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Q13E15 (SYL_RHOPS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:RPD_0436
OrganismRhodopseudomonas palustris (strain BisB5) [Complete proteome] [HAMAP]
Taxonomic identifier316057 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas

Protein attributes

Sequence length878 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 878878Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009412

Regions

Motif43 – 5311"HIGH" region HAMAP-Rule MF_00049
Motif630 – 6345"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6331ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q13E15 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: 49BF702776813E9F

FASTA87897,773
        10         20         30         40         50         60 
MSNERYNARE SEPKWQAKWD EAKIFATRND DPRPKYYVLE MFPYPSGRIH MGHVRNYTMG 

        70         80         90        100        110        120 
DVVARTMRAR GHNVLHPMGW DAFGLPAENA AIERKVAPKA WTYANIAAMK KQLQTMGLSL 

       130        140        150        160        170        180 
DWAREFATCD PTYYKHQQKM FLDFLKAGLA ERETRKLNWD PVDMTVLANE QVIDGRGWRS 

       190        200        210        220        230        240 
GAVVEQREMN QWVFKITRYA QELLDALETL DRWPDKVRLM QRNWIGRSEG LLVRFALDSA 

       250        260        270        280        290        300 
TTPAGETELK IFTTRPDTLF GAKFMAIAAD HPLAQAAAAK DPKIAAFVED CKKRGTAQAE 

       310        320        330        340        350        360 
IDTAEKLGID TGIRALHPFD PNWQIPVYVA NFVLMEYGTG AIFGCPAHDQ RDLDFVNKYQ 

       370        380        390        400        410        420 
LGNTPVVCPE GQDPSSFVIT DEAYDGDGRL INSRFLDGMS IAEAKEDVAK RLETATLGNA 

       430        440        450        460        470        480 
PVGERKVNFR LRDWGISRQR YWGCPIPVIH CEVCGVVPVP DKDLPVVLPE DVSFDKPGNA 

       490        500        510        520        530        540 
LDHHPTWKHT ACPQCGAKAT RETDTMDTFV DSSWYFARFT DPWNENAPTT PDVVNRMLPV 

       550        560        570        580        590        600 
DQYIGGVEHA ILHLLYSRFF TRAMKATGHV GLDEPFRGMF TQGMVVHETY RKADGMFASP 

       610        620        630        640        650        660 
AEVAIVAEGD GRRATLLDDG TPIEIGPIEK MSKSKRNTVD PDDIIGSYGA DTARWFMLSD 

       670        680        690        700        710        720 
SPPDRDVIWS EEGVKGASRF VQRLWRMIND AAEIAKAAPA ARPDAFGPEA LAVRKAAHGA 

       730        740        750        760        770        780 
LDKVLSGIER LAFNVSLAHI REFSNSLGEA LARPGAASPD VAPDLAWAIR EGAVILVQLF 

       790        800        810        820        830        840 
HPMMPHLAEE CWAALGQPGL VSEALWPQIE RDLLLEDSIT LPVQVNGKKR GEVTVARDAN 

       850        860        870 
NPEIEAAVLA LDAVRQALDG KPVRKVIVVP QRIVNVVG 

« Hide

References

[1]"Complete sequence of Rhodopseudomonas palustris BisB5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Pelletier D.A., Kyrpides N., Lykidis A., Oda Y., Harwood C.S., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BisB5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000283 Genomic DNA. Translation: ABE37674.1.
RefSeqYP_567575.1. NC_007958.1.

3D structure databases

ProteinModelPortalQ13E15.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316057.RPD_0436.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE37674; ABE37674; RPD_0436.
GeneID4020902.
KEGGrpd:RPD_0436.
PATRIC23275721. VBIRhoPal120395_0449.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHELEVYT.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycRPAL316057:GHDC-448-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_RHOPS
AccessionPrimary (citable) accession number: Q13E15
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries