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Protein

Protein CASP

Gene

CUX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in intra-Golgi retrograde transport.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000170275-MONOMER
ReactomeiR-HSA-6811438 Intra-Golgi traffic
SignaLinkiQ13948

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CASP
Gene namesi
Name:CUX1
Synonyms:CUTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000257923.9
HGNCiHGNC:2557 CUX1
MIMi116896 gene
neXtProtiNX_Q13948

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 619CytoplasmicSequence analysisAdd BLAST619
Transmembranei620 – 640Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini641 – 678LumenalSequence analysisAdd BLAST38

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi624Y → L: Retained in the endoplasmic reticulum. 1 Publication1
Mutagenesisi629H → L: No effect on subcellular location. 1 Publication1

Organism-specific databases

DisGeNETi1523
OpenTargetsiENSG00000257923
PharmGKBiPA162382924

Polymorphism and mutation databases

BioMutaiHSPA4L
DMDMi85681028

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717901 – 678Protein CASPAdd BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei586PhosphoserineCombined sources1
Isoform 11 (identifier: P39880-9)
Modified residuei540Phosphoserine1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ13948
MaxQBiQ13948
PeptideAtlasiQ13948
PRIDEiQ13948
ProteomicsDBi59765
59766 [Q13948-2]

PTM databases

iPTMnetiQ13948

Expressioni

Gene expression databases

BgeeiENSG00000257923
CleanExiHS_CUX1
ExpressionAtlasiQ13948 baseline and differential
GenevisibleiQ13948 HS

Organism-specific databases

HPAiHPA003317

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with GOLGA5.2 Publications

Protein-protein interaction databases

BioGridi107903, 57 interactors
IntActiQ13948, 2 interactors
MINTiQ13948

Structurei

3D structure databases

ProteinModelPortaliQ13948
SMRiQ13948
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili67 – 450Sequence analysisAdd BLAST384
Coiled coili502 – 556Sequence analysisAdd BLAST55

Sequence similaritiesi

Belongs to the CASP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0963 Eukaryota
KOG2252 Eukaryota
ENOG410XPKP LUCA
GeneTreeiENSGT00530000063019
HOVERGENiHBG053415
KOiK09313

Family and domain databases

InterProiView protein in InterPro
IPR012955 CASP_C
PfamiView protein in Pfam
PF08172 CASP_C, 1 hit

Sequences (11)i

Sequence statusi: Complete.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 4 (identifier: Q13948-1) [UniParc]FASTAAdd to basket
Also known as: CASP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR
60 70 80 90 100
EFKKNTPEDL RKQVAPLLKS FQGEIDALSK RSKEAEAAFL NVYKRLIDVP
110 120 130 140 150
DPVPALDLGQ QLQLKVQRLH DIETENQKLR ETLEEYNKEF AEVKNQEVTI
160 170 180 190 200
KALKEKIREY EQTLKNQAET IALEKEQKLQ NDFAEKERKL QETQMSTTSK
210 220 230 240 250
LEEAEHKVQS LQTALEKTRT ELFDLKTKYD EETTAKADEI EMIMTDLERA
260 270 280 290 300
NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVEQA IEVLTRSSLE
310 320 330 340 350
VELAAKEREI AQLVEDVQRL QASLTKLREN SASQISQLEQ QLSAKNSTLK
360 370 380 390 400
QLEEKLKGQA DYEEVKKELN ILKSMEFAPS EGAGTQDAAK PLEVLLLEKN
410 420 430 440 450
RSLQSENAAL RISNSDLSGR CAELQVRITE AVATATEQRE LIARLEQDLS
460 470 480 490 500
IIQSIQRPDA EGAAEHRLEK IPEPIKEATA LFYGPAAPAS GALPEGQVDS
510 520 530 540 550
LLSIISSQRE RFRARNQELE AENRLAQHTL QALQSELDSL RADNIKLFEK
560 570 580 590 600
IKFLQSYPGR GSGSDDTELR YSSQYEERLD PFSSFSKRER QRKYLSLSPW
610 620 630 640 650
DKATLSMGRL VLSNKMARTI GFFYTLFLHC LVFLVLYKLA WSESMERDCA
660 670
TFCAKKFADH LHKFHENDNG AAAGDLWQ
Length:678
Mass (Da):77,455
Last modified:January 10, 2006 - v2
Checksum:iE587F222825EA47E
GO
Isoform 11 (identifier: P39880-9) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:632
Mass (Da):72,024
GO
Isoform 1 (identifier: P39880-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,505
Mass (Da):164,187
GO
Isoform 2 (identifier: P39880-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,483
Mass (Da):161,650
GO
Isoform 3 (identifier: P39880-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:1,516
Mass (Da):165,688
GO
Isoform 5 (identifier: P39880-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,403
Mass (Da):153,364
GO
Isoform 6 (identifier: P39880-5) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,449
Mass (Da):157,895
GO
Isoform 7 (identifier: P39880-6) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,347
Mass (Da):147,072
GO
Isoform 8 (identifier: Q13948-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     288-289: Missing.

Note: No experimental confirmation available.
Show »
Length:676
Mass (Da):77,198
Checksum:i727AC64B50C59153
GO
Isoform 9 (identifier: Q13948-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-58: Missing.
     288-289: Missing.

Note: No experimental confirmation available.
Show »
Length:639
Mass (Da):72,841
Checksum:i92BB146A2065C5CE
GO
Isoform 10 (identifier: Q13948-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-73: Missing.

Note: No experimental confirmation available.
Show »
Length:662
Mass (Da):75,644
Checksum:iCBAF60CA80A21247
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti407N → S in AAH25422 (PubMed:15489334).Curated1
Sequence conflicti455I → V in BAG64254 (PubMed:14702039).Curated1
Sequence conflicti525L → V in BAG64254 (PubMed:14702039).Curated1
Sequence conflicti551I → V in BAD96552 (Ref. 3) Curated1
Sequence conflicti613S → P in BAG54140 (PubMed:14702039).Curated1
Sequence conflicti657F → L in AAA35654 (PubMed:9332351).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024923464A → T2 PublicationsCorresponds to variant dbSNP:rs803064Ensembl.1
Natural variantiVAR_036285490S → G in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_024924545I → V1 PublicationCorresponds to variant dbSNP:rs2230103Ensembl.1
Natural variantiVAR_036286609R → C in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04559322 – 58Missing in isoform 9. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_04592758 – 73Missing in isoform 10. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_040094288 – 289Missing in isoform 8 and isoform 9. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12579 mRNA Translation: AAA35654.1
AK125076 mRNA Translation: BAG54135.1
AK125097 mRNA Translation: BAG54140.1
AK303151 mRNA Translation: BAG64254.1
AK222832 mRNA Translation: BAD96552.1
AC005072 Genomic DNA No translation available.
AC005086 Genomic DNA Translation: AAP22331.1
AC005088 Genomic DNA No translation available.
AC005096 Genomic DNA Translation: AAS07410.1
AC005103 Genomic DNA Translation: AAS07388.1
AC092788 Genomic DNA Translation: AAS07523.1
CH471197 Genomic DNA Translation: EAW50227.1
BC025422 mRNA Translation: AAH25422.1
CCDSiCCDS47672.1 [Q13948-2]
CCDS56500.1 [Q13948-10]
CCDS5720.1 [Q13948-1]
CCDS59071.1 [Q13948-9]
RefSeqiNP_001189473.1, NM_001202544.2 [Q13948-10]
NP_001189474.1, NM_001202545.2
NP_001189475.1, NM_001202546.2 [Q13948-9]
NP_001904.2, NM_001913.4 [Q13948-1]
NP_852477.1, NM_181500.3 [Q13948-2]
UniGeneiHs.191482

Genome annotation databases

EnsembliENST00000292538; ENSP00000292538; ENSG00000257923 [Q13948-1]
ENST00000393824; ENSP00000377410; ENSG00000257923 [Q13948-9]
ENST00000437600; ENSP00000414091; ENSG00000257923 [Q13948-2]
ENST00000547394; ENSP00000449371; ENSG00000257923 [Q13948-10]
ENST00000622516; ENSP00000484760; ENSG00000257923 [Q13948-1]
GeneIDi1523
KEGGihsa:1523
UCSCiuc003uyt.4 human [Q13948-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCASP_HUMAN
AccessioniPrimary (citable) accession number: Q13948
Secondary accession number(s): B3KWH3
, B3KWH8, B4DZZ2, G3V1Z6, J3KPQ6, Q53GU9, Q8TBS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: June 20, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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