Q13948 (CASP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein CASP

Gene names

Name:	CUX1
Synonyms:	CUTL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	678 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in intra-Golgi retrograde transport. Ref.9
Subunit structure	Homodimer; disulfide-linked. Interacts with GOLGA5. Ref.8 Ref.9
Subcellular location	Golgi apparatus membrane; Single-pass type IV membrane protein Ref.8.
Sequence similarities	Belongs to the CASP family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intra-Golgi vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to Golgi membrane Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 4 (identifier: Q13948-1)

Also known as: CASP;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 11 (identifier: P39880-9)

The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Isoform 1 (identifier: P39880-1)

The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 2 (identifier: P39880-2)

The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 3 (identifier: P39880-3)

The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Isoform 5 (identifier: P39880-4)

The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 6 (identifier: P39880-5)

The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 7 (identifier: P39880-6)

The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 8 (identifier: Q13948-2)

The sequence of this isoform differs from the canonical sequence as follows:
     288-289: Missing.

Note: No experimental confirmation available.

Isoform 9 (identifier: Q13948-9)

The sequence of this isoform differs from the canonical sequence as follows:
     22-58: Missing.
     288-289: Missing.

Note: No experimental confirmation available.

Isoform 10 (identifier: Q13948-10)

The sequence of this isoform differs from the canonical sequence as follows:
     58-73: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 678	678	Protein CASP		PRO_0000071790
Regions
	Topological domain	1 – 619	619	Cytoplasmic Potential
	Transmembrane	620 – 640	21	Helical; Anchor for type IV membrane protein; Potential
	Topological domain	641 – 678	38	Lumenal Potential
	Coiled coil	67 – 450	384	Potential
	Coiled coil	502 – 556	55	Potential
Natural variations
	Alternative sequence	22 – 58	37	Missing in isoform 9.		VSP_045593
	Alternative sequence	58 – 73	16	Missing in isoform 10.		VSP_045927
	Alternative sequence	288 – 289	2	Missing in isoform 8 and isoform 9.		VSP_040094
	Natural variant	464	1	A → T. Ref.2 Ref.3 Corresponds to variant rs803064 [ dbSNP | Ensembl ].		VAR_024923
	Natural variant	490	1	S → G in a breast cancer sample; somatic mutation. Ref.12		VAR_036285
	Natural variant	545	1	I → V. Ref.6 Corresponds to variant rs2230103 [ dbSNP | Ensembl ].		VAR_024924
	Natural variant	609	1	R → C in a colorectal cancer sample; somatic mutation. Ref.12		VAR_036286
Experimental info
	Mutagenesis	624	1	Y → L: Retained in the endoplasmic reticulum. Ref.8
	Mutagenesis	629	1	H → L: No effect on subcellular location. Ref.8
	Sequence conflict	407	1	N → S in AAH25422. Ref.6
	Sequence conflict	455	1	I → V in BAG64254. Ref.2
	Sequence conflict	525	1	L → V in BAG64254. Ref.2
	Sequence conflict	551	1	I → V in BAD96552. Ref.3
	Sequence conflict	613	1	S → P in BAG54140. Ref.2
	Sequence conflict	657	1	F → L in AAA35654. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 4 (CASP) [UniParc]. Last modified January 10, 2006. Version 2. Checksum: E587F222825EA47E	FASTA	678	77,455
	10 20 30 40 50 60 MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR EFKKNTPEDL 70 80 90 100 110 120 RKQVAPLLKS FQGEIDALSK RSKEAEAAFL NVYKRLIDVP DPVPALDLGQ QLQLKVQRLH 130 140 150 160 170 180 DIETENQKLR ETLEEYNKEF AEVKNQEVTI KALKEKIREY EQTLKNQAET IALEKEQKLQ 190 200 210 220 230 240 NDFAEKERKL QETQMSTTSK LEEAEHKVQS LQTALEKTRT ELFDLKTKYD EETTAKADEI 250 260 270 280 290 300 EMIMTDLERA NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVEQA IEVLTRSSLE 310 320 330 340 350 360 VELAAKEREI AQLVEDVQRL QASLTKLREN SASQISQLEQ QLSAKNSTLK QLEEKLKGQA 370 380 390 400 410 420 DYEEVKKELN ILKSMEFAPS EGAGTQDAAK PLEVLLLEKN RSLQSENAAL RISNSDLSGR 430 440 450 460 470 480 CAELQVRITE AVATATEQRE LIARLEQDLS IIQSIQRPDA EGAAEHRLEK IPEPIKEATA 490 500 510 520 530 540 LFYGPAAPAS GALPEGQVDS LLSIISSQRE RFRARNQELE AENRLAQHTL QALQSELDSL 550 560 570 580 590 600 RADNIKLFEK IKFLQSYPGR GSGSDDTELR YSSQYEERLD PFSSFSKRER QRKYLSLSPW 610 620 630 640 650 660 DKATLSMGRL VLSNKMARTI GFFYTLFLHC LVFLVLYKLA WSESMERDCA TFCAKKFADH 670 LHKFHENDNG AAAGDLWQ
	Isoform 11 [UniParc]. See P39880.		–	–
	Isoform 1 [UniParc]. See P39880.		–	–
	Isoform 2 [UniParc]. See P39880.		–	–
	Isoform 3 [UniParc]. See P39880.		–	–
	Isoform 5 [UniParc]. See P39880.		–	–
	Isoform 6 [UniParc]. See P39880.		–	–
	Isoform 7 [UniParc]. See P39880.		–	–
	Isoform 8 [UniParc]. Checksum: 727AC64B50C59153	FASTA	676	77,198
	10 20 30 40 50 60 MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR EFKKNTPEDL 70 80 90 100 110 120 RKQVAPLLKS FQGEIDALSK RSKEAEAAFL NVYKRLIDVP DPVPALDLGQ QLQLKVQRLH 130 140 150 160 170 180 DIETENQKLR ETLEEYNKEF AEVKNQEVTI KALKEKIREY EQTLKNQAET IALEKEQKLQ 190 200 210 220 230 240 NDFAEKERKL QETQMSTTSK LEEAEHKVQS LQTALEKTRT ELFDLKTKYD EETTAKADEI 250 260 270 280 290 300 EMIMTDLERA NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVAIE VLTRSSLEVE 310 320 330 340 350 360 LAAKEREIAQ LVEDVQRLQA SLTKLRENSA SQISQLEQQL SAKNSTLKQL EEKLKGQADY 370 380 390 400 410 420 EEVKKELNIL KSMEFAPSEG AGTQDAAKPL EVLLLEKNRS LQSENAALRI SNSDLSGRCA 430 440 450 460 470 480 ELQVRITEAV ATATEQRELI ARLEQDLSII QSIQRPDAEG AAEHRLEKIP EPIKEATALF 490 500 510 520 530 540 YGPAAPASGA LPEGQVDSLL SIISSQRERF RARNQELEAE NRLAQHTLQA LQSELDSLRA 550 560 570 580 590 600 DNIKLFEKIK FLQSYPGRGS GSDDTELRYS SQYEERLDPF SSFSKRERQR KYLSLSPWDK 610 620 630 640 650 660 ATLSMGRLVL SNKMARTIGF FYTLFLHCLV FLVLYKLAWS ESMERDCATF CAKKFADHLH 670 KFHENDNGAA AGDLWQ
	Isoform 9 [UniParc]. Checksum: 92BB146A2065C5CE	FASTA	639	72,841
	10 20 30 40 50 60 MAANVGSMFQ YWKRFDLQQL QDLRKQVAPL LKSFQGEIDA LSKRSKEAEA AFLNVYKRLI 70 80 90 100 110 120 DVPDPVPALD LGQQLQLKVQ RLHDIETENQ KLRETLEEYN KEFAEVKNQE VTIKALKEKI 130 140 150 160 170 180 REYEQTLKNQ AETIALEKEQ KLQNDFAEKE RKLQETQMST TSKLEEAEHK VQSLQTALEK 190 200 210 220 230 240 TRTELFDLKT KYDEETTAKA DEIEMIMTDL ERANQRAEVA QREAETLREQ LSSANHSLQL 250 260 270 280 290 300 ASQIQKAPDV AIEVLTRSSL EVELAAKERE IAQLVEDVQR LQASLTKLRE NSASQISQLE 310 320 330 340 350 360 QQLSAKNSTL KQLEEKLKGQ ADYEEVKKEL NILKSMEFAP SEGAGTQDAA KPLEVLLLEK 370 380 390 400 410 420 NRSLQSENAA LRISNSDLSG RCAELQVRIT EAVATATEQR ELIARLEQDL SIIQSIQRPD 430 440 450 460 470 480 AEGAAEHRLE KIPEPIKEAT ALFYGPAAPA SGALPEGQVD SLLSIISSQR ERFRARNQEL 490 500 510 520 530 540 EAENRLAQHT LQALQSELDS LRADNIKLFE KIKFLQSYPG RGSGSDDTEL RYSSQYEERL 550 560 570 580 590 600 DPFSSFSKRE RQRKYLSLSP WDKATLSMGR LVLSNKMART IGFFYTLFLH CLVFLVLYKL 610 620 630 AWSESMERDC ATFCAKKFAD HLHKFHENDN GAAAGDLWQ
	Isoform 10 [UniParc]. Checksum: CBAF60CA80A21247	FASTA	662	75,644
	10 20 30 40 50 60 MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR EFKKNTPEID 70 80 90 100 110 120 ALSKRSKEAE AAFLNVYKRL IDVPDPVPAL DLGQQLQLKV QRLHDIETEN QKLRETLEEY 130 140 150 160 170 180 NKEFAEVKNQ EVTIKALKEK IREYEQTLKN QAETIALEKE QKLQNDFAEK ERKLQETQMS 190 200 210 220 230 240 TTSKLEEAEH KVQSLQTALE KTRTELFDLK TKYDEETTAK ADEIEMIMTD LERANQRAEV 250 260 270 280 290 300 AQREAETLRE QLSSANHSLQ LASQIQKAPD VEQAIEVLTR SSLEVELAAK EREIAQLVED 310 320 330 340 350 360 VQRLQASLTK LRENSASQIS QLEQQLSAKN STLKQLEEKL KGQADYEEVK KELNILKSME 370 380 390 400 410 420 FAPSEGAGTQ DAAKPLEVLL LEKNRSLQSE NAALRISNSD LSGRCAELQV RITEAVATAT 430 440 450 460 470 480 EQRELIARLE QDLSIIQSIQ RPDAEGAAEH RLEKIPEPIK EATALFYGPA APASGALPEG 490 500 510 520 530 540 QVDSLLSIIS SQRERFRARN QELEAENRLA QHTLQALQSE LDSLRADNIK LFEKIKFLQS 550 560 570 580 590 600 YPGRGSGSDD TELRYSSQYE ERLDPFSSFS KRERQRKYLS LSPWDKATLS MGRLVLSNKM 610 620 630 640 650 660 ARTIGFFYTL FLHCLVFLVL YKLAWSESME RDCATFCAKK FADHLHKFHE NDNGAAAGDL WQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CASP, a novel, highly conserved alternative-splicing product of the CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and interacts with full-length CDP in vitro." Lievens P.M.-J., Tufarelli C., Donady J.J., Stagg A., Neufeld E.J. Gene 197:73-81(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Umbilical vein.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 9 AND 10), VARIANT THR-464. Tissue: Thalamus, Thymus and Tongue.
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-464. Tissue: Liver.
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-545. Tissue: Colon.
[7]	"Exon/intron structure and alternative transcripts of the CUTL1 gene." Rong Zeng W., Soucie E., Sung Moon N., Martin-Soudant N., Berube G., Leduy L., Nepveu A. Gene 241:75-85(2000) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING.
[8]	"CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin." Gillingham A.K., Pfeifer A.C., Munro S. Mol. Biol. Cell 13:3761-3774(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, SUBUNIT, MUTAGENESIS OF TYR-624 AND HIS-629.
[9]	"Golgin tethers define subpopulations of COPI vesicles." Malsam J., Satoh A., Pelletier L., Warren G. Science 307:1095-1098(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH GOLGA5.
[10]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Embryonic kidney.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-490 AND CYS-609.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L12579 mRNA. Translation: AAA35654.1. AK125076 mRNA. Translation: BAG54135.1. AK125097 mRNA. Translation: BAG54140.1. AK303151 mRNA. Translation: BAG64254.1. AK222832 mRNA. Translation: BAD96552.1. AC005072 Genomic DNA. No translation available. AC005086 Genomic DNA. Translation: AAP22331.1. AC005088 Genomic DNA. No translation available. AC005096 Genomic DNA. Translation: AAS07410.1. AC005103 Genomic DNA. Translation: AAS07388.1. AC092788 Genomic DNA. Translation: AAS07523.1. CH471197 Genomic DNA. Translation: EAW50227.1. BC025422 mRNA. Translation: AAH25422.1.
IPI	IPI00071696. IPI00926621. IPI00927318. IPI00979706.
RefSeq	NP_001189473.1. NM_001202544.1. NP_001189474.1. NM_001202545.1. NP_001189475.1. NM_001202546.1. NP_001904.2. NM_001913.3. NP_852477.1. NM_181500.2.
UniGene	Hs.191482.
3D structure databases
ProteinModelPortal	Q13948.
SMR	Q13948. Positions 15-41.
ModBase	Search...
Polymorphism databases
DMDM	85681028.
Proteomic databases
PaxDb	Q13948.
PRIDE	Q13948.
Protocols and materials databases
DNASU	1523.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292538; ENSP00000292538; ENSG00000257923. ENST00000393824; ENSP00000377410; ENSG00000257923. ENST00000437600; ENSP00000414091; ENSG00000257923. ENST00000547394; ENSP00000449371; ENSG00000257923. ENST00000561974; ENSP00000455766; ENSG00000259938. ENST00000562243; ENSP00000457546; ENSG00000259938. ENST00000565172; ENSP00000456937; ENSG00000259938. ENST00000567764; ENSP00000455653; ENSG00000259938.
GeneID	1523.
KEGG	hsa:1523.
UCSC	uc003uyt.3. human. uc003uyu.3. human.
Organism-specific databases
CTD	1523.
GeneCards	GC07P101459.
HGNC	HGNC:2557. CUX1.
HPA	HPA003317.
MIM	116896. gene.
neXtProt	NX_Q13948.
PharmGKB	PA162382924.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG325167.
HOVERGEN	HBG053415.
KO	K09313.
OrthoDB	EOG412M69.
Gene expression databases
ArrayExpress	Q13948.
Bgee	Q13948.
CleanEx	HS_CUX1.
Genevestigator	Q13948.
Family and domain databases
InterPro	IPR012955. CASP_C. [Graphical view]
Pfam	PF08172. CASP_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CUX1. human.
GenomeRNAi	1523.
NextBio	35535186.
SOURCE	Search...

Entry information

Entry name

CASP_HUMAN

Accession

Primary (citable) accession number: Q13948
Secondary accession number(s): B3KWH3 , B3KWH8, B4DZZ2, G3V1Z6, J3KPQ6, Q53GU9, Q8TBS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.