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Protein

Calicin

Gene

CCIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Possible morphogenetic cytoskeletal element in spermiogenic differentiation.

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Calicin
Gene namesi
Name:CCIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:1568. CCIN.

Subcellular locationi

GO - Cellular componenti

  • Cul3-RING ubiquitin ligase complex Source: GO_Central
  • cytoskeletal calyx Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185972.
PharmGKBiPA26140.

Polymorphism and mutation databases

BioMutaiCCIN.
DMDMi143811369.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190671 – 588CalicinAdd BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei149PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ13939.
PeptideAtlasiQ13939.
PRIDEiQ13939.

PTM databases

iPTMnetiQ13939.
PhosphoSitePlusiQ13939.

Expressioni

Tissue specificityi

Testis. Not detectable or shows a drastically altered pattern of arrangement in the heads of malformed spermatozoa.1 Publication

Gene expression databases

BgeeiENSG00000185972.
CleanExiHS_CCIN.
ExpressionAtlasiQ13939. baseline and differential.
GenevisibleiQ13939. HS.

Interactioni

Protein-protein interaction databases

BioGridi107324. 2 interactors.
STRINGi9606.ENSP00000334996.

Structurei

3D structure databases

ProteinModelPortaliQ13939.
SMRiQ13939.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 124BTBPROSITE-ProRule annotationAdd BLAST113
Domaini133 – 235BACKAdd BLAST103
Repeati280 – 327Kelch 1Add BLAST48
Repeati328 – 375Kelch 2Add BLAST48
Repeati377 – 423Kelch 3Add BLAST47
Repeati425 – 475Kelch 4Add BLAST51
Repeati476 – 525Kelch 5Add BLAST50
Repeati526 – 580Kelch 6Add BLAST55

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00800000124141.
HOGENOMiHOG000060293.
HOVERGENiHBG003874.
InParanoidiQ13939.
OMAiRCPPVIF.
OrthoDBiEOG090B03Q2.
PhylomeDBiQ13939.
TreeFamiTF331981.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiView protein in InterPro
IPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
PfamiView protein in Pfam
PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
SMARTiView protein in SMART
SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLEFTEKNY NSFVLQNLNR QRKRKEYWDM ALSVDNHVFF AHRNVLAAVS
60 70 80 90 100
PLVRSLISSN DMKTADELFI TIDTSYLSPV TVDQLLDYFY SGKVVISEQN
110 120 130 140 150
VEELLRGAQY FNTPRLRVHC NDFLIKSICR ANCLRYLFLA ELFELKEVSD
160 170 180 190 200
VAYSGIRDNF HYWASPEGSM HFMRCPPVIF GRLLRDENLH VLNEDQALSA
210 220 230 240 250
LINWVYFRKE DREKYFKKFF NYINLNAVSN KTLVFASNKL VGMENTSSHT
260 270 280 290 300
TLIESVLMDR KQERPCSLLV YQRKGALLDS VVILGGQKAH GQFNDGVFAY
310 320 330 340 350
IIQENLWMKL SDMPYRAAAL SATSAGRYIY ISGGTTEQIS GLKTAWRYDM
360 370 380 390 400
DDNSWTKLPD LPIGLVFHTM VTCGGTVYSV GGSIAPRRYV SNIYRYDERK
410 420 430 440 450
EVWCLAGKMS IPMDGTAVIT KGDRHLYIVT GRCLVKGYIS RVGVVDCFDT
460 470 480 490 500
STGDVVQCIT FPIEFNHRPL LSFQQDNILC VHSHRQSVEI NLQKVKASKT
510 520 530 540 550
TTSVPVLPNS CPLDVSHAIC SIGDSKVFVC GGVTTASDVQ TKDYTINPNA
560 570 580
FLLDQKTGKW KTLAPPPEAL DCPACCLAKL PCKILQRI
Length:588
Mass (Da):66,582
Last modified:April 3, 2007 - v3
Checksum:i8EEB910611BBA98B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226N → S in AAK20829 (Ref. 1) Curated1
Sequence conflicti433C → W in CAA87088 (PubMed:7641791).Curated1
Sequence conflicti490I → N in AAK20829 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05003975S → N. Corresponds to variant dbSNP:rs34789048Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333334 mRNA. Translation: AAK20829.1.
Z46967 mRNA. Translation: CAA87088.1.
CCDSiCCDS6599.1.
PIRiI37216.
RefSeqiNP_005884.2. NM_005893.2.
UniGeneiHs.115460.

Genome annotation databases

EnsembliENST00000335119; ENSP00000334996; ENSG00000185972.
GeneIDi881.
KEGGihsa:881.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333334 mRNA. Translation: AAK20829.1.
Z46967 mRNA. Translation: CAA87088.1.
CCDSiCCDS6599.1.
PIRiI37216.
RefSeqiNP_005884.2. NM_005893.2.
UniGeneiHs.115460.

3D structure databases

ProteinModelPortaliQ13939.
SMRiQ13939.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107324. 2 interactors.
STRINGi9606.ENSP00000334996.

PTM databases

iPTMnetiQ13939.
PhosphoSitePlusiQ13939.

Polymorphism and mutation databases

BioMutaiCCIN.
DMDMi143811369.

Proteomic databases

PaxDbiQ13939.
PeptideAtlasiQ13939.
PRIDEiQ13939.

Protocols and materials databases

DNASUi881.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335119; ENSP00000334996; ENSG00000185972.
GeneIDi881.
KEGGihsa:881.

Organism-specific databases

CTDi881.
GeneCardsiCCIN.
H-InvDBHIX0008029.
HGNCiHGNC:1568. CCIN.
MIMi603960. gene.
neXtProtiNX_Q13939.
OpenTargetsiENSG00000185972.
PharmGKBiPA26140.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00800000124141.
HOGENOMiHOG000060293.
HOVERGENiHBG003874.
InParanoidiQ13939.
OMAiRCPPVIF.
OrthoDBiEOG090B03Q2.
PhylomeDBiQ13939.
TreeFamiTF331981.

Miscellaneous databases

ChiTaRSiCCIN. human.
GenomeRNAii881.
PROiQ13939.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185972.
CleanExiHS_CCIN.
ExpressionAtlasiQ13939. baseline and differential.
GenevisibleiQ13939. HS.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiView protein in InterPro
IPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
PfamiView protein in Pfam
PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
SMARTiView protein in SMART
SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCALI_HUMAN
AccessioniPrimary (citable) accession number: Q13939
Secondary accession number(s): Q9BXG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 3, 2007
Last modified: February 15, 2017
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.