Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Krueppel-like factor 9

Gene

KLF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri143 – 167C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri173 – 197C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri203 – 225C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • cellular response to cortisol stimulus Source: UniProtKB
  • cellular response to thyroid hormone stimulus Source: UniProtKB
  • circadian rhythm Source: UniProtKB
  • negative regulation of keratinocyte proliferation Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ13886

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 9
Alternative name(s):
Basic transcription element-binding protein 1
Short name:
BTE-binding protein 1
GC-box-binding protein 1
Transcription factor BTEB1
Gene namesi
Name:KLF9
Synonyms:BTEB, BTEB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000119138.4
HGNCiHGNC:1123 KLF9
MIMi602902 gene
neXtProtiNX_Q13886

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi687
OpenTargetsiENSG00000119138
PharmGKBiPA25444

Polymorphism and mutation databases

BioMutaiKLF9
DMDMi3913177

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471541 – 244Krueppel-like factor 9Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13886
PaxDbiQ13886
PeptideAtlasiQ13886
PRIDEiQ13886

PTM databases

iPTMnetiQ13886
PhosphoSitePlusiQ13886

Expressioni

Tissue specificityi

Epidermis (at protein level).1 Publication

Inductioni

Expression is highly sensitive to glucocorticoids and shows diurnal expression patterns. A strong induction of expression seen during keratinocyte differentiation in a cortisol dependent manner.1 Publication

Gene expression databases

BgeeiENSG00000119138
CleanExiHS_KLF9
ExpressionAtlasiQ13886 baseline and differential
GenevisibleiQ13886 HS

Organism-specific databases

HPAiHPA029308

Interactioni

Protein-protein interaction databases

BioGridi107152, 4 interactors
ELMiQ13886
IntActiQ13886, 1 interactor
STRINGi9606.ENSP00000366330

Structurei

3D structure databases

ProteinModelPortaliQ13886
SMRiQ13886
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi84 – 116Asp/Glu-rich (acidic)Add BLAST33

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri143 – 167C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri173 – 197C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri203 – 225C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000233575
HOVERGENiHBG050746
InParanoidiQ13886
KOiK09208
OMAiDAWKDYC
OrthoDBiEOG091G1BN0
PhylomeDBiQ13886
TreeFamiTF351003

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q13886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAAYMDFV AAQCLVSISN RAAVPEHGVA PDAERLRLPE REVTKEHGDP
60 70 80 90 100
GDTWKDYCTL VTIAKSLLDL NKYRPIQTPS VCSDSLESPD EDMGSDSDVT
110 120 130 140 150
TESGSSPSHS PEERQDPGSA PSPLSLLHPG VAAKGKHASE KRHKCPYSGC
160 170 180 190 200
GKVYGKSSHL KAHYRVHTGE RPFPCTWPDC LKKFSRSDEL TRHYRTHTGE
210 220 230 240
KQFRCPLCEK RFMRSDHLTK HARRHTEFHP SMIKRSKKAL ANAL
Length:244
Mass (Da):27,235
Last modified:November 1, 1996 - v1
Checksum:i2D1B5A5BB9D42221
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31716 mRNA Translation: BAA06524.1
AK313631 mRNA Translation: BAG36390.1
AL162390 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62503.1
BC069431 mRNA Translation: AAH69431.1
BC074879 mRNA Translation: AAH74879.1
BC074880 mRNA Translation: AAH74880.1
S72504 mRNA Translation: AAD14110.1
CCDSiCCDS6633.1
PIRiI59602
RefSeqiNP_001197.1, NM_001206.2
UniGeneiHs.150557
Hs.602267

Genome annotation databases

EnsembliENST00000377126; ENSP00000366330; ENSG00000119138
GeneIDi687
KEGGihsa:687
UCSCiuc004aht.4 human

Similar proteinsi

Entry informationi

Entry nameiKLF9_HUMAN
AccessioniPrimary (citable) accession number: Q13886
Secondary accession number(s): B2R943, Q16196
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health