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Protein

Catalase-peroxidase

Gene

katG

Organism
Rhodopseudomonas palustris (strain BisB5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei94 – 941Transition state stabilizerUniRule annotation
Active sitei98 – 981Proton acceptorUniRule annotation
Metal bindingi260 – 2601Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRPAL316057:GHDC-227-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:RPD_0223
OrganismiRhodopseudomonas palustris (strain BisB5)
Taxonomic identifieri316057 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000001818 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Catalase-peroxidasePRO_0000354895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki97 ↔ 219Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-245)UniRule annotation
Cross-linki219 ↔ 245Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi316057.RPD_0223.

Structurei

3D structure databases

ProteinModelPortaliQ13EM6.
SMRiQ13EM6. Positions 22-730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13EM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKTDDQGG KCPFPHGGGS RGHRNRDWWP EQLDINMLHR NSTLSDPLGK
60 70 80 90 100
AFDYAKEFES LDLDAVIKDL HALMTDSQDW WPADFGHYGG LMIRMAWHSA
110 120 130 140 150
GTYRTTDGRG GAGAGQQRFA PLNSWPDNAN LDKARRLLWP IKQKYGNKIS
160 170 180 190 200
WADLYVLTGN VALESMGFKT FGFAGGRADT WEPEELFWGP EGSWLGDERY
210 220 230 240 250
SGERQLHDAL GAVQMGLIYV NPEGPNGNPD PVAAAKDIRE TFARMAMNDE
260 270 280 290 300
ETVALIAGGH TFGKTHGAGD PSLIGAEPEG GALEDQGLGW KSKFGTGFGA
310 320 330 340 350
DAITGGPEVI WTQTPTQWSN FFFENLFGFE WELDKSPAGA KQWKAKGAEA
360 370 380 390 400
TVPDPFDPTK KRVPTMLTTD LSLRFDPAYE KISRRFFENP DQFADAFARA
410 420 430 440 450
WFKLTHRDMG PKVRYRGKLV PKEDLIWQDP IPPVDHELVS AKDIADLKAR
460 470 480 490 500
ILASGLSVSQ LVSTAFASAS TYRHSDKRGG ANGARIRFAP QKDWEVNQPA
510 520 530 540 550
DLAQVLGKLE AIQKAFNDAQ SGGKKVSLAD LIVLGGSAAV EKAAKDAGTE
560 570 580 590 600
VEVPFTPGRM DALEEQTDGD SFKVLEPRAD GFRNFIGKRH QFMQPEEALV
610 620 630 640 650
DRAQLLNLTA PEMTVLLGGL RVLGGNVGHD SHGVFTDRPE KLTNDFFVNL
660 670 680 690 700
LDMKTAWSLS ATAEGVYEGR DRKTGDLRWT GTRVDLIFGS HSQLRALAEV
710 720 730
YGQSDAQTKF AQDFVAAWTK VMNADRFDLA AK
Length:732
Mass (Da):80,620
Last modified:October 31, 2006 - v1
Checksum:i0798EE92BEEC9A6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000283 Genomic DNA. Translation: ABE37463.1.
RefSeqiWP_011500653.1. NC_007958.1.

Genome annotation databases

EnsemblBacteriaiABE37463; ABE37463; RPD_0223.
KEGGirpd:RPD_0223.
PATRICi23275263. VBIRhoPal120395_0228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000283 Genomic DNA. Translation: ABE37463.1.
RefSeqiWP_011500653.1. NC_007958.1.

3D structure databases

ProteinModelPortaliQ13EM6.
SMRiQ13EM6. Positions 22-730.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316057.RPD_0223.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE37463; ABE37463; RPD_0223.
KEGGirpd:RPD_0223.
PATRICi23275263. VBIRhoPal120395_0228.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciRPAL316057:GHDC-227-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_RHOPS
AccessioniPrimary (citable) accession number: Q13EM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.