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Protein

Krueppel-like factor 5

Gene

KLF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 397C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri403 – 427C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri433 – 455C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkiQ13887
SIGNORiQ13887

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 5
Alternative name(s):
Basic transcription element-binding protein 2
Short name:
BTE-binding protein 2
Colon krueppel-like factor
GC-box-binding protein 2
Intestinal-enriched krueppel-like factor
Transcription factor BTEB2
Gene namesi
Name:KLF5
Synonyms:BTEB2, CKLF, IKLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102554.13
HGNCiHGNC:6349 KLF5
MIMi602903 gene
neXtProtiNX_Q13887

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi324 – 328Missing : Impairs ubiquitination and degradation. 1 Publication5

Organism-specific databases

DisGeNETi688
OpenTargetsiENSG00000102554
PharmGKBiPA30139

Chemistry databases

ChEMBLiCHEMBL1293249

Polymorphism and mutation databases

DMDMi12644412

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471691 – 457Krueppel-like factor 5Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ13887
PaxDbiQ13887
PeptideAtlasiQ13887
PRIDEiQ13887
ProteomicsDBi59715

PTM databases

iPTMnetiQ13887
PhosphoSitePlusiQ13887

Expressioni

Tissue specificityi

Expressed only in testis and placenta.

Gene expression databases

BgeeiENSG00000102554
CleanExiHS_CKLF
HS_KLF5
ExpressionAtlasiQ13887 baseline and differential
GenevisibleiQ13887 HS

Organism-specific databases

HPAiHPA040398

Interactioni

Subunit structurei

Interacts with WWP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UBCP0CG482EBI-2696013,EBI-3390054

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107153, 51 interactors
IntActiQ13887, 5 interactors
MINTiQ13887
STRINGi9606.ENSP00000366915

Chemistry databases

BindingDBiQ13887

Structurei

Secondary structure

1457
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi377 – 379Combined sources3
Beta strandi383 – 385Combined sources3
Helixi387 – 397Combined sources11
Beta strandi407 – 409Combined sources3
Beta strandi413 – 416Combined sources4
Helixi417 – 427Combined sources11
Beta strandi436 – 438Combined sources3
Helixi445 – 455Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBTNMR-A365-457[»]
ProteinModelPortaliQ13887
SMRiQ13887
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13887

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni324 – 328Interaction with WWP11 Publication5

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 397C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri403 – 427C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri433 – 455C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000261607
HOVERGENiHBG003474
InParanoidiQ13887
KOiK09206
OMAiMPNQFLQ
OrthoDBiEOG091G1BN0
PhylomeDBiQ13887
TreeFamiTF350556

Family and domain databases

InterProiView protein in InterPro
IPR030401 KLF5
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44295:SF4 PTHR44295:SF4, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13887-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE
60 70 80 90 100
LKHAHHRPQA QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL
110 120 130 140 150
PPVPIIPEHK KYRRDSASVV DQFFTDTEGL PYSINMNVFL PDITHLRTGL
160 170 180 190 200
YKSQRPCVTH IKTEPVAIFS HQSETTAPPP APTQALPEFT SIFSSHQTAA
210 220 230 240 250
PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP SSTNQTAAMD
260 270 280 290 300
TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF
310 320 330 340 350
PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN
360 370 380 390 400
SQNIQPVRYN RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE
410 420 430 440 450
KPYKCTWEGC DWRFARSDEL TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL

HMKRHQN
Length:457
Mass (Da):50,792
Last modified:December 1, 2000 - v2
Checksum:i3BF12BE272716E57
GO
Isoform 2 (identifier: Q13887-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-239: Missing.

Show »
Length:305
Mass (Da):33,618
Checksum:i0C584B65B6ED3BD1
GO
Isoform 3 (identifier: Q13887-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-166: IIPEHKKYRR...CVTHIKTEPV → MLLQLLLNWQ...AQKFIPSLLI
     167-457: Missing.

Show »
Length:166
Mass (Da):18,116
Checksum:i4210629ABFC9175C
GO
Isoform 4 (identifier: Q13887-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.

Show »
Length:366
Mass (Da):41,180
Checksum:i81C5C45788433D2F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035555301P → S in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0575671 – 91Missing in isoform 4. Add BLAST91
Alternative sequenceiVSP_04747488 – 239Missing in isoform 2. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_047475105 – 166IIPEH…KTEPV → MLLQLLLNWQFTIQIYPPPC QLTHKTSNLSDTIEGVTPIW RNDASTTAITLVAQKFIPSL LI in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_047476167 – 457Missing in isoform 3. 1 PublicationAdd BLAST291

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132818 mRNA Translation: AAF18307.1
HF546203 mRNA Translation: CCO02789.1
HF546204 mRNA Translation: CCO02790.1
AB030824 mRNA Translation: BAA96461.1
AF287272 mRNA Translation: AAF88068.1
EF208215 mRNA Translation: ABM97548.1
AK302280 mRNA Translation: BAG63623.1
AL354720 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80526.1
BC007695 mRNA Translation: AAH07695.1
BC042131 mRNA Translation: AAH42131.1
D14520 mRNA Translation: BAA03393.1
CCDSiCCDS66562.1 [Q13887-4]
CCDS9448.1 [Q13887-1]
PIRiS35643
RefSeqiNP_001273747.1, NM_001286818.1 [Q13887-4]
NP_001721.2, NM_001730.4 [Q13887-1]
UniGeneiHs.508234

Genome annotation databases

EnsembliENST00000377687; ENSP00000366915; ENSG00000102554 [Q13887-1]
ENST00000539231; ENSP00000440407; ENSG00000102554 [Q13887-4]
GeneIDi688
KEGGihsa:688
UCSCiuc001vjd.5 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKLF5_HUMAN
AccessioniPrimary (citable) accession number: Q13887
Secondary accession number(s): A2TJX0
, L0R3U5, L0R4T9, Q9UHP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 1, 2000
Last modified: June 20, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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