Q13887A2TJX0L0R3U5L0R4T9Q9UHP8KLF5_HUMANKrueppel-like factor 5Basic transcription element-binding protein 2BTE-binding protein 2Colon krueppel-like factorGC-box-binding protein 2Intestinal-enriched krueppel-like factorTranscription factor BTEB2KLF5BTEB2CKLFIKLFHomo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoIsolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3)ALTERNATIVE SPLICINGHuman basic transcription element binding protein 2.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)Human Kruppel like factor5/KLF5: expression in human skin and hair follicles.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)Functional identification testis-specific transcript of Kruppel-like factor 5 (tKLF5).NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)Complete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)The DNA sequence and analysis of human chromosome 13.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2.NUCLEOTIDE SEQUENCE [MRNA] OF 239-457 (ISOFORM 1)Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.SUBCELLULAR LOCATIONINTERACTION WITH WWP1UBIQUITINATIONMUTAGENESIS OF 324-PRO--TYR-328Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5.INTERACTION WITH ANP32BSite-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-31; LYS-52; LYS-94 AND LYS-110IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.9AATAD MOTIFSolution structure of three tandem repeats of ZF-C2H2 domains from human kruppel-like factor 5.STRUCTURE BY NMR OF 363-457The consensus coding sequences of human breast and colorectal cancers.VARIANT [LARGE SCALE ANALYSIS] SER-301Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krueppel-like factor 5 (KLF5).DEUBIQUITINATION BY ATXN3LTranscription factor that binds to GC box promoter elements. Activates the transcription of these genes.Interacts with WWP1. Interacts with ANP32B; this interaction induces promoter region-specific histone incorporation and inhibition of histone acetylation by ANP32B.Q13887P54253false7Q13887P46379-2false3Q13887Q96A83-2false3Q13887O75190-2false3Q13887O14645false3Q13887Q9UMF0false3Q13887O14901false3Q13887P28331-2false3Q13887Q9BVL2false3Q13887P0CG48false2NucleusQ13887-11Q13887-22Q13887-33Q13887-44Expressed only in testis and placenta.The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (PubMed:15735697). Deubiquitinated by ATXN3L (PubMed:26079537).Belongs to the krueppel C2H2-type zinc-finger protein family.3D-structureActivatorAlternative splicingDNA-bindingIsopeptide bondMetal-bindingNucleusReference proteomeRepeatTranscriptionTranscription regulationUbl conjugationZincZinc-fingerIIPEHKKYRRDSASVVDQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTHIKTEPVMLLQLLLNWQFTIQIYPPPCQLTHKTSNLSDTIEGVTPIWRNDASTTAITLVAQKFIPSLLIPSMATRVLSMSARLGPVPQPPAPQDEPVFAQLKPVLGAANPARDAALFPGEELKHAHHRPQAQPAPAQAPQPAQPPATGPRLPPEDLVQTRCEMEKYLTPQLPPVPIIPEHKKYRRDSASVVDQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTHIKTEPVAIFSHQSETTAPPPAPTQALPEFTSIFSSHQTAAPEVNNIFIKQELPTPDLHLSVPTQQGHLYQLLNTPDLDMPSSTNQTAAMDTLNVSMSAAMAGLNTHTSAVPQTAVKQFQGMPPCTYTMPSQFLPQQATYFPPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPTTLPVNSQNIQPVRYNRRSNPDLEKRRIHYCDYPGCTKVYTKSSHLKAHLRTHTGEKPYKCTWEGCDWRFARSDELTRHYRKHTGAKPFQCGVCNRSFSRSDHLALHMKRHQN
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