Q13DN0 (PROA_RHOPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-glutamyl phosphate reductase
Short name=GPR
EC=1.2.1.41

Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name=GSA dehydrogenase

Gene names

Name:	proA
Ordered Locus Names:	RPD_0571

Organism

Rhodopseudomonas palustris (strain BisB5) [Complete proteome] [HAMAP]

Taxonomic identifier

316057 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412
Subcellular location	Cytoplasm By similarity HAMAP MF_00412.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 430	430	Gamma-glutamyl phosphate reductase HAMAP MF_00412		PRO_1000049990

Sequences

	Sequence		Length	Mass (Da)
	Q13DN0 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: DD72EF0F20B02627	FASTA	430	44,974
	10 20 30 40 50 60 MTASLKANDG SAELAALMTD LGRRARAAAR VLALAPPEQK NRALEAMERA IRAGAAAILD 70 80 90 100 110 120 ANAEDVADAK GSGANSAFLD RLTLTPARVE AMAEGIAVVR GIADPVGAVT ESWQRPNGMT 130 140 150 160 170 180 IERVRVPLGV VAVIFESRPN VTADAGVLCL KSGNAVILRG GSESFRSGRA IHACLVQGLR 190 200 210 220 230 240 EAGLPEAAIT LVPTRERAAV GLLLGGLNGT VDVIVPRGGK SLVARVESEA RVPVFAHLEG 250 260 270 280 290 300 INHVYVDRTA DLDMAKSIVL NAKMRRTGVC GAAETLLIDR AAADTHLAPL VGMLIDAGCE 310 320 330 340 350 360 VRGDDAVQRA DARVKPATDQ DWDTEYLDAV IAAKVVDDVD DAITHIHEHG SHHTDAIVAE 370 380 390 400 410 420 DAKTAAKFLG EVDSAIVLHN ASTQFADGGE FGFGAEIGIA TGKFHARGPV GAEQLTTFKY 430 RIHGTGQTRP

References

[1]

"Complete sequence of Rhodopseudomonas palustris BisB5." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Pelletier D.A., Kyrpides N., Lykidis A., Oda Y., Harwood C.S., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BisB5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000283 Genomic DNA. Translation: ABE37809.1.
RefSeq	YP_567710.1. NC_007958.1.
3D structure databases
ProteinModelPortal	Q13DN0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q13DN0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4021039.
GenomeReviews	Gene locus RPD_0571 in contig CP000283_GR.
KEGG	rpd:RPD_0571.
PATRIC	23276011. VBIRhoPal120395_0592.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0014.
HOGENOM	HBG318080.
OMA	YGICGAM.
ProtClustDB	PRK00197.
Enzyme and pathway databases
BioCyc	RPAL316057:RPD_0571-MONOMER.
Family and domain databases
HAMAP	MF_00412. ProA. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR000965. G-glutamylP_reductase. IPR020593. G-glutamylP_reductase_CS. IPR012134. Glu-5-SA_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KO	K00147.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF000151. GPR. 1 hit.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR00407. ProA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROA_RHOPS

Accession

Primary (citable) accession number: Q13DN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 31, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program