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Q13905

- RPGF1_HUMAN

UniProt

Q13905 - RPGF1_HUMAN

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Protein

Rap guanine nucleotide exchange factor 1

Gene

RAPGEF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.3 Publications

GO - Molecular functioni

  1. Rap guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  1. activation of MAPKK activity Source: Reactome
  2. blood vessel development Source: Ensembl
  3. cellular response to cAMP Source: UniProtKB
  4. cellular response to nerve growth factor stimulus Source: UniProtKB
  5. establishment of endothelial barrier Source: UniProtKB
  6. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  7. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
  8. negative regulation of neural precursor cell proliferation Source: Ensembl
  9. negative regulation of protein kinase B signaling Source: Ensembl
  10. negative regulation of Ras protein signal transduction Source: Ensembl
  11. nerve growth factor signaling pathway Source: UniProtKB
  12. neurotrophin TRK receptor signaling pathway Source: Reactome
  13. platelet-derived growth factor receptor signaling pathway Source: Ensembl
  14. positive regulation of neuron projection development Source: UniProtKB
  15. positive regulation of Rap GTPase activity Source: UniProtKB
  16. Rap protein signal transduction Source: UniProtKB
  17. regulation of cell junction assembly Source: UniProtKB
  18. signal transduction Source: ProtInc
  19. single organismal cell-cell adhesion Source: Ensembl
  20. transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_12076. Frs2-mediated activation.
REACT_17025. Downstream signal transduction.
REACT_23787. Regulation of signaling by CBL.

Names & Taxonomyi

Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor 1
Alternative name(s):
CRK SH3-binding GNRP
Guanine nucleotide-releasing factor 2
Protein C3G
Gene namesi
Name:RAPGEF1
Synonyms:GRF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:4568. RAPGEF1.

Subcellular locationi

Early endosome 1 Publication

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. early endosome Source: UniProtKB
  3. endosome Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi504 – 5041Y → F: Abolishes phosphorylation by HCK. 1 Publication

Organism-specific databases

PharmGKBiPA28964.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10771077Rap guanine nucleotide exchange factor 1PRO_0000068864Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei293 – 2931Phosphoserine1 Publication
Modified residuei360 – 3601Phosphoserine1 Publication
Modified residuei504 – 5041Phosphotyrosine; by HCK1 Publication

Post-translational modificationi

Phosphorylation at Tyr-504 enhances activity as Rap guanine nucleotide exchange factor.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13905.
PaxDbiQ13905.
PRIDEiQ13905.

PTM databases

PhosphoSiteiQ13905.

Expressioni

Tissue specificityi

Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver.

Gene expression databases

BgeeiQ13905.
CleanExiHS_RAPGEF1.
ExpressionAtlasiQ13905. baseline and differential.
GenevestigatoriQ13905.

Organism-specific databases

HPAiHPA006426.

Interactioni

Subunit structurei

Interacts with CRK via its SH3-binding sites.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005194EBI-976876,EBI-375543
CRKP461083EBI-976876,EBI-886
CRKLP461092EBI-976876,EBI-910
FYNP062412EBI-976876,EBI-515315
NCK1P163332EBI-976876,EBI-389883
PIK3R1P279862EBI-976876,EBI-79464
SRCP129312EBI-976876,EBI-621482

Protein-protein interaction databases

BioGridi109146. 13 interactions.
DIPiDIP-29392N.
IntActiQ13905. 14 interactions.
MINTiMINT-107377.
STRINGi9606.ENSP00000361264.

Structurei

3D structure databases

ProteinModelPortaliQ13905.
SMRiQ13905. Positions 685-1065.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini688 – 810123N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini840 – 1064225Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi281 – 29212SH3-bindingAdd
BLAST
Motifi451 – 46212SH3-bindingAdd
BLAST
Motifi538 – 54912SH3-bindingAdd
BLAST
Motifi606 – 61712SH3-bindingAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi963 – 9664Poly-Ser

Sequence similaritiesi

Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiNOG288712.
GeneTreeiENSGT00760000118829.
HOGENOMiHOG000048190.
HOVERGENiHBG058477.
InParanoidiQ13905.
KOiK06277.
OMAiDHYDPDY.
OrthoDBiEOG7SR4M9.
PhylomeDBiQ13905.
TreeFamiTF317296.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q13905-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTDSQRSHL SSFTMKLMDK FHSPKIKRTP SKKGKPAEVS VKIPEKPVNK
60 70 80 90 100
EATDRFLPEG YPLPLDLEQQ AVEFMSTSAV ASRSQRQKNL SWLEEKEKEV
110 120 130 140 150
VSALRYFKTI VDKMAIDKKV LEMLPGSASK VLEAILPLVQ NDPRIQHSSA
160 170 180 190 200
LSSCYSRVYQ SLANLIRWSD QVMLEGVNSE DKEMVTTVKG VIKAVLDGVK
210 220 230 240 250
ELVRLTIEKQ GRPSPTSPVK PSSPASKPDG PAELPLTDRE VEILNKTTGM
260 270 280 290 300
SQSTELLPDA TDEEVAPPKP PLPGIRVVDN SPPPALPPKK RQSAPSPTRV
310 320 330 340 350
AVVAPMSRAT SGSSLPVGIN RQDFDVDCYA QRRLSGGSHS YGGESPRLSP
360 370 380 390 400
CSSIGKLSKS DEQLSSLDRD SGQCSRNTSC ETLDHYDPDY EFLQQDLSNA
410 420 430 440 450
DQIPQQTAWN LSPLPESLGE SGSPFLGPPF QLPLGGHPQP DGPLAPGQQT
460 470 480 490 500
DTPPALPEKK RRSAASQTAD GSGCRVSYER HPSQYDNISG EDLQSTAPIP
510 520 530 540 550
SVPYAPFAAI LPFQHGGSSA PVEFVGDFTA PESTGDPEKP PPLPEKKNKH
560 570 580 590 600
MLAYMQLLED YSEPQPSMFY QTPQNEHIYQ QKNKLLMEVY GFSDSFSGVD
610 620 630 640 650
SVQELAPPPA LPPKQRQLEP PAGKDGHPRD PSAVSGVPGK DSRDGSERAP
660 670 680 690 700
KSPDALESAQ SEEEVDELSL IDHNEIMSRL TLKQEGDDGP DVRGGSGDIL
710 720 730 740 750
LVHATETDRK DLVLYCEAFL TTYRTFISPE ELIKKLQYRY EKFSPFADTF
760 770 780 790 800
KKRVSKNTFF VLVRVVDELC LVELTEEILK LLMELVFRLV CNGELSLARV
810 820 830 840 850
LRKNILDKVD QKKLLRCATS SQPLAARGVA ARPGTLHDFH SHEIAEQLTL
860 870 880 890 900
LDAELFYKIE IPEVLLWAKE QNEEKSPNLT QFTEHFNNMS YWVRSIIMLQ
910 920 930 940 950
EKAQDRERLL LKFIKIMKHL RKLNNFNSYL AILSALDSAP IRRLEWQKQT
960 970 980 990 1000
SEGLAEYCTL IDSSSSFRAY RAALSEVEPP CIPYLGLILQ DLTFVHLGNP
1010 1020 1030 1040 1050
DYIDGKVNFS KRWQQFNILD SMRCFQQAHY DMRRNDDIIN FFNDFSDHLA
1060 1070
EEALWELSLK IKPRNITRRK TDREEKT
Length:1,077
Mass (Da):120,548
Last modified:April 3, 2007 - v3
Checksum:iE700631A0EE76CA1
GO
Isoform Short (identifier: Q13905-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-88: Missing.

Show »
Length:1,038
Mass (Da):116,141
Checksum:i34F0A1BD9C8B0732
GO
Isoform 3 (identifier: Q13905-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MDT → MGNAIEKQKPLKRSHLYPWKQ

Note: No experimental confirmation available.

Show »
Length:1,095
Mass (Da):122,735
Checksum:i04C19860FF7F11E8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371P → R(PubMed:7806500)Curated
Sequence conflicti183 – 1831E → G(PubMed:7806500)Curated
Sequence conflicti217 – 2171S → C(PubMed:7806500)Curated
Sequence conflicti254 – 2541T → S(PubMed:7806500)Curated
Sequence conflicti287 – 2871P → T in BAA04770. (PubMed:7512734)Curated
Sequence conflicti355 – 3551G → D in BAA04770. (PubMed:7512734)Curated
Sequence conflicti636 – 6361G → V(PubMed:7806500)Curated
Sequence conflicti698 – 6981D → N(PubMed:7806500)Curated
Sequence conflicti846 – 8472EQ → DE(PubMed:7806500)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1012 – 10121R → Q Found in a patient with mental retardation, frontal epilepsy and mild facial dysmorphism. 1 Publication
VAR_069375

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 33MDT → MGNAIEKQKPLKRSHLYPWK Q in isoform 3. 1 PublicationVSP_042052
Alternative sequencei50 – 8839Missing in isoform Short. CuratedVSP_001822Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D21239 mRNA. Translation: BAA04770.1.
AL160271, AL160276 Genomic DNA. Translation: CAI13382.1.
AL160276, AL160271 Genomic DNA. Translation: CAI40646.1.
BC041710 mRNA. Translation: AAH41710.1.
CCDSiCCDS48047.1. [Q13905-1]
RefSeqiNP_005303.2. NM_005312.2. [Q13905-1]
NP_941372.1. NM_198679.1. [Q13905-3]
UniGeneiHs.127897.

Genome annotation databases

EnsembliENST00000372189; ENSP00000361263; ENSG00000107263. [Q13905-1]
ENST00000372190; ENSP00000361264; ENSG00000107263. [Q13905-3]
GeneIDi2889.
KEGGihsa:2889.
UCSCiuc022bos.1. human. [Q13905-3]
uc022bot.1. human. [Q13905-1]

Polymorphism databases

DMDMi143811452.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D21239 mRNA. Translation: BAA04770.1 .
AL160271 , AL160276 Genomic DNA. Translation: CAI13382.1 .
AL160276 , AL160271 Genomic DNA. Translation: CAI40646.1 .
BC041710 mRNA. Translation: AAH41710.1 .
CCDSi CCDS48047.1. [Q13905-1 ]
RefSeqi NP_005303.2. NM_005312.2. [Q13905-1 ]
NP_941372.1. NM_198679.1. [Q13905-3 ]
UniGenei Hs.127897.

3D structure databases

ProteinModelPortali Q13905.
SMRi Q13905. Positions 685-1065.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109146. 13 interactions.
DIPi DIP-29392N.
IntActi Q13905. 14 interactions.
MINTi MINT-107377.
STRINGi 9606.ENSP00000361264.

PTM databases

PhosphoSitei Q13905.

Polymorphism databases

DMDMi 143811452.

Proteomic databases

MaxQBi Q13905.
PaxDbi Q13905.
PRIDEi Q13905.

Protocols and materials databases

DNASUi 2889.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372189 ; ENSP00000361263 ; ENSG00000107263 . [Q13905-1 ]
ENST00000372190 ; ENSP00000361264 ; ENSG00000107263 . [Q13905-3 ]
GeneIDi 2889.
KEGGi hsa:2889.
UCSCi uc022bos.1. human. [Q13905-3 ]
uc022bot.1. human. [Q13905-1 ]

Organism-specific databases

CTDi 2889.
GeneCardsi GC09M134452.
HGNCi HGNC:4568. RAPGEF1.
HPAi HPA006426.
MIMi 600303. gene.
neXtProti NX_Q13905.
PharmGKBi PA28964.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288712.
GeneTreei ENSGT00760000118829.
HOGENOMi HOG000048190.
HOVERGENi HBG058477.
InParanoidi Q13905.
KOi K06277.
OMAi DHYDPDY.
OrthoDBi EOG7SR4M9.
PhylomeDBi Q13905.
TreeFami TF317296.

Enzyme and pathway databases

Reactomei REACT_12076. Frs2-mediated activation.
REACT_17025. Downstream signal transduction.
REACT_23787. Regulation of signaling by CBL.

Miscellaneous databases

ChiTaRSi RAPGEF1. human.
GeneWikii RAPGEF1.
GenomeRNAii 2889.
NextBioi 11419.
PROi Q13905.
SOURCEi Search...

Gene expression databases

Bgeei Q13905.
CleanExi HS_RAPGEF1.
ExpressionAtlasi Q13905. baseline and differential.
Genevestigatori Q13905.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
InterProi IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view ]
Pfami PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view ]
SMARTi SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
PROSITEi PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins."
    Tanaka S., Morishita T., Hashimoto Y., Hattori S., Nakamura S., Shibuya M., Matuoka K., Takenawa T., Kurata T., Nagashima K., Matsuda M.
    Proc. Natl. Acad. Sci. U.S.A. 91:3443-3447(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), CHARACTERIZATION.
    Tissue: Placenta and Spleen.
  2. "Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk."
    Knudsen B., Feller S., Hanafusa H.
    J. Biol. Chem. 269:32781-32787(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ALTERNATIVE SPLICING.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Skin.
  5. "Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins."
    Matsuda M., Ota S., Tanimura R., Nakamura H., Matuoka K., Takenawa T., Nagashima K., Kurata T.
    J. Biol. Chem. 271:14468-14472(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRK.
  6. "Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain."
    Shivakrupa R., Radha V., Sudhakar C., Swarup G.
    J. Biol. Chem. 278:52188-52194(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HCK, MUTAGENESIS OF TYR-504, PHOSPHORYLATION AT TYR-504.
  7. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth."
    Hisata S., Sakisaka T., Baba T., Yamada T., Aoki K., Matsuda M., Takai Y.
    J. Cell Biol. 178:843-860(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: FUNCTION.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: VARIANT GLN-1012.

Entry informationi

Entry nameiRPGF1_HUMAN
AccessioniPrimary (citable) accession number: Q13905
Secondary accession number(s): Q5JUE4, Q8IV73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3