Q13952 (NFYC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear transcription factor Y subunit gamma

Alternative name(s):
CAAT box DNA-binding protein subunit C
Nuclear transcription factor Y subunit C
Short name=NF-YC
Transactivator HSM-1/2

Gene names

Name:

NFYC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
Subunit structure	Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Ref.14
Subcellular location	Nucleus.
Sequence similarities	Belongs to the NFYC/HAP5 subunit family.
Sequence caution	The sequence BAD92212.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
Molecular function	Activator
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular lipid metabolic process Traceable author statement. Source: Reactome positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara protein folding Traceable author statement Ref.4. Source: ProtInc regulation of transcription from RNA polymerase II promoter Traceable author statement Ref.4. Source: ProtInc small molecule metabolic process Traceable author statement. Source: Reactome transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	CCAAT-binding factor complex Inferred from direct assay PubMed 15243141. Source: UniProtKB
Molecular_function	DNA binding Inferred from direct assay PubMed 15243141. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Traceable author statement Ref.4Ref.3. Source: ProtInc transcription coactivator activity Traceable author statement Ref.4. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NFYA	P23511	3	EBI-389755,EBI-389739
NFYB	P25208	3	EBI-389755,EBI-389728

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: Q13952-1)

Also known as: DS2.8;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q13952-2)

Also known as: Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     277-295: Missing.
     316-419: Missing.

Isoform 2 (identifier: Q13952-3)

The sequence of this isoform differs from the canonical sequence as follows:
     277-295: Missing.

Isoform 4 (identifier: Q13952-4)

The sequence of this isoform differs from the canonical sequence as follows:
     60-97: Missing.
     277-295: Missing.
     316-419: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q13952-5)

The sequence of this isoform differs from the canonical sequence as follows:
     316-419: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q13952-6)

The sequence of this isoform differs from the canonical sequence as follows:
     186-219: Missing.
     277-295: Missing.
     316-419: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q13952-7)

The sequence of this isoform differs from the canonical sequence as follows:
     277-295: Missing.
     315-315: Missing.
     316-419: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 458

458

Nuclear transcription factor Y subunit gamma

PRO_0000218246

Natural variations

Alternative sequence

60 – 97

38

Missing in isoform 4.

VSP_043348

Alternative sequence

186 – 219

34

Missing in isoform 6.

VSP_043349

Alternative sequence

277 – 295

19

Missing in isoform 1, isoform 2, isoform 4, isoform 6 and isoform 7.

VSP_000851

Alternative sequence

315

1

Missing in isoform 7.

VSP_046350

Alternative sequence

316 – 419

104

Missing in isoform 1, isoform 4, isoform 5, isoform 6 and isoform 7.

VSP_000852

Natural variant

165

1

Q → H in a breast cancer sample; somatic mutation. Ref.15

VAR_035702

Natural variant

297

1

T → I.
Corresponds to variant rs2230746 [ dbSNP | Ensembl ].

VAR_059460

Experimental info

Sequence conflict

52

1

M → I in CAA99055. Ref.3

Sequence conflict

90

1

D → N in BAA14051. Ref.4

Sequence conflict

155

1

V → L in AAC50816. Ref.1

Sequence conflict

158

1

Q → H in BAA14051. Ref.4

Sequence conflict

171

1

T → N in BAA14051. Ref.4

Sequence conflict

175

1

P → A in AAC50816. Ref.1

Sequence conflict

179

1

I → F in BAA14051. Ref.4

Sequence conflict

198

1

G → S in BAA12818. Ref.4

Sequence conflict

198

1

G → S in BAA14051. Ref.4

Sequence conflict

202

1

Q → K in BAA12818. Ref.4

Sequence conflict

216 – 217

2

QS → HN in BAA14051. Ref.4

Sequence conflict

248

1

L → V in AAC50816. Ref.1

Sequence conflict

271

1

A → V in AAC50816. Ref.1

Sequence conflict

451

1

Q → K in BAA14051. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

458

Helix Strand Turn

Details...

Helix

45 – 52

8

Beta strand

55 – 57

3

Helix

64 – 90

27

Beta strand

94 – 96

3

Helix

98 – 105

8

Helix

109 – 114

6

Turn

115 – 117

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 (DS2.8) [UniParc]. Last modified January 23, 2002. Version 3. Checksum: B17B2C7F622653B9	FASTA	458	50,302
	10 20 30 40 50 60 MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK IMKLDEDVKM 70 80 90 100 110 120 ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND IAMAITKFDQ FDFLIDIVPR 130 140 150 160 170 180 DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ QPTAVQVQGQ QQGQQTTSST TTIQPGQIII 190 200 210 220 230 240 AQPQQGQTTP VTMQVGEGQQ VQIVQAQPQG QAQQAQSGTG QTMQVMQQII TNTGEIQQIP 250 260 270 280 290 300 VQLNAGQLQY IRLAQPVSGT QVVQGQIQTL ATNAQQGQRN ASQGKPRRCL KETLQITQTE 310 320 330 340 350 360 VQQGQQQFSQ FTDGQRNSVQ QARVSELTGE AEPREVKATG NSTPCTSSLP TTHPPSHRAG 370 380 390 400 410 420 ASCVCCSQPQ QSSTSPPPSD ALQWVVVEVS GTPNQLETHR ELHAPLPGMT SLSPLHPSQQ 430 440 450 LYQIQQVTMP AGQDLAQPMF IQSANQPSDG QAPQVTGD
	Isoform 1 (Gamma) [UniParc]. Checksum: D83635C1773C3895	FASTA	335	37,194
	10 20 30 40 50 60 MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK IMKLDEDVKM 70 80 90 100 110 120 ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND IAMAITKFDQ FDFLIDIVPR 130 140 150 160 170 180 DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ QPTAVQVQGQ QQGQQTTSST TTIQPGQIII 190 200 210 220 230 240 AQPQQGQTTP VTMQVGEGQQ VQIVQAQPQG QAQQAQSGTG QTMQVMQQII TNTGEIQQIP 250 260 270 280 290 300 VQLNAGQLQY IRLAQPVSGT QVVQGQIQTL ATNAQQITQT EVQQGQQQFS QFTDGQQLYQ 310 320 330 IQQVTMPAGQ DLAQPMFIQS ANQPSDGQAP QVTGD
	Isoform 2 [UniParc]. Checksum: E3FED3512983A402	FASTA	439	48,150
	10 20 30 40 50 60 MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK IMKLDEDVKM 70 80 90 100 110 120 ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND IAMAITKFDQ FDFLIDIVPR 130 140 150 160 170 180 DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ QPTAVQVQGQ QQGQQTTSST TTIQPGQIII 190 200 210 220 230 240 AQPQQGQTTP VTMQVGEGQQ VQIVQAQPQG QAQQAQSGTG QTMQVMQQII TNTGEIQQIP 250 260 270 280 290 300 VQLNAGQLQY IRLAQPVSGT QVVQGQIQTL ATNAQQITQT EVQQGQQQFS QFTDGQRNSV 310 320 330 340 350 360 QQARVSELTG EAEPREVKAT GNSTPCTSSL PTTHPPSHRA GASCVCCSQP QQSSTSPPPS 370 380 390 400 410 420 DALQWVVVEV SGTPNQLETH RELHAPLPGM TSLSPLHPSQ QLYQIQQVTM PAGQDLAQPM 430 FIQSANQPSD GQAPQVTGD
	Isoform 4 [UniParc]. Checksum: 6E5693FBF9D838ED	FASTA	297	32,828
	10 20 30 40 50 60 MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK IMKLDEDVKR 70 80 90 100 110 120 NDIAMAITKF DQFDFLIDIV PRDELKPPKR QEEVRQSVTP AEPVQYYFTL AQQPTAVQVQ 130 140 150 160 170 180 GQQQGQQTTS STTTIQPGQI IIAQPQQGQT TPVTMQVGEG QQVQIVQAQP QGQAQQAQSG 190 200 210 220 230 240 TGQTMQVMQQ IITNTGEIQQ IPVQLNAGQL QYIRLAQPVS GTQVVQGQIQ TLATNAQQIT 250 260 270 280 290 QTEVQQGQQQ FSQFTDGQQL YQIQQVTMPA GQDLAQPMFI QSANQPSDGQ APQVTGD
	Isoform 5 [UniParc]. Checksum: 80887376BB8125F3	FASTA	354	39,346
	10 20 30 40 50 60 MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK IMKLDEDVKM 70 80 90 100 110 120 ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND IAMAITKFDQ FDFLIDIVPR 130 140 150 160 170 180 DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ QPTAVQVQGQ QQGQQTTSST TTIQPGQIII 190 200 210 220 230 240 AQPQQGQTTP VTMQVGEGQQ VQIVQAQPQG QAQQAQSGTG QTMQVMQQII TNTGEIQQIP 250 260 270 280 290 300 VQLNAGQLQY IRLAQPVSGT QVVQGQIQTL ATNAQQGQRN ASQGKPRRCL KETLQITQTE 310 320 330 340 350 VQQGQQQFSQ FTDGQQLYQI QQVTMPAGQD LAQPMFIQSA NQPSDGQAPQ VTGD
	Isoform 6 [UniParc]. Checksum: 1BC4774E7E20894A	FASTA	301	33,702
	10 20 30 40 50 60 MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK IMKLDEDVKM 70 80 90 100 110 120 ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND IAMAITKFDQ FDFLIDIVPR 130 140 150 160 170 180 DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ QPTAVQVQGQ QQGQQTTSST TTIQPGQIII 190 200 210 220 230 240 AQPQQGQTMQ VMQQIITNTG EIQQIPVQLN AGQLQYIRLA QPVSGTQVVQ GQIQTLATNA 250 260 270 280 290 300 QQITQTEVQQ GQQQFSQFTD GQQLYQIQQV TMPAGQDLAQ PMFIQSANQP SDGQAPQVTG D
	Isoform 7 [UniParc]. Checksum: 685A01326BF0FFB1	FASTA	334	37,066
	10 20 30 40 50 60 MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK IMKLDEDVKM 70 80 90 100 110 120 ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND IAMAITKFDQ FDFLIDIVPR 130 140 150 160 170 180 DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ QPTAVQVQGQ QQGQQTTSST TTIQPGQIII 190 200 210 220 230 240 AQPQQGQTTP VTMQVGEGQQ VQIVQAQPQG QAQQAQSGTG QTMQVMQQII TNTGEIQQIP 250 260 270 280 290 300 VQLNAGQLQY IRLAQPVSGT QVVQGQIQTL ATNAQQITQT EVQQGQQQFS QFTDGQLYQI 310 320 330 QQVTMPAGQD LAQPMFIQSA NQPSDGQAPQ VTGD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox." Nakshatri H., Bhat-Nakshatri P., Currie R.A. J. Biol. Chem. 271:28784-28791(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Cloning and expression of human NF-YC." Bellorini M., Zemzoumi K., Farina A., Berthelsen J., Piaggio G., Mantovani R. Gene 193:119-125(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor." Dmitrenko V.V., Garifulin O.M., Kavsan V.M. Gene 197:161-163(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Cell cycle-dependent switch of up- and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y." Taira T., Sawai M., Ikeda M., Tamai K., Iguchi-Ariga S.M.M., Ariga H. J. Biol. Chem. 274:24270-24279(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"Cloning of a new variant of NFY-C." Bringuier P.P., Schalken J.A., Yamasaki H., Giroldi L.A. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4; 5 AND 6). Tissue: Synovium.
[7]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). Tissue: Brain.
[9]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y." Romier C., Cocchiarella F., Mantovani R., Moras D. J. Biol. Chem. 278:1336-1345(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS) OF 27-120 IN COMPLEX WITH NF-YB.
[14]	"Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination." Nardini M., Gnesutta N., Donati G., Gatta R., Forni C., Fossati A., Vonrhein C., Moras D., Romier C., Bolognesi M., Mantovani R. Cell 152:132-143(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.08 ANGSTROMS) OF 27-120 IN COMPLEX WITH NYFA; NYFB AND PROMOTER DNA, SUBUNIT.
[15]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-165.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U62296 mRNA. Translation: AAC50816.1.
U78774 mRNA. Translation: AAC51669.1.
Z74792 mRNA. Translation: CAA99055.1.
D85425 mRNA. Translation: BAA12818.1.
D89986 mRNA. Translation: BAA14051.1.
AF191744 mRNA. Translation: AAG28389.1.
AK000346 mRNA. Translation: BAA91100.1.
AK127677 mRNA. Translation: BAG54549.1.
AK300774 mRNA. Translation: BAG62438.1.
AK301385 mRNA. Translation: BAG62925.1.
BT020081 mRNA. Translation: AAV38884.1.
AB208975 mRNA. Translation: BAD92212.1. Different initiation.
AL031289 Genomic DNA. No translation available.
AL354914, AC119677 Genomic DNA. Translation: CAI16530.1.
AL354914, AC119677 Genomic DNA. Translation: CAI16531.1.
AL354914, AC119677 Genomic DNA. Translation: CAI16532.1.
AL354914, AC119677 Genomic DNA. Translation: CAI16533.1.
CH471059 Genomic DNA. Translation: EAX07198.1.
CH471059 Genomic DNA. Translation: EAX07201.1.
CH471059 Genomic DNA. Translation: EAX07202.1.
CH471059 Genomic DNA. Translation: EAX07203.1.
BC005003 mRNA. Translation: AAH05003.1.

IPI

IPI00071697.
IPI00216407.
IPI00514289.
IPI00645066.
IPI00646320.
IPI00911001.
IPI00943050.

RefSeq

NP_001136059.1. NM_001142587.1.
NP_001136060.1. NM_001142588.1.
NP_001136061.1. NM_001142589.1.
NP_001136062.1. NM_001142590.1.
NP_055038.2. NM_014223.4.

UniGene

Hs.713051.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1N1J	X-ray	1.67	B	27-120	[»]
4AWL	X-ray	3.08	C	27-120	[»]

ProteinModelPortal

Q13952.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q13952. 19 interactions.

MINT

MINT-249381.

PTM databases

PhosphoSite

Q13952.

Polymorphism databases

DMDM

20137773.

Proteomic databases

PaxDb

Q13952.

PRIDE

Q13952.

Protocols and materials databases

DNASU

4802.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000308733; ENSP00000312617; ENSG00000066136.
ENST00000372651; ENSP00000361734; ENSG00000066136.
ENST00000372652; ENSP00000361736; ENSG00000066136.
ENST00000372653; ENSP00000361737; ENSG00000066136.
ENST00000372654; ENSP00000361738; ENSG00000066136.
ENST00000425457; ENSP00000396620; ENSG00000066136.
ENST00000427410; ENSP00000408315; ENSG00000066136.
ENST00000440226; ENSP00000414299; ENSG00000066136.
ENST00000447388; ENSP00000404427; ENSG00000066136.
ENST00000456393; ENSP00000408867; ENSG00000066136.

GeneID

4802.

KEGG

hsa:4802.

UCSC

uc001cfx.4. human.
uc001cfy.4. human.
uc001cfz.3. human.
uc001cgb.3. human.
uc001cgc.3. human.
uc001cge.3. human.
uc010ojn.2. human.

Organism-specific databases

CTD

4802.

GeneCards

GC01P041159.

HGNC

HGNC:7806. NFYC.

MIM

605344. gene.

neXtProt

NX_Q13952.

PharmGKB

PA31611.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5208.

HOGENOM

HOG000231074.

HOVERGEN

HBG002885.

InParanoid

Q13952.

KO

K08066.

OMA

ATNAQQI.

PhylomeDB

Q13952.

Enzyme and pathway databases

Reactome

REACT_111217. Metabolism.

Gene expression databases

ArrayExpress

Q13952.

Bgee

Q13952.

Genevestigator

Q13952.

GermOnline

ENSG00000066136. Homo sapiens.

Family and domain databases

Gene3D

1.10.20.10. 1 hit.

InterPro

IPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
IPR027170. NFYC/HAP5_su.
[Graphical view]

PANTHER

PTHR10252:SF14. PTHR10252:SF14. 1 hit.

Pfam

PF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]

SUPFAM

SSF47113. Histone-fold. 1 hit.

ProtoNet

Search...

Other

ChiTaRS

NFYC. human.

EvolutionaryTrace

Q13952.

GenomeRNAi

4802.

NextBio

18510.

SOURCE

Search...

Entry information

Entry name

NFYC_HUMAN

Accession

Primary (citable) accession number: Q13952
Secondary accession number(s): B4DUS6 , B4DW63, D3DPV9, F8VWM3, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	January 23, 2002
Last modified:	May 29, 2013
This is version 138 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.