Reviewed,
UniProtKB/Swiss-Prot Q13952 (NFYC_HUMAN)
Last modified
January 19, 2010.
Version 104.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Nuclear transcription factor Y subunit gamma Alternative name(s): Nuclear transcription factor Y subunit C Short name=NF-YC CAAT-box DNA-binding protein subunit C Transactivator HSM-1/2 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 458 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. |
| Subunit structure | Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. |
| Subcellular location | |
| Sequence similarities | Belongs to the NFYC/HAP5 subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Ligand | DNA-binding |
| Molecular function | Activator |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | protein folding Ref.4 Traceable author statement. Source: ProtInc regulation of transcription from RNA polymerase II promoter Ref.4Traceable author statement. Source: ProtInc transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | CCAAT-binding factor complex Inferred from direct assay. Source: UniProtKB |
| Molecular function | RNA polymerase II transcription factor activity Ref.4 Traceable author statement. Source: ProtInc sequence-specific DNA bindingInferred from electronic annotation. Source: InterPro transcription coactivator activity Ref.4Traceable author statement. Source: ProtInc transcription factor activity Ref.3 Ref.4Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 3 (identifier: Q13952-1) Also known as: DS2.8; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 1 (identifier: Q13952-2) Also known as: Gamma; The sequence of this isoform differs from the canonical sequence as follows: 277-295: Missing. 316-419: Missing. | ||||||
| Isoform 2 (identifier: Q13952-3) The sequence of this isoform differs from the canonical sequence as follows: 277-295: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||
Molecule processing | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 458 | 458 | Nuclear transcription factor Y subunit gamma | PRO_0000218246 | ||||||||||||||||
Natural variations | ||||||||||||||||||||
| Alternative sequence | 277 – 295 | 19 | Missing in isoform 1 and isoform 2. | VSP_000851 | ||||||||||||||||
| Alternative sequence | 316 – 419 | 104 | Missing in isoform 1. | VSP_000852 | ||||||||||||||||
| Natural variant | 165 | 1 | Q → H in a breast cancer sample; somatic mutation. Ref.12 | VAR_035702 | ||||||||||||||||
| Natural variant | 297 | 1 | T → I: dbSNP rs2230746. | VAR_059460 | ||||||||||||||||
Experimental info | ||||||||||||||||||||
| Sequence conflict | 52 | 1 | M → I in CAA99055. Ref.3 | |||||||||||||||||
| Sequence conflict | 90 | 1 | D → N in BAA14051. Ref.4 | |||||||||||||||||
| Sequence conflict | 155 | 1 | V → L in AAC50816. Ref.1 | |||||||||||||||||
| Sequence conflict | 158 | 1 | Q → H in BAA14051. Ref.4 | |||||||||||||||||
| Sequence conflict | 171 | 1 | T → N in BAA14051. Ref.4 | |||||||||||||||||
| Sequence conflict | 175 | 1 | P → A in AAC50816. Ref.1 | |||||||||||||||||
| Sequence conflict | 179 | 1 | I → F in BAA14051. Ref.4 | |||||||||||||||||
| Sequence conflict | 198 | 1 | G → S in BAA12818. Ref.4 | |||||||||||||||||
| Sequence conflict | 198 | 1 | G → S in BAA14051. Ref.4 | |||||||||||||||||
| Sequence conflict | 202 | 1 | Q → K in BAA12818. Ref.4 | |||||||||||||||||
| Sequence conflict | 216 – 217 | 2 | QS → HN in BAA14051. Ref.4 | |||||||||||||||||
| Sequence conflict | 248 | 1 | L → V in AAC50816. Ref.1 | |||||||||||||||||
| Sequence conflict | 271 | 1 | A → V in AAC50816. Ref.1 | |||||||||||||||||
| Sequence conflict | 451 | 1 | Q → K in BAA14051. Ref.4 | |||||||||||||||||
Secondary structure | ||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||
| Helix | 45 – 52 | 8 | ||||||||||||||||||
| Helix | 64 – 90 | 27 | ||||||||||||||||||
| Beta strand | 94 – 96 | 3 | ||||||||||||||||||
| Helix | 98 – 105 | 8 | ||||||||||||||||||
| Helix | 109 – 114 | 6 | ||||||||||||||||||
| Turn | 115 – 117 | 3 | ||||||||||||||||||
Sequences
| ||||||||||||||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox." Nakshatri H., Bhat-Nakshatri P., Currie R.A. J. Biol. Chem. 271:28784-28791(1996) [PubMed: 8910521] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). |
| [2] | "Cloning and expression of human NF-YC." Bellorini M., Zemzoumi K., Farina A., Berthelsen J., Piaggio G., Mantovani R. Gene 193:119-125(1997) [PubMed: 9249075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). |
| [3] | "Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor." Dmitrenko V.V., Garifulin O.M., Kavsan V.M. Gene 197:161-163(1997) [PubMed: 9332362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain. |
| [4] | "Cell cycle-dependent switch of up- and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y." Taira T., Sawai M., Ikeda M., Tamai K., Iguchi-Ariga S.M.M., Ariga H. J. Biol. Chem. 274:24270-24279(1999) [PubMed: 10446203] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain. |
| [5] | "Cloning of a new variant of NFY-C." Bringuier P.P., Schalken J.A., Yamasaki H., Giroldi L.A. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). |
| [6] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). |
| [7] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). |
| [8] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [9] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain. |
| [10] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [11] | "The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y." Romier C., Cocchiarella F., Mantovani R., Moras D. J. Biol. Chem. 278:1336-1345(2003) [PubMed: 12401788] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS) OF 27-120 IN COMPLEX WITH NF-YB. |
| [12] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-165. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | U62296 mRNA. Translation: AAC50816.1. U78774 mRNA. Translation: AAC51669.1. Z74792 mRNA. Translation: CAA99055.1. D85425 mRNA. Translation: BAA12818.1. D89986 mRNA. Translation: BAA14051.1. AF191744 mRNA. Translation: AAG28389.1. AK000346 mRNA. Translation: BAA91100.1. BT020081 mRNA. Translation: AAV38884.1. AL354914, AC119677 Genomic DNA. Translation: CAI16530.1. AL354914, AC119677 Genomic DNA. Translation: CAI16531.1. AL354914, AC119677 Genomic DNA. Translation: CAI16533.1. BC005003 mRNA. Translation: AAH05003.1. | ||||||||||||
| IPI | IPI00071697. IPI00216407. IPI00911001. | ||||||||||||
| RefSeq | NP_001136059.1. NP_001136060.1. NP_001136061.1. NP_001136062.1. NP_055038.2. | ||||||||||||
| UniGene | Hs.233458 Hs.713051 | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q13952. 2 interactions. | ||||||||||||
| STRING | Q13952. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q13952. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000308733; ENSP00000312617; ENSG00000066136; Homo sapiens. [Genome view] ENST00000372657; ENSP00000361741; ENSG00000066136; Homo sapiens. [Genome view] | ||||||||||||
| GeneID | 4802. | ||||||||||||
| KEGG | hsa:4802. | ||||||||||||
| UCSC | uc001cfy.2. human. uc001cgb.2. human. uc001cge.2. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 4802. | ||||||||||||
| GeneCards | GC01P040929. | ||||||||||||
| H-InvDB | HIX0000478. | ||||||||||||
| HGNC | HGNC:7806. NFYC. | ||||||||||||
| MIM | 605344. gene. | ||||||||||||
| PharmGKB | PA31611. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG04809. | ||||||||||||
| HOVERGEN | Q13952. | ||||||||||||
| InParanoid | Q13952. | ||||||||||||
| OMA | ATNAQQI. | ||||||||||||
| PhylomeDB | Q13952. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q13952. | ||||||||||||
| Bgee | Q13952. | ||||||||||||
| Genevestigator | Q13952. | ||||||||||||
| GermOnline | ENSG00000066136. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR003958. CBFA_NFYB_domain. IPR009072. Histone-fold. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:1.10.20.10. Histone-fold. 1 hit. | ||||||||||||
| Pfam | PF00808. CBFD_NFYB_HMF. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 18510. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | NFYC_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13952 Secondary accession number(s): Q5T6K8 Q9UMT7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


