ID   CASP_HUMAN              Reviewed;         678 AA.
AC   Q13948; B3KWH3; B3KWH8; B4DZZ2; G3V1Z6; J3KPQ6; Q53GU9; Q8TBS3;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 2.
DT   27-MAR-2024, entry version 158.
DE   RecName: Full=Protein CASP;
GN   Name=CUX1; Synonyms=CUTL1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Umbilical vein;
RX   PubMed=9332351; DOI=10.1016/s0378-1119(97)00243-6;
RA   Lievens P.M.-J., Tufarelli C., Donady J.J., Stagg A., Neufeld E.J.;
RT   "CASP, a novel, highly conserved alternative-splicing product of the
RT   CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and
RT   interacts with full-length CDP in vitro.";
RL   Gene 197:73-81(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 9 AND 10), AND VARIANT
RP   THR-464.
RC   TISSUE=Thalamus, Thymus, and Tongue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT THR-464.
RC   TISSUE=Liver;
RA   Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA   Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT VAL-545.
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   ALTERNATIVE SPLICING.
RX   PubMed=10607901; DOI=10.1016/s0378-1119(99)00465-5;
RA   Rong Zeng W., Soucie E., Sung Moon N., Martin-Soudant N., Berube G.,
RA   Leduy L., Nepveu A.;
RT   "Exon/intron structure and alternative transcripts of the CUTL1 gene.";
RL   Gene 241:75-85(2000).
RN   [8]
RP   SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, SUBUNIT, AND MUTAGENESIS OF
RP   TYR-624 AND HIS-629.
RX   PubMed=12429822; DOI=10.1091/mbc.e02-06-0349;
RA   Gillingham A.K., Pfeifer A.C., Munro S.;
RT   "CASP, the alternatively spliced product of the gene encoding the CCAAT-
RT   displacement protein transcription factor, is a Golgi membrane protein
RT   related to giantin.";
RL   Mol. Biol. Cell 13:3761-3774(2002).
RN   [9]
RP   FUNCTION, AND INTERACTION WITH GOLGA5.
RX   PubMed=15718469; DOI=10.1126/science.1108061;
RA   Malsam J., Satoh A., Pelletier L., Warren G.;
RT   "Golgin tethers define subpopulations of COPI vesicles.";
RL   Science 307:1095-1098(2005).
RN   [10]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Embryonic kidney;
RX   PubMed=17525332; DOI=10.1126/science.1140321;
RA   Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA   Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA   Gygi S.P., Elledge S.J.;
RT   "ATM and ATR substrate analysis reveals extensive protein networks
RT   responsive to DNA damage.";
RL   Science 316:1160-1166(2007).
RN   [11]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [12]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-586, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [13]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712; DOI=10.1002/pmic.201400617;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA   Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [14]
RP   VARIANTS [LARGE SCALE ANALYSIS] GLY-490 AND CYS-609.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May be involved in intra-Golgi retrograde transport.
CC       {ECO:0000269|PubMed:15718469}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with GOLGA5.
CC       {ECO:0000269|PubMed:12429822, ECO:0000269|PubMed:15718469}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000269|PubMed:12429822}; Single-pass type IV membrane protein
CC       {ECO:0000269|PubMed:12429822}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=11;
CC         Comment=Additional isoforms seem to exist.;
CC       Name=4; Synonyms=CASP;
CC         IsoId=Q13948-1; Sequence=Displayed;
CC       Name=11;
CC         IsoId=P39880-9; Sequence=External;
CC       Name=1;
CC         IsoId=P39880-1; Sequence=External;
CC       Name=2;
CC         IsoId=P39880-2; Sequence=External;
CC       Name=3;
CC         IsoId=P39880-3; Sequence=External;
CC       Name=5;
CC         IsoId=P39880-4; Sequence=External;
CC       Name=6;
CC         IsoId=P39880-5; Sequence=External;
CC       Name=7;
CC         IsoId=P39880-6; Sequence=External;
CC       Name=8;
CC         IsoId=Q13948-2; Sequence=VSP_040094;
CC       Name=9;
CC         IsoId=Q13948-9; Sequence=VSP_045593, VSP_040094;
CC       Name=10;
CC         IsoId=Q13948-10; Sequence=VSP_045927;
CC   -!- SIMILARITY: Belongs to the CASP family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC       Haematology;
CC       URL="https://atlasgeneticsoncology.org/gene/403/CUX1";
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DR   EMBL; L12579; AAA35654.1; -; mRNA.
DR   EMBL; AK125076; BAG54135.1; -; mRNA.
DR   EMBL; AK125097; BAG54140.1; -; mRNA.
DR   EMBL; AK303151; BAG64254.1; -; mRNA.
DR   EMBL; AK222832; BAD96552.1; -; mRNA.
DR   EMBL; AC005072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005086; AAP22331.1; -; Genomic_DNA.
DR   EMBL; AC005088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005096; AAS07410.1; -; Genomic_DNA.
DR   EMBL; AC005103; AAS07388.1; -; Genomic_DNA.
DR   EMBL; AC092788; AAS07523.1; -; Genomic_DNA.
DR   EMBL; CH471197; EAW50227.1; -; Genomic_DNA.
DR   EMBL; BC025422; AAH25422.1; -; mRNA.
DR   CCDS; CCDS47672.1; -. [Q13948-2]
DR   CCDS; CCDS56500.1; -. [Q13948-10]
DR   CCDS; CCDS5720.1; -. [Q13948-1]
DR   CCDS; CCDS59071.1; -. [Q13948-9]
DR   RefSeq; NP_001189473.1; NM_001202544.2. [Q13948-10]
DR   RefSeq; NP_001189474.1; NM_001202545.2.
DR   RefSeq; NP_001189475.1; NM_001202546.2. [Q13948-9]
DR   RefSeq; NP_001904.2; NM_001913.4. [Q13948-1]
DR   RefSeq; NP_852477.1; NM_181500.3. [Q13948-2]
DR   AlphaFoldDB; Q13948; -.
DR   SMR; Q13948; -.
DR   BioGRID; 107903; 209.
DR   IntAct; Q13948; 38.
DR   MINT; Q13948; -.
DR   iPTMnet; Q13948; -.
DR   SwissPalm; Q13948; -.
DR   BioMuta; CUX1; -.
DR   DMDM; 85681028; -.
DR   EPD; Q13948; -.
DR   jPOST; Q13948; -.
DR   MassIVE; Q13948; -.
DR   MaxQB; Q13948; -.
DR   PeptideAtlas; Q13948; -.
DR   ProteomicsDB; 32483; -.
DR   ProteomicsDB; 59765; -. [Q13948-1]
DR   ProteomicsDB; 59766; -. [Q13948-2]
DR   Pumba; Q13948; -.
DR   Antibodypedia; 48390; 504 antibodies from 35 providers.
DR   DNASU; 1523; -.
DR   Ensembl; ENST00000292538.9; ENSP00000292538.4; ENSG00000257923.12. [Q13948-1]
DR   Ensembl; ENST00000393824.7; ENSP00000377410.3; ENSG00000257923.12. [Q13948-9]
DR   Ensembl; ENST00000437600.9; ENSP00000414091.5; ENSG00000257923.12. [Q13948-2]
DR   Ensembl; ENST00000547394.6; ENSP00000449371.2; ENSG00000257923.12. [Q13948-10]
DR   Ensembl; ENST00000622516.6; ENSP00000484760.2; ENSG00000257923.12. [Q13948-1]
DR   GeneID; 1523; -.
DR   KEGG; hsa:1523; -.
DR   UCSC; uc003uyt.4; human. [Q13948-1]
DR   AGR; HGNC:2557; -.
DR   CTD; 1523; -.
DR   DisGeNET; 1523; -.
DR   GeneCards; CUX1; -.
DR   HGNC; HGNC:2557; CUX1.
DR   HPA; ENSG00000257923; Low tissue specificity.
DR   MalaCards; CUX1; -.
DR   MIM; 116896; gene.
DR   neXtProt; NX_Q13948; -.
DR   OpenTargets; ENSG00000257923; -.
DR   PharmGKB; PA162382924; -.
DR   VEuPathDB; HostDB:ENSG00000257923; -.
DR   GeneTree; ENSGT00940000159751; -.
DR   OrthoDB; 74668at2759; -.
DR   BioCyc; MetaCyc:ENSG00000170275-MONOMER; -.
DR   PathwayCommons; Q13948; -.
DR   Reactome; R-HSA-6811438; Intra-Golgi traffic.
DR   SignaLink; Q13948; -.
DR   BioGRID-ORCS; 1523; 26 hits in 1205 CRISPR screens.
DR   ChiTaRS; CUX1; human.
DR   GenomeRNAi; 1523; -.
DR   Pharos; Q13948; Tbio.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000257923; Expressed in secondary oocyte and 208 other cell types or tissues.
DR   ExpressionAtlas; Q13948; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR   GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR012955; CASP_C.
DR   PANTHER; PTHR14043; CCAAT DISPLACEMENT PROTEIN-RELATED; 1.
DR   PANTHER; PTHR14043:SF15; SIMILAR TO CCAAT DISPLACEMENT PROTEIN ISOFORM B; 1.
DR   Pfam; PF08172; CASP_C; 1.
DR   Genevisible; Q13948; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Disulfide bond; Golgi apparatus;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..678
FT                   /note="Protein CASP"
FT                   /id="PRO_0000071790"
FT   TOPO_DOM        1..619
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        620..640
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        641..678
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   COILED          67..450
FT                   /evidence="ECO:0000255"
FT   COILED          502..556
FT                   /evidence="ECO:0000255"
FT   MOD_RES         586
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VAR_SEQ         22..58
FT                   /note="Missing (in isoform 9)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_045593"
FT   VAR_SEQ         58..73
FT                   /note="Missing (in isoform 10)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_045927"
FT   VAR_SEQ         288..289
FT                   /note="Missing (in isoform 8 and isoform 9)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_040094"
FT   VARIANT         464
FT                   /note="A -> T (in dbSNP:rs803064)"
FT                   /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.3"
FT                   /id="VAR_024923"
FT   VARIANT         490
FT                   /note="S -> G (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036285"
FT   VARIANT         545
FT                   /note="I -> V (in dbSNP:rs2230103)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_024924"
FT   VARIANT         609
FT                   /note="R -> C (in a colorectal cancer sample; somatic
FT                   mutation; dbSNP:rs1287689842)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036286"
FT   MUTAGEN         624
FT                   /note="Y->L: Retained in the endoplasmic reticulum."
FT                   /evidence="ECO:0000269|PubMed:12429822"
FT   MUTAGEN         629
FT                   /note="H->L: No effect on subcellular location."
FT                   /evidence="ECO:0000269|PubMed:12429822"
FT   CONFLICT        407
FT                   /note="N -> S (in Ref. 6; AAH25422)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        455
FT                   /note="I -> V (in Ref. 2; BAG64254)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        525
FT                   /note="L -> V (in Ref. 2; BAG64254)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        551
FT                   /note="I -> V (in Ref. 3; BAD96552)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        613
FT                   /note="S -> P (in Ref. 2; BAG54140)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        657
FT                   /note="F -> L (in Ref. 1; AAA35654)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   678 AA;  77455 MW;  E587F222825EA47E CRC64;
     MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR EFKKNTPEDL
     RKQVAPLLKS FQGEIDALSK RSKEAEAAFL NVYKRLIDVP DPVPALDLGQ QLQLKVQRLH
     DIETENQKLR ETLEEYNKEF AEVKNQEVTI KALKEKIREY EQTLKNQAET IALEKEQKLQ
     NDFAEKERKL QETQMSTTSK LEEAEHKVQS LQTALEKTRT ELFDLKTKYD EETTAKADEI
     EMIMTDLERA NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVEQA IEVLTRSSLE
     VELAAKEREI AQLVEDVQRL QASLTKLREN SASQISQLEQ QLSAKNSTLK QLEEKLKGQA
     DYEEVKKELN ILKSMEFAPS EGAGTQDAAK PLEVLLLEKN RSLQSENAAL RISNSDLSGR
     CAELQVRITE AVATATEQRE LIARLEQDLS IIQSIQRPDA EGAAEHRLEK IPEPIKEATA
     LFYGPAAPAS GALPEGQVDS LLSIISSQRE RFRARNQELE AENRLAQHTL QALQSELDSL
     RADNIKLFEK IKFLQSYPGR GSGSDDTELR YSSQYEERLD PFSSFSKRER QRKYLSLSPW
     DKATLSMGRL VLSNKMARTI GFFYTLFLHC LVFLVLYKLA WSESMERDCA TFCAKKFADH
     LHKFHENDNG AAAGDLWQ
//