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Q13972

- RGRF1_HUMAN

UniProt

Q13972 - RGRF1_HUMAN

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Protein
Ras-specific guanine nucleotide-releasing factor 1
Gene
RASGRF1, CDC25, GNRP, GRF1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes the exchange of Ras-bound GDP by GTP.1 Publication

GO - Molecular functioni

  1. Ras guanyl-nucleotide exchange factor activity Source: ProtInc
  2. Rho guanyl-nucleotide exchange factor activity Source: InterPro
  3. guanyl-nucleotide exchange factor activity Source: ProtInc

GO - Biological processi

  1. activation of Rac GTPase activity Source: HGNC
  2. long-term memory Source: UniProtKB
  3. neuron projection development Source: HGNC
  4. positive regulation of Ras GTPase activity Source: HGNC
  5. positive regulation of Ras protein signal transduction Source: UniProtKB
  6. regulation of Rac protein signal transduction Source: HGNC
  7. regulation of Ras protein signal transduction Source: HGNC
  8. regulation of synaptic plasticity Source: UniProtKB
  9. signal transduction Source: ProtInc
  10. small GTPase mediated signal transduction Source: InterPro
  11. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-specific guanine nucleotide-releasing factor 1
Short name:
Ras-GRF1
Alternative name(s):
Guanine nucleotide-releasing protein
Short name:
GNRP
Ras-specific nucleotide exchange factor CDC25
Gene namesi
Name:RASGRF1
Synonyms:CDC25, GNRP, GRF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:9875. RASGRF1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: HGNC
  2. growth cone Source: HGNC
  3. neuron projection Source: UniProtKB
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12731273Ras-specific guanine nucleotide-releasing factor 1
PRO_0000068880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei577 – 5771Phosphoserine; by PLK2 By similarity
Modified residuei626 – 6261Phosphoserine; by PLK2 By similarity
Modified residuei779 – 7791Phosphoserine; by PLK2 By similarity
Modified residuei800 – 8001Phosphoserine; by PLK2 By similarity

Post-translational modificationi

Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome By similarity.1 Publication
Ubiquitinated and degraded following phosphorylation by PLK2 By similarity.
Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ13972.
PRIDEiQ13972.

PTM databases

PhosphoSiteiQ13972.

Expressioni

Gene expression databases

ArrayExpressiQ13972.
BgeeiQ13972.
CleanExiHS_RASGRF1.
GenevestigatoriQ13972.

Organism-specific databases

HPAiCAB010413.
HPA041965.

Interactioni

Subunit structurei

Homooligomer and heterooligomer with RASGRF2. Interacts with USP8, thereby regulating its stability By similarity.1 Publication

Protein-protein interaction databases

BioGridi111858. 10 interactions.
IntActiQ13972. 7 interactions.
MINTiMINT-2634734.
STRINGi9606.ENSP00000405963.

Structurei

3D structure databases

ProteinModelPortaliQ13972.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 129108PH 1
Add
BLAST
Domaini204 – 22926IQ
Add
BLAST
Domaini240 – 426187DH
Add
BLAST
Domaini467 – 584118PH 2
Add
BLAST
Domaini644 – 761118N-terminal Ras-GEF
Add
BLAST
Domaini1038 – 1270233Ras-GEF
Add
BLAST

Domaini

The DH (DBL-homology) domain mediates interaction with RASGRF2.

Sequence similaritiesi

Contains 1 IQ domain.
Contains 2 PH domains.
Contains 1 Ras-GEF domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG307992.
HOGENOMiHOG000046000.
HOVERGENiHBG005208.
InParanoidiQ13972.
KOiK04349.
OMAiSMYSAMS.
OrthoDBiEOG7H1JKP.
PhylomeDBiQ13972.
TreeFamiTF317296.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR000048. IQ_motif_EF-hand-BS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00015. IQ. 1 hit.
SM00233. PH. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 2 hits.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13972-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQKGIRLNDG HVASLGLLAR KDGTRKGYLS KRSSDNTKWQ TKWFALLQNL     50
LFYFESDSSS RPSGLYLLEG CVCDRAPSPK PALSAKEPLE KQHYFTVNFS 100
HENQKALELR TEDAKDCDEW VAAIAHASYR TLATEHEALM QKYLHLLQIV 150
ETEKTVAKQL RQQIEDGEIE IERLKAEITS LLKDNERIQS TQTVAPNDED 200
SDIKKIKKVQ SFLRGWLCRR KWKTIIQDYI RSPHADSMRK RNQVVFSMLE 250
AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH 300
QIFYQGLKAR ISSWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC 350
KQNRDFDKLL KHYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP 400
HEHVERNSLD YAKSKLEELS RIMHDEVSET ENIRKNLAIE RMIIEGCEIL 450
LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG SLSLKKEGER QCFLFSKHLI 500
ICTRGSGGKL HLTKNGVISL IDCTLLEEPE STEEEAKGSG QDIDHLDFKI 550
GVEPKDSPPF TVILVASSRQ EKAAWTSDIS QCVDNIRCNG LMMNAFEENS 600
KVTVPQMIKR TREGTREAEM SRSDASLYCD DVDIRFSKTM NSCKVLQIRY 650
ASVERLLERL TDLRFLSIDF LNTFLHSYRV FTTAIVVLDK LITIYKKPIS 700
AIPARWLRSL ELLFASGQNN KLLYGEPPKS PRATRKFSSP PPLSITKTSS 750
PSRRRKLSLN IPIITGGKAL DLAALSCNSN GYTSMYSAMS PFSKATLDTS 800
KLYVSSSFTN KIPDEGDTTP EKPEDPSALS KQSSEVSMRE ESDIDQNQSD 850
DGDTETSPTK SPTTPKSVKN KNSSEFPLFS YNNGVVMTSC RELDNNRSAL 900
SAASAFAIAT AGANEGTPNK EKYRRMSLAS AGFPPDQRNG DKEFVIRRAA 950
TNRVLNVLRH WVSKHSQDFE TNDELKCKVI GFLEEVMHDP ELLTQERKAA 1000
ANIIRTLTQE DPGDNQITLE EITQMAEGVK AEPFENHSAL EIAEQLTLLD 1050
HLVFKKIPYE EFFGQGWMKL EKNERTPYIM KTTKHFNDIS NLIASEIIRN 1100
EDINARVSAI EKWVAVADIC RCLHNYNAVL EITSSMNRSA IFRLKKTWLK 1150
VSKQTKALID KLQKLVSSEG RFKNLREALK NCDPPCVPYL GMYLTDLAFI 1200
EEGTPNYTED GLVNFSKMRM ISHIIREIRQ FQQTAYKIEH QAKVTQYLLD 1250
QSFVMDEESL YESSLRIEPK LPT 1273
Length:1,273
Mass (Da):145,234
Last modified:April 16, 2014 - v2
Checksum:iB629AEAFDC7E500A
GO
Isoform 2 (identifier: Q13972-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-784: Missing.

Show »
Length:489
Mass (Da):55,489
Checksum:iDDF1EDAD9793F3EF
GO
Isoform 3 (identifier: Q13972-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     610-622: Missing.
     705-707: Missing.

Show »
Length:1,257
Mass (Da):143,218
Checksum:i097E066E032DFFDB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 784784Missing in isoform 2.
VSP_012032Add
BLAST
Alternative sequencei610 – 62213Missing in isoform 3.
VSP_054072Add
BLAST
Alternative sequencei705 – 7073Missing in isoform 3.
VSP_054073

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1053 – 10531V → A in M91815. 1 Publication
Sequence conflicti1111 – 11111E → G in M91815. 1 Publication
Sequence conflicti1134 – 11341S → C in M91815. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26584 mRNA. Translation: AAA58417.1.
S62035 mRNA. Translation: AAB26881.1.
AC011944 Genomic DNA. No translation available.
AC104231 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99141.1.
AK226101 mRNA. No translation available.
M91815 mRNA. No translation available.
CCDSiCCDS10309.1. [Q13972-1]
CCDS42065.1. [Q13972-2]
CCDS45320.1. [Q13972-3]
PIRiA38985.
RefSeqiNP_002882.3. NM_002891.4. [Q13972-1]
NP_722522.1. NM_153815.2. [Q13972-2]
UniGeneiHs.459035.

Genome annotation databases

EnsembliENST00000394745; ENSP00000378228; ENSG00000058335. [Q13972-2]
ENST00000419573; ENSP00000405963; ENSG00000058335.
ENST00000558480; ENSP00000452781; ENSG00000058335.
GeneIDi5923.
KEGGihsa:5923.
UCSCiuc002beo.3. human. [Q13972-2]
uc002beq.3. human.

Polymorphism databases

DMDMi13124259.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26584 mRNA. Translation: AAA58417.1 .
S62035 mRNA. Translation: AAB26881.1 .
AC011944 Genomic DNA. No translation available.
AC104231 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99141.1 .
AK226101 mRNA. No translation available.
M91815 mRNA. No translation available.
CCDSi CCDS10309.1. [Q13972-1 ]
CCDS42065.1. [Q13972-2 ]
CCDS45320.1. [Q13972-3 ]
PIRi A38985.
RefSeqi NP_002882.3. NM_002891.4. [Q13972-1 ]
NP_722522.1. NM_153815.2. [Q13972-2 ]
UniGenei Hs.459035.

3D structure databases

ProteinModelPortali Q13972.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111858. 10 interactions.
IntActi Q13972. 7 interactions.
MINTi MINT-2634734.
STRINGi 9606.ENSP00000405963.

Chemistry

ChEMBLi CHEMBL5468.

PTM databases

PhosphoSitei Q13972.

Polymorphism databases

DMDMi 13124259.

Proteomic databases

PaxDbi Q13972.
PRIDEi Q13972.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000394745 ; ENSP00000378228 ; ENSG00000058335 . [Q13972-2 ]
ENST00000419573 ; ENSP00000405963 ; ENSG00000058335 .
ENST00000558480 ; ENSP00000452781 ; ENSG00000058335 .
GeneIDi 5923.
KEGGi hsa:5923.
UCSCi uc002beo.3. human. [Q13972-2 ]
uc002beq.3. human.

Organism-specific databases

CTDi 5923.
GeneCardsi GC15M079252.
H-InvDB HIX0023098.
HGNCi HGNC:9875. RASGRF1.
HPAi CAB010413.
HPA041965.
MIMi 606600. gene.
neXtProti NX_Q13972.
PharmGKBi PA34238.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307992.
HOGENOMi HOG000046000.
HOVERGENi HBG005208.
InParanoidi Q13972.
KOi K04349.
OMAi SMYSAMS.
OrthoDBi EOG7H1JKP.
PhylomeDBi Q13972.
TreeFami TF317296.

Enzyme and pathway databases

Reactomei REACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.

Miscellaneous databases

GenomeRNAii 5923.
NextBioi 23066.
PROi Q13972.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13972.
Bgeei Q13972.
CleanExi HS_RASGRF1.
Genevestigatori Q13972.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
InterProi IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR000048. IQ_motif_EF-hand-BS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00015. IQ. 1 hit.
SM00233. PH. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 2 hits.
PROSITEi PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50096. IQ. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and analysis of human cDNAs encoding a 140-kDa brain guanine nucleotide-exchange factor, Cdc25GEF, which regulates the function of Ras."
    Wei W., Das B., Park W., Broek D.
    Gene 151:279-284(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Identification of a human guanine nucleotide-releasing factor (H-GRF55) specific for Ras proteins."
    Schweighoffer F., Faure M., Fath I., Chevallier-Multon M.C., Apiou F., Dutrillaux B., Sturani E., Jacquet M., Tocque B.
    Oncogene 8:1477-1485(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 115-1273 (ISOFORM 3).
    Tissue: Brain.
  6. "Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae."
    Wei W., Mosteller R.D., Sanyal P., Gonzales E., McKinney D., Dasgupta C., Li P., Liu B.-X., Broek D.
    Proc. Natl. Acad. Sci. U.S.A. 89:7100-7104(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1045-1273 (ISOFORM 1).
  7. "Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf."
    Anborgh P.H., Qian X., Papageorge A.G., Vass W.C., DeClue J.E., Lowy D.R.
    Mol. Cell. Biol. 19:4611-4622(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: OLIGOMERIZATION, INTERACTION WITH RASGRF2.
  8. "Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm."
    Giglione C., Gonfloni S., Parmeggiani A.
    Eur. J. Biochem. 268:3275-3283(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, FUNCTION.

Entry informationi

Entry nameiRGRF1_HUMAN
AccessioniPrimary (citable) accession number: Q13972
Secondary accession number(s): F8VPA5
, H0YKF2, J3KQP9, Q16027
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: April 16, 2014
Last modified: September 3, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi