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Q13946

- PDE7A_HUMAN

UniProt

Q13946 - PDE7A_HUMAN

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Protein

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

Gene
PDE7A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.1 Publication

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.1 Publication

Enzyme regulationi

Insensitive to all selective PDE inhibitors.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei212 – 2121Proton donor By similarity
Metal bindingi216 – 2161Divalent metal cation 1
Metal bindingi252 – 2521Divalent metal cation 1
Metal bindingi253 – 2531Divalent metal cation 1
Metal bindingi253 – 2531Divalent metal cation 2
Metal bindingi362 – 3621Divalent metal cation 1

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cAMP catabolic process Source: UniProtKB-UniPathway
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_19327. G alpha (s) signalling events.
UniPathwayiUPA00762; UER00747.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC:3.1.4.53)
Alternative name(s):
HCP1
TM22
Gene namesi
Name:PDE7A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:8791. PDE7A.

Subcellular locationi

Isoform PDE7A1 : Cytoplasmcytosol
Note: PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.
Isoform PDE7A2 : Cytoplasm
Note: PDE7A2 (50 kDa) is located to particulate cellular fractions.

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33139.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7APRO_0000198833Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 841Phosphoserine Reviewed prediction

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13946.
PaxDbiQ13946.
PRIDEiQ13946.

PTM databases

PhosphoSiteiQ13946.

Expressioni

Tissue specificityi

PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.

Developmental stagei

Developmentally regulated. PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development. It persists strongly only in adult skeletal muscle.

Gene expression databases

ArrayExpressiQ13946.
BgeeiQ13946.
CleanExiHS_PDE7A.
GenevestigatoriQ13946.

Organism-specific databases

HPAiCAB018770.
HPA027340.

Interactioni

Subunit structurei

Interacts with CBFA2T3.1 Publication

Protein-protein interaction databases

BioGridi111176. 1 interaction.
IntActiQ13946. 1 interaction.
STRINGi9606.ENSP00000368730.

Structurei

Secondary structure

1
482
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi140 – 1489
Turni149 – 1524
Helixi158 – 1647
Helixi169 – 18012
Helixi183 – 1864
Helixi191 – 20313
Beta strandi209 – 2135
Helixi214 – 22815
Helixi231 – 2344
Helixi239 – 25113
Turni252 – 2554
Helixi261 – 2666
Helixi270 – 2745
Turni275 – 2773
Helixi280 – 29617
Turni297 – 3015
Helixi304 – 31916
Helixi323 – 3253
Helixi326 – 33914
Helixi347 – 36216
Helixi365 – 3673
Helixi370 – 39324
Turni404 – 4063
Helixi409 – 41911
Helixi421 – 43111
Helixi435 – 45319

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZKLX-ray1.67A130-482[»]
3G3NX-ray2.40A139-456[»]
ProteinModelPortaliQ13946.
SMRiQ13946. Positions 139-456.

Miscellaneous databases

EvolutionaryTraceiQ13946.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni187 – 451265Catalytic By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 336Poly-Ser

Domaini

Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG300643.
HOGENOMiHOG000220881.
HOVERGENiHBG053543.
InParanoidiQ13946.
KOiK01120.
OMAiLCDRQTE.
OrthoDBiEOG7M98G3.
PhylomeDBiQ13946.
TreeFamiTF314638.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform PDE7A1 (identifier: Q13946-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEVCYQLPVL PLDRPVPQHV LSRRGAISFS SSSALFGCPN PRQLSQRRGA    50
ISYDSSDQTA LYIRMLGDVR VRSRAGFESE RRGSHPYIDF RIFHSQSEIE 100
VSVSARNIRR LLSFQRYLRS SRFFRGTAVS NSLNILDDDY NGQAKCMLEK 150
VGNWNFDIFL FDRLTNGNSL VSLTFHLFSL HGLIEYFHLD MMKLRRFLVM 200
IQEDYHSQNP YHNAVHAADV TQAMHCYLKE PKLANSVTPW DILLSLIAAA 250
THDLDHPGVN QPFLIKTNHY LATLYKNTSV LENHHWRSAV GLLRESGLFS 300
HLPLESRQQM ETQIGALILA TDISRQNEYL SLFRSHLDRG DLCLEDTRHR 350
HLVLQMALKC ADICNPCRTW ELSKQWSEKV TEEFFHQGDI EKKYHLGVSP 400
LCDRHTESIA NIQIGFMTYL VEPLFTEWAR FSNTRLSQTM LGHVGLNKAS 450
WKGLQREQSS SEDTDAAFEL NSQLLPQENR LS 482
Length:482
Mass (Da):55,505
Last modified:July 15, 1998 - v2
Checksum:i3B3C8F6E9154F88C
GO
Isoform PDE7A2 (identifier: Q13946-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQ → MGITLIWCLALVLIKWITSK

Show »
Length:456
Mass (Da):52,725
Checksum:iCAA62B0BFEF074AF
GO
Isoform PDE7A3 (identifier: Q13946-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-424: FMTYLVEPL → NYTYLDIAG
     425-482: Missing.

Show »
Length:424
Mass (Da):48,828
Checksum:iA7DBF40D08A7B561
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761G → E.
Corresponds to variant rs11557049 [ dbSNP | Ensembl ].
VAR_056661

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4646MEVCY…RQLSQ → MGITLIWCLALVLIKWITSK in isoform PDE7A2. VSP_004593Add
BLAST
Alternative sequencei416 – 4249FMTYLVEPL → NYTYLDIAG in isoform PDE7A3. VSP_038645
Alternative sequencei425 – 48258Missing in isoform PDE7A3. VSP_038646Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041D → G in BAF83490. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12052 mRNA. Translation: AAA35644.2.
U67932 mRNA. Translation: AAB65772.1.
AF332652 mRNA. Translation: AAK57640.1.
AK290801 mRNA. Translation: BAF83490.1.
AK292680 mRNA. Translation: BAF85369.1.
AC055822 Genomic DNA. No translation available.
AC100812 Genomic DNA. No translation available.
BC126360 mRNA. Translation: AAI26361.1.
CCDSiCCDS34901.1. [Q13946-2]
CCDS56538.1. [Q13946-1]
RefSeqiNP_001229247.1. NM_001242318.2. [Q13946-1]
NP_002594.1. NM_002603.3. [Q13946-2]
UniGeneiHs.527119.

Genome annotation databases

EnsembliENST00000379419; ENSP00000368730; ENSG00000205268. [Q13946-2]
ENST00000396642; ENSP00000379881; ENSG00000205268. [Q13946-3]
ENST00000401827; ENSP00000385632; ENSG00000205268. [Q13946-1]
GeneIDi5150.
KEGGihsa:5150.
UCSCiuc003xvp.3. human. [Q13946-2]
uc003xvq.3. human. [Q13946-1]
uc003xvr.3. human. [Q13946-3]

Polymorphism databases

DMDMi3182958.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12052 mRNA. Translation: AAA35644.2 .
U67932 mRNA. Translation: AAB65772.1 .
AF332652 mRNA. Translation: AAK57640.1 .
AK290801 mRNA. Translation: BAF83490.1 .
AK292680 mRNA. Translation: BAF85369.1 .
AC055822 Genomic DNA. No translation available.
AC100812 Genomic DNA. No translation available.
BC126360 mRNA. Translation: AAI26361.1 .
CCDSi CCDS34901.1. [Q13946-2 ]
CCDS56538.1. [Q13946-1 ]
RefSeqi NP_001229247.1. NM_001242318.2. [Q13946-1 ]
NP_002594.1. NM_002603.3. [Q13946-2 ]
UniGenei Hs.527119.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ZKL X-ray 1.67 A 130-482 [» ]
3G3N X-ray 2.40 A 139-456 [» ]
ProteinModelPortali Q13946.
SMRi Q13946. Positions 139-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111176. 1 interaction.
IntActi Q13946. 1 interaction.
STRINGi 9606.ENSP00000368730.

Chemistry

BindingDBi Q13946.
ChEMBLi CHEMBL3012.
DrugBanki DB00651. Dyphylline.
DB00920. Ketotifen.
GuidetoPHARMACOLOGYi 1305.

PTM databases

PhosphoSitei Q13946.

Polymorphism databases

DMDMi 3182958.

Proteomic databases

MaxQBi Q13946.
PaxDbi Q13946.
PRIDEi Q13946.

Protocols and materials databases

DNASUi 5150.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379419 ; ENSP00000368730 ; ENSG00000205268 . [Q13946-2 ]
ENST00000396642 ; ENSP00000379881 ; ENSG00000205268 . [Q13946-3 ]
ENST00000401827 ; ENSP00000385632 ; ENSG00000205268 . [Q13946-1 ]
GeneIDi 5150.
KEGGi hsa:5150.
UCSCi uc003xvp.3. human. [Q13946-2 ]
uc003xvq.3. human. [Q13946-1 ]
uc003xvr.3. human. [Q13946-3 ]

Organism-specific databases

CTDi 5150.
GeneCardsi GC08M066629.
HGNCi HGNC:8791. PDE7A.
HPAi CAB018770.
HPA027340.
MIMi 171885. gene.
neXtProti NX_Q13946.
PharmGKBi PA33139.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300643.
HOGENOMi HOG000220881.
HOVERGENi HBG053543.
InParanoidi Q13946.
KOi K01120.
OMAi LCDRQTE.
OrthoDBi EOG7M98G3.
PhylomeDBi Q13946.
TreeFami TF314638.

Enzyme and pathway databases

UniPathwayi UPA00762 ; UER00747 .
Reactomei REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

EvolutionaryTracei Q13946.
GeneWikii PDE7A.
GenomeRNAii 5150.
NextBioi 19872.
PROi Q13946.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13946.
Bgeei Q13946.
CleanExi HS_PDE7A.
Genevestigatori Q13946.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
InterProi IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae."
    Michaeli T., Bloom T.J., Martins T., Loughney K., Ferguson K., Riggs M., Rodgers L., Beavo J.A., Wigler M.
    J. Biol. Chem. 268:12925-12932(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE7A1).
  2. "Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart."
    Han P., Zhu X., Michaeli T.
    J. Biol. Chem. 272:16152-16157(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE7A2).
    Tissue: Skeletal muscle.
  3. "T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3."
    Glavas N.A., Ostenson C., Schaefer J.B., Vasta V., Beavo J.A.
    Proc. Natl. Acad. Sci. U.S.A. 98:6319-6324(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE7A3).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PDE7A1).
    Tissue: Kidney and Thymus.
  5. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PDE7A2).
  7. "A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines."
    Asirvatham A.L., Galligan S.G., Schillace R.V., Davey M.P., Vasta V., Beavo J.A., Carr D.W.
    J. Immunol. 173:4806-4814(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CBFA2T3.
  8. "Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7."
    Wang H., Liu Y., Chen Y., Robinson H., Ke H.
    J. Biol. Chem. 280:30949-30955(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS) OF 130-482 IN COMPLEX WITH METAL IONS AND THE INHIBITOR IBMX.
  9. "Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors."
    Castano T., Wang H., Campillo N.E., Ballester S., Gonzalez-Garcia C., Hernandez J., Perez C., Cuenca J., Perez-Castillo A., Martinez A., Huertas O., Gelpi J.L., Luque F.J., Ke H., Gil C.
    ChemMedChem 4:866-876(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 139-456 IN COMPLEX WITH METAL IONS, FUNCTION, COFACTOR.

Entry informationi

Entry nameiPDE7A_HUMAN
AccessioniPrimary (citable) accession number: Q13946
Secondary accession number(s): A0AVH6
, A8K436, A8K9G5, O15380, Q96T72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 3, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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