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Q13905

- RPGF1_HUMAN

UniProt

Q13905 - RPGF1_HUMAN

Protein

Rap guanine nucleotide exchange factor 1

Gene

RAPGEF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 3 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. Rap guanyl-nucleotide exchange factor activity Source: UniProtKB

    GO - Biological processi

    1. activation of MAPKK activity Source: Reactome
    2. blood vessel development Source: Ensembl
    3. cellular response to cAMP Source: UniProtKB
    4. cellular response to nerve growth factor stimulus Source: UniProtKB
    5. establishment of endothelial barrier Source: UniProtKB
    6. nerve growth factor signaling pathway Source: UniProtKB
    7. neurotrophin TRK receptor signaling pathway Source: Reactome
    8. platelet-derived growth factor receptor signaling pathway Source: Ensembl
    9. positive regulation of neuron projection development Source: UniProtKB
    10. positive regulation of Rap GTPase activity Source: UniProtKB
    11. Rap protein signal transduction Source: UniProtKB
    12. regulation of cell junction assembly Source: UniProtKB
    13. signal transduction Source: ProtInc
    14. single organismal cell-cell adhesion Source: Ensembl
    15. transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Neurogenesis

    Enzyme and pathway databases

    ReactomeiREACT_12076. Frs2-mediated activation.
    REACT_17025. Downstream signal transduction.
    REACT_23787. Regulation of signaling by CBL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rap guanine nucleotide exchange factor 1
    Alternative name(s):
    CRK SH3-binding GNRP
    Guanine nucleotide-releasing factor 2
    Protein C3G
    Gene namesi
    Name:RAPGEF1
    Synonyms:GRF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:4568. RAPGEF1.

    Subcellular locationi

    Early endosome 1 Publication

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. early endosome Source: UniProtKB
    3. endosome Source: Reactome

    Keywords - Cellular componenti

    Endosome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi504 – 5041Y → F: Abolishes phosphorylation by HCK. 1 Publication

    Organism-specific databases

    PharmGKBiPA28964.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10771077Rap guanine nucleotide exchange factor 1PRO_0000068864Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei293 – 2931Phosphoserine1 Publication
    Modified residuei360 – 3601Phosphoserine1 Publication
    Modified residuei504 – 5041Phosphotyrosine; by HCK1 Publication

    Post-translational modificationi

    Phosphorylation at Tyr-504 enhances activity as Rap guanine nucleotide exchange factor.3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ13905.
    PaxDbiQ13905.
    PRIDEiQ13905.

    PTM databases

    PhosphoSiteiQ13905.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver.

    Gene expression databases

    ArrayExpressiQ13905.
    BgeeiQ13905.
    CleanExiHS_RAPGEF1.
    GenevestigatoriQ13905.

    Organism-specific databases

    HPAiHPA006426.

    Interactioni

    Subunit structurei

    Interacts with CRK via its SH3-binding sites.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABL1P005194EBI-976876,EBI-375543
    CRKP461083EBI-976876,EBI-886
    CRKLP461092EBI-976876,EBI-910
    FYNP062412EBI-976876,EBI-515315
    NCK1P163332EBI-976876,EBI-389883
    PIK3R1P279862EBI-976876,EBI-79464
    SRCP129312EBI-976876,EBI-621482

    Protein-protein interaction databases

    BioGridi109146. 13 interactions.
    DIPiDIP-29392N.
    IntActiQ13905. 13 interactions.
    MINTiMINT-107377.
    STRINGi9606.ENSP00000361264.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13905.
    SMRiQ13905. Positions 715-1065.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini688 – 810123N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini840 – 1064225Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi281 – 29212SH3-bindingAdd
    BLAST
    Motifi451 – 46212SH3-bindingAdd
    BLAST
    Motifi538 – 54912SH3-bindingAdd
    BLAST
    Motifi606 – 61712SH3-bindingAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi963 – 9664Poly-Ser

    Sequence similaritiesi

    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3-binding

    Phylogenomic databases

    eggNOGiNOG288712.
    HOGENOMiHOG000048190.
    HOVERGENiHBG058477.
    KOiK06277.
    OMAiDHYDPDY.
    OrthoDBiEOG7SR4M9.
    PhylomeDBiQ13905.
    TreeFamiTF317296.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view]
    PfamiPF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    SMARTiSM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 1 hit.
    PROSITEiPS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q13905-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDTDSQRSHL SSFTMKLMDK FHSPKIKRTP SKKGKPAEVS VKIPEKPVNK     50
    EATDRFLPEG YPLPLDLEQQ AVEFMSTSAV ASRSQRQKNL SWLEEKEKEV 100
    VSALRYFKTI VDKMAIDKKV LEMLPGSASK VLEAILPLVQ NDPRIQHSSA 150
    LSSCYSRVYQ SLANLIRWSD QVMLEGVNSE DKEMVTTVKG VIKAVLDGVK 200
    ELVRLTIEKQ GRPSPTSPVK PSSPASKPDG PAELPLTDRE VEILNKTTGM 250
    SQSTELLPDA TDEEVAPPKP PLPGIRVVDN SPPPALPPKK RQSAPSPTRV 300
    AVVAPMSRAT SGSSLPVGIN RQDFDVDCYA QRRLSGGSHS YGGESPRLSP 350
    CSSIGKLSKS DEQLSSLDRD SGQCSRNTSC ETLDHYDPDY EFLQQDLSNA 400
    DQIPQQTAWN LSPLPESLGE SGSPFLGPPF QLPLGGHPQP DGPLAPGQQT 450
    DTPPALPEKK RRSAASQTAD GSGCRVSYER HPSQYDNISG EDLQSTAPIP 500
    SVPYAPFAAI LPFQHGGSSA PVEFVGDFTA PESTGDPEKP PPLPEKKNKH 550
    MLAYMQLLED YSEPQPSMFY QTPQNEHIYQ QKNKLLMEVY GFSDSFSGVD 600
    SVQELAPPPA LPPKQRQLEP PAGKDGHPRD PSAVSGVPGK DSRDGSERAP 650
    KSPDALESAQ SEEEVDELSL IDHNEIMSRL TLKQEGDDGP DVRGGSGDIL 700
    LVHATETDRK DLVLYCEAFL TTYRTFISPE ELIKKLQYRY EKFSPFADTF 750
    KKRVSKNTFF VLVRVVDELC LVELTEEILK LLMELVFRLV CNGELSLARV 800
    LRKNILDKVD QKKLLRCATS SQPLAARGVA ARPGTLHDFH SHEIAEQLTL 850
    LDAELFYKIE IPEVLLWAKE QNEEKSPNLT QFTEHFNNMS YWVRSIIMLQ 900
    EKAQDRERLL LKFIKIMKHL RKLNNFNSYL AILSALDSAP IRRLEWQKQT 950
    SEGLAEYCTL IDSSSSFRAY RAALSEVEPP CIPYLGLILQ DLTFVHLGNP 1000
    DYIDGKVNFS KRWQQFNILD SMRCFQQAHY DMRRNDDIIN FFNDFSDHLA 1050
    EEALWELSLK IKPRNITRRK TDREEKT 1077
    Length:1,077
    Mass (Da):120,548
    Last modified:April 3, 2007 - v3
    Checksum:iE700631A0EE76CA1
    GO
    Isoform Short (identifier: Q13905-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         50-88: Missing.

    Show »
    Length:1,038
    Mass (Da):116,141
    Checksum:i34F0A1BD9C8B0732
    GO
    Isoform 3 (identifier: Q13905-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-3: MDT → MGNAIEKQKPLKRSHLYPWKQ

    Note: No experimental confirmation available.

    Show »
    Length:1,095
    Mass (Da):122,735
    Checksum:i04C19860FF7F11E8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti137 – 1371P → R(PubMed:7806500)Curated
    Sequence conflicti183 – 1831E → G(PubMed:7806500)Curated
    Sequence conflicti217 – 2171S → C(PubMed:7806500)Curated
    Sequence conflicti254 – 2541T → S(PubMed:7806500)Curated
    Sequence conflicti287 – 2871P → T in BAA04770. (PubMed:7512734)Curated
    Sequence conflicti355 – 3551G → D in BAA04770. (PubMed:7512734)Curated
    Sequence conflicti636 – 6361G → V(PubMed:7806500)Curated
    Sequence conflicti698 – 6981D → N(PubMed:7806500)Curated
    Sequence conflicti846 – 8472EQ → DE(PubMed:7806500)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1012 – 10121R → Q Found in a patient with mental retardation, frontal epilepsy and mild facial dysmorphism. 1 Publication
    VAR_069375

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 33MDT → MGNAIEKQKPLKRSHLYPWK Q in isoform 3. 1 PublicationVSP_042052
    Alternative sequencei50 – 8839Missing in isoform Short. CuratedVSP_001822Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21239 mRNA. Translation: BAA04770.1.
    AL160271, AL160276 Genomic DNA. Translation: CAI13382.1.
    AL160276, AL160271 Genomic DNA. Translation: CAI40646.1.
    BC041710 mRNA. Translation: AAH41710.1.
    CCDSiCCDS48047.1. [Q13905-1]
    CCDS48048.1. [Q13905-3]
    RefSeqiNP_005303.2. NM_005312.2. [Q13905-1]
    NP_941372.1. NM_198679.1. [Q13905-3]
    UniGeneiHs.127897.

    Genome annotation databases

    EnsembliENST00000372189; ENSP00000361263; ENSG00000107263. [Q13905-1]
    ENST00000372190; ENSP00000361264; ENSG00000107263. [Q13905-3]
    GeneIDi2889.
    KEGGihsa:2889.
    UCSCiuc022bos.1. human. [Q13905-3]
    uc022bot.1. human. [Q13905-1]

    Polymorphism databases

    DMDMi143811452.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21239 mRNA. Translation: BAA04770.1 .
    AL160271 , AL160276 Genomic DNA. Translation: CAI13382.1 .
    AL160276 , AL160271 Genomic DNA. Translation: CAI40646.1 .
    BC041710 mRNA. Translation: AAH41710.1 .
    CCDSi CCDS48047.1. [Q13905-1 ]
    CCDS48048.1. [Q13905-3 ]
    RefSeqi NP_005303.2. NM_005312.2. [Q13905-1 ]
    NP_941372.1. NM_198679.1. [Q13905-3 ]
    UniGenei Hs.127897.

    3D structure databases

    ProteinModelPortali Q13905.
    SMRi Q13905. Positions 715-1065.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109146. 13 interactions.
    DIPi DIP-29392N.
    IntActi Q13905. 13 interactions.
    MINTi MINT-107377.
    STRINGi 9606.ENSP00000361264.

    PTM databases

    PhosphoSitei Q13905.

    Polymorphism databases

    DMDMi 143811452.

    Proteomic databases

    MaxQBi Q13905.
    PaxDbi Q13905.
    PRIDEi Q13905.

    Protocols and materials databases

    DNASUi 2889.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372189 ; ENSP00000361263 ; ENSG00000107263 . [Q13905-1 ]
    ENST00000372190 ; ENSP00000361264 ; ENSG00000107263 . [Q13905-3 ]
    GeneIDi 2889.
    KEGGi hsa:2889.
    UCSCi uc022bos.1. human. [Q13905-3 ]
    uc022bot.1. human. [Q13905-1 ]

    Organism-specific databases

    CTDi 2889.
    GeneCardsi GC09M134452.
    HGNCi HGNC:4568. RAPGEF1.
    HPAi HPA006426.
    MIMi 600303. gene.
    neXtProti NX_Q13905.
    PharmGKBi PA28964.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288712.
    HOGENOMi HOG000048190.
    HOVERGENi HBG058477.
    KOi K06277.
    OMAi DHYDPDY.
    OrthoDBi EOG7SR4M9.
    PhylomeDBi Q13905.
    TreeFami TF317296.

    Enzyme and pathway databases

    Reactomei REACT_12076. Frs2-mediated activation.
    REACT_17025. Downstream signal transduction.
    REACT_23787. Regulation of signaling by CBL.

    Miscellaneous databases

    ChiTaRSi RAPGEF1. human.
    GeneWikii RAPGEF1.
    GenomeRNAii 2889.
    NextBioi 11419.
    PROi Q13905.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13905.
    Bgeei Q13905.
    CleanExi HS_RAPGEF1.
    Genevestigatori Q13905.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    InterProi IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view ]
    Pfami PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    SMARTi SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 1 hit.
    PROSITEi PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins."
      Tanaka S., Morishita T., Hashimoto Y., Hattori S., Nakamura S., Shibuya M., Matuoka K., Takenawa T., Kurata T., Nagashima K., Matsuda M.
      Proc. Natl. Acad. Sci. U.S.A. 91:3443-3447(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), CHARACTERIZATION.
      Tissue: Placenta and Spleen.
    2. "Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk."
      Knudsen B., Feller S., Hanafusa H.
      J. Biol. Chem. 269:32781-32787(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ALTERNATIVE SPLICING.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Skin.
    5. "Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins."
      Matsuda M., Ota S., Tanimura R., Nakamura H., Matuoka K., Takenawa T., Nagashima K., Kurata T.
      J. Biol. Chem. 271:14468-14472(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRK.
    6. "Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain."
      Shivakrupa R., Radha V., Sudhakar C., Swarup G.
      J. Biol. Chem. 278:52188-52194(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HCK, MUTAGENESIS OF TYR-504, PHOSPHORYLATION AT TYR-504.
    7. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
      Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth."
      Hisata S., Sakisaka T., Baba T., Yamada T., Aoki K., Matsuda M., Takai Y.
      J. Cell Biol. 178:843-860(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: FUNCTION.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: VARIANT GLN-1012.

    Entry informationi

    Entry nameiRPGF1_HUMAN
    AccessioniPrimary (citable) accession number: Q13905
    Secondary accession number(s): Q5JUE4, Q8IV73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 136 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3