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Protein

Ras-specific guanine nucleotide-releasing factor 1

Gene

RASGRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes the exchange of Ras-bound GDP by GTP.1 Publication

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: ProtInc
  2. Ras guanyl-nucleotide exchange factor activity Source: ProtInc
  3. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. activation of Rac GTPase activity Source: HGNC
  2. cell proliferation Source: Ensembl
  3. long-term memory Source: UniProtKB
  4. neuron projection development Source: HGNC
  5. positive regulation of Ras GTPase activity Source: HGNC
  6. positive regulation of Ras protein signal transduction Source: UniProtKB
  7. regulation of neuronal synaptic plasticity Source: Ensembl
  8. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl
  9. regulation of Rac protein signal transduction Source: HGNC
  10. regulation of Ras protein signal transduction Source: HGNC
  11. regulation of synaptic plasticity Source: UniProtKB
  12. signal transduction Source: ProtInc
  13. small GTPase mediated signal transduction Source: InterPro
  14. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-specific guanine nucleotide-releasing factor 1
Short name:
Ras-GRF1
Alternative name(s):
Guanine nucleotide-releasing protein
Short name:
GNRP
Ras-specific nucleotide exchange factor CDC25
Gene namesi
Name:RASGRF1
Synonyms:CDC25, GNRP, GRF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:9875. RASGRF1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: HGNC
  2. growth cone Source: HGNC
  3. neuron projection Source: UniProtKB
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12731273Ras-specific guanine nucleotide-releasing factor 1PRO_0000068880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei577 – 5771Phosphoserine; by PLK2By similarity
Modified residuei626 – 6261Phosphoserine; by PLK2By similarity
Modified residuei779 – 7791Phosphoserine; by PLK2By similarity
Modified residuei800 – 8001Phosphoserine; by PLK2By similarity

Post-translational modificationi

Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome.By similarity
Ubiquitinated and degraded following phosphorylation by PLK2.By similarity
Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ13972.
PRIDEiQ13972.

PTM databases

PhosphoSiteiQ13972.

Expressioni

Gene expression databases

BgeeiQ13972.
CleanExiHS_RASGRF1.
GenevestigatoriQ13972.

Organism-specific databases

HPAiCAB010413.
HPA041965.

Interactioni

Subunit structurei

Homooligomer and heterooligomer with RASGRF2. Interacts with USP8, thereby regulating its stability (By similarity).By similarity

Protein-protein interaction databases

BioGridi111858. 10 interactions.
IntActiQ13972. 7 interactions.
MINTiMINT-2634734.
STRINGi9606.ENSP00000405963.

Structurei

3D structure databases

ProteinModelPortaliQ13972.
SMRiQ13972. Positions 225-610, 953-1272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 129108PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini204 – 22926IQPROSITE-ProRule annotationAdd
BLAST
Domaini240 – 426187DHPROSITE-ProRule annotationAdd
BLAST
Domaini467 – 584118PH 2PROSITE-ProRule annotationAdd
BLAST
Domaini644 – 761118N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini1038 – 1270233Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Domaini

The DH (DBL-homology) domain mediates interaction with RASGRF2.

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG307992.
GeneTreeiENSGT00780000121844.
HOGENOMiHOG000046000.
HOVERGENiHBG005208.
InParanoidiQ13972.
KOiK04349.
OMAiKNSSEFP.
OrthoDBiEOG7H1JKP.
PhylomeDBiQ13972.
TreeFamiTF317296.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR000048. IQ_motif_EF-hand-BS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00015. IQ. 1 hit.
SM00233. PH. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 2 hits.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13972-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKGIRLNDG HVASLGLLAR KDGTRKGYLS KRSSDNTKWQ TKWFALLQNL
60 70 80 90 100
LFYFESDSSS RPSGLYLLEG CVCDRAPSPK PALSAKEPLE KQHYFTVNFS
110 120 130 140 150
HENQKALELR TEDAKDCDEW VAAIAHASYR TLATEHEALM QKYLHLLQIV
160 170 180 190 200
ETEKTVAKQL RQQIEDGEIE IERLKAEITS LLKDNERIQS TQTVAPNDED
210 220 230 240 250
SDIKKIKKVQ SFLRGWLCRR KWKTIIQDYI RSPHADSMRK RNQVVFSMLE
260 270 280 290 300
AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH
310 320 330 340 350
QIFYQGLKAR ISSWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC
360 370 380 390 400
KQNRDFDKLL KHYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP
410 420 430 440 450
HEHVERNSLD YAKSKLEELS RIMHDEVSET ENIRKNLAIE RMIIEGCEIL
460 470 480 490 500
LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG SLSLKKEGER QCFLFSKHLI
510 520 530 540 550
ICTRGSGGKL HLTKNGVISL IDCTLLEEPE STEEEAKGSG QDIDHLDFKI
560 570 580 590 600
GVEPKDSPPF TVILVASSRQ EKAAWTSDIS QCVDNIRCNG LMMNAFEENS
610 620 630 640 650
KVTVPQMIKR TREGTREAEM SRSDASLYCD DVDIRFSKTM NSCKVLQIRY
660 670 680 690 700
ASVERLLERL TDLRFLSIDF LNTFLHSYRV FTTAIVVLDK LITIYKKPIS
710 720 730 740 750
AIPARWLRSL ELLFASGQNN KLLYGEPPKS PRATRKFSSP PPLSITKTSS
760 770 780 790 800
PSRRRKLSLN IPIITGGKAL DLAALSCNSN GYTSMYSAMS PFSKATLDTS
810 820 830 840 850
KLYVSSSFTN KIPDEGDTTP EKPEDPSALS KQSSEVSMRE ESDIDQNQSD
860 870 880 890 900
DGDTETSPTK SPTTPKSVKN KNSSEFPLFS YNNGVVMTSC RELDNNRSAL
910 920 930 940 950
SAASAFAIAT AGANEGTPNK EKYRRMSLAS AGFPPDQRNG DKEFVIRRAA
960 970 980 990 1000
TNRVLNVLRH WVSKHSQDFE TNDELKCKVI GFLEEVMHDP ELLTQERKAA
1010 1020 1030 1040 1050
ANIIRTLTQE DPGDNQITLE EITQMAEGVK AEPFENHSAL EIAEQLTLLD
1060 1070 1080 1090 1100
HLVFKKIPYE EFFGQGWMKL EKNERTPYIM KTTKHFNDIS NLIASEIIRN
1110 1120 1130 1140 1150
EDINARVSAI EKWVAVADIC RCLHNYNAVL EITSSMNRSA IFRLKKTWLK
1160 1170 1180 1190 1200
VSKQTKALID KLQKLVSSEG RFKNLREALK NCDPPCVPYL GMYLTDLAFI
1210 1220 1230 1240 1250
EEGTPNYTED GLVNFSKMRM ISHIIREIRQ FQQTAYKIEH QAKVTQYLLD
1260 1270
QSFVMDEESL YESSLRIEPK LPT
Length:1,273
Mass (Da):145,234
Last modified:April 15, 2014 - v2
Checksum:iB629AEAFDC7E500A
GO
Isoform 2 (identifier: Q13972-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-784: Missing.

Show »
Length:489
Mass (Da):55,489
Checksum:iDDF1EDAD9793F3EF
GO
Isoform 3 (identifier: Q13972-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     610-622: Missing.
     705-707: Missing.

Show »
Length:1,257
Mass (Da):143,218
Checksum:i097E066E032DFFDB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1053 – 10531V → A in M91815 (PubMed:1379731).Curated
Sequence conflicti1111 – 11111E → G in M91815 (PubMed:1379731).Curated
Sequence conflicti1134 – 11341S → C in M91815 (PubMed:1379731).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 784784Missing in isoform 2. 1 PublicationVSP_012032Add
BLAST
Alternative sequencei610 – 62213Missing in isoform 3. 1 PublicationVSP_054072Add
BLAST
Alternative sequencei705 – 7073Missing in isoform 3. 1 PublicationVSP_054073

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26584 mRNA. Translation: AAA58417.1.
S62035 mRNA. Translation: AAB26881.1.
AC011944 Genomic DNA. No translation available.
AC104231 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99141.1.
AK226101 mRNA. No translation available.
M91815 mRNA. No translation available.
CCDSiCCDS10309.1. [Q13972-1]
CCDS42065.1. [Q13972-2]
CCDS45320.1. [Q13972-3]
PIRiA38985.
RefSeqiNP_002882.3. NM_002891.4. [Q13972-1]
NP_722522.1. NM_153815.2. [Q13972-2]
UniGeneiHs.459035.

Genome annotation databases

EnsembliENST00000394745; ENSP00000378228; ENSG00000058335. [Q13972-2]
ENST00000419573; ENSP00000405963; ENSG00000058335. [Q13972-1]
ENST00000558480; ENSP00000452781; ENSG00000058335. [Q13972-3]
GeneIDi5923.
KEGGihsa:5923.
UCSCiuc002beo.3. human. [Q13972-2]
uc002beq.3. human.

Polymorphism databases

DMDMi13124259.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26584 mRNA. Translation: AAA58417.1.
S62035 mRNA. Translation: AAB26881.1.
AC011944 Genomic DNA. No translation available.
AC104231 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99141.1.
AK226101 mRNA. No translation available.
M91815 mRNA. No translation available.
CCDSiCCDS10309.1. [Q13972-1]
CCDS42065.1. [Q13972-2]
CCDS45320.1. [Q13972-3]
PIRiA38985.
RefSeqiNP_002882.3. NM_002891.4. [Q13972-1]
NP_722522.1. NM_153815.2. [Q13972-2]
UniGeneiHs.459035.

3D structure databases

ProteinModelPortaliQ13972.
SMRiQ13972. Positions 225-610, 953-1272.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111858. 10 interactions.
IntActiQ13972. 7 interactions.
MINTiMINT-2634734.
STRINGi9606.ENSP00000405963.

Chemistry

ChEMBLiCHEMBL5468.

PTM databases

PhosphoSiteiQ13972.

Polymorphism databases

DMDMi13124259.

Proteomic databases

PaxDbiQ13972.
PRIDEiQ13972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394745; ENSP00000378228; ENSG00000058335. [Q13972-2]
ENST00000419573; ENSP00000405963; ENSG00000058335. [Q13972-1]
ENST00000558480; ENSP00000452781; ENSG00000058335. [Q13972-3]
GeneIDi5923.
KEGGihsa:5923.
UCSCiuc002beo.3. human. [Q13972-2]
uc002beq.3. human.

Organism-specific databases

CTDi5923.
GeneCardsiGC15M079252.
H-InvDBHIX0023098.
HGNCiHGNC:9875. RASGRF1.
HPAiCAB010413.
HPA041965.
MIMi606600. gene.
neXtProtiNX_Q13972.
PharmGKBiPA34238.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG307992.
GeneTreeiENSGT00780000121844.
HOGENOMiHOG000046000.
HOVERGENiHBG005208.
InParanoidiQ13972.
KOiK04349.
OMAiKNSSEFP.
OrthoDBiEOG7H1JKP.
PhylomeDBiQ13972.
TreeFamiTF317296.

Enzyme and pathway databases

ReactomeiREACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.

Miscellaneous databases

ChiTaRSiRASGRF1. human.
GenomeRNAii5923.
NextBioi23066.
PROiQ13972.
SOURCEiSearch...

Gene expression databases

BgeeiQ13972.
CleanExiHS_RASGRF1.
GenevestigatoriQ13972.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR000048. IQ_motif_EF-hand-BS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00015. IQ. 1 hit.
SM00233. PH. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 2 hits.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and analysis of human cDNAs encoding a 140-kDa brain guanine nucleotide-exchange factor, Cdc25GEF, which regulates the function of Ras."
    Wei W., Das B., Park W., Broek D.
    Gene 151:279-284(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Identification of a human guanine nucleotide-releasing factor (H-GRF55) specific for Ras proteins."
    Schweighoffer F., Faure M., Fath I., Chevallier-Multon M.C., Apiou F., Dutrillaux B., Sturani E., Jacquet M., Tocque B.
    Oncogene 8:1477-1485(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 115-1273 (ISOFORM 3).
    Tissue: Brain.
  6. "Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae."
    Wei W., Mosteller R.D., Sanyal P., Gonzales E., McKinney D., Dasgupta C., Li P., Liu B.-X., Broek D.
    Proc. Natl. Acad. Sci. U.S.A. 89:7100-7104(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1045-1273 (ISOFORM 1).
  7. "Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf."
    Anborgh P.H., Qian X., Papageorge A.G., Vass W.C., DeClue J.E., Lowy D.R.
    Mol. Cell. Biol. 19:4611-4622(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: OLIGOMERIZATION, INTERACTION WITH RASGRF2.
  8. "Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm."
    Giglione C., Gonfloni S., Parmeggiani A.
    Eur. J. Biochem. 268:3275-3283(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, FUNCTION.

Entry informationi

Entry nameiRGRF1_HUMAN
AccessioniPrimary (citable) accession number: Q13972
Secondary accession number(s): F8VPA5
, H0YKF2, J3KQP9, Q16027
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2001
Last sequence update: April 15, 2014
Last modified: February 3, 2015
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.