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Q13887

- KLF5_HUMAN

UniProt

Q13887 - KLF5_HUMAN

Protein

Krueppel-like factor 5

Gene

KLF5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri373 – 39725C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri403 – 42725C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri433 – 45523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. cellular response to organic cyclic compound Source: Ensembl
    3. cellular response to peptide Source: Ensembl
    4. microvillus assembly Source: Ensembl
    5. positive regulation of cell proliferation Source: Ensembl
    6. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    7. skeletal muscle cell differentiation Source: Ensembl
    8. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinkiQ13887.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 5
    Alternative name(s):
    Basic transcription element-binding protein 2
    Short name:
    BTE-binding protein 2
    Colon krueppel-like factor
    GC-box-binding protein 2
    Intestinal-enriched krueppel-like factor
    Transcription factor BTEB2
    Gene namesi
    Name:KLF5
    Synonyms:BTEB2, CKLF, IKLF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:6349. KLF5.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. Golgi apparatus Source: HPA
    3. intracellular membrane-bounded organelle Source: HPA
    4. nucleus Source: HPA
    5. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi324 – 3285Missing: Impairs ubiquitination and degradation. 1 Publication

    Organism-specific databases

    PharmGKBiPA30139.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Krueppel-like factor 5PRO_0000047169Add
    BLAST

    Post-translational modificationi

    Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiQ13887.
    PaxDbiQ13887.
    PRIDEiQ13887.

    PTM databases

    PhosphoSiteiQ13887.

    Expressioni

    Tissue specificityi

    Expressed only in testis and placenta.

    Gene expression databases

    ArrayExpressiQ13887.
    BgeeiQ13887.
    CleanExiHS_CKLF.
    HS_KLF5.
    GenevestigatoriQ13887.

    Organism-specific databases

    HPAiHPA040398.
    HPA044231.

    Interactioni

    Subunit structurei

    Interacts with WWP1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UBCP0CG482EBI-2696013,EBI-3390054

    Protein-protein interaction databases

    BioGridi107153. 27 interactions.
    IntActiQ13887. 2 interactions.
    MINTiMINT-3028757.
    STRINGi9606.ENSP00000366915.

    Structurei

    Secondary structure

    1
    457
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi377 – 3793
    Beta strandi383 – 3853
    Helixi387 – 39711
    Beta strandi407 – 4093
    Beta strandi413 – 4164
    Helixi417 – 42711
    Beta strandi436 – 4383
    Helixi445 – 45511

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EBTNMR-A365-457[»]
    ProteinModelPortaliQ13887.
    SMRiQ13887. Positions 363-457.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13887.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni324 – 3285Interaction with WWP1

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri373 – 39725C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri403 – 42725C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri433 – 45523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000261607.
    HOVERGENiHBG003474.
    InParanoidiQ13887.
    KOiK09206.
    OMAiMPNQFLQ.
    OrthoDBiEOG747PJ4.
    PhylomeDBiQ13887.
    TreeFamiTF350556.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13887-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE    50
    LKHAHHRPQA QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL 100
    PPVPIIPEHK KYRRDSASVV DQFFTDTEGL PYSINMNVFL PDITHLRTGL 150
    YKSQRPCVTH IKTEPVAIFS HQSETTAPPP APTQALPEFT SIFSSHQTAA 200
    PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP SSTNQTAAMD 250
    TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF 300
    PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN 350
    SQNIQPVRYN RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE 400
    KPYKCTWEGC DWRFARSDEL TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL 450
    HMKRHQN 457
    Length:457
    Mass (Da):50,792
    Last modified:December 1, 2000 - v2
    Checksum:i3BF12BE272716E57
    GO
    Isoform 2 (identifier: Q13887-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         88-239: Missing.

    Show »
    Length:305
    Mass (Da):33,618
    Checksum:i0C584B65B6ED3BD1
    GO
    Isoform 3 (identifier: Q13887-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         105-166: IIPEHKKYRR...CVTHIKTEPV → MLLQLLLNWQ...AQKFIPSLLI
         167-457: Missing.

    Show »
    Length:166
    Mass (Da):18,116
    Checksum:i4210629ABFC9175C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti301 – 3011P → S in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035555

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei88 – 239152Missing in isoform 2. 1 PublicationVSP_047474Add
    BLAST
    Alternative sequencei105 – 16662IIPEH…KTEPV → MLLQLLLNWQFTIQIYPPPC QLTHKTSNLSDTIEGVTPIW RNDASTTAITLVAQKFIPSL LI in isoform 3. 1 PublicationVSP_047475Add
    BLAST
    Alternative sequencei167 – 457291Missing in isoform 3. 1 PublicationVSP_047476Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132818 mRNA. Translation: AAF18307.1.
    HF546203 mRNA. Translation: CCO02789.1.
    HF546204 mRNA. Translation: CCO02790.1.
    AB030824 mRNA. Translation: BAA96461.1.
    AF287272 mRNA. Translation: AAF88068.1.
    BC007695 mRNA. Translation: AAH07695.1.
    BC042131 mRNA. Translation: AAH42131.1.
    D14520 mRNA. Translation: BAA03393.1.
    CCDSiCCDS9448.1. [Q13887-1]
    PIRiS35643.
    RefSeqiNP_001273747.1. NM_001286818.1.
    NP_001721.2. NM_001730.4. [Q13887-1]
    UniGeneiHs.508234.

    Genome annotation databases

    EnsembliENST00000377687; ENSP00000366915; ENSG00000102554. [Q13887-1]
    GeneIDi688.
    KEGGihsa:688.
    UCSCiuc001vjd.3. human. [Q13887-1]

    Polymorphism databases

    DMDMi12644412.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132818 mRNA. Translation: AAF18307.1 .
    HF546203 mRNA. Translation: CCO02789.1 .
    HF546204 mRNA. Translation: CCO02790.1 .
    AB030824 mRNA. Translation: BAA96461.1 .
    AF287272 mRNA. Translation: AAF88068.1 .
    BC007695 mRNA. Translation: AAH07695.1 .
    BC042131 mRNA. Translation: AAH42131.1 .
    D14520 mRNA. Translation: BAA03393.1 .
    CCDSi CCDS9448.1. [Q13887-1 ]
    PIRi S35643.
    RefSeqi NP_001273747.1. NM_001286818.1.
    NP_001721.2. NM_001730.4. [Q13887-1 ]
    UniGenei Hs.508234.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EBT NMR - A 365-457 [» ]
    ProteinModelPortali Q13887.
    SMRi Q13887. Positions 363-457.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107153. 27 interactions.
    IntActi Q13887. 2 interactions.
    MINTi MINT-3028757.
    STRINGi 9606.ENSP00000366915.

    Chemistry

    BindingDBi Q13887.

    PTM databases

    PhosphoSitei Q13887.

    Polymorphism databases

    DMDMi 12644412.

    Proteomic databases

    MaxQBi Q13887.
    PaxDbi Q13887.
    PRIDEi Q13887.

    Protocols and materials databases

    DNASUi 688.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377687 ; ENSP00000366915 ; ENSG00000102554 . [Q13887-1 ]
    GeneIDi 688.
    KEGGi hsa:688.
    UCSCi uc001vjd.3. human. [Q13887-1 ]

    Organism-specific databases

    CTDi 688.
    GeneCardsi GC13P073629.
    HGNCi HGNC:6349. KLF5.
    HPAi HPA040398.
    HPA044231.
    MIMi 602903. gene.
    neXtProti NX_Q13887.
    PharmGKBi PA30139.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000261607.
    HOVERGENi HBG003474.
    InParanoidi Q13887.
    KOi K09206.
    OMAi MPNQFLQ.
    OrthoDBi EOG747PJ4.
    PhylomeDBi Q13887.
    TreeFami TF350556.

    Enzyme and pathway databases

    Reactomei REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinki Q13887.

    Miscellaneous databases

    ChiTaRSi KLF5. human.
    EvolutionaryTracei Q13887.
    GeneWikii KLF5.
    GenomeRNAii 688.
    NextBioi 2832.
    PROi Q13887.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13887.
    Bgeei Q13887.
    CleanExi HS_CKLF.
    HS_KLF5.
    Genevestigatori Q13887.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter."
      Shi H., Zhang Z., Wang X., Liu S., Teng C.T.
      Nucleic Acids Res. 27:4807-4815(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors."
      Camacho-Vanegas O., Till J., Miranda-Lorenzo I., Ozturk B., Camacho S.C., Martignetti J.A.
      FASEB J. 27:432-436(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), ALTERNATIVE SPLICING.
    3. "Human basic transcription element binding protein 2."
      Ohnishi S., Yoshida T., Ramirez F., Terada M., Friedrich L.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Human Kruppel like factor5/KLF5: expression in human skin and hair follicles."
      Sur I., Unden A.-B., Toftgard R.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Placenta.
    6. "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2."
      Sogawa K., Imataka H., Yamasaki Y., Kusume H., Abe H., Fujii-Kuriyama Y.
      Nucleic Acids Res. 21:1527-1532(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 239-457 (ISOFORM 1).
      Tissue: Placenta.
    7. "Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells."
      Chen C., Sun X., Ran Q., Wilkinson K.D., Murphy T.J., Simons J.W., Dong J.T.
      Oncogene 24:3319-3327(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH WWP1, UBIQUITINATION, MUTAGENESIS OF 324-PRO--TYR-328.
    8. "Solution structure of three tandem repeats of ZF-C2H2 domains from human kruppel-like factor 5."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2008) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 363-457.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-301.

    Entry informationi

    Entry nameiKLF5_HUMAN
    AccessioniPrimary (citable) accession number: Q13887
    Secondary accession number(s): L0R3U5, L0R4T9, Q9UHP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 139 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3