Q13938 (CAYP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcyphosin

Alternative name(s):
Calcyphosine

Gene names

Name:

CAPS

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Calcium-binding protein. May play a role in cellular signaling events Potential.
Subunit structure	Monomer. Does not form oligomers in the presence of calcium. Ref.4
Subcellular location	Cytoplasm.
Sequence similarities	Contains 4 EF-hand domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	Calcium Metal-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Traceable author statement PubMed 2540953. Source: ProtInc
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	calcium ion binding Traceable author statement PubMed 2540953. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 189

189

Calcyphosin

PRO_0000073538

Regions

Domain

21 – 56

36

EF-hand 1

Domain

57 – 92

36

EF-hand 2

Domain

93 – 128

36

EF-hand 3

Domain

136 – 172

37

EF-hand 4

Calcium binding

34 – 45

12

1 Ref.4

Calcium binding

70 – 81

12

2 Ref.4

Calcium binding

106 – 117

12

3 Ref.4

Calcium binding

149 – 161

13

4 Ref.4

Amino acid modifications

Modified residue

40

1

Phosphoserine; by PKA Potential

Natural variations

Natural variant

39

1

R → G.
Corresponds to variant rs7249419 [ dbSNP | Ensembl ].

VAR_048638

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

189

Helix Strand Turn

Details...

Helix

2 – 12

11

Helix

28 – 33

6

Beta strand

39 – 41

3

Helix

43 – 51

9

Turn

52 – 54

3

Helix

59 – 69

11

Beta strand

74 – 77

4

Helix

79 – 85

7

Helix

92 – 105

14

Beta strand

110 – 113

4

Helix

115 – 121

7

Helix

128 – 131

4

Helix

137 – 148

12

Helix

159 – 172

14

Helix

176 – 187

12

Sequences

	Sequence		Length	Mass (Da)
	Q13938 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: E57291A996D7D1D5	FASTA	189	20,967
	10 20 30 40 50 60 MDAVDATMEK LRAQCLSRGA SGIQGLARFF RQLDRDGSRS LDADEFRQGL AKLGLVLDQA 70 80 90 100 110 120 EAEGVCRKWD RNGSGTLDLE EFLRALRPPM SQAREAVIAA AFAKLDRSGD GVVTVDDLRG 130 140 150 160 170 180 VYSGRAHPKV RSGEWTEDEV LRRFLDNFDS SEKDGQVTLA EFQDYYSGVS ASMNTDEEFV AMMTSAWQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequence analysis of human calcyphosine complementary DNA." el Housni H., Radulescu A., Lecocq R., Dumont J.E., Christophe D. Biochim. Biophys. Acta 1352:249-252(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thyroid.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Skin.
[4]	"Crystal-structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family." Dong H., Li X., Lou Z., Xu X., Su D., Zhou X., Zhou W., Bartlam M., Rao Z. J. Mol. Biol. 383:455-464(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) IN COMPLEX WITH CALCIUM, CALCIUM-BINDING, SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X97966 mRNA. Translation: CAA66609.1.
AC004602 Genomic DNA. Translation: AAC14484.1.
BC080599 mRNA. Translation: AAH80599.1.
BC101513 mRNA. Translation: AAI01514.1.
BC104766 mRNA. Translation: AAI04767.1.

IPI

IPI00465352.

RefSeq

NP_004049.1. NM_004058.3.

UniGene

Hs.584744.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3E3R	X-ray	2.65	A/B	1-189	[»]

ProteinModelPortal

Q13938.

ModBase

Search...

PTM databases

PhosphoSite

Q13938.

Polymorphism databases

DMDM

2493439.

Proteomic databases

PaxDb

Q13938.

PRIDE

Q13938.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000222125; ENSP00000222125; ENSG00000105519.

GeneID

828.

KEGG

hsa:828.

UCSC

uc002mdt.3. human.

Organism-specific databases

CTD

828.

GeneCards

GC19P005865.

HGNC

HGNC:1487. CAPS.

HPA

HPA043520.

MIM

114212. gene.

neXtProt

NX_Q13938.

PharmGKB

PA26068.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG288524.

HOGENOM

HOG000008004.

HOVERGEN

HBG050808.

InParanoid

Q13938.

OrthoDB

EOG47WNP5.

PhylomeDB

Q13938.

Gene expression databases

ArrayExpress

Q13938.

Bgee

Q13938.

CleanEx

HS_CAPS.

Genevestigator

Q13938.

GermOnline

ENSG00000105519. Homo sapiens.

Family and domain databases

Gene3D

1.10.238.10. 1 hit.

InterPro

IPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]

Pfam

PF13499. EF_hand_5. 2 hits.
[Graphical view]

SMART

SM00054. EFh. 4 hits.
[Graphical view]

PROSITE

PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q13938.

GenomeRNAi

828.

NextBio

3408.

SOURCE

Search...

Entry information

Entry name

CAYP1_HUMAN

Accession

Primary (citable) accession number: Q13938
Secondary accession number(s): Q3MJA7, Q8WUZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.