Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q13972

- RGRF1_HUMAN

UniProt

Q13972 - RGRF1_HUMAN

Protein

Ras-specific guanine nucleotide-releasing factor 1

Gene

RASGRF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (16 Apr 2014)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Promotes the exchange of Ras-bound GDP by GTP.1 Publication

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: ProtInc
    2. Ras guanyl-nucleotide exchange factor activity Source: ProtInc
    3. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. activation of Rac GTPase activity Source: HGNC
    2. long-term memory Source: UniProtKB
    3. neuron projection development Source: HGNC
    4. positive regulation of Ras GTPase activity Source: HGNC
    5. positive regulation of Ras protein signal transduction Source: UniProtKB
    6. regulation of Rac protein signal transduction Source: HGNC
    7. regulation of Ras protein signal transduction Source: HGNC
    8. regulation of synaptic plasticity Source: UniProtKB
    9. signal transduction Source: ProtInc
    10. small GTPase mediated signal transduction Source: InterPro
    11. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-specific guanine nucleotide-releasing factor 1
    Short name:
    Ras-GRF1
    Alternative name(s):
    Guanine nucleotide-releasing protein
    Short name:
    GNRP
    Ras-specific nucleotide exchange factor CDC25
    Gene namesi
    Name:RASGRF1
    Synonyms:CDC25, GNRP, GRF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:9875. RASGRF1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: HGNC
    2. growth cone Source: HGNC
    3. neuron projection Source: UniProtKB
    4. plasma membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34238.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12731273Ras-specific guanine nucleotide-releasing factor 1PRO_0000068880Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei577 – 5771Phosphoserine; by PLK2By similarity
    Modified residuei626 – 6261Phosphoserine; by PLK2By similarity
    Modified residuei779 – 7791Phosphoserine; by PLK2By similarity
    Modified residuei800 – 8001Phosphoserine; by PLK2By similarity

    Post-translational modificationi

    Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome.By similarity
    Ubiquitinated and degraded following phosphorylation by PLK2.By similarity
    Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ13972.
    PRIDEiQ13972.

    PTM databases

    PhosphoSiteiQ13972.

    Expressioni

    Gene expression databases

    ArrayExpressiQ13972.
    BgeeiQ13972.
    CleanExiHS_RASGRF1.
    GenevestigatoriQ13972.

    Organism-specific databases

    HPAiCAB010413.
    HPA041965.

    Interactioni

    Subunit structurei

    Homooligomer and heterooligomer with RASGRF2. Interacts with USP8, thereby regulating its stability By similarity.By similarity

    Protein-protein interaction databases

    BioGridi111858. 10 interactions.
    IntActiQ13972. 7 interactions.
    MINTiMINT-2634734.
    STRINGi9606.ENSP00000405963.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13972.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 129108PH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini204 – 22926IQPROSITE-ProRule annotationAdd
    BLAST
    Domaini240 – 426187DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini467 – 584118PH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini644 – 761118N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini1038 – 1270233Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The DH (DBL-homology) domain mediates interaction with RASGRF2.

    Sequence similaritiesi

    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 1 IQ domain.PROSITE-ProRule annotation
    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 2 PH domains.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG307992.
    HOGENOMiHOG000046000.
    HOVERGENiHBG005208.
    InParanoidiQ13972.
    KOiK04349.
    OMAiSMYSAMS.
    OrthoDBiEOG7H1JKP.
    PhylomeDBiQ13972.
    TreeFamiTF317296.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 2 hits.
    InterProiIPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00015. IQ. 1 hit.
    SM00233. PH. 2 hits.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 2 hits.
    SM00325. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF48366. SSF48366. 2 hits.
    PROSITEiPS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50096. IQ. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13972-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQKGIRLNDG HVASLGLLAR KDGTRKGYLS KRSSDNTKWQ TKWFALLQNL     50
    LFYFESDSSS RPSGLYLLEG CVCDRAPSPK PALSAKEPLE KQHYFTVNFS 100
    HENQKALELR TEDAKDCDEW VAAIAHASYR TLATEHEALM QKYLHLLQIV 150
    ETEKTVAKQL RQQIEDGEIE IERLKAEITS LLKDNERIQS TQTVAPNDED 200
    SDIKKIKKVQ SFLRGWLCRR KWKTIIQDYI RSPHADSMRK RNQVVFSMLE 250
    AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH 300
    QIFYQGLKAR ISSWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC 350
    KQNRDFDKLL KHYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP 400
    HEHVERNSLD YAKSKLEELS RIMHDEVSET ENIRKNLAIE RMIIEGCEIL 450
    LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG SLSLKKEGER QCFLFSKHLI 500
    ICTRGSGGKL HLTKNGVISL IDCTLLEEPE STEEEAKGSG QDIDHLDFKI 550
    GVEPKDSPPF TVILVASSRQ EKAAWTSDIS QCVDNIRCNG LMMNAFEENS 600
    KVTVPQMIKR TREGTREAEM SRSDASLYCD DVDIRFSKTM NSCKVLQIRY 650
    ASVERLLERL TDLRFLSIDF LNTFLHSYRV FTTAIVVLDK LITIYKKPIS 700
    AIPARWLRSL ELLFASGQNN KLLYGEPPKS PRATRKFSSP PPLSITKTSS 750
    PSRRRKLSLN IPIITGGKAL DLAALSCNSN GYTSMYSAMS PFSKATLDTS 800
    KLYVSSSFTN KIPDEGDTTP EKPEDPSALS KQSSEVSMRE ESDIDQNQSD 850
    DGDTETSPTK SPTTPKSVKN KNSSEFPLFS YNNGVVMTSC RELDNNRSAL 900
    SAASAFAIAT AGANEGTPNK EKYRRMSLAS AGFPPDQRNG DKEFVIRRAA 950
    TNRVLNVLRH WVSKHSQDFE TNDELKCKVI GFLEEVMHDP ELLTQERKAA 1000
    ANIIRTLTQE DPGDNQITLE EITQMAEGVK AEPFENHSAL EIAEQLTLLD 1050
    HLVFKKIPYE EFFGQGWMKL EKNERTPYIM KTTKHFNDIS NLIASEIIRN 1100
    EDINARVSAI EKWVAVADIC RCLHNYNAVL EITSSMNRSA IFRLKKTWLK 1150
    VSKQTKALID KLQKLVSSEG RFKNLREALK NCDPPCVPYL GMYLTDLAFI 1200
    EEGTPNYTED GLVNFSKMRM ISHIIREIRQ FQQTAYKIEH QAKVTQYLLD 1250
    QSFVMDEESL YESSLRIEPK LPT 1273
    Length:1,273
    Mass (Da):145,234
    Last modified:April 16, 2014 - v2
    Checksum:iB629AEAFDC7E500A
    GO
    Isoform 2 (identifier: Q13972-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-784: Missing.

    Show »
    Length:489
    Mass (Da):55,489
    Checksum:iDDF1EDAD9793F3EF
    GO
    Isoform 3 (identifier: Q13972-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         610-622: Missing.
         705-707: Missing.

    Show »
    Length:1,257
    Mass (Da):143,218
    Checksum:i097E066E032DFFDB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1053 – 10531V → A in M91815. (PubMed:1379731)Curated
    Sequence conflicti1111 – 11111E → G in M91815. (PubMed:1379731)Curated
    Sequence conflicti1134 – 11341S → C in M91815. (PubMed:1379731)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 784784Missing in isoform 2. 1 PublicationVSP_012032Add
    BLAST
    Alternative sequencei610 – 62213Missing in isoform 3. 1 PublicationVSP_054072Add
    BLAST
    Alternative sequencei705 – 7073Missing in isoform 3. 1 PublicationVSP_054073

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26584 mRNA. Translation: AAA58417.1.
    S62035 mRNA. Translation: AAB26881.1.
    AC011944 Genomic DNA. No translation available.
    AC104231 Genomic DNA. No translation available.
    CH471136 Genomic DNA. Translation: EAW99141.1.
    AK226101 mRNA. No translation available.
    M91815 mRNA. No translation available.
    CCDSiCCDS10309.1. [Q13972-1]
    CCDS42065.1. [Q13972-2]
    CCDS45320.1. [Q13972-3]
    PIRiA38985.
    RefSeqiNP_002882.3. NM_002891.4. [Q13972-1]
    NP_722522.1. NM_153815.2. [Q13972-2]
    UniGeneiHs.459035.

    Genome annotation databases

    EnsembliENST00000394745; ENSP00000378228; ENSG00000058335. [Q13972-2]
    ENST00000419573; ENSP00000405963; ENSG00000058335. [Q13972-1]
    ENST00000558480; ENSP00000452781; ENSG00000058335. [Q13972-3]
    GeneIDi5923.
    KEGGihsa:5923.
    UCSCiuc002beo.3. human. [Q13972-2]
    uc002beq.3. human.

    Polymorphism databases

    DMDMi13124259.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26584 mRNA. Translation: AAA58417.1 .
    S62035 mRNA. Translation: AAB26881.1 .
    AC011944 Genomic DNA. No translation available.
    AC104231 Genomic DNA. No translation available.
    CH471136 Genomic DNA. Translation: EAW99141.1 .
    AK226101 mRNA. No translation available.
    M91815 mRNA. No translation available.
    CCDSi CCDS10309.1. [Q13972-1 ]
    CCDS42065.1. [Q13972-2 ]
    CCDS45320.1. [Q13972-3 ]
    PIRi A38985.
    RefSeqi NP_002882.3. NM_002891.4. [Q13972-1 ]
    NP_722522.1. NM_153815.2. [Q13972-2 ]
    UniGenei Hs.459035.

    3D structure databases

    ProteinModelPortali Q13972.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111858. 10 interactions.
    IntActi Q13972. 7 interactions.
    MINTi MINT-2634734.
    STRINGi 9606.ENSP00000405963.

    Chemistry

    ChEMBLi CHEMBL5468.

    PTM databases

    PhosphoSitei Q13972.

    Polymorphism databases

    DMDMi 13124259.

    Proteomic databases

    PaxDbi Q13972.
    PRIDEi Q13972.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394745 ; ENSP00000378228 ; ENSG00000058335 . [Q13972-2 ]
    ENST00000419573 ; ENSP00000405963 ; ENSG00000058335 . [Q13972-1 ]
    ENST00000558480 ; ENSP00000452781 ; ENSG00000058335 . [Q13972-3 ]
    GeneIDi 5923.
    KEGGi hsa:5923.
    UCSCi uc002beo.3. human. [Q13972-2 ]
    uc002beq.3. human.

    Organism-specific databases

    CTDi 5923.
    GeneCardsi GC15M079252.
    H-InvDB HIX0023098.
    HGNCi HGNC:9875. RASGRF1.
    HPAi CAB010413.
    HPA041965.
    MIMi 606600. gene.
    neXtProti NX_Q13972.
    PharmGKBi PA34238.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307992.
    HOGENOMi HOG000046000.
    HOVERGENi HBG005208.
    InParanoidi Q13972.
    KOi K04349.
    OMAi SMYSAMS.
    OrthoDBi EOG7H1JKP.
    PhylomeDBi Q13972.
    TreeFami TF317296.

    Enzyme and pathway databases

    Reactomei REACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.

    Miscellaneous databases

    GenomeRNAii 5923.
    NextBioi 23066.
    PROi Q13972.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13972.
    Bgeei Q13972.
    CleanExi HS_RASGRF1.
    Genevestigatori Q13972.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 2 hits.
    InterProi IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00015. IQ. 1 hit.
    SM00233. PH. 2 hits.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 2 hits.
    SM00325. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF48366. SSF48366. 2 hits.
    PROSITEi PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50096. IQ. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and analysis of human cDNAs encoding a 140-kDa brain guanine nucleotide-exchange factor, Cdc25GEF, which regulates the function of Ras."
      Wei W., Das B., Park W., Broek D.
      Gene 151:279-284(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Identification of a human guanine nucleotide-releasing factor (H-GRF55) specific for Ras proteins."
      Schweighoffer F., Faure M., Fath I., Chevallier-Multon M.C., Apiou F., Dutrillaux B., Sturani E., Jacquet M., Tocque B.
      Oncogene 8:1477-1485(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 115-1273 (ISOFORM 3).
      Tissue: Brain.
    6. "Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae."
      Wei W., Mosteller R.D., Sanyal P., Gonzales E., McKinney D., Dasgupta C., Li P., Liu B.-X., Broek D.
      Proc. Natl. Acad. Sci. U.S.A. 89:7100-7104(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1045-1273 (ISOFORM 1).
    7. "Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf."
      Anborgh P.H., Qian X., Papageorge A.G., Vass W.C., DeClue J.E., Lowy D.R.
      Mol. Cell. Biol. 19:4611-4622(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: OLIGOMERIZATION, INTERACTION WITH RASGRF2.
    8. "Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm."
      Giglione C., Gonfloni S., Parmeggiani A.
      Eur. J. Biochem. 268:3275-3283(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, FUNCTION.

    Entry informationi

    Entry nameiRGRF1_HUMAN
    AccessioniPrimary (citable) accession number: Q13972
    Secondary accession number(s): F8VPA5
    , H0YKF2, J3KQP9, Q16027
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: April 16, 2014
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3