Krueppel-like factor 5 - Homo sapiens (Human)

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Q13887 (KLF5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 112. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Krueppel-like factor 5

Alternative name(s):
Basic transcription element-binding protein 2
Short name=BTE-binding protein 2
Colon krueppel-like factor
GC-box-binding protein 2
Intestinal-enriched krueppel-like factor
Transcription factor BTEB2

Gene names

Name:	KLF5
Synonyms:	BTEB2, CKLF, IKLF

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	457 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.
Subunit structure	Interacts with WWP1. Ref.6
Subcellular location	Nucleus Ref.6.
Tissue specificity	Expressed only in testis and placenta.
Post-translational modification	Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. Ref.6
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc
Cellular component	Golgi apparatus Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 457

457

Krueppel-like factor 5

PRO_0000047169

Regions

Zinc finger

373 – 397

C2H2-type 1

Zinc finger

403 – 427

C2H2-type 2

Zinc finger

433 – 455

C2H2-type 3

Region

324 – 328

Interaction with WWP1

Natural variations

Natural variant

301

P → S in a colorectal cancer sample; somatic mutation. Ref.8

VAR_035555

Experimental info

Mutagenesis

324 – 328

Missing: Impairs ubiquitination and degradation. Ref.6

Secondary structure

457

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q13887 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 3BF12BE272716E57
Show »

FASTA

457

50,792

        10         20         30         40         50         60 
MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE LKHAHHRPQA 

        70         80         90        100        110        120 
QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL PPVPIIPEHK KYRRDSASVV 

       130        140        150        160        170        180 
DQFFTDTEGL PYSINMNVFL PDITHLRTGL YKSQRPCVTH IKTEPVAIFS HQSETTAPPP 

       190        200        210        220        230        240 
APTQALPEFT SIFSSHQTAA PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP 

       250        260        270        280        290        300 
SSTNQTAAMD TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF 

       310        320        330        340        350        360 
PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN SQNIQPVRYN 

       370        380        390        400        410        420 
RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE KPYKCTWEGC DWRFARSDEL 

       430        440        450 
TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL HMKRHQN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter." Shi H., Zhang Z., Wang X., Liu S., Teng C.T. Nucleic Acids Res. 27:4807-4815(1999) [PubMed: 10572182] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human basic transcription element binding protein 2." Ohnishi S., Yoshida T., Ramirez F., Terada M., Friedrich L. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Human Kruppel like factor5/KLF5: expression in human skin and hair follicles." Sur I., Unden A.-B., Toftgard R. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Placenta.
[5]	"cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2." Sogawa K., Imataka H., Yamasaki Y., Kusume H., Abe H., Fujii-Kuriyama Y. Nucleic Acids Res. 21:1527-1532(1993) [PubMed: 8479902] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 239-457. Tissue: Placenta.
[6]	"Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells." Chen C., Sun X., Ran Q., Wilkinson K.D., Murphy T.J., Simons J.W., Dong J.T. Oncogene 24:3319-3327(2005) [PubMed: 15735697] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH WWP1, UBIQUITINATION, MUTAGENESIS OF 324-PRO--TYR-328.
[7]	"Solution structure of three tandem repeats of ZF-C2H2 domains from human kruppel-like factor 5." RIKEN structural genomics initiative (RSGI) Submitted (FEB-2008) to the PDB data bank Cited for: STRUCTURE BY NMR OF 363-457.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-301.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF132818 mRNA. Translation: AAF18307.1.
AB030824 mRNA. Translation: BAA96461.1.
AF287272 mRNA. Translation: AAF88068.1.
BC007695 mRNA. Translation: AAH07695.1.
BC042131 mRNA. Translation: AAH42131.1.
D14520 mRNA. Translation: BAA03393.1.

IPI

IPI00015934.

PIR

S35643.

RefSeq

NP_001721.2. NM_001730.3.

UniGene

Hs.508234.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EBT	NMR	-	A	365-457	[»]

ProteinModelPortal

Q13887.

SMR

Q13887. Positions 363-457.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q13887. 1 interaction.

MINT

MINT-3028757.

STRING

Q13887.

PTM databases

PhosphoSite

Q13887.

Polymorphism databases

DMDM

12644412.

Proteomic databases

PRIDE

Q13887.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000377687; ENSP00000366915; ENSG00000102554.

GeneID

688.

KEGG

hsa:688.

UCSC

uc001vje.1. human.

Organism-specific databases

CTD

688.

GeneCards

GC13P073629.

H-InvDB

HIX0011366.

HGNC

HGNC:6349. KLF5.

HPA

HPA040398.

MIM

602903. gene.

neXtProt

NX_Q13887.

PharmGKB

PA30139.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

HBG716547.

HOVERGEN

HBG003474.

InParanoid

Q13887.

OMA

CVTHIKT.

OrthoDB

EOG42NJ0W.

PhylomeDB

Q13887.

Enzyme and pathway databases

Reactome

REACT_111045. Developmental Biology.

Gene expression databases

ArrayExpress

Q13887.

Bgee

Q13887.

CleanEx

HS_CKLF.
HS_KLF5.

Genevestigator

Q13887.

GermOnline

ENSG00000102554. Homo sapiens.

Family and domain databases

InterPro

IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

Gene3D

G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.

K09206.

Pfam

PF00096. zf-C2H2. 3 hits.
[Graphical view]

SMART

SM00355. ZnF_C2H2. 3 hits.
[Graphical view]

PROSITE

PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

2832.

SOURCE

Search...

Entry information

Entry name

KLF5_HUMAN

Accession

Primary (citable) accession number: Q13887
Secondary accession number(s): Q9UHP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Secondary structure

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents