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Q13BC6

- MASZ_RHOPS

UniProt

Q13BC6 - MASZ_RHOPS

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Protein

Malate synthase G

Gene
glcB, RPD_1375
Organism
Rhodopseudomonas palustris (strain BisB5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei273 – 2731Acetyl-CoA By similarity
Binding sitei310 – 3101Acetyl-CoA By similarity
Active sitei337 – 3371Proton acceptor By similarity
Binding sitei337 – 3371Glyoxylate By similarity
Metal bindingi429 – 4291Magnesium By similarity
Binding sitei429 – 4291Glyoxylate By similarity
Metal bindingi457 – 4571Magnesium By similarity
Binding sitei538 – 5381Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei628 – 6281Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRPAL316057:GHDC-1398-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:RPD_1375
OrganismiRhodopseudomonas palustris (strain BisB5)
Taxonomic identifieri316057 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001818: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Malate synthase GUniRule annotationPRO_1000056925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei614 – 6141Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi316057.RPD_1375.

Structurei

3D structure databases

ProteinModelPortaliQ13BC6.
SMRiQ13BC6. Positions 2-717.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 1252Acetyl-CoA binding By similarity
Regioni454 – 4574Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13BC6-1 [UniParc]FASTAAdd to Basket

« Hide

MNRIDAHGLK IAPVLFDFIA KEAAPKTGVA PDAFWAGLAA IVRDLTPKLR    50
KALTTRDDLQ AKIDAWHLAN KGKKQDLAVY TAFLKEIGYL QPEPATVAVE 100
TANVDEEIGK LCGPQLVVPL SNARYALNAA NARWGSLYDA FYGTDAIPQE 150
ATQAKGYDKA RGDKVIAKAK AFLDQAAPLV AGSHSDVTAY SVIAGQFSAK 200
LKSGNATGLK KPEQFAGYLG DAASPSAVLV VNNGLHIEIK IDRANTIGKD 250
DPAGVADLVI ESAVSTILDM EDSVAAVDAE DKVLIYRNVL GLMDGTLSES 300
FDKGGKTVTR ALNGDRTYTG PDGKDITLHG RSLLLMRNVG HHMWTDAVLD 350
ADGAEIPEGF LDAAVSGLIA IHDLKALGKT RNSRSGSVYI VKPKMHGPDE 400
VALTCELFGR VEKMLGLNDN TLKVGIMDEE RRTTVNLKAC IQNASKRIVF 450
INTGFLDRTG DEIHTSMEAG PMIRKNEMKA QPWIKAYEDW NVDTGLIDGL 500
PGHAQIGKGM WAAPDKMADM LAQKIGHPQA GATTAWVPSP TAATLHALHY 550
HQVDVIARQQ ELQKGGPRAK LDDILTIPVS QSNWAPDDVR QEIDNNCQGI 600
LGYVVRWIDQ GVGCSKVPDI HDVGLMEDRA TLRISSQHLA NWLHHGVVTK 650
EQVLESLKRM AAVVDKQNAS DPLYRPMAPD FDGVAFEAAC DLIFKGREQP 700
NGYTEFILHI RRREAKAAHL QDLR 724
Length:724
Mass (Da):78,605
Last modified:October 31, 2006 - v1
Checksum:i634C61A5438BB0F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000283 Genomic DNA. Translation: ABE38613.1.
RefSeqiWP_011501797.1. NC_007958.1.
YP_568514.1. NC_007958.1.

Genome annotation databases

EnsemblBacteriaiABE38613; ABE38613; RPD_1375.
GeneIDi4021852.
KEGGirpd:RPD_1375.
PATRICi23277690. VBIRhoPal120395_1426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000283 Genomic DNA. Translation: ABE38613.1 .
RefSeqi WP_011501797.1. NC_007958.1.
YP_568514.1. NC_007958.1.

3D structure databases

ProteinModelPortali Q13BC6.
SMRi Q13BC6. Positions 2-717.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316057.RPD_1375.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE38613 ; ABE38613 ; RPD_1375 .
GeneIDi 4021852.
KEGGi rpd:RPD_1375.
PATRICi 23277690. VBIRhoPal120395_1426.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci RPAL316057:GHDC-1398-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisB5.

Entry informationi

Entry nameiMASZ_RHOPS
AccessioniPrimary (citable) accession number: Q13BC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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