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Protein

Krueppel-like factor 5

Gene

KLF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 397C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri403 – 427C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri433 – 455C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102554-MONOMER.
ReactomeiR-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiQ13887.
SIGNORiQ13887.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 5
Alternative name(s):
Basic transcription element-binding protein 2
Short name:
BTE-binding protein 2
Colon krueppel-like factor
GC-box-binding protein 2
Intestinal-enriched krueppel-like factor
Transcription factor BTEB2
Gene namesi
Name:KLF5
Synonyms:BTEB2, CKLF, IKLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:6349. KLF5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi324 – 328Missing : Impairs ubiquitination and degradation. 1 Publication5

Organism-specific databases

DisGeNETi688.
OpenTargetsiENSG00000102554.
PharmGKBiPA30139.

Chemistry databases

ChEMBLiCHEMBL1293249.

Polymorphism and mutation databases

DMDMi12644412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471691 – 457Krueppel-like factor 5Add BLAST457

Post-translational modificationi

Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ13887.
PaxDbiQ13887.
PeptideAtlasiQ13887.
PRIDEiQ13887.

PTM databases

iPTMnetiQ13887.
PhosphoSitePlusiQ13887.

Expressioni

Tissue specificityi

Expressed only in testis and placenta.

Gene expression databases

BgeeiENSG00000102554.
CleanExiHS_CKLF.
HS_KLF5.
ExpressionAtlasiQ13887. baseline and differential.
GenevisibleiQ13887. HS.

Organism-specific databases

HPAiHPA040398.
HPA044231.

Interactioni

Subunit structurei

Interacts with WWP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UBCP0CG482EBI-2696013,EBI-3390054

Protein-protein interaction databases

BioGridi107153. 50 interactors.
IntActiQ13887. 5 interactors.
MINTiMINT-3028757.
STRINGi9606.ENSP00000366915.

Chemistry databases

BindingDBiQ13887.

Structurei

Secondary structure

1457
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi377 – 379Combined sources3
Beta strandi383 – 385Combined sources3
Helixi387 – 397Combined sources11
Beta strandi407 – 409Combined sources3
Beta strandi413 – 416Combined sources4
Helixi417 – 427Combined sources11
Beta strandi436 – 438Combined sources3
Helixi445 – 455Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBTNMR-A365-457[»]
ProteinModelPortaliQ13887.
SMRiQ13887.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13887.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni324 – 328Interaction with WWP11 Publication5

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 397C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri403 – 427C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri433 – 455C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000261607.
HOVERGENiHBG003474.
InParanoidiQ13887.
KOiK09206.
OMAiMPNQFLQ.
OrthoDBiEOG091G1BN0.
PhylomeDBiQ13887.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13887-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE
60 70 80 90 100
LKHAHHRPQA QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL
110 120 130 140 150
PPVPIIPEHK KYRRDSASVV DQFFTDTEGL PYSINMNVFL PDITHLRTGL
160 170 180 190 200
YKSQRPCVTH IKTEPVAIFS HQSETTAPPP APTQALPEFT SIFSSHQTAA
210 220 230 240 250
PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP SSTNQTAAMD
260 270 280 290 300
TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF
310 320 330 340 350
PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN
360 370 380 390 400
SQNIQPVRYN RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE
410 420 430 440 450
KPYKCTWEGC DWRFARSDEL TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL

HMKRHQN
Length:457
Mass (Da):50,792
Last modified:December 1, 2000 - v2
Checksum:i3BF12BE272716E57
GO
Isoform 2 (identifier: Q13887-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-239: Missing.

Show »
Length:305
Mass (Da):33,618
Checksum:i0C584B65B6ED3BD1
GO
Isoform 3 (identifier: Q13887-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-166: IIPEHKKYRR...CVTHIKTEPV → MLLQLLLNWQ...AQKFIPSLLI
     167-457: Missing.

Show »
Length:166
Mass (Da):18,116
Checksum:i4210629ABFC9175C
GO
Isoform 4 (identifier: Q13887-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.

Show »
Length:366
Mass (Da):41,180
Checksum:i81C5C45788433D2F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035555301P → S in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0575671 – 91Missing in isoform 4. Add BLAST91
Alternative sequenceiVSP_04747488 – 239Missing in isoform 2. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_047475105 – 166IIPEH…KTEPV → MLLQLLLNWQFTIQIYPPPC QLTHKTSNLSDTIEGVTPIW RNDASTTAITLVAQKFIPSL LI in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_047476167 – 457Missing in isoform 3. 1 PublicationAdd BLAST291

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132818 mRNA. Translation: AAF18307.1.
HF546203 mRNA. Translation: CCO02789.1.
HF546204 mRNA. Translation: CCO02790.1.
AB030824 mRNA. Translation: BAA96461.1.
AF287272 mRNA. Translation: AAF88068.1.
EF208215 mRNA. Translation: ABM97548.1.
AK302280 mRNA. Translation: BAG63623.1.
AL354720 Genomic DNA. No translation available.
CH471093 Genomic DNA. Translation: EAW80526.1.
BC007695 mRNA. Translation: AAH07695.1.
BC042131 mRNA. Translation: AAH42131.1.
D14520 mRNA. Translation: BAA03393.1.
CCDSiCCDS66562.1. [Q13887-4]
CCDS9448.1. [Q13887-1]
PIRiS35643.
RefSeqiNP_001273747.1. NM_001286818.1. [Q13887-4]
NP_001721.2. NM_001730.4. [Q13887-1]
UniGeneiHs.508234.

Genome annotation databases

EnsembliENST00000377687; ENSP00000366915; ENSG00000102554. [Q13887-1]
ENST00000539231; ENSP00000440407; ENSG00000102554. [Q13887-4]
GeneIDi688.
KEGGihsa:688.
UCSCiuc001vjd.5. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132818 mRNA. Translation: AAF18307.1.
HF546203 mRNA. Translation: CCO02789.1.
HF546204 mRNA. Translation: CCO02790.1.
AB030824 mRNA. Translation: BAA96461.1.
AF287272 mRNA. Translation: AAF88068.1.
EF208215 mRNA. Translation: ABM97548.1.
AK302280 mRNA. Translation: BAG63623.1.
AL354720 Genomic DNA. No translation available.
CH471093 Genomic DNA. Translation: EAW80526.1.
BC007695 mRNA. Translation: AAH07695.1.
BC042131 mRNA. Translation: AAH42131.1.
D14520 mRNA. Translation: BAA03393.1.
CCDSiCCDS66562.1. [Q13887-4]
CCDS9448.1. [Q13887-1]
PIRiS35643.
RefSeqiNP_001273747.1. NM_001286818.1. [Q13887-4]
NP_001721.2. NM_001730.4. [Q13887-1]
UniGeneiHs.508234.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBTNMR-A365-457[»]
ProteinModelPortaliQ13887.
SMRiQ13887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107153. 50 interactors.
IntActiQ13887. 5 interactors.
MINTiMINT-3028757.
STRINGi9606.ENSP00000366915.

Chemistry databases

BindingDBiQ13887.
ChEMBLiCHEMBL1293249.

PTM databases

iPTMnetiQ13887.
PhosphoSitePlusiQ13887.

Polymorphism and mutation databases

DMDMi12644412.

Proteomic databases

EPDiQ13887.
PaxDbiQ13887.
PeptideAtlasiQ13887.
PRIDEiQ13887.

Protocols and materials databases

DNASUi688.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377687; ENSP00000366915; ENSG00000102554. [Q13887-1]
ENST00000539231; ENSP00000440407; ENSG00000102554. [Q13887-4]
GeneIDi688.
KEGGihsa:688.
UCSCiuc001vjd.5. human.

Organism-specific databases

CTDi688.
DisGeNETi688.
GeneCardsiKLF5.
HGNCiHGNC:6349. KLF5.
HPAiHPA040398.
HPA044231.
MIMi602903. gene.
neXtProtiNX_Q13887.
OpenTargetsiENSG00000102554.
PharmGKBiPA30139.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000261607.
HOVERGENiHBG003474.
InParanoidiQ13887.
KOiK09206.
OMAiMPNQFLQ.
OrthoDBiEOG091G1BN0.
PhylomeDBiQ13887.
TreeFamiTF350556.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102554-MONOMER.
ReactomeiR-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiQ13887.
SIGNORiQ13887.

Miscellaneous databases

ChiTaRSiKLF5. human.
EvolutionaryTraceiQ13887.
GeneWikiiKLF5.
GenomeRNAii688.
PROiQ13887.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102554.
CleanExiHS_CKLF.
HS_KLF5.
ExpressionAtlasiQ13887. baseline and differential.
GenevisibleiQ13887. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLF5_HUMAN
AccessioniPrimary (citable) accession number: Q13887
Secondary accession number(s): A2TJX0
, L0R3U5, L0R4T9, Q9UHP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.