Reviewed, UniProtKB/Swiss-Prot Q139V1 (DNAE2_RHOPS)

Names and origin

Protein names

Recommended name:
    Error-prone DNA polymerase
    EC=2.7.7.7

Gene names

Name:	dnaE2
Ordered Locus Names:	RPD_1903

Organism

Rhodopseudomonas palustris (strain BisB5) [Complete proteome] [HAMAP]

Taxonomic identifier

316057 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	1110 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity.
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Subcellular location	CytoplasmProbable.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Ontologies

Keywords
Biological process	DNA damage DNA repair DNA replication
Cellular component	Cytoplasm
Molecular function	DNA-directed DNA polymerase Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: InterPro error-prone DNA repair Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1110	1110	Error-prone DNA polymerase		PRO_1000070597

Sequences

	Sequence		Length	Mass (Da)
	Q139V1-1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: CC1D06567E5E3390	FASTA	1,110	123,650
	10 20 30 40 50 60 MKVPAYAEIG VTTNFSFLEG GSHPQDYVHE ASRLGLEAIG IADRNTLAGV VRAYSELGNE 70 80 90 100 110 120 DLIHKPRLLI GARLVFADGT PDVLAYPVDR AAYGRLCRLL SVGKLRGAKG ECHLAVADLE 130 140 150 160 170 180 AFSQGLSLVL MPPYRFQASA IAAALQRLTA LESGGVWLGL TPYYRGDDKR RLARLKRVAW 190 200 210 220 230 240 AARVPGIATN DVLYHHPERR ALQDVLSCVR EKTTIDKIGR RLEANAERHL KPAAEMARLF 250 260 270 280 290 300 RADPDAIAET LRFAAGISFT LDELKYHYPD EPVPPGKTAQ QHLEDLTWEG VAEYFPAGIS 310 320 330 340 350 360 DKLHATIDKE LGIIAHRGYA QYFLTVHDIV RYARSQDILC QGRGSAANSA VCYVLGITCV 370 380 390 400 410 420 DPTEIDLLFE RFVSEERDEP PDIDVDFEHS RREEVMQYIY RRYGRHRAAI VATVIHYRPR 430 440 450 460 470 480 SAIRDVGKAL GLSEDVTAAL ADTVWGSWGK GLNEMQVKQA GLDPHNPLIG RAVELATELI 490 500 510 520 530 540 GFPRHLSQHV GGYVLTQDRL DSYVPIGNAA MEGRTFIEWD KDDIDAIKMM KVDVLALGML 550 560 570 580 590 600 TCIRKGFDLI AQHKGVRYAL SDIKSEDDNA VYQMLQRGES IGVFQVESRA QMNMLPRLKP 610 620 630 640 650 660 KCFYDLVIEV AIVRPGPIQG DMVHPYLRRR NKQEPVVYPA PAGHAGDANE LEVILGKTLG 670 680 690 700 710 720 VPLFQEQAMR IAIEAAHFTP DEANQLRRAM ATFRNVGTIG KFESKMVGNL VARGYDPVFA 730 740 750 760 770 780 KNCFEQIKGF GSYGFPESHA ASFAKLVYVS AWMKCEHPDA FCCALLNSQP MGFYAPAQIV 790 800 810 820 830 840 GDARANEVEV RPVDVSFSDG QCTLEERCGK HHAVRLGFRQ IDGFVWADPD EERVRREAGL 850 860 870 880 890 900 LPSEDWAARI VAARARGPFN SLERFARLTA LPKRALILLA DADAFRSLGL DRRAALWAVR 910 920 930 940 950 960 RLPDDVPLPL FEAASASEQL DENAAPLPQM PTAEHVVADY QTVRLSLKGH PMEFLRPLFA 970 980 990 1000 1010 1020 AERVVTCRSI SESRVSGQRM RCAGVVLVRQ RPGSAKGVVF ITLEDETGIA NLVVWPAVME 1030 1040 1050 1060 1070 1080 TFRKEVMGAR LLWVEGRIQA SPEGVVHLVA ERLSDRSFEM TRLSDNLAAP RLGELHEPLN 1090 1100 1110 DDRREHPDNP AQRIRHPRDV RILPPSRDFH

References

[1]

"Complete sequence of Rhodopseudomonas palustris BisB5." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Pelletier D.A., Kyrpides N., Lykidis A., Oda Y., Harwood C.S., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000283 Genomic DNA. Translation: ABE39138.1.
RefSeq	YP_569039.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4022385.
GenomeReviews	Gene locus RPD_1903 in contig CP000283_GR.
KEGG	rpd:RPD_1903.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q139V1.
Enzyme and pathway databases
BioCyc	RPAL316057:RPD_1903-MON.
Family and domain databases
HAMAP	MF_01902. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR004365. NA_bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. PHP_N. IPR004805. PolC_alpha. [Graphical view]
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
TIGRFAMs	TIGR00594. polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DNAE2_RHOPS

Accession

Primary (citable) accession number: Q139V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 31, 2006
Last modified:	November 25, 2008
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)