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Q13884

- SNTB1_HUMAN

UniProt

Q13884 - SNTB1_HUMAN

Protein

Beta-1-syntrophin

Gene

SNTB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. muscle contraction Source: ProtInc

    Keywords - Ligandi

    Actin-binding, Calcium, Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-1-syntrophin
    Alternative name(s):
    59 kDa dystrophin-associated protein A1 basic component 1
    Short name:
    DAPA1B
    BSYN2
    Syntrophin-2
    Tax interaction protein 43
    Short name:
    TIP-43
    Gene namesi
    Name:SNTB1
    Synonyms:SNT2B1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:11168. SNTB1.

    Subcellular locationi

    Cell membranesarcolemma By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cell junction By similarity. Cytoplasmcytoskeleton By similarity
    Note: In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-KW
    3. cytoskeleton Source: UniProtKB-SubCell
    4. dystrophin-associated glycoprotein complex Source: ProtInc
    5. protein complex Source: MGI
    6. sarcolemma Source: UniProtKB-SubCell
    7. synapse Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36008.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 538537Beta-1-syntrophinPRO_0000184009Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei87 – 871Phosphoserine2 Publications
    Modified residuei214 – 2141PhosphothreonineBy similarity
    Modified residuei219 – 2191Phosphoserine2 Publications
    Modified residuei389 – 3891Phosphoserine3 Publications

    Post-translational modificationi

    Phosphorylated by CaM-kinase II.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ13884.
    PaxDbiQ13884.
    PRIDEiQ13884.

    PTM databases

    PhosphoSiteiQ13884.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ13884.
    BgeeiQ13884.
    CleanExiHS_SNTB1.
    GenevestigatoriQ13884.

    Organism-specific databases

    HPAiHPA024659.

    Interactioni

    Subunit structurei

    Monomer and homodimer Probable. Interacts with the other members of the syntrophin family SNTA1 and SNTB2; with the sodium channel proteins SCN4A and SCN5A By similarity. Interacts with the viral HTLV-1 TAX protein and with dystrophin protein DMD and related proteins DTNA and UTRN.By similarity2 PublicationsCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABCA1O954773EBI-295843,EBI-784112
    DMDP115323EBI-295843,EBI-295827

    Protein-protein interaction databases

    BioGridi112524. 9 interactions.
    DIPiDIP-466N.
    IntActiQ13884. 5 interactions.
    STRINGi9606.ENSP00000378965.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13884.
    SMRiQ13884. Positions 15-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 298280PH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini112 – 19584PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini322 – 433112PH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini482 – 53857SUAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni518 – 53821Calmodulin-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 109Poly-Ala

    Domaini

    The PH 1 domain mediates the oligomerization in a calcium dependent manner.By similarity
    The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane By similarity.By similarity
    The SU domain binds calmodulin in a calcium-dependent manner.By similarity

    Sequence similaritiesi

    Belongs to the syntrophin family.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 2 PH domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG318350.
    HOGENOMiHOG000231596.
    HOVERGENiHBG054204.
    InParanoidiQ13884.
    OMAiDAKHTVV.
    OrthoDBiEOG7R56VZ.
    PhylomeDBiQ13884.
    TreeFamiTF317932.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015482. Syntrophin.
    [Graphical view]
    PANTHERiPTHR10554. PTHR10554. 1 hit.
    PfamiPF00595. PDZ. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    SM00233. PH. 2 hits.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13884-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVAAAAAAA GPAGAGGGRA QRSGLLEVLV RDRWHKVLVN LSEDALVLSS    50
    EEGAAAYNGI GTATNGSFCR GAGAGHPGAG GAQPPDSPAG VRTAFTDLPE 100
    QVPESISNQK RGVKVLKQEL GGLGISIKGG KENKMPILIS KIFKGLAADQ 150
    TQALYVGDAI LSVNGADLRD ATHDEAVQAL KRAGKEVLLE VKYMREATPY 200
    VKKGSPVSEI GWETPPPESP RLGGSTSDPP SSQSFSFHRD RKSIPLKMCY 250
    VTRSMALADP ENRQLEIHSP DAKHTVILRS KDSATAQAWF SAIHSNVNDL 300
    LTRVIAEVRE QLGKTGIAGS REIRHLGWLA EKVPGESKKQ WKPALVVLTE 350
    KDLLIYDSMP RRKEAWFSPV HTYPLLATRL VHSGPGKGSP QAGVDLSFAT 400
    RTGTRQGIET HLFRAETSRD LSHWTRSIVQ GCHNSAELIA EISTACTYKN 450
    QECRLTIHYE NGFSITTEPQ EGAFPKTIIQ SPYEKLKMSS DDGIRMLYLD 500
    FGGKDGEIQL DLHSCPKPIV FIIHSFLSAK ITRLGLVA 538
    Length:538
    Mass (Da):58,061
    Last modified:January 23, 2007 - v3
    Checksum:iBF8E7B416D5CF289
    GO
    Isoform 2 (identifier: Q13884-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         379-382: RLVH → SPHP
         383-538: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:382
    Mass (Da):40,805
    Checksum:i5857392A7FCE200D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei379 – 3824RLVH → SPHP in isoform 2. 1 PublicationVSP_006354
    Alternative sequencei383 – 538156Missing in isoform 2. 1 PublicationVSP_006355Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L31529 Genomic DNA. Translation: AAA81523.1.
    AK292655 mRNA. Translation: BAF85344.1.
    BC098573 mRNA. Translation: AAH98573.1.
    AF028828 mRNA. Translation: AAB84253.1.
    CCDSiCCDS6334.1. [Q13884-1]
    PIRiI59291.
    RefSeqiNP_066301.1. NM_021021.3. [Q13884-1]
    UniGeneiHs.46701.

    Genome annotation databases

    EnsembliENST00000395601; ENSP00000378965; ENSG00000172164. [Q13884-1]
    ENST00000517992; ENSP00000431124; ENSG00000172164. [Q13884-1]
    GeneIDi6641.
    KEGGihsa:6641.
    UCSCiuc003ype.3. human. [Q13884-2]
    uc010mdg.3. human. [Q13884-1]

    Polymorphism databases

    DMDMi23822159.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L31529 Genomic DNA. Translation: AAA81523.1 .
    AK292655 mRNA. Translation: BAF85344.1 .
    BC098573 mRNA. Translation: AAH98573.1 .
    AF028828 mRNA. Translation: AAB84253.1 .
    CCDSi CCDS6334.1. [Q13884-1 ]
    PIRi I59291.
    RefSeqi NP_066301.1. NM_021021.3. [Q13884-1 ]
    UniGenei Hs.46701.

    3D structure databases

    ProteinModelPortali Q13884.
    SMRi Q13884. Positions 15-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112524. 9 interactions.
    DIPi DIP-466N.
    IntActi Q13884. 5 interactions.
    STRINGi 9606.ENSP00000378965.

    PTM databases

    PhosphoSitei Q13884.

    Polymorphism databases

    DMDMi 23822159.

    Proteomic databases

    MaxQBi Q13884.
    PaxDbi Q13884.
    PRIDEi Q13884.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395601 ; ENSP00000378965 ; ENSG00000172164 . [Q13884-1 ]
    ENST00000517992 ; ENSP00000431124 ; ENSG00000172164 . [Q13884-1 ]
    GeneIDi 6641.
    KEGGi hsa:6641.
    UCSCi uc003ype.3. human. [Q13884-2 ]
    uc010mdg.3. human. [Q13884-1 ]

    Organism-specific databases

    CTDi 6641.
    GeneCardsi GC08M121619.
    H-InvDB HIX0168940.
    HGNCi HGNC:11168. SNTB1.
    HPAi HPA024659.
    MIMi 600026. gene.
    neXtProti NX_Q13884.
    PharmGKBi PA36008.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG318350.
    HOGENOMi HOG000231596.
    HOVERGENi HBG054204.
    InParanoidi Q13884.
    OMAi DAKHTVV.
    OrthoDBi EOG7R56VZ.
    PhylomeDBi Q13884.
    TreeFami TF317932.

    Miscellaneous databases

    ChiTaRSi SNTB1. human.
    GeneWikii SNTB1.
    GenomeRNAii 6641.
    NextBioi 25877.
    PROi Q13884.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13884.
    Bgeei Q13884.
    CleanExi HS_SNTB1.
    Genevestigatori Q13884.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015482. Syntrophin.
    [Graphical view ]
    PANTHERi PTHR10554. PTHR10554. 1 hit.
    Pfami PF00595. PDZ. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    SM00233. PH. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24."
      Ahn A.H., Yoshida M., Anderson M.S., Feener C.A., Selig S., Hagiwara Y., Ozawa E., Kunkel L.M.
      Proc. Natl. Acad. Sci. U.S.A. 91:4446-4450(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), PROTEIN SEQUENCE OF 105-114; 197-208; 339-348 AND 351-355, TISSUE SPECIFICITY.
      Tissue: Skeletal muscle.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    4. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-19, ACETYLATION AT ALA-2.
      Tissue: Platelet.
    5. Bienvenut W.V., Okada H.
      Submitted (OCT-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-19; 23-31; 145-169; 325-332 AND 364-379, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Histiocytic lymphoma.
    6. "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins."
      Rousset R., Fabre S., Desbois C., Bantignies F., Jalinot P.
      Oncogene 16:643-654(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 95-538 (ISOFORM 2), INTERACTION WITH HTLV-1 TAX.
      Tissue: Lymphocyte.
    7. "Syntrophin binds to an alternatively spliced exon of dystrophin."
      Ahn A.H., Kunkel L.M.
      J. Cell Biol. 128:363-371(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DMD; DTNA AND UTRN.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87; SER-219 AND SER-389, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND SER-389, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSNTB1_HUMAN
    AccessioniPrimary (citable) accession number: Q13884
    Secondary accession number(s): A8K9E0, O14912, Q4KMG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3