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Q13895

- BYST_HUMAN

UniProt

Q13895 - BYST_HUMAN

Protein

Bystin

Gene

BYSL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 3 (30 May 2006)
      Previous versions | rss
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    Functioni

    Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos.2 Publications

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell adhesion Source: ProtInc
    2. cell proliferation Source: Ensembl
    3. female pregnancy Source: ProtInc
    4. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: Ensembl
    5. trophectodermal cell differentiation Source: Ensembl

    Keywords - Biological processi

    Ribosome biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bystin
    Gene namesi
    Name:BYSL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:1157. BYSL.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleusnucleolus 1 Publication
    Note: Associated with 40S ribosomal subunits.

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. cytoplasm Source: ProtInc
    3. intracellular membrane-bounded organelle Source: HPA
    4. membrane Source: UniProtKB
    5. nucleolus Source: HPA
    6. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25472.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437BystinPRO_0000186114Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei98 – 981Phosphoserine7 Publications
    Modified residuei167 – 1671Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ13895.
    PaxDbiQ13895.
    PeptideAtlasiQ13895.
    PRIDEiQ13895.

    2D gel databases

    SWISS-2DPAGEQ13895.

    Expressioni

    Tissue specificityi

    Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi.

    Gene expression databases

    ArrayExpressiQ13895.
    BgeeiQ13895.
    CleanExiHS_BYSL.
    GenevestigatoriQ13895.

    Organism-specific databases

    HPAiHPA031217.
    HPA031219.

    Interactioni

    Subunit structurei

    Binds trophinin, tastin and cytokeratins.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TROQ128164EBI-358049,EBI-950001
    TROAPQ128159EBI-358049,EBI-2349743

    Protein-protein interaction databases

    BioGridi107167. 32 interactions.
    DIPiDIP-50092N.
    IntActiQ13895. 12 interactions.
    MINTiMINT-1148396.
    STRINGi9606.ENSP00000230340.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13895.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bystin family.Curated

    Phylogenomic databases

    eggNOGiNOG280148.
    HOGENOMiHOG000178028.
    HOVERGENiHBG024425.
    InParanoidiQ13895.
    KOiK14797.
    OMAiCLLTLAQ.
    OrthoDBiEOG7J1804.
    PhylomeDBiQ13895.
    TreeFamiTF312968.

    Family and domain databases

    InterProiIPR007955. Bystin.
    [Graphical view]
    PANTHERiPTHR12821. PTHR12821. 1 hit.
    PfamiPF05291. Bystin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13895-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKFKAARGV GGQEKHAPLA DQILAGNAVR AGVREKRRGR GTGEAEEEYV    50
    GPRLSRRILQ QARQQQEELE AEHGTGDKPA APRERTTRLG PRMPQDGSDD 100
    EDEEWPTLEK AATMTAAGHH AEVVVDPEDE RAIEMFMNKN PPARRTLADI 150
    IMEKLTEKQT EVETVMSEVS GFPMPQLDPR VLEVYRGVRE VLSKYRSGKL 200
    PKAFKIIPAL SNWEQILYVT EPEAWTAAAM YQATRIFASN LKERMAQRFY 250
    NLVLLPRVRD DVAEYKRLNF HLYMALKKAL FKPGAWFKGI LIPLCESGTC 300
    TLREAIIVGS IITKCSIPVL HSSAAMLKIA EMEYSGANSI FLRLLLDKKY 350
    ALPYRVLDAL VFHFLGFRTE KRELPVLWHQ CLLTLVQRYK ADLATDQKEA 400
    LLELLRLQPH PQLSPEIRRE LQSAVPRDVE DVPITVE 437
    Length:437
    Mass (Da):49,601
    Last modified:May 30, 2006 - v3
    Checksum:i1A8C5E5EB108DF1A
    GO

    Sequence cautioni

    The sequence AAC16603.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti214 – 2141E → D in AAH07340. (PubMed:15489334)Curated
    Sequence conflicti263 – 2631A → G in AAC16603. (PubMed:9560222)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti103 – 1031E → K.
    Corresponds to variant rs2296916 [ dbSNP | Ensembl ].
    VAR_033641
    Natural varianti426 – 4261P → S.
    Corresponds to variant rs3828855 [ dbSNP | Ensembl ].
    VAR_048439

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC007340 mRNA. Translation: AAH07340.3.
    BC050645 mRNA. Translation: AAH50645.1.
    BC062627 mRNA. Translation: AAH62627.2.
    L36720 mRNA. Translation: AAC16603.2. Different initiation.
    CCDSiCCDS34450.1.
    RefSeqiNP_004044.3. NM_004053.3.
    UniGeneiHs.106880.

    Genome annotation databases

    EnsembliENST00000230340; ENSP00000230340; ENSG00000112578.
    GeneIDi705.
    KEGGihsa:705.
    UCSCiuc003orl.3. human.

    Polymorphism databases

    DMDMi108884834.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC007340 mRNA. Translation: AAH07340.3 .
    BC050645 mRNA. Translation: AAH50645.1 .
    BC062627 mRNA. Translation: AAH62627.2 .
    L36720 mRNA. Translation: AAC16603.2 . Different initiation.
    CCDSi CCDS34450.1.
    RefSeqi NP_004044.3. NM_004053.3.
    UniGenei Hs.106880.

    3D structure databases

    ProteinModelPortali Q13895.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107167. 32 interactions.
    DIPi DIP-50092N.
    IntActi Q13895. 12 interactions.
    MINTi MINT-1148396.
    STRINGi 9606.ENSP00000230340.

    Polymorphism databases

    DMDMi 108884834.

    2D gel databases

    SWISS-2DPAGE Q13895.

    Proteomic databases

    MaxQBi Q13895.
    PaxDbi Q13895.
    PeptideAtlasi Q13895.
    PRIDEi Q13895.

    Protocols and materials databases

    DNASUi 705.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000230340 ; ENSP00000230340 ; ENSG00000112578 .
    GeneIDi 705.
    KEGGi hsa:705.
    UCSCi uc003orl.3. human.

    Organism-specific databases

    CTDi 705.
    GeneCardsi GC06P041888.
    HGNCi HGNC:1157. BYSL.
    HPAi HPA031217.
    HPA031219.
    MIMi 603871. gene.
    neXtProti NX_Q13895.
    PharmGKBi PA25472.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG280148.
    HOGENOMi HOG000178028.
    HOVERGENi HBG024425.
    InParanoidi Q13895.
    KOi K14797.
    OMAi CLLTLAQ.
    OrthoDBi EOG7J1804.
    PhylomeDBi Q13895.
    TreeFami TF312968.

    Miscellaneous databases

    GeneWikii BYSL.
    GenomeRNAii 705.
    NextBioi 2870.
    PROi Q13895.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13895.
    Bgeei Q13895.
    CleanExi HS_BYSL.
    Genevestigatori Q13895.

    Family and domain databases

    InterProi IPR007955. Bystin.
    [Graphical view ]
    PANTHERi PTHR12821. PTHR12821. 1 hit.
    Pfami PF05291. Bystin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung, Ovary and Pancreas.
    2. "A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells."
      Suzuki N., Zara J., Sato T., Ong E., Bakhiet N., Oshima R.G., Watson K.L., Fukuda M.N.
      Proc. Natl. Acad. Sci. U.S.A. 95:5027-5032(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 131-437.
      Tissue: Choriocarcinoma.
    3. Fukuda M.N.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis."
      Miyoshi M., Okajima T., Matsuda T., Fukuda M.N., Nadano D.
      Biochem. J. 404:373-381(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. Cited for: FUNCTION.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBYST_HUMAN
    AccessioniPrimary (citable) accession number: Q13895
    Secondary accession number(s): Q6P5W4, Q86W44, Q96IP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 119 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    HeLa cells lacking BYSL show a delay in the processing of the 18S rRNA component of the 40S ribosomal subunit. HT-H cells lacking BYSL show trophinin-independent signaling through ERBB4.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3