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Q13889

- TF2H3_HUMAN

UniProt

Q13889 - TF2H3_HUMAN

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Protein
General transcription factor IIH subunit 3
Gene
GTF2H3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Anchors XPB.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri268 – 28518C4-type
Add
BLAST

GO - Molecular functioni

  1. damaged DNA binding Source: ProtInc
  2. metal ion binding Source: UniProtKB-KW
  3. protein N-terminus binding Source: UniProtKB
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc
  5. translation factor activity, nucleic acid binding Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. 7-methylguanosine mRNA capping Source: Reactome
  2. ATP catabolic process Source: GOC
  3. DNA repair Source: Reactome
  4. gene expression Source: Reactome
  5. nucleotide-excision repair Source: InterPro
  6. nucleotide-excision repair, DNA damage removal Source: Reactome
  7. positive regulation of viral transcription Source: Reactome
  8. protein phosphorylation Source: GOC
  9. regulation of transcription, DNA-templated Source: InterPro
  10. termination of RNA polymerase I transcription Source: Reactome
  11. transcription elongation from RNA polymerase I promoter Source: Reactome
  12. transcription elongation from RNA polymerase II promoter Source: Reactome
  13. transcription from RNA polymerase I promoter Source: Reactome
  14. transcription from RNA polymerase II promoter Source: UniProtKB
  15. transcription initiation from RNA polymerase I promoter Source: Reactome
  16. transcription initiation from RNA polymerase II promoter Source: Reactome
  17. transcription-coupled nucleotide-excision repair Source: Reactome
  18. translation Source: GOC
  19. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_1074. RNA Polymerase I Transcription Termination.
REACT_1470. mRNA Capping.
REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_1851. RNA Polymerase II Transcription Initiation.
REACT_1913. RNA Polymerase I Promoter Escape.
REACT_1941. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_200856. NoRC negatively regulates rRNA expression.
REACT_2089. RNA Polymerase II Promoter Escape.
REACT_2204. RNA Polymerase I Chain Elongation.
REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_22201. Formation of HIV elongation complex in the absence of HIV Tat.
REACT_2222. Dual incision reaction in TC-NER.
REACT_257. Formation of incision complex in GG-NER.
REACT_311. Dual incision reaction in GG-NER.
REACT_6162. Tat-mediated elongation of the HIV-1 transcript.
REACT_6233. Transcription of the HIV genome.
REACT_6237. RNA Pol II CTD phosphorylation and interaction with CE.
REACT_6253. RNA Polymerase II HIV Promoter Escape.
REACT_6319. Formation of the HIV-1 Early Elongation Complex.
REACT_6332. HIV Transcription Initiation.
REACT_6346. Formation of HIV-1 elongation complex containing HIV-1 Tat.
REACT_833. RNA Polymerase II Transcription Elongation.
REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_846. Formation of the Early Elongation Complex.
REACT_953. RNA Polymerase I Transcription Initiation.
REACT_975. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 3
Alternative name(s):
Basic transcription factor 2 34 kDa subunit
Short name:
BTF2 p34
General transcription factor IIH polypeptide 3
TFIIH basal transcription factor complex p34 subunit
Gene namesi
Name:GTF2H3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:4657. GTF2H3.

Subcellular locationi

GO - Cellular componenti

  1. core TFIIH complex Source: InterPro
  2. holo TFIIH complex Source: UniProtKB
  3. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29043.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308General transcription factor IIH subunit 3
PRO_0000119251Add
BLAST

Proteomic databases

MaxQBiQ13889.
PaxDbiQ13889.
PRIDEiQ13889.

PTM databases

PhosphoSiteiQ13889.

Expressioni

Gene expression databases

ArrayExpressiQ13889.
BgeeiQ13889.
CleanExiHS_GTF2H3.
GenevestigatoriQ13889.

Organism-specific databases

HPAiHPA004844.
HPA053562.

Interactioni

Subunit structurei

One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7 By similarity.1 Publication

Protein-protein interaction databases

BioGridi109222. 14 interactions.
DIPiDIP-787N.
IntActiQ13889. 1 interaction.
MINTi