Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bystin

Gene

BYSL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos.2 Publications

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: ProtInc
  • cell proliferation Source: Ensembl
  • female pregnancy Source: ProtInc
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: Ensembl
  • rRNA processing Source: Reactome
  • trophectodermal cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112578-MONOMER.
ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Bystin
Gene namesi
Name:BYSL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1157. BYSL.

Subcellular locationi

GO - Cellular componenti

  • apical part of cell Source: Ensembl
  • cytoplasm Source: ProtInc
  • cytosol Source: Reactome
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: Reactome
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi705.
OpenTargetsiENSG00000112578.
PharmGKBiPA25472.

Polymorphism and mutation databases

BioMutaiBYSL.
DMDMi108884834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861141 – 437BystinAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40Omega-N-methylarginineCombined sources1
Modified residuei55PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Modified residuei156PhosphothreonineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ13895.
MaxQBiQ13895.
PaxDbiQ13895.
PeptideAtlasiQ13895.
PRIDEiQ13895.

2D gel databases

SWISS-2DPAGEQ13895.

PTM databases

iPTMnetiQ13895.
PhosphoSitePlusiQ13895.
SwissPalmiQ13895.

Expressioni

Tissue specificityi

Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi.

Gene expression databases

BgeeiENSG00000112578.
CleanExiHS_BYSL.
ExpressionAtlasiQ13895. baseline and differential.
GenevisibleiQ13895. HS.

Organism-specific databases

HPAiHPA031217.
HPA031219.

Interactioni

Subunit structurei

Binds trophinin, tastin and cytokeratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081175EBI-358049,EBI-717810
AESQ08117-24EBI-358049,EBI-11741437
AIMP2Q131555EBI-358049,EBI-745226
BEND7Q8N7W2-25EBI-358049,EBI-10181188
C1orf94Q6P1W53EBI-358049,EBI-946029
CCDC102BA1A4H13EBI-358049,EBI-10171570
CCDC136Q96JN2-25EBI-358049,EBI-10171416
CDC23Q9UJX25EBI-358049,EBI-396137
CDCA7LQ96GN55EBI-358049,EBI-5278764
CEP44Q9C0F15EBI-358049,EBI-744115
CEP57L1Q8IYX8-25EBI-358049,EBI-10181988
CEP70Q8NHQ15EBI-358049,EBI-739624
COILP3843210EBI-358049,EBI-945751
DDX17Q928415EBI-358049,EBI-746012
DOCK8Q8NF50-25EBI-358049,EBI-10174653
EMDP504023EBI-358049,EBI-489887
EPS8Q129293EBI-358049,EBI-375576
FAM9BQ8IZU05EBI-358049,EBI-10175124
FLJ13057Q53SE73EBI-358049,EBI-10172181
FXR2P511165EBI-358049,EBI-740459
GMCL1Q96IK54EBI-358049,EBI-2548508
GOLGA2Q083795EBI-358049,EBI-618309
HMBOX1Q6NT767EBI-358049,EBI-2549423
IKZF1Q134225EBI-358049,EBI-745305
KRT31Q153233EBI-358049,EBI-948001
KRT40Q6A1627EBI-358049,EBI-10171697
KRTAP10-5P603705EBI-358049,EBI-10172150
KRTAP10-7P604095EBI-358049,EBI-10172290
KRTAP4-2Q9BYR53EBI-358049,EBI-10172511
L3MBTL3Q96JM75EBI-358049,EBI-2686809
LONRF1Q17RB85EBI-358049,EBI-2341787
LTV1Q96GA37EBI-358049,EBI-2558389
LZTS2Q9BRK45EBI-358049,EBI-741037
MID1O153443EBI-358049,EBI-2340316
MID2Q9UJV3-27EBI-358049,EBI-10172526
MIPOL1Q8TD107EBI-358049,EBI-2548751
MRFAP1L1Q96HT812EBI-358049,EBI-748896
MTUS2Q5JR595EBI-358049,EBI-742948
NECAB2H3BTW25EBI-358049,EBI-10172876
OLIG3Q7RTU35EBI-358049,EBI-10225049
PDE4DIPQ5VU435EBI-358049,EBI-1105124
PHC2Q8IXK06EBI-358049,EBI-713786
PNMA1Q8ND903EBI-358049,EBI-302345
PNMA2Q9UL425EBI-358049,EBI-302355
RALYLQ86SE53EBI-358049,EBI-741520
SMN2Q166377EBI-358049,EBI-395421
SSX2IPQ9Y2D85EBI-358049,EBI-2212028
STX11O755587EBI-358049,EBI-714135
TEKT1Q969V45EBI-358049,EBI-10180409
THAP1Q9NVV97EBI-358049,EBI-741515
TNIP1Q150257EBI-358049,EBI-357849
TRAF4Q9BUZ48EBI-358049,EBI-3650647
TRIM27P143735EBI-358049,EBI-719493
TRIM37O949728EBI-358049,EBI-741602
TRIM54Q9BYV26EBI-358049,EBI-2130429
TRIP6Q156546EBI-358049,EBI-742327
TROQ128164EBI-358049,EBI-950001
TROAPQ128159EBI-358049,EBI-2349743
UBE2HA4D1L53EBI-358049,EBI-10230777
VPS37BQ9H9H47EBI-358049,EBI-4400866
ZBTB14O438295EBI-358049,EBI-10176632
ZBTB8AQ96BR97EBI-358049,EBI-742740
ZFP64Q9NTW75EBI-358049,EBI-745730

Protein-protein interaction databases

BioGridi107167. 119 interactors.
DIPiDIP-50092N.
IntActiQ13895. 111 interactors.
MINTiMINT-1148396.
STRINGi9606.ENSP00000230340.

Structurei

3D structure databases

ProteinModelPortaliQ13895.
SMRiQ13895.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bystin family.Curated

Phylogenomic databases

eggNOGiKOG3871. Eukaryota.
ENOG410XPH5. LUCA.
GeneTreeiENSGT00390000007241.
HOGENOMiHOG000178028.
HOVERGENiHBG024425.
InParanoidiQ13895.
KOiK14797.
OMAiMTGAGHH.
OrthoDBiEOG091G08JE.
PhylomeDBiQ13895.
TreeFamiTF312968.

Family and domain databases

InterProiIPR007955. Bystin.
[Graphical view]
PANTHERiPTHR12821. PTHR12821. 1 hit.
PfamiPF05291. Bystin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKFKAARGV GGQEKHAPLA DQILAGNAVR AGVREKRRGR GTGEAEEEYV
60 70 80 90 100
GPRLSRRILQ QARQQQEELE AEHGTGDKPA APRERTTRLG PRMPQDGSDD
110 120 130 140 150
EDEEWPTLEK AATMTAAGHH AEVVVDPEDE RAIEMFMNKN PPARRTLADI
160 170 180 190 200
IMEKLTEKQT EVETVMSEVS GFPMPQLDPR VLEVYRGVRE VLSKYRSGKL
210 220 230 240 250
PKAFKIIPAL SNWEQILYVT EPEAWTAAAM YQATRIFASN LKERMAQRFY
260 270 280 290 300
NLVLLPRVRD DVAEYKRLNF HLYMALKKAL FKPGAWFKGI LIPLCESGTC
310 320 330 340 350
TLREAIIVGS IITKCSIPVL HSSAAMLKIA EMEYSGANSI FLRLLLDKKY
360 370 380 390 400
ALPYRVLDAL VFHFLGFRTE KRELPVLWHQ CLLTLVQRYK ADLATDQKEA
410 420 430
LLELLRLQPH PQLSPEIRRE LQSAVPRDVE DVPITVE
Length:437
Mass (Da):49,601
Last modified:May 30, 2006 - v3
Checksum:i1A8C5E5EB108DF1A
GO

Sequence cautioni

The sequence AAC16603 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214E → D in AAH07340 (PubMed:15489334).Curated1
Sequence conflicti263A → G in AAC16603 (PubMed:9560222).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033641103E → K.Corresponds to variant rs2296916dbSNPEnsembl.1
Natural variantiVAR_048439426P → S.Corresponds to variant rs3828855dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007340 mRNA. Translation: AAH07340.3.
BC050645 mRNA. Translation: AAH50645.1.
BC062627 mRNA. Translation: AAH62627.2.
L36720 mRNA. Translation: AAC16603.2. Different initiation.
CCDSiCCDS34450.1.
RefSeqiNP_004044.3. NM_004053.3.
UniGeneiHs.106880.

Genome annotation databases

EnsembliENST00000230340; ENSP00000230340; ENSG00000112578.
GeneIDi705.
KEGGihsa:705.
UCSCiuc003orl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007340 mRNA. Translation: AAH07340.3.
BC050645 mRNA. Translation: AAH50645.1.
BC062627 mRNA. Translation: AAH62627.2.
L36720 mRNA. Translation: AAC16603.2. Different initiation.
CCDSiCCDS34450.1.
RefSeqiNP_004044.3. NM_004053.3.
UniGeneiHs.106880.

3D structure databases

ProteinModelPortaliQ13895.
SMRiQ13895.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107167. 119 interactors.
DIPiDIP-50092N.
IntActiQ13895. 111 interactors.
MINTiMINT-1148396.
STRINGi9606.ENSP00000230340.

PTM databases

iPTMnetiQ13895.
PhosphoSitePlusiQ13895.
SwissPalmiQ13895.

Polymorphism and mutation databases

BioMutaiBYSL.
DMDMi108884834.

2D gel databases

SWISS-2DPAGEQ13895.

Proteomic databases

EPDiQ13895.
MaxQBiQ13895.
PaxDbiQ13895.
PeptideAtlasiQ13895.
PRIDEiQ13895.

Protocols and materials databases

DNASUi705.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230340; ENSP00000230340; ENSG00000112578.
GeneIDi705.
KEGGihsa:705.
UCSCiuc003orl.4. human.

Organism-specific databases

CTDi705.
DisGeNETi705.
GeneCardsiBYSL.
HGNCiHGNC:1157. BYSL.
HPAiHPA031217.
HPA031219.
MIMi603871. gene.
neXtProtiNX_Q13895.
OpenTargetsiENSG00000112578.
PharmGKBiPA25472.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3871. Eukaryota.
ENOG410XPH5. LUCA.
GeneTreeiENSGT00390000007241.
HOGENOMiHOG000178028.
HOVERGENiHBG024425.
InParanoidiQ13895.
KOiK14797.
OMAiMTGAGHH.
OrthoDBiEOG091G08JE.
PhylomeDBiQ13895.
TreeFamiTF312968.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112578-MONOMER.
ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

ChiTaRSiBYSL. human.
GeneWikiiBYSL.
GenomeRNAii705.
PROiQ13895.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112578.
CleanExiHS_BYSL.
ExpressionAtlasiQ13895. baseline and differential.
GenevisibleiQ13895. HS.

Family and domain databases

InterProiIPR007955. Bystin.
[Graphical view]
PANTHERiPTHR12821. PTHR12821. 1 hit.
PfamiPF05291. Bystin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBYST_HUMAN
AccessioniPrimary (citable) accession number: Q13895
Secondary accession number(s): Q6P5W4, Q86W44, Q96IP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 30, 2006
Last modified: November 30, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

HeLa cells lacking BYSL show a delay in the processing of the 18S rRNA component of the 40S ribosomal subunit. HT-H cells lacking BYSL show trophinin-independent signaling through ERBB4.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.