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Q13CU0 (HEMH_RHOPS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:RPD_0861
OrganismRhodopseudomonas palustris (strain BisB5) [Complete proteome] [HAMAP]
Taxonomic identifier316057 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Ferrochelatase HAMAP MF_00323
PRO_1000019362

Sites

Metal binding2151Iron By similarity
Metal binding2961Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q13CU0 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: 03E1EBFBA96A0EDA

FASTA34538,640
        10         20         30         40         50         60 
MTVIVPIHGP APAPAPVPER VGVLLVNLGT PDSCDTKGVR VYLREFLSDP RVIENQGLFW 

        70         80         90        100        110        120 
KLALNGIILN TRPARKAKDY QKIWNHEKNE SPLKTITRAQ AEKLAASLTD RSHLVVDWAM 

       130        140        150        160        170        180 
RYGNPSLRSR IEALVARGCS RLLVVPLYPQ YSAATSATVC DQAFRVLREL RAQPTLRVTP 

       190        200        210        220        230        240 
PYYRDDAYID ALANSINAHL ATLSFEPEMI VASFHGMPQA YIEKGDPYQS QCVATVDALR 

       250        260        270        280        290        300 
ERMGLDEKKL LLTFQSRFGF DQWLQPYTDK TIEKLAKDGV RKLAVVMPGF ASDCLETLEE 

       310        320        330        340 
IAQENAEIFM HNGGEEFSAI PCLNDSDDGI AVIRQLVMRE LQGWL

« Hide

References

[1]"Complete sequence of Rhodopseudomonas palustris BisB5."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Pelletier D.A., Kyrpides N., Lykidis A., Oda Y., Harwood C.S., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BisB5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000283 Genomic DNA. Translation: ABE38099.1.
RefSeqYP_568000.1. NC_007958.1.

3D structure databases

ProteinModelPortalQ13CU0.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ13CU0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4021335.
GenomeReviewsGene locus RPD_0861 in contig CP000283_GR.
KEGGrpd:RPD_0861.
PATRIC23276614. VBIRhoPal120395_0890.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMATIEEIGM.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycRPAL316057:RPD_0861-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_RHOPS
AccessionPrimary (citable) accession number: Q13CU0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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