain BisB5)
    Taxonomic identifieri316057 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001818: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Undecaprenyl-diphosphatasePRO_0000290757Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316057.RPD_0172.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6721HelicalUniRule annotationAdd
    BLAST
    Transmembranei83 – 10321HelicalUniRule annotationAdd
    BLAST
    Transmembranei109 – 12921HelicalUniRule annotationAdd
    BLAST
    Transmembranei144 – 16421HelicalUniRule annotationAdd
    BLAST
    Transmembranei184 – 20421HelicalUniRule annotationAdd
    BLAST
    Transmembranei218 – 23821HelicalUniRule annotationAdd
    BLAST
    Transmembranei246 – 26621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiVIYFRNE.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q13ES7-1 [UniParc]FASTAAdd to Basket

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    MLFDIFRAVI LGVVEGVTEF LPVSSTGHLL LVGRFFNLGE DSFWKSFAVL    50
    IQLGAILAIL SIYFAKLWRI ALGMFSDPAA RRFVIGVLVA FLPAAMIGAV 100
    AGSYIKLYLF NPWVVCFSLI VGGAILLWVD QLDLNPQQHD ATAFPLPMYF 150
    YIGCAQCLAM IPGVSRSGAS IVAAMLFGAD KRSAAEFSFF LAIPTMVGAF 200
    VYDFYKNRGE MTTDHLTIVA IGFVVSFITA VIVVKTFLGY VTRHGFELFA 250
    WWRVIVGTLG LIALAMGR 268
    Length:268
    Mass (Da):29,365
    Last modified:October 31, 2006 - v1
    Checksum:iCA64F4CB89AC039E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000283 Genomic DNA. Translation: ABE37412.1.
    RefSeqiWP_011500604.1. NC_007958.1.
    YP_567313.1. NC_007958.1.

    Genome annotation databases

    EnsemblBacteriaiABE37412; ABE37412; RPD_0172.
    GeneIDi4020628.
    KEGGirpd:RPD_0172.
    PATRICi23275157. VBIRhoPal120395_0177.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000283 Genomic DNA. Translation: ABE37412.1 .
    RefSeqi WP_011500604.1. NC_007958.1.
    YP_567313.1. NC_007958.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316057.RPD_0172.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE37412 ; ABE37412 ; RPD_0172 .
    GeneIDi 4020628.
    KEGGi rpd:RPD_0172.
    PATRICi 23275157. VBIRhoPal120395_0177.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi VIYFRNE.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci RPAL316057:GHDC-174-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BisB5.

    Entry informationi

    Entry nameiUPPP_RHOPS
    AccessioniPrimary (citable) accession number: Q13ES7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3