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Q13886

- KLF9_HUMAN

UniProt

Q13886 - KLF9_HUMAN

Protein

Krueppel-like factor 9

Gene

KLF9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri143 – 16725C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri173 – 19725C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri203 – 22523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. cellular response to thyroid hormone stimulus Source: UniProtKB
    2. embryo implantation Source: Ensembl
    3. progesterone receptor signaling pathway Source: Ensembl
    4. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 9
    Alternative name(s):
    Basic transcription element-binding protein 1
    Short name:
    BTE-binding protein 1
    GC-box-binding protein 1
    Transcription factor BTEB1
    Gene namesi
    Name:KLF9
    Synonyms:BTEB, BTEB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:1123. KLF9.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA
    3. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25444.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244Krueppel-like factor 9PRO_0000047154Add
    BLAST

    Proteomic databases

    PaxDbiQ13886.
    PRIDEiQ13886.

    PTM databases

    PhosphoSiteiQ13886.

    Expressioni

    Gene expression databases

    BgeeiQ13886.
    CleanExiHS_KLF9.
    GenevestigatoriQ13886.

    Organism-specific databases

    HPAiHPA029308.

    Interactioni

    Protein-protein interaction databases

    BioGridi107152. 6 interactions.
    STRINGi9606.ENSP00000366330.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13886.
    SMRiQ13886. Positions 6-39, 105-230.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi84 – 11633Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri143 – 16725C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri173 – 19725C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri203 – 22523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000233575.
    HOVERGENiHBG050746.
    InParanoidiQ13886.
    KOiK09208.
    OMAiDAWKDYC.
    OrthoDBiEOG7FJH0Q.
    PhylomeDBiQ13886.
    TreeFamiTF351003.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13886-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAAAYMDFV AAQCLVSISN RAAVPEHGVA PDAERLRLPE REVTKEHGDP    50
    GDTWKDYCTL VTIAKSLLDL NKYRPIQTPS VCSDSLESPD EDMGSDSDVT 100
    TESGSSPSHS PEERQDPGSA PSPLSLLHPG VAAKGKHASE KRHKCPYSGC 150
    GKVYGKSSHL KAHYRVHTGE RPFPCTWPDC LKKFSRSDEL TRHYRTHTGE 200
    KQFRCPLCEK RFMRSDHLTK HARRHTEFHP SMIKRSKKAL ANAL 244
    Length:244
    Mass (Da):27,235
    Last modified:November 1, 1996 - v1
    Checksum:i2D1B5A5BB9D42221
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31716 mRNA. Translation: BAA06524.1.
    AK313631 mRNA. Translation: BAG36390.1.
    AL162390 Genomic DNA. Translation: CAB99349.1.
    CH471089 Genomic DNA. Translation: EAW62503.1.
    BC069431 mRNA. Translation: AAH69431.1.
    BC074879 mRNA. Translation: AAH74879.1.
    BC074880 mRNA. Translation: AAH74880.1.
    S72504 mRNA. Translation: AAD14110.1.
    CCDSiCCDS6633.1.
    PIRiI59602.
    RefSeqiNP_001197.1. NM_001206.2.
    UniGeneiHs.150557.
    Hs.602267.

    Genome annotation databases

    EnsembliENST00000377126; ENSP00000366330; ENSG00000119138.
    GeneIDi687.
    KEGGihsa:687.
    UCSCiuc004aht.3. human.

    Polymorphism databases

    DMDMi3913177.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31716 mRNA. Translation: BAA06524.1 .
    AK313631 mRNA. Translation: BAG36390.1 .
    AL162390 Genomic DNA. Translation: CAB99349.1 .
    CH471089 Genomic DNA. Translation: EAW62503.1 .
    BC069431 mRNA. Translation: AAH69431.1 .
    BC074879 mRNA. Translation: AAH74879.1 .
    BC074880 mRNA. Translation: AAH74880.1 .
    S72504 mRNA. Translation: AAD14110.1 .
    CCDSi CCDS6633.1.
    PIRi I59602.
    RefSeqi NP_001197.1. NM_001206.2.
    UniGenei Hs.150557.
    Hs.602267.

    3D structure databases

    ProteinModelPortali Q13886.
    SMRi Q13886. Positions 6-39, 105-230.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107152. 6 interactions.
    STRINGi 9606.ENSP00000366330.

    PTM databases

    PhosphoSitei Q13886.

    Polymorphism databases

    DMDMi 3913177.

    Proteomic databases

    PaxDbi Q13886.
    PRIDEi Q13886.

    Protocols and materials databases

    DNASUi 687.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377126 ; ENSP00000366330 ; ENSG00000119138 .
    GeneIDi 687.
    KEGGi hsa:687.
    UCSCi uc004aht.3. human.

    Organism-specific databases

    CTDi 687.
    GeneCardsi GC09M072999.
    H-InvDB HIX0035285.
    HGNCi HGNC:1123. KLF9.
    HPAi HPA029308.
    MIMi 602902. gene.
    neXtProti NX_Q13886.
    PharmGKBi PA25444.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000233575.
    HOVERGENi HBG050746.
    InParanoidi Q13886.
    KOi K09208.
    OMAi DAWKDYC.
    OrthoDBi EOG7FJH0Q.
    PhylomeDBi Q13886.
    TreeFami TF351003.

    Miscellaneous databases

    GeneWikii KLF9.
    GenomeRNAii 687.
    NextBioi 2828.
    PROi Q13886.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q13886.
    CleanExi HS_KLF9.
    Genevestigatori Q13886.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein."
      Ohe N., Yamasaki Y., Sogawa K., Inazawa J., Ariyama T., Oshimura M., Fujii-Kuriyama Y.
      Somat. Cell Mol. Genet. 19:499-503(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    6. "Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5'-untranslated region."
      Imataka H., Nakayama K., Yasumoto K., Mizuno A., Fujii-Kuriyama Y., Hayami M.
      J. Biol. Chem. 269:20668-20673(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31.

    Entry informationi

    Entry nameiKLF9_HUMAN
    AccessioniPrimary (citable) accession number: Q13886
    Secondary accession number(s): B2R943, Q16196
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3