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Q13E15

- SYL_RHOPS

UniProt

Q13E15 - SYL_RHOPS

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Protein
Leucine--tRNA ligase
Gene
leuS, RPD_0436
Organism
Rhodopseudomonas palustris (strain BisB5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei633 – 6331ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPAL316057:GHDC-448-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:RPD_0436
OrganismiRhodopseudomonas palustris (strain BisB5)
Taxonomic identifieri316057 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001818: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Leucine--tRNA ligaseUniRule annotation
PRO_1000009412Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316057.RPD_0436.

Structurei

3D structure databases

ProteinModelPortaliQ13E15.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotation
Add
BLAST
Motifi630 – 6345"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13E15-1 [UniParc]FASTAAdd to Basket

« Hide

MSNERYNARE SEPKWQAKWD EAKIFATRND DPRPKYYVLE MFPYPSGRIH    50
MGHVRNYTMG DVVARTMRAR GHNVLHPMGW DAFGLPAENA AIERKVAPKA 100
WTYANIAAMK KQLQTMGLSL DWAREFATCD PTYYKHQQKM FLDFLKAGLA 150
ERETRKLNWD PVDMTVLANE QVIDGRGWRS GAVVEQREMN QWVFKITRYA 200
QELLDALETL DRWPDKVRLM QRNWIGRSEG LLVRFALDSA TTPAGETELK 250
IFTTRPDTLF GAKFMAIAAD HPLAQAAAAK DPKIAAFVED CKKRGTAQAE 300
IDTAEKLGID TGIRALHPFD PNWQIPVYVA NFVLMEYGTG AIFGCPAHDQ 350
RDLDFVNKYQ LGNTPVVCPE GQDPSSFVIT DEAYDGDGRL INSRFLDGMS 400
IAEAKEDVAK RLETATLGNA PVGERKVNFR LRDWGISRQR YWGCPIPVIH 450
CEVCGVVPVP DKDLPVVLPE DVSFDKPGNA LDHHPTWKHT ACPQCGAKAT 500
RETDTMDTFV DSSWYFARFT DPWNENAPTT PDVVNRMLPV DQYIGGVEHA 550
ILHLLYSRFF TRAMKATGHV GLDEPFRGMF TQGMVVHETY RKADGMFASP 600
AEVAIVAEGD GRRATLLDDG TPIEIGPIEK MSKSKRNTVD PDDIIGSYGA 650
DTARWFMLSD SPPDRDVIWS EEGVKGASRF VQRLWRMIND AAEIAKAAPA 700
ARPDAFGPEA LAVRKAAHGA LDKVLSGIER LAFNVSLAHI REFSNSLGEA 750
LARPGAASPD VAPDLAWAIR EGAVILVQLF HPMMPHLAEE CWAALGQPGL 800
VSEALWPQIE RDLLLEDSIT LPVQVNGKKR GEVTVARDAN NPEIEAAVLA 850
LDAVRQALDG KPVRKVIVVP QRIVNVVG 878
Length:878
Mass (Da):97,773
Last modified:October 31, 2006 - v1
Checksum:i49BF702776813E9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000283 Genomic DNA. Translation: ABE37674.1.
RefSeqiYP_567575.1. NC_007958.1.

Genome annotation databases

EnsemblBacteriaiABE37674; ABE37674; RPD_0436.
GeneIDi4020902.
KEGGirpd:RPD_0436.
PATRICi23275721. VBIRhoPal120395_0449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000283 Genomic DNA. Translation: ABE37674.1 .
RefSeqi YP_567575.1. NC_007958.1.

3D structure databases

ProteinModelPortali Q13E15.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316057.RPD_0436.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE37674 ; ABE37674 ; RPD_0436 .
GeneIDi 4020902.
KEGGi rpd:RPD_0436.
PATRICi 23275721. VBIRhoPal120395_0449.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RPAL316057:GHDC-448-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisB5.

Entry informationi

Entry nameiSYL_RHOPS
AccessioniPrimary (citable) accession number: Q13E15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi