Reviewed,
UniProtKB/Swiss-Prot Q13938 (CAYP1_HUMAN)
Last modified
January 19, 2010.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Calcyphosin Alternative name(s): Calcyphosine | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 189 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Calcium-binding protein. May play a role in cellular signaling events Potential. |
| Subunit structure | Monomer. Does not form oligomers in the presence of calcium. Ref.4 |
| Subcellular location | |
| Sequence similarities | Contains 4 EF-hand domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat |
| Ligand | Calcium |
| PTM | Phosphoprotein |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | intracellular signaling cascade Traceable author statement. Source: ProtInc |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | calcium ion binding Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 189 | 189 | Calcyphosin | PRO_0000073538 | |||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||
| Domain | 21 – 56 | 36 | EF-hand 1 | ||||||||||||||||||||||||||||||||
| Domain | 57 – 92 | 36 | EF-hand 2 | ||||||||||||||||||||||||||||||||
| Domain | 93 – 128 | 36 | EF-hand 3 | ||||||||||||||||||||||||||||||||
| Domain | 136 – 172 | 37 | EF-hand 4 | ||||||||||||||||||||||||||||||||
| Calcium binding | 34 – 45 | 12 | 1 Ref.4 | ||||||||||||||||||||||||||||||||
| Calcium binding | 70 – 81 | 12 | 2 Ref.4 | ||||||||||||||||||||||||||||||||
| Calcium binding | 106 – 117 | 12 | 3 Ref.4 | ||||||||||||||||||||||||||||||||
| Calcium binding | 149 – 161 | 13 | 4 Ref.4 | ||||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||||
| Modified residue | 40 | 1 | Phosphoserine; by PKA Potential | ||||||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||||||
| Natural variant | 39 | 1 | R → G: dbSNP rs7249419. | VAR_048638 | |||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||
| Helix | 2 – 12 | 11 | |||||||||||||||||||||||||||||||||
| Helix | 28 – 34 | 7 | |||||||||||||||||||||||||||||||||
| Helix | 43 – 47 | 5 | |||||||||||||||||||||||||||||||||
| Helix | 59 – 62 | 4 | |||||||||||||||||||||||||||||||||
| Helix | 66 – 69 | 4 | |||||||||||||||||||||||||||||||||
| Helix | 79 – 85 | 7 | |||||||||||||||||||||||||||||||||
| Helix | 92 – 105 | 14 | |||||||||||||||||||||||||||||||||
| Helix | 115 – 118 | 4 | |||||||||||||||||||||||||||||||||
| Helix | 128 – 131 | 4 | |||||||||||||||||||||||||||||||||
| Helix | 137 – 148 | 12 | |||||||||||||||||||||||||||||||||
| Helix | 159 – 166 | 8 | |||||||||||||||||||||||||||||||||
| Helix | 170 – 172 | 3 | |||||||||||||||||||||||||||||||||
| Helix | 176 – 187 | 12 | |||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and sequence analysis of human calcyphosine complementary DNA." el Housni H., Radulescu A., Lecocq R., Dumont J.E., Christophe D. Biochim. Biophys. Acta 1352:249-252(1997) [PubMed: 9224948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thyroid. |
| [2] | "The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M.Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Skin. |
| [4] | "Crystal-structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family." Dong H., Li X., Lou Z., Xu X., Su D., Zhou X., Zhou W., Bartlam M., Rao Z. J. Mol. Biol. 383:455-464(2008) [PubMed: 18775726] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) IN COMPLEX WITH CALCIUM, CALCIUM-BINDING, SUBUNIT. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | X97966 mRNA. Translation: CAA66609.1. AC004602 Genomic DNA. Translation: AAC14484.1. BC080599 mRNA. Translation: AAH80599.1. BC101513 mRNA. Translation: AAI01514.1. BC104766 mRNA. Translation: AAI04767.1. | ||||||||||||
| IPI | IPI00465352. | ||||||||||||
| RefSeq | NP_004049.1. | ||||||||||||
| UniGene | Hs.584744 | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| STRING | Q13938. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q13938. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000222125; ENSP00000222125; ENSG00000105519; Homo sapiens. [Genome view] ENST00000394521; ENSP00000378029; ENSG00000105519; Homo sapiens. [Genome view] | ||||||||||||
| GeneID | 828. | ||||||||||||
| KEGG | hsa:828. | ||||||||||||
| UCSC | uc002mdt.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 828. | ||||||||||||
| GeneCards | GC19P005865. | ||||||||||||
| H-InvDB | HIX0020699. | ||||||||||||
| HGNC | HGNC:1487. CAPS. | ||||||||||||
| MIM | 114212. gene. | ||||||||||||
| PharmGKB | PA26068. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG17544. | ||||||||||||
| HOVERGEN | Q13938. | ||||||||||||
| InParanoid | Q13938. | ||||||||||||
| PhylomeDB | Q13938. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q13938. | ||||||||||||
| Bgee | Q13938. | ||||||||||||
| CleanEx | HS_CAPS. | ||||||||||||
| Genevestigator | Q13938. | ||||||||||||
| GermOnline | ENSG00000105519. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca_bd. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:1.10.238.10. EF-Hand_type. 1 hit. | ||||||||||||
| SMART | SM00054. EFh. 4 hits. [Graphical view] | ||||||||||||
| PROSITE | PS00018. EF_HAND_1. 3 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 3408. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | CAYP1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13938 Secondary accession number(s): Q3MJA7, Q8WUZ3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


