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Q13952

- NFYC_HUMAN

UniProt

Q13952 - NFYC_HUMAN

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Protein

Nuclear transcription factor Y subunit gamma

Gene
NFYC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc
  5. transcription coactivator activity Source: ProtInc

GO - Biological processi

  1. cellular lipid metabolic process Source: Reactome
  2. positive regulation of transcription, DNA-templated Source: Ensembl
  3. protein folding Source: ProtInc
  4. regulation of transcription, DNA-templated Source: UniProtKB
  5. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  6. small molecule metabolic process Source: Reactome
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.
REACT_147904. Activation of gene expression by SREBF (SREBP).
REACT_18355. ATF4 activates genes.
REACT_18423. ATF6-alpha activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transcription factor Y subunit gamma
Alternative name(s):
CAAT box DNA-binding protein subunit C
Nuclear transcription factor Y subunit C
Short name:
NF-YC
Transactivator HSM-1/2
Gene namesi
Name:NFYC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:7806. NFYC.

Subcellular locationi

GO - Cellular componenti

  1. CCAAT-binding factor complex Source: UniProtKB
  2. nucleoplasm Source: Reactome
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Nuclear transcription factor Y subunit gammaPRO_0000218246Add
BLAST

Proteomic databases

MaxQBiQ13952.
PaxDbiQ13952.
PRIDEiQ13952.

PTM databases

PhosphoSiteiQ13952.

Expressioni

Gene expression databases

ArrayExpressiQ13952.
BgeeiQ13952.
GenevestigatoriQ13952.

Organism-specific databases

HPAiHPA055011.

Interactioni

Subunit structurei

Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NFYAP235114EBI-389755,EBI-389739
NFYBP252083EBI-389755,EBI-389728

Protein-protein interaction databases

BioGridi110868. 36 interactions.
IntActiQ13952. 20 interactions.
MINTiMINT-249381.

Structurei

Secondary structure

1
458
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi45 – 528
Beta strandi55 – 573
Helixi64 – 9027
Beta strandi94 – 963
Helixi98 – 1058
Helixi109 – 1146
Turni115 – 1173

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1N1JX-ray1.67B27-120[»]
4AWLX-ray3.08C27-120[»]
ProteinModelPortaliQ13952.
SMRiQ13952. Positions 6-120.

Miscellaneous databases

EvolutionaryTraceiQ13952.

Family & Domainsi

Sequence similaritiesi

Belongs to the NFYC/HAP5 subunit family.

Phylogenomic databases

eggNOGiCOG5208.
HOGENOMiHOG000231074.
HOVERGENiHBG002885.
InParanoidiQ13952.
KOiK08066.
OMAiATNAQQI.
OrthoDBiEOG7BGHNS.
PhylomeDBiQ13952.
TreeFamiTF354207.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
IPR027170. NFYC/HAP5_su.
[Graphical view]
PANTHERiPTHR10252:SF8. PTHR10252:SF8. 1 hit.
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: Q13952-1) [UniParc]FASTAAdd to Basket

Also known as: DS2.8

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK    50
IMKLDEDVKM ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND 100
IAMAITKFDQ FDFLIDIVPR DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ 150
QPTAVQVQGQ QQGQQTTSST TTIQPGQIII AQPQQGQTTP VTMQVGEGQQ 200
VQIVQAQPQG QAQQAQSGTG QTMQVMQQII TNTGEIQQIP VQLNAGQLQY 250
IRLAQPVSGT QVVQGQIQTL ATNAQQGQRN ASQGKPRRCL KETLQITQTE 300
VQQGQQQFSQ FTDGQRNSVQ QARVSELTGE AEPREVKATG NSTPCTSSLP 350
TTHPPSHRAG ASCVCCSQPQ QSSTSPPPSD ALQWVVVEVS GTPNQLETHR 400
ELHAPLPGMT SLSPLHPSQQ LYQIQQVTMP AGQDLAQPMF IQSANQPSDG 450
QAPQVTGD 458
Length:458
Mass (Da):50,302
Last modified:January 23, 2002 - v3
Checksum:iB17B2C7F622653B9
GO
Isoform 1 (identifier: Q13952-2) [UniParc]FASTAAdd to Basket

Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     277-295: Missing.
     316-419: Missing.

Show »
Length:335
Mass (Da):37,194
Checksum:iD83635C1773C3895
GO
Isoform 2 (identifier: Q13952-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     277-295: Missing.

Show »
Length:439
Mass (Da):48,150
Checksum:iE3FED3512983A402
GO
Isoform 4 (identifier: Q13952-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-97: Missing.
     277-295: Missing.
     316-419: Missing.

Note: No experimental confirmation available.

Show »
Length:297
Mass (Da):32,828
Checksum:i6E5693FBF9D838ED
GO
Isoform 5 (identifier: Q13952-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-419: Missing.

Note: No experimental confirmation available.

Show »
Length:354
Mass (Da):39,346
Checksum:i80887376BB8125F3
GO
Isoform 6 (identifier: Q13952-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-219: Missing.
     277-295: Missing.
     316-419: Missing.

Note: No experimental confirmation available.

Show »
Length:301
Mass (Da):33,702
Checksum:i1BC4774E7E20894A
GO
Isoform 7 (identifier: Q13952-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     277-295: Missing.
     315-315: Missing.
     316-419: Missing.

Note: No experimental confirmation available.

Show »
Length:334
Mass (Da):37,066
Checksum:i685A01326BF0FFB1
GO

Sequence cautioni

The sequence BAD92212.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti165 – 1651Q → H in a breast cancer sample; somatic mutation. 1 Publication
VAR_035702
Natural varianti297 – 2971T → I.
Corresponds to variant rs2230746 [ dbSNP | Ensembl ].
VAR_059460

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei60 – 9738Missing in isoform 4. VSP_043348Add
BLAST
Alternative sequencei186 – 21934Missing in isoform 6. VSP_043349Add
BLAST
Alternative sequencei277 – 29519Missing in isoform 1, isoform 2, isoform 4, isoform 6 and isoform 7. VSP_000851Add
BLAST
Alternative sequencei315 – 3151Missing in isoform 7. VSP_046350
Alternative sequencei316 – 419104Missing in isoform 1, isoform 4, isoform 5, isoform 6 and isoform 7. VSP_000852Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521M → I in CAA99055. 1 Publication
Sequence conflicti90 – 901D → N in BAA14051. 1 Publication
Sequence conflicti155 – 1551V → L in AAC50816. 1 Publication
Sequence conflicti158 – 1581Q → H in BAA14051. 1 Publication
Sequence conflicti171 – 1711T → N in BAA14051. 1 Publication
Sequence conflicti175 – 1751P → A in AAC50816. 1 Publication
Sequence conflicti179 – 1791I → F in BAA14051. 1 Publication
Sequence conflicti198 – 1981G → S in BAA12818. 1 Publication
Sequence conflicti198 – 1981G → S in BAA14051. 1 Publication
Sequence conflicti202 – 2021Q → K in BAA12818. 1 Publication
Sequence conflicti216 – 2172QS → HN in BAA14051. 1 Publication
Sequence conflicti248 – 2481L → V in AAC50816. 1 Publication
Sequence conflicti271 – 2711A → V in AAC50816. 1 Publication
Sequence conflicti451 – 4511Q → K in BAA14051. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62296 mRNA. Translation: AAC50816.1.
U78774 mRNA. Translation: AAC51669.1.
Z74792 mRNA. Translation: CAA99055.1.
D85425 mRNA. Translation: BAA12818.1.
D89986 mRNA. Translation: BAA14051.1.
AF191744 mRNA. Translation: AAG28389.1.
AK000346 mRNA. Translation: BAA91100.1.
AK127677 mRNA. Translation: BAG54549.1.
AK300774 mRNA. Translation: BAG62438.1.
AK301385 mRNA. Translation: BAG62925.1.
BT020081 mRNA. Translation: AAV38884.1.
AB208975 mRNA. Translation: BAD92212.1. Different initiation.
AL031289 Genomic DNA. No translation available.
AL354914, AC119677 Genomic DNA. Translation: CAI16530.1.
AL354914, AC119677 Genomic DNA. Translation: CAI16531.1.
AL354914, AC119677 Genomic DNA. Translation: CAI16532.1.
AL354914, AC119677 Genomic DNA. Translation: CAI16533.1.
CH471059 Genomic DNA. Translation: EAX07198.1.
CH471059 Genomic DNA. Translation: EAX07201.1.
CH471059 Genomic DNA. Translation: EAX07202.1.
CH471059 Genomic DNA. Translation: EAX07203.1.
BC005003 mRNA. Translation: AAH05003.1.
CCDSiCCDS44120.1. [Q13952-5]
CCDS44121.1. [Q13952-7]
CCDS44122.1. [Q13952-6]
CCDS44123.1. [Q13952-4]
CCDS455.1. [Q13952-2]
RefSeqiNP_001136059.1. NM_001142587.1. [Q13952-7]
NP_001136060.1. NM_001142588.1. [Q13952-5]
NP_001136061.1. NM_001142589.1. [Q13952-4]
NP_001136062.1. NM_001142590.1. [Q13952-6]
NP_055038.2. NM_014223.4. [Q13952-2]
XP_005270950.1. XM_005270893.1. [Q13952-1]
XP_005270951.1. XM_005270894.1. [Q13952-1]
XP_005270953.1. XM_005270896.1. [Q13952-3]
XP_006710724.1. XM_006710661.1. [Q13952-3]
UniGeneiHs.713051.

Genome annotation databases

EnsembliENST00000308733; ENSP00000312617; ENSG00000066136. [Q13952-1]
ENST00000372651; ENSP00000361734; ENSG00000066136. [Q13952-2]
ENST00000372652; ENSP00000361736; ENSG00000066136. [Q13952-3]
ENST00000372653; ENSP00000361737; ENSG00000066136. [Q13952-6]
ENST00000372654; ENSP00000361738; ENSG00000066136. [Q13952-2]
ENST00000425457; ENSP00000396620; ENSG00000066136. [Q13952-5]
ENST00000427410; ENSP00000408315; ENSG00000066136. [Q13952-4]
ENST00000440226; ENSP00000414299; ENSG00000066136. [Q13952-2]
ENST00000447388; ENSP00000404427; ENSG00000066136. [Q13952-2]
ENST00000456393; ENSP00000408867; ENSG00000066136. [Q13952-7]
GeneIDi4802.
KEGGihsa:4802.
UCSCiuc001cfx.4. human. [Q13952-5]
uc001cfy.4. human. [Q13952-2]
uc001cgb.3. human. [Q13952-3]
uc001cgc.3. human. [Q13952-6]
uc001cge.3. human. [Q13952-1]
uc010ojn.2. human. [Q13952-4]

Polymorphism databases

DMDMi20137773.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62296 mRNA. Translation: AAC50816.1 .
U78774 mRNA. Translation: AAC51669.1 .
Z74792 mRNA. Translation: CAA99055.1 .
D85425 mRNA. Translation: BAA12818.1 .
D89986 mRNA. Translation: BAA14051.1 .
AF191744 mRNA. Translation: AAG28389.1 .
AK000346 mRNA. Translation: BAA91100.1 .
AK127677 mRNA. Translation: BAG54549.1 .
AK300774 mRNA. Translation: BAG62438.1 .
AK301385 mRNA. Translation: BAG62925.1 .
BT020081 mRNA. Translation: AAV38884.1 .
AB208975 mRNA. Translation: BAD92212.1 . Different initiation.
AL031289 Genomic DNA. No translation available.
AL354914 , AC119677 Genomic DNA. Translation: CAI16530.1 .
AL354914 , AC119677 Genomic DNA. Translation: CAI16531.1 .
AL354914 , AC119677 Genomic DNA. Translation: CAI16532.1 .
AL354914 , AC119677 Genomic DNA. Translation: CAI16533.1 .
CH471059 Genomic DNA. Translation: EAX07198.1 .
CH471059 Genomic DNA. Translation: EAX07201.1 .
CH471059 Genomic DNA. Translation: EAX07202.1 .
CH471059 Genomic DNA. Translation: EAX07203.1 .
BC005003 mRNA. Translation: AAH05003.1 .
CCDSi CCDS44120.1. [Q13952-5 ]
CCDS44121.1. [Q13952-7 ]
CCDS44122.1. [Q13952-6 ]
CCDS44123.1. [Q13952-4 ]
CCDS455.1. [Q13952-2 ]
RefSeqi NP_001136059.1. NM_001142587.1. [Q13952-7 ]
NP_001136060.1. NM_001142588.1. [Q13952-5 ]
NP_001136061.1. NM_001142589.1. [Q13952-4 ]
NP_001136062.1. NM_001142590.1. [Q13952-6 ]
NP_055038.2. NM_014223.4. [Q13952-2 ]
XP_005270950.1. XM_005270893.1. [Q13952-1 ]
XP_005270951.1. XM_005270894.1. [Q13952-1 ]
XP_005270953.1. XM_005270896.1. [Q13952-3 ]
XP_006710724.1. XM_006710661.1. [Q13952-3 ]
UniGenei Hs.713051.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1N1J X-ray 1.67 B 27-120 [» ]
4AWL X-ray 3.08 C 27-120 [» ]
ProteinModelPortali Q13952.
SMRi Q13952. Positions 6-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110868. 36 interactions.
IntActi Q13952. 20 interactions.
MINTi MINT-249381.

PTM databases

PhosphoSitei Q13952.

Polymorphism databases

DMDMi 20137773.

Proteomic databases

MaxQBi Q13952.
PaxDbi Q13952.
PRIDEi Q13952.

Protocols and materials databases

DNASUi 4802.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308733 ; ENSP00000312617 ; ENSG00000066136 . [Q13952-1 ]
ENST00000372651 ; ENSP00000361734 ; ENSG00000066136 . [Q13952-2 ]
ENST00000372652 ; ENSP00000361736 ; ENSG00000066136 . [Q13952-3 ]
ENST00000372653 ; ENSP00000361737 ; ENSG00000066136 . [Q13952-6 ]
ENST00000372654 ; ENSP00000361738 ; ENSG00000066136 . [Q13952-2 ]
ENST00000425457 ; ENSP00000396620 ; ENSG00000066136 . [Q13952-5 ]
ENST00000427410 ; ENSP00000408315 ; ENSG00000066136 . [Q13952-4 ]
ENST00000440226 ; ENSP00000414299 ; ENSG00000066136 . [Q13952-2 ]
ENST00000447388 ; ENSP00000404427 ; ENSG00000066136 . [Q13952-2 ]
ENST00000456393 ; ENSP00000408867 ; ENSG00000066136 . [Q13952-7 ]
GeneIDi 4802.
KEGGi hsa:4802.
UCSCi uc001cfx.4. human. [Q13952-5 ]
uc001cfy.4. human. [Q13952-2 ]
uc001cgb.3. human. [Q13952-3 ]
uc001cgc.3. human. [Q13952-6 ]
uc001cge.3. human. [Q13952-1 ]
uc010ojn.2. human. [Q13952-4 ]

Organism-specific databases

CTDi 4802.
GeneCardsi GC01P041159.
HGNCi HGNC:7806. NFYC.
HPAi HPA055011.
MIMi 605344. gene.
neXtProti NX_Q13952.
PharmGKBi PA31611.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5208.
HOGENOMi HOG000231074.
HOVERGENi HBG002885.
InParanoidi Q13952.
KOi K08066.
OMAi ATNAQQI.
OrthoDBi EOG7BGHNS.
PhylomeDBi Q13952.
TreeFami TF354207.

Enzyme and pathway databases

Reactomei REACT_116145. PPARA activates gene expression.
REACT_147904. Activation of gene expression by SREBF (SREBP).
REACT_18355. ATF4 activates genes.
REACT_18423. ATF6-alpha activates chaperone genes.

Miscellaneous databases

ChiTaRSi NFYC. human.
EvolutionaryTracei Q13952.
GeneWikii NFYC.
GenomeRNAii 4802.
NextBioi 18510.
PROi Q13952.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13952.
Bgeei Q13952.
Genevestigatori Q13952.

Family and domain databases

Gene3Di 1.10.20.10. 1 hit.
InterProi IPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
IPR027170. NFYC/HAP5_su.
[Graphical view ]
PANTHERi PTHR10252:SF8. PTHR10252:SF8. 1 hit.
Pfami PF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view ]
SUPFAMi SSF47113. SSF47113. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox."
    Nakshatri H., Bhat-Nakshatri P., Currie R.A.
    J. Biol. Chem. 271:28784-28791(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor."
    Dmitrenko V.V., Garifulin O.M., Kavsan V.M.
    Gene 197:161-163(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Cell cycle-dependent switch of up- and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y."
    Taira T., Sawai M., Ikeda M., Tamai K., Iguchi-Ariga S.M.M., Ariga H.
    J. Biol. Chem. 274:24270-24279(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Cloning of a new variant of NFY-C."
    Bringuier P.P., Schalken J.A., Yamasaki H., Giroldi L.A.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4; 5 AND 6).
    Tissue: Synovium.
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
    Tissue: Brain.
  9. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y."
    Romier C., Cocchiarella F., Mantovani R., Moras D.
    J. Biol. Chem. 278:1336-1345(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS) OF 27-120 IN COMPLEX WITH NF-YB.
  14. "Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination."
    Nardini M., Gnesutta N., Donati G., Gatta R., Forni C., Fossati A., Vonrhein C., Moras D., Romier C., Bolognesi M., Mantovani R.
    Cell 152:132-143(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.08 ANGSTROMS) OF 27-120 IN COMPLEX WITH NYFA; NYFB AND PROMOTER DNA, SUBUNIT.
  15. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-165.

Entry informationi

Entry nameiNFYC_HUMAN
AccessioniPrimary (citable) accession number: Q13952
Secondary accession number(s): B4DUS6
, B4DW63, D3DPV9, F8VWM3, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: September 3, 2014
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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