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Q13887

- KLF5_HUMAN

UniProt

Q13887 - KLF5_HUMAN

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Protein

Krueppel-like factor 5

Gene
KLF5, BTEB2, CKLF, IKLF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri373 – 39725C2H2-type 1Add
BLAST
Zinc fingeri403 – 42725C2H2-type 2Add
BLAST
Zinc fingeri433 – 45523C2H2-type 3Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: IntAct
  4. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. cellular response to organic cyclic compound Source: Ensembl
  3. cellular response to peptide Source: Ensembl
  4. microvillus assembly Source: Ensembl
  5. positive regulation of cell proliferation Source: Ensembl
  6. positive regulation of transcription, DNA-templated Source: Ensembl
  7. skeletal muscle cell differentiation Source: Ensembl
  8. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_27161. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiQ13887.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 5
Alternative name(s):
Basic transcription element-binding protein 2
Short name:
BTE-binding protein 2
Colon krueppel-like factor
GC-box-binding protein 2
Intestinal-enriched krueppel-like factor
Transcription factor BTEB2
Gene namesi
Name:KLF5
Synonyms:BTEB2, CKLF, IKLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:6349. KLF5.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. Golgi apparatus Source: HPA
  3. intracellular membrane-bounded organelle Source: HPA
  4. nucleus Source: HPA
  5. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi324 – 3285Missing: Impairs ubiquitination and degradation. 1 Publication

Organism-specific databases

PharmGKBiPA30139.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Krueppel-like factor 5PRO_0000047169Add
BLAST

Post-translational modificationi

Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ13887.
PaxDbiQ13887.
PRIDEiQ13887.

PTM databases

PhosphoSiteiQ13887.

Expressioni

Tissue specificityi

Expressed only in testis and placenta.

Gene expression databases

ArrayExpressiQ13887.
BgeeiQ13887.
CleanExiHS_CKLF.
HS_KLF5.
GenevestigatoriQ13887.

Organism-specific databases

HPAiHPA040398.
HPA044231.

Interactioni

Subunit structurei

Interacts with WWP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UBCP0CG482EBI-2696013,EBI-3390054

Protein-protein interaction databases

BioGridi107153. 27 interactions.
IntActiQ13887. 2 interactions.
MINTiMINT-3028757.
STRINGi9606.ENSP00000366915.

Structurei

Secondary structure

1
457
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi377 – 3793
Beta strandi383 – 3853
Helixi387 – 39711
Beta strandi407 – 4093
Beta strandi413 – 4164
Helixi417 – 42711
Beta strandi436 – 4383
Helixi445 – 45511

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EBTNMR-A365-457[»]
ProteinModelPortaliQ13887.
SMRiQ13887. Positions 363-457.

Miscellaneous databases

EvolutionaryTraceiQ13887.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni324 – 3285Interaction with WWP1

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri373 – 39725C2H2-type 1Add
BLAST
Zinc fingeri403 – 42725C2H2-type 2Add
BLAST
Zinc fingeri433 – 45523C2H2-type 3Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000261607.
HOVERGENiHBG003474.
InParanoidiQ13887.
KOiK09206.
OMAiMPNQFLQ.
OrthoDBiEOG747PJ4.
PhylomeDBiQ13887.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13887-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE    50
LKHAHHRPQA QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL 100
PPVPIIPEHK KYRRDSASVV DQFFTDTEGL PYSINMNVFL PDITHLRTGL 150
YKSQRPCVTH IKTEPVAIFS HQSETTAPPP APTQALPEFT SIFSSHQTAA 200
PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP SSTNQTAAMD 250
TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF 300
PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN 350
SQNIQPVRYN RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE 400
KPYKCTWEGC DWRFARSDEL TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL 450
HMKRHQN 457
Length:457
Mass (Da):50,792
Last modified:December 1, 2000 - v2
Checksum:i3BF12BE272716E57
GO
Isoform 2 (identifier: Q13887-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-239: Missing.

Show »
Length:305
Mass (Da):33,618
Checksum:i0C584B65B6ED3BD1
GO
Isoform 3 (identifier: Q13887-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-166: IIPEHKKYRR...CVTHIKTEPV → MLLQLLLNWQ...AQKFIPSLLI
     167-457: Missing.

Show »
Length:166
Mass (Da):18,116
Checksum:i4210629ABFC9175C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti301 – 3011P → S in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035555

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei88 – 239152Missing in isoform 2. VSP_047474Add
BLAST
Alternative sequencei105 – 16662IIPEH…KTEPV → MLLQLLLNWQFTIQIYPPPC QLTHKTSNLSDTIEGVTPIW RNDASTTAITLVAQKFIPSL LI in isoform 3. VSP_047475Add
BLAST
Alternative sequencei167 – 457291Missing in isoform 3. VSP_047476Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132818 mRNA. Translation: AAF18307.1.
HF546203 mRNA. Translation: CCO02789.1.
HF546204 mRNA. Translation: CCO02790.1.
AB030824 mRNA. Translation: BAA96461.1.
AF287272 mRNA. Translation: AAF88068.1.
BC007695 mRNA. Translation: AAH07695.1.
BC042131 mRNA. Translation: AAH42131.1.
D14520 mRNA. Translation: BAA03393.1.
CCDSiCCDS9448.1. [Q13887-1]
PIRiS35643.
RefSeqiNP_001273747.1. NM_001286818.1.
NP_001721.2. NM_001730.4. [Q13887-1]
UniGeneiHs.508234.

Genome annotation databases

EnsembliENST00000377687; ENSP00000366915; ENSG00000102554. [Q13887-1]
GeneIDi688.
KEGGihsa:688.
UCSCiuc001vjd.3. human. [Q13887-1]

Polymorphism databases

DMDMi12644412.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132818 mRNA. Translation: AAF18307.1 .
HF546203 mRNA. Translation: CCO02789.1 .
HF546204 mRNA. Translation: CCO02790.1 .
AB030824 mRNA. Translation: BAA96461.1 .
AF287272 mRNA. Translation: AAF88068.1 .
BC007695 mRNA. Translation: AAH07695.1 .
BC042131 mRNA. Translation: AAH42131.1 .
D14520 mRNA. Translation: BAA03393.1 .
CCDSi CCDS9448.1. [Q13887-1 ]
PIRi S35643.
RefSeqi NP_001273747.1. NM_001286818.1.
NP_001721.2. NM_001730.4. [Q13887-1 ]
UniGenei Hs.508234.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EBT NMR - A 365-457 [» ]
ProteinModelPortali Q13887.
SMRi Q13887. Positions 363-457.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107153. 27 interactions.
IntActi Q13887. 2 interactions.
MINTi MINT-3028757.
STRINGi 9606.ENSP00000366915.

Chemistry

BindingDBi Q13887.

PTM databases

PhosphoSitei Q13887.

Polymorphism databases

DMDMi 12644412.

Proteomic databases

MaxQBi Q13887.
PaxDbi Q13887.
PRIDEi Q13887.

Protocols and materials databases

DNASUi 688.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377687 ; ENSP00000366915 ; ENSG00000102554 . [Q13887-1 ]
GeneIDi 688.
KEGGi hsa:688.
UCSCi uc001vjd.3. human. [Q13887-1 ]

Organism-specific databases

CTDi 688.
GeneCardsi GC13P073629.
HGNCi HGNC:6349. KLF5.
HPAi HPA040398.
HPA044231.
MIMi 602903. gene.
neXtProti NX_Q13887.
PharmGKBi PA30139.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000261607.
HOVERGENi HBG003474.
InParanoidi Q13887.
KOi K09206.
OMAi MPNQFLQ.
OrthoDBi EOG747PJ4.
PhylomeDBi Q13887.
TreeFami TF350556.

Enzyme and pathway databases

Reactomei REACT_27161. Transcriptional regulation of white adipocyte differentiation.
SignaLinki Q13887.

Miscellaneous databases

ChiTaRSi KLF5. human.
EvolutionaryTracei Q13887.
GeneWikii KLF5.
GenomeRNAii 688.
NextBioi 2832.
PROi Q13887.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13887.
Bgeei Q13887.
CleanExi HS_CKLF.
HS_KLF5.
Genevestigatori Q13887.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter."
    Shi H., Zhang Z., Wang X., Liu S., Teng C.T.
    Nucleic Acids Res. 27:4807-4815(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors."
    Camacho-Vanegas O., Till J., Miranda-Lorenzo I., Ozturk B., Camacho S.C., Martignetti J.A.
    FASEB J. 27:432-436(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), ALTERNATIVE SPLICING.
  3. "Human basic transcription element binding protein 2."
    Ohnishi S., Yoshida T., Ramirez F., Terada M., Friedrich L.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Human Kruppel like factor5/KLF5: expression in human skin and hair follicles."
    Sur I., Unden A.-B., Toftgard R.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Placenta.
  6. "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2."
    Sogawa K., Imataka H., Yamasaki Y., Kusume H., Abe H., Fujii-Kuriyama Y.
    Nucleic Acids Res. 21:1527-1532(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 239-457 (ISOFORM 1).
    Tissue: Placenta.
  7. "Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells."
    Chen C., Sun X., Ran Q., Wilkinson K.D., Murphy T.J., Simons J.W., Dong J.T.
    Oncogene 24:3319-3327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH WWP1, UBIQUITINATION, MUTAGENESIS OF 324-PRO--TYR-328.
  8. "Solution structure of three tandem repeats of ZF-C2H2 domains from human kruppel-like factor 5."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2008) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 363-457.
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-301.

Entry informationi

Entry nameiKLF5_HUMAN
AccessioniPrimary (citable) accession number: Q13887
Secondary accession number(s): L0R3U5, L0R4T9, Q9UHP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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