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Protein

Krueppel-like factor 9

Gene

KLF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri143 – 16725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19725C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  • cellular response to cortisol stimulus Source: UniProtKB
  • cellular response to thyroid hormone stimulus Source: UniProtKB
  • circadian rhythm Source: UniProtKB
  • negative regulation of keratinocyte proliferation Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 9
Alternative name(s):
Basic transcription element-binding protein 1
Short name:
BTE-binding protein 1
GC-box-binding protein 1
Transcription factor BTEB1
Gene namesi
Name:KLF9
Synonyms:BTEB, BTEB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:1123. KLF9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25444.

Polymorphism and mutation databases

BioMutaiKLF9.
DMDMi3913177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Krueppel-like factor 9PRO_0000047154Add
BLAST

Proteomic databases

MaxQBiQ13886.
PaxDbiQ13886.
PRIDEiQ13886.

PTM databases

PhosphoSiteiQ13886.

Expressioni

Tissue specificityi

Epidermis (at protein level).1 Publication

Inductioni

Expression is highly sensitive to glucocorticoids and shows diurnal expression patterns. A strong induction of expression seen during keratinocyte differentiation in a cortisol dependent manner.1 Publication

Gene expression databases

BgeeiQ13886.
CleanExiHS_KLF9.
ExpressionAtlasiQ13886. baseline and differential.
GenevisibleiQ13886. HS.

Organism-specific databases

HPAiHPA029308.

Interactioni

Protein-protein interaction databases

BioGridi107152. 4 interactions.
STRINGi9606.ENSP00000366330.

Structurei

3D structure databases

ProteinModelPortaliQ13886.
SMRiQ13886. Positions 140-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi84 – 11633Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri143 – 16725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19725C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiQ13886.
KOiK09208.
OMAiDAWKDYC.
OrthoDBiEOG7FJH0Q.
PhylomeDBiQ13886.
TreeFamiTF351003.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAAYMDFV AAQCLVSISN RAAVPEHGVA PDAERLRLPE REVTKEHGDP
60 70 80 90 100
GDTWKDYCTL VTIAKSLLDL NKYRPIQTPS VCSDSLESPD EDMGSDSDVT
110 120 130 140 150
TESGSSPSHS PEERQDPGSA PSPLSLLHPG VAAKGKHASE KRHKCPYSGC
160 170 180 190 200
GKVYGKSSHL KAHYRVHTGE RPFPCTWPDC LKKFSRSDEL TRHYRTHTGE
210 220 230 240
KQFRCPLCEK RFMRSDHLTK HARRHTEFHP SMIKRSKKAL ANAL
Length:244
Mass (Da):27,235
Last modified:November 1, 1996 - v1
Checksum:i2D1B5A5BB9D42221
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31716 mRNA. Translation: BAA06524.1.
AK313631 mRNA. Translation: BAG36390.1.
AL162390 Genomic DNA. Translation: CAB99349.1.
CH471089 Genomic DNA. Translation: EAW62503.1.
BC069431 mRNA. Translation: AAH69431.1.
BC074879 mRNA. Translation: AAH74879.1.
BC074880 mRNA. Translation: AAH74880.1.
S72504 mRNA. Translation: AAD14110.1.
CCDSiCCDS6633.1.
PIRiI59602.
RefSeqiNP_001197.1. NM_001206.2.
UniGeneiHs.150557.
Hs.602267.

Genome annotation databases

EnsembliENST00000377126; ENSP00000366330; ENSG00000119138.
GeneIDi687.
KEGGihsa:687.
UCSCiuc004aht.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31716 mRNA. Translation: BAA06524.1.
AK313631 mRNA. Translation: BAG36390.1.
AL162390 Genomic DNA. Translation: CAB99349.1.
CH471089 Genomic DNA. Translation: EAW62503.1.
BC069431 mRNA. Translation: AAH69431.1.
BC074879 mRNA. Translation: AAH74879.1.
BC074880 mRNA. Translation: AAH74880.1.
S72504 mRNA. Translation: AAD14110.1.
CCDSiCCDS6633.1.
PIRiI59602.
RefSeqiNP_001197.1. NM_001206.2.
UniGeneiHs.150557.
Hs.602267.

3D structure databases

ProteinModelPortaliQ13886.
SMRiQ13886. Positions 140-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107152. 4 interactions.
STRINGi9606.ENSP00000366330.

PTM databases

PhosphoSiteiQ13886.

Polymorphism and mutation databases

BioMutaiKLF9.
DMDMi3913177.

Proteomic databases

MaxQBiQ13886.
PaxDbiQ13886.
PRIDEiQ13886.

Protocols and materials databases

DNASUi687.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377126; ENSP00000366330; ENSG00000119138.
GeneIDi687.
KEGGihsa:687.
UCSCiuc004aht.3. human.

Organism-specific databases

CTDi687.
GeneCardsiGC09M072999.
H-InvDBHIX0035285.
HGNCiHGNC:1123. KLF9.
HPAiHPA029308.
MIMi602902. gene.
neXtProtiNX_Q13886.
PharmGKBiPA25444.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiQ13886.
KOiK09208.
OMAiDAWKDYC.
OrthoDBiEOG7FJH0Q.
PhylomeDBiQ13886.
TreeFamiTF351003.

Miscellaneous databases

GeneWikiiKLF9.
GenomeRNAii687.
NextBioi2828.
PROiQ13886.
SOURCEiSearch...

Gene expression databases

BgeeiQ13886.
CleanExiHS_KLF9.
ExpressionAtlasiQ13886. baseline and differential.
GenevisibleiQ13886. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein."
    Ohe N., Yamasaki Y., Sogawa K., Inazawa J., Ariyama T., Oshimura M., Fujii-Kuriyama Y.
    Somat. Cell Mol. Genet. 19:499-503(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5'-untranslated region."
    Imataka H., Nakayama K., Yasumoto K., Mizuno A., Fujii-Kuriyama Y., Hayami M.
    J. Biol. Chem. 269:20668-20673(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31.
  7. "Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes."
    Sporl F., Korge S., Jurchott K., Wunderskirchner M., Schellenberg K., Heins S., Specht A., Stoll C., Klemz R., Maier B., Wenck H., Schrader A., Kunz D., Blatt T., Kramer A.
    Proc. Natl. Acad. Sci. U.S.A. 109:10903-10908(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiKLF9_HUMAN
AccessioniPrimary (citable) accession number: Q13886
Secondary accession number(s): B2R943, Q16196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.