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Protein

Calicin

Gene

CCIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Possible morphogenetic cytoskeletal element in spermiogenic differentiation.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Calicin
Gene namesi
Name:CCIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:1568. CCIN.

Subcellular locationi

GO - Cellular componenti

  • Cul3-RING ubiquitin ligase complex Source: GO_Central
  • cytoskeletal calyx Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26140.

Polymorphism and mutation databases

BioMutaiCCIN.
DMDMi143811369.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588CalicinPRO_0000119067Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ13939.
PRIDEiQ13939.

PTM databases

iPTMnetiQ13939.
PhosphoSiteiQ13939.

Expressioni

Tissue specificityi

Testis. Not detectable or shows a drastically altered pattern of arrangement in the heads of malformed spermatozoa.1 Publication

Gene expression databases

BgeeiQ13939.
CleanExiHS_CCIN.
ExpressionAtlasiQ13939. baseline and differential.
GenevisibleiQ13939. HS.

Organism-specific databases

HPAiHPA019611.

Interactioni

Protein-protein interaction databases

BioGridi107324. 2 interactions.
STRINGi9606.ENSP00000334996.

Structurei

3D structure databases

ProteinModelPortaliQ13939.
SMRiQ13939. Positions 10-226, 307-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 124113BTBPROSITE-ProRule annotationAdd
BLAST
Domaini133 – 235103BACKAdd
BLAST
Repeati280 – 32748Kelch 1Add
BLAST
Repeati328 – 37548Kelch 2Add
BLAST
Repeati377 – 42347Kelch 3Add
BLAST
Repeati425 – 47551Kelch 4Add
BLAST
Repeati476 – 52550Kelch 5Add
BLAST
Repeati526 – 58055Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
HOGENOMiHOG000060293.
HOVERGENiHBG003874.
InParanoidiQ13939.
OMAiRCPPVIF.
OrthoDBiEOG7WT40Q.
PhylomeDBiQ13939.
TreeFamiTF331981.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLEFTEKNY NSFVLQNLNR QRKRKEYWDM ALSVDNHVFF AHRNVLAAVS
60 70 80 90 100
PLVRSLISSN DMKTADELFI TIDTSYLSPV TVDQLLDYFY SGKVVISEQN
110 120 130 140 150
VEELLRGAQY FNTPRLRVHC NDFLIKSICR ANCLRYLFLA ELFELKEVSD
160 170 180 190 200
VAYSGIRDNF HYWASPEGSM HFMRCPPVIF GRLLRDENLH VLNEDQALSA
210 220 230 240 250
LINWVYFRKE DREKYFKKFF NYINLNAVSN KTLVFASNKL VGMENTSSHT
260 270 280 290 300
TLIESVLMDR KQERPCSLLV YQRKGALLDS VVILGGQKAH GQFNDGVFAY
310 320 330 340 350
IIQENLWMKL SDMPYRAAAL SATSAGRYIY ISGGTTEQIS GLKTAWRYDM
360 370 380 390 400
DDNSWTKLPD LPIGLVFHTM VTCGGTVYSV GGSIAPRRYV SNIYRYDERK
410 420 430 440 450
EVWCLAGKMS IPMDGTAVIT KGDRHLYIVT GRCLVKGYIS RVGVVDCFDT
460 470 480 490 500
STGDVVQCIT FPIEFNHRPL LSFQQDNILC VHSHRQSVEI NLQKVKASKT
510 520 530 540 550
TTSVPVLPNS CPLDVSHAIC SIGDSKVFVC GGVTTASDVQ TKDYTINPNA
560 570 580
FLLDQKTGKW KTLAPPPEAL DCPACCLAKL PCKILQRI
Length:588
Mass (Da):66,582
Last modified:April 3, 2007 - v3
Checksum:i8EEB910611BBA98B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti226 – 2261N → S in AAK20829 (Ref. 1) Curated
Sequence conflicti433 – 4331C → W in CAA87088 (PubMed:7641791).Curated
Sequence conflicti490 – 4901I → N in AAK20829 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751S → N.
Corresponds to variant rs34789048 [ dbSNP | Ensembl ].
VAR_050039

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333334 mRNA. Translation: AAK20829.1.
Z46967 mRNA. Translation: CAA87088.1.
CCDSiCCDS6599.1.
PIRiI37216.
RefSeqiNP_005884.2. NM_005893.2.
UniGeneiHs.115460.

Genome annotation databases

EnsembliENST00000335119; ENSP00000334996; ENSG00000185972.
GeneIDi881.
KEGGihsa:881.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333334 mRNA. Translation: AAK20829.1.
Z46967 mRNA. Translation: CAA87088.1.
CCDSiCCDS6599.1.
PIRiI37216.
RefSeqiNP_005884.2. NM_005893.2.
UniGeneiHs.115460.

3D structure databases

ProteinModelPortaliQ13939.
SMRiQ13939. Positions 10-226, 307-473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107324. 2 interactions.
STRINGi9606.ENSP00000334996.

PTM databases

iPTMnetiQ13939.
PhosphoSiteiQ13939.

Polymorphism and mutation databases

BioMutaiCCIN.
DMDMi143811369.

Proteomic databases

PaxDbiQ13939.
PRIDEiQ13939.

Protocols and materials databases

DNASUi881.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335119; ENSP00000334996; ENSG00000185972.
GeneIDi881.
KEGGihsa:881.

Organism-specific databases

CTDi881.
GeneCardsiCCIN.
H-InvDBHIX0008029.
HGNCiHGNC:1568. CCIN.
HPAiHPA019611.
MIMi603960. gene.
neXtProtiNX_Q13939.
PharmGKBiPA26140.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
HOGENOMiHOG000060293.
HOVERGENiHBG003874.
InParanoidiQ13939.
OMAiRCPPVIF.
OrthoDBiEOG7WT40Q.
PhylomeDBiQ13939.
TreeFamiTF331981.

Miscellaneous databases

ChiTaRSiCCIN. human.
GenomeRNAii881.
PROiQ13939.
SOURCEiSearch...

Gene expression databases

BgeeiQ13939.
CleanExiHS_CCIN.
ExpressionAtlasiQ13939. baseline and differential.
GenevisibleiQ13939. HS.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Sha J.H., Zhou Z.M., Li J.M.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Molecular nature of calicin, a major basic protein of the mammalian sperm head cytoskeleton."
    von Buelow M., Heid H.W., Hess H., Franke W.W.
    Exp. Cell Res. 219:407-413(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-588, TISSUE SPECIFICITY.
    Tissue: Sperm.

Entry informationi

Entry nameiCALI_HUMAN
AccessioniPrimary (citable) accession number: Q13939
Secondary accession number(s): Q9BXG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 3, 2007
Last modified: June 8, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.