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Protein

Protein CASP

Gene

CUX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in intra-Golgi retrograde transport.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170275-MONOMER.
ReactomeiR-HSA-6811438. Intra-Golgi traffic.
SignaLinkiQ13948.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CASP
Gene namesi
Name:CUX1
Synonyms:CUTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:2557. CUX1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 619CytoplasmicSequence analysisAdd BLAST619
Transmembranei620 – 640Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini641 – 678LumenalSequence analysisAdd BLAST38

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi624Y → L: Retained in the endoplasmic reticulum. 1 Publication1
Mutagenesisi629H → L: No effect on subcellular location. 1 Publication1

Organism-specific databases

DisGeNETi1523.
OpenTargetsiENSG00000257923.
PharmGKBiPA162382924.

Polymorphism and mutation databases

BioMutaiHSPA4L.
DMDMi85681028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717901 – 678Protein CASPAdd BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei586PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ13948.
MaxQBiQ13948.
PaxDbiQ13948.
PeptideAtlasiQ13948.
PRIDEiQ13948.

PTM databases

iPTMnetiQ13948.

Expressioni

Gene expression databases

BgeeiENSG00000257923.
CleanExiHS_CUX1.
ExpressionAtlasiQ13948. baseline and differential.
GenevisibleiQ13948. HS.

Organism-specific databases

HPAiHPA003317.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with GOLGA5.2 Publications

Protein-protein interaction databases

BioGridi107903. 50 interactors.
IntActiQ13948. 1 interactor.
STRINGi9606.ENSP00000353401.

Structurei

3D structure databases

ProteinModelPortaliQ13948.
SMRiQ13948.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili67 – 450Sequence analysisAdd BLAST384
Coiled coili502 – 556Sequence analysisAdd BLAST55

Sequence similaritiesi

Belongs to the CASP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0963. Eukaryota.
KOG2252. Eukaryota.
ENOG410XPKP. LUCA.
GeneTreeiENSGT00530000063019.
HOVERGENiHBG053415.
KOiK09313.

Family and domain databases

InterProiIPR012955. CASP_C.
[Graphical view]
PfamiPF08172. CASP_C. 1 hit.
[Graphical view]

Sequences (11)i

Sequence statusi: Complete.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 4 (identifier: Q13948-1) [UniParc]FASTAAdd to basket
Also known as: CASP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR
60 70 80 90 100
EFKKNTPEDL RKQVAPLLKS FQGEIDALSK RSKEAEAAFL NVYKRLIDVP
110 120 130 140 150
DPVPALDLGQ QLQLKVQRLH DIETENQKLR ETLEEYNKEF AEVKNQEVTI
160 170 180 190 200
KALKEKIREY EQTLKNQAET IALEKEQKLQ NDFAEKERKL QETQMSTTSK
210 220 230 240 250
LEEAEHKVQS LQTALEKTRT ELFDLKTKYD EETTAKADEI EMIMTDLERA
260 270 280 290 300
NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVEQA IEVLTRSSLE
310 320 330 340 350
VELAAKEREI AQLVEDVQRL QASLTKLREN SASQISQLEQ QLSAKNSTLK
360 370 380 390 400
QLEEKLKGQA DYEEVKKELN ILKSMEFAPS EGAGTQDAAK PLEVLLLEKN
410 420 430 440 450
RSLQSENAAL RISNSDLSGR CAELQVRITE AVATATEQRE LIARLEQDLS
460 470 480 490 500
IIQSIQRPDA EGAAEHRLEK IPEPIKEATA LFYGPAAPAS GALPEGQVDS
510 520 530 540 550
LLSIISSQRE RFRARNQELE AENRLAQHTL QALQSELDSL RADNIKLFEK
560 570 580 590 600
IKFLQSYPGR GSGSDDTELR YSSQYEERLD PFSSFSKRER QRKYLSLSPW
610 620 630 640 650
DKATLSMGRL VLSNKMARTI GFFYTLFLHC LVFLVLYKLA WSESMERDCA
660 670
TFCAKKFADH LHKFHENDNG AAAGDLWQ
Length:678
Mass (Da):77,455
Last modified:January 10, 2006 - v2
Checksum:iE587F222825EA47E
GO
Isoform 11 (identifier: P39880-9) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:632
Mass (Da):72,024
GO
Isoform 1 (identifier: P39880-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,505
Mass (Da):164,187
GO
Isoform 2 (identifier: P39880-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,483
Mass (Da):161,650
GO
Isoform 3 (identifier: P39880-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:1,516
Mass (Da):165,688
GO
Isoform 5 (identifier: P39880-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,403
Mass (Da):153,364
GO
Isoform 6 (identifier: P39880-5) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,449
Mass (Da):157,895
GO
Isoform 7 (identifier: P39880-6) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P39880.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,347
Mass (Da):147,072
GO
Isoform 8 (identifier: Q13948-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     288-289: Missing.

Note: No experimental confirmation available.
Show »
Length:676
Mass (Da):77,198
Checksum:i727AC64B50C59153
GO
Isoform 9 (identifier: Q13948-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-58: Missing.
     288-289: Missing.

Note: No experimental confirmation available.
Show »
Length:639
Mass (Da):72,841
Checksum:i92BB146A2065C5CE
GO
Isoform 10 (identifier: Q13948-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-73: Missing.

Note: No experimental confirmation available.
Show »
Length:662
Mass (Da):75,644
Checksum:iCBAF60CA80A21247
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti407N → S in AAH25422 (PubMed:15489334).Curated1
Sequence conflicti455I → V in BAG64254 (PubMed:14702039).Curated1
Sequence conflicti525L → V in BAG64254 (PubMed:14702039).Curated1
Sequence conflicti551I → V in BAD96552 (Ref. 3) Curated1
Sequence conflicti613S → P in BAG54140 (PubMed:14702039).Curated1
Sequence conflicti657F → L in AAA35654 (PubMed:9332351).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024923464A → T.2 PublicationsCorresponds to variant rs803064dbSNPEnsembl.1
Natural variantiVAR_036285490S → G in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_024924545I → V.1 PublicationCorresponds to variant rs2230103dbSNPEnsembl.1
Natural variantiVAR_036286609R → C in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04559322 – 58Missing in isoform 9. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_04592758 – 73Missing in isoform 10. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_040094288 – 289Missing in isoform 8 and isoform 9. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12579 mRNA. Translation: AAA35654.1.
AK125076 mRNA. Translation: BAG54135.1.
AK125097 mRNA. Translation: BAG54140.1.
AK303151 mRNA. Translation: BAG64254.1.
AK222832 mRNA. Translation: BAD96552.1.
AC005072 Genomic DNA. No translation available.
AC005086 Genomic DNA. Translation: AAP22331.1.
AC005088 Genomic DNA. No translation available.
AC005096 Genomic DNA. Translation: AAS07410.1.
AC005103 Genomic DNA. Translation: AAS07388.1.
AC092788 Genomic DNA. Translation: AAS07523.1.
CH471197 Genomic DNA. Translation: EAW50227.1.
BC025422 mRNA. Translation: AAH25422.1.
CCDSiCCDS47672.1. [Q13948-2]
CCDS56500.1. [Q13948-10]
CCDS5720.1. [Q13948-1]
CCDS59071.1. [Q13948-9]
RefSeqiNP_001189473.1. NM_001202544.2. [Q13948-10]
NP_001189474.1. NM_001202545.2.
NP_001189475.1. NM_001202546.2. [Q13948-9]
NP_001904.2. NM_001913.4. [Q13948-1]
NP_852477.1. NM_181500.3. [Q13948-2]
UniGeneiHs.191482.

Genome annotation databases

EnsembliENST00000292538; ENSP00000292538; ENSG00000257923. [Q13948-1]
ENST00000393824; ENSP00000377410; ENSG00000257923. [Q13948-9]
ENST00000437600; ENSP00000414091; ENSG00000257923. [Q13948-1]
ENST00000547394; ENSP00000449371; ENSG00000257923. [Q13948-10]
ENST00000622516; ENSP00000484760; ENSG00000257923. [Q13948-2]
GeneIDi1523.
KEGGihsa:1523.
UCSCiuc003uyt.4. human. [Q13948-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12579 mRNA. Translation: AAA35654.1.
AK125076 mRNA. Translation: BAG54135.1.
AK125097 mRNA. Translation: BAG54140.1.
AK303151 mRNA. Translation: BAG64254.1.
AK222832 mRNA. Translation: BAD96552.1.
AC005072 Genomic DNA. No translation available.
AC005086 Genomic DNA. Translation: AAP22331.1.
AC005088 Genomic DNA. No translation available.
AC005096 Genomic DNA. Translation: AAS07410.1.
AC005103 Genomic DNA. Translation: AAS07388.1.
AC092788 Genomic DNA. Translation: AAS07523.1.
CH471197 Genomic DNA. Translation: EAW50227.1.
BC025422 mRNA. Translation: AAH25422.1.
CCDSiCCDS47672.1. [Q13948-2]
CCDS56500.1. [Q13948-10]
CCDS5720.1. [Q13948-1]
CCDS59071.1. [Q13948-9]
RefSeqiNP_001189473.1. NM_001202544.2. [Q13948-10]
NP_001189474.1. NM_001202545.2.
NP_001189475.1. NM_001202546.2. [Q13948-9]
NP_001904.2. NM_001913.4. [Q13948-1]
NP_852477.1. NM_181500.3. [Q13948-2]
UniGeneiHs.191482.

3D structure databases

ProteinModelPortaliQ13948.
SMRiQ13948.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107903. 50 interactors.
IntActiQ13948. 1 interactor.
STRINGi9606.ENSP00000353401.

PTM databases

iPTMnetiQ13948.

Polymorphism and mutation databases

BioMutaiHSPA4L.
DMDMi85681028.

Proteomic databases

EPDiQ13948.
MaxQBiQ13948.
PaxDbiQ13948.
PeptideAtlasiQ13948.
PRIDEiQ13948.

Protocols and materials databases

DNASUi1523.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292538; ENSP00000292538; ENSG00000257923. [Q13948-1]
ENST00000393824; ENSP00000377410; ENSG00000257923. [Q13948-9]
ENST00000437600; ENSP00000414091; ENSG00000257923. [Q13948-1]
ENST00000547394; ENSP00000449371; ENSG00000257923. [Q13948-10]
ENST00000622516; ENSP00000484760; ENSG00000257923. [Q13948-2]
GeneIDi1523.
KEGGihsa:1523.
UCSCiuc003uyt.4. human. [Q13948-1]

Organism-specific databases

CTDi1523.
DisGeNETi1523.
GeneCardsiCUX1.
HGNCiHGNC:2557. CUX1.
HPAiHPA003317.
MIMi116896. gene.
neXtProtiNX_Q13948.
OpenTargetsiENSG00000257923.
PharmGKBiPA162382924.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0963. Eukaryota.
KOG2252. Eukaryota.
ENOG410XPKP. LUCA.
GeneTreeiENSGT00530000063019.
HOVERGENiHBG053415.
KOiK09313.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170275-MONOMER.
ReactomeiR-HSA-6811438. Intra-Golgi traffic.
SignaLinkiQ13948.

Miscellaneous databases

ChiTaRSiCUX1. human.
GenomeRNAii1523.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000257923.
CleanExiHS_CUX1.
ExpressionAtlasiQ13948. baseline and differential.
GenevisibleiQ13948. HS.

Family and domain databases

InterProiIPR012955. CASP_C.
[Graphical view]
PfamiPF08172. CASP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCASP_HUMAN
AccessioniPrimary (citable) accession number: Q13948
Secondary accession number(s): B3KWH3
, B3KWH8, B4DZZ2, G3V1Z6, J3KPQ6, Q53GU9, Q8TBS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.