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Protein

Calcyphosin

Gene

CAPS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-binding protein. May play a role in cellular signaling events (Potential).Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi34 – 45121Add
BLAST
Calcium bindingi70 – 81122Add
BLAST
Calcium bindingi106 – 117123Add
BLAST
Calcium bindingi149 – 161134Add
BLAST

GO - Molecular functioni

  • calcium ion binding Source: ProtInc

GO - Biological processi

  • intracellular signal transduction Source: ProtInc
  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcyphosin
Alternative name(s):
Calcyphosine
Gene namesi
Name:CAPS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1487. CAPS.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • nucleus Source: HPA
  • plasma membrane Source: HPA
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26068.

Polymorphism and mutation databases

BioMutaiCAPS.
DMDMi2493439.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189CalcyphosinPRO_0000073538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401Phosphoserine; by PKASequence analysis

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13938.
PaxDbiQ13938.
PRIDEiQ13938.

PTM databases

PhosphoSiteiQ13938.

Expressioni

Gene expression databases

BgeeiQ13938.
CleanExiHS_CAPS.
ExpressionAtlasiQ13938. baseline and differential.
GenevisibleiQ13938. HS.

Organism-specific databases

HPAiHPA043520.

Interactioni

Subunit structurei

Monomer. Does not form oligomers in the presence of calcium.1 Publication

Protein-protein interaction databases

BioGridi107278. 1 interaction.
STRINGi9606.ENSP00000222125.

Structurei

Secondary structure

1
189
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1211Combined sources
Turni16 – 183Combined sources
Helixi28 – 336Combined sources
Beta strandi39 – 413Combined sources
Helixi43 – 519Combined sources
Turni52 – 543Combined sources
Helixi59 – 6911Combined sources
Beta strandi74 – 774Combined sources
Helixi79 – 857Combined sources
Helixi92 – 10514Combined sources
Beta strandi110 – 1134Combined sources
Helixi115 – 1217Combined sources
Helixi128 – 1314Combined sources
Helixi137 – 14812Combined sources
Helixi159 – 17214Combined sources
Helixi176 – 18712Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E3RX-ray2.65A/B1-189[»]
ProteinModelPortaliQ13938.
SMRiQ13938. Positions 4-189.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13938.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 5636EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini57 – 9236EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini93 – 12836EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini136 – 17237EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00390000000679.
HOGENOMiHOG000008004.
HOVERGENiHBG050808.
InParanoidiQ13938.
PhylomeDBiQ13938.
TreeFamiTF318191.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13938-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAVDATMEK LRAQCLSRGA SGIQGLARFF RQLDRDGSRS LDADEFRQGL
60 70 80 90 100
AKLGLVLDQA EAEGVCRKWD RNGSGTLDLE EFLRALRPPM SQAREAVIAA
110 120 130 140 150
AFAKLDRSGD GVVTVDDLRG VYSGRAHPKV RSGEWTEDEV LRRFLDNFDS
160 170 180
SEKDGQVTLA EFQDYYSGVS ASMNTDEEFV AMMTSAWQL
Length:189
Mass (Da):20,967
Last modified:November 1, 1997 - v1
Checksum:iE57291A996D7D1D5
GO
Isoform 2 (identifier: Q13938-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-156: Missing.

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):17,770
Checksum:i4B9440BCD9F2208B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391R → G.
Corresponds to variant rs7249419 [ dbSNP | Ensembl ].
VAR_048638

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei130 – 15627Missing in isoform 2. 1 PublicationVSP_055154Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97966 mRNA. Translation: CAA66609.1.
AC004602 Genomic DNA. Translation: AAC14484.1.
BC019065 mRNA. No translation available.
BC080599 mRNA. Translation: AAH80599.1.
BC101513 mRNA. Translation: AAI01514.1.
BC104766 mRNA. Translation: AAI04767.1.
UniGeneiHs.584744.
Hs.627868.

Genome annotation databases

EnsembliENST00000222125; ENSP00000222125; ENSG00000283027. [Q13938-3]
ENST00000618299; ENSP00000484912; ENSG00000105519. [Q13938-1]
UCSCiuc002mdt.4. human. [Q13938-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97966 mRNA. Translation: CAA66609.1.
AC004602 Genomic DNA. Translation: AAC14484.1.
BC019065 mRNA. No translation available.
BC080599 mRNA. Translation: AAH80599.1.
BC101513 mRNA. Translation: AAI01514.1.
BC104766 mRNA. Translation: AAI04767.1.
UniGeneiHs.584744.
Hs.627868.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E3RX-ray2.65A/B1-189[»]
ProteinModelPortaliQ13938.
SMRiQ13938. Positions 4-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107278. 1 interaction.
STRINGi9606.ENSP00000222125.

PTM databases

PhosphoSiteiQ13938.

Polymorphism and mutation databases

BioMutaiCAPS.
DMDMi2493439.

Proteomic databases

MaxQBiQ13938.
PaxDbiQ13938.
PRIDEiQ13938.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222125; ENSP00000222125; ENSG00000283027. [Q13938-3]
ENST00000618299; ENSP00000484912; ENSG00000105519. [Q13938-1]
UCSCiuc002mdt.4. human. [Q13938-1]

Organism-specific databases

GeneCardsiCAPS.
HGNCiHGNC:1487. CAPS.
HPAiHPA043520.
MIMi114212. gene.
neXtProtiNX_Q13938.
PharmGKBiPA26068.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00390000000679.
HOGENOMiHOG000008004.
HOVERGENiHBG050808.
InParanoidiQ13938.
PhylomeDBiQ13938.
TreeFamiTF318191.

Miscellaneous databases

ChiTaRSiCAPS. human.
EvolutionaryTraceiQ13938.
GeneWikiiCAPS_(gene).
NextBioi3408.
PROiQ13938.
SOURCEiSearch...

Gene expression databases

BgeeiQ13938.
CleanExiHS_CAPS.
ExpressionAtlasiQ13938. baseline and differential.
GenevisibleiQ13938. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of human calcyphosine complementary DNA."
    el Housni H., Radulescu A., Lecocq R., Dumont J.E., Christophe D.
    Biochim. Biophys. Acta 1352:249-252(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Thyroid.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Skin.
  4. "Crystal-structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family."
    Dong H., Li X., Lou Z., Xu X., Su D., Zhou X., Zhou W., Bartlam M., Rao Z.
    J. Mol. Biol. 383:455-464(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) IN COMPLEX WITH CALCIUM, CALCIUM-BINDING, SUBUNIT.

Entry informationi

Entry nameiCAYP1_HUMAN
AccessioniPrimary (citable) accession number: Q13938
Secondary accession number(s): Q3MJA7, Q8WUZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 11, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.