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Q13875 (MOBP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myelin-associated oligodendrocyte basic protein
Gene names
Name:MOBP
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane By similarity.

Subcellular location

Cytoplasm › perinuclear region. Note: Present in the major dense line of CNS myelin By similarity.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processnervous system development

Traceable author statement. Source: ProtInc

   Cellular componentnucleolus

Inferred from direct assay. Source: HPA

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

soluble fraction

Traceable author statement. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q13875-1)

Also known as: OPRP2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q13875-2)

Also known as: OPRP1;

The sequence of this isoform differs from the canonical sequence as follows:
     183-183: Missing.
Isoform 3 (identifier: Q13875-3)

The sequence of this isoform differs from the canonical sequence as follows:
     70-81: TSRRAKSPQRPK → LKRKIRPTPKKK
     82-183: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 183183Myelin-associated oligodendrocyte basic protein
PRO_0000281025

Regions

Repeat97 – 106101
Repeat107 – 116102
Repeat117 – 126103
Repeat127 – 136104
Region97 – 136404 X 10 AA tandem repeats of P-R-S-P-P-R-S-E-R-Q
Compositional bias77 – 16892Pro-rich

Natural variations

Alternative sequence70 – 8112TSRRA…PQRPK → LKRKIRPTPKKK in isoform 3.
VSP_023933
Alternative sequence82 – 183102Missing in isoform 3.
VSP_023934
Alternative sequence1831Missing in isoform 2.
VSP_023935

Experimental info

Sequence conflict281P → R in AAH75796. Ref.4
Sequence conflict761S → P in BAA05660. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (OPRP2) [UniParc].

Last modified March 20, 2007. Version 2.
Checksum: 81831413BCC6A041

FASTA18320,959
        10         20         30         40         50         60 
MSQKPAKEGP RLSKNQKYSE HFSIHCCPPF TFLNSKKEIV DRKYSICKSG CFYQKKEEDW 

        70         80         90        100        110        120 
ICCACQKTRT SRRAKSPQRP KQQPAAPPAV VRAPAKPRSP PRSERQPRSP PRSERQPRSP 

       130        140        150        160        170        180 
PRSERQPRSP PRSERQPRPR PEVRPPPAKQ RPPQKSKQQP RSSPLRGPGA SRGGSPVKAS 


RFW

« Hide

Isoform 2 (OPRP1) [UniParc].

Checksum: E31413BCC6A041B5
Show »

FASTA18220,773
Isoform 3 [UniParc].

Checksum: 741E059219155AAF
Show »

FASTA819,614

References

« Hide 'large scale' references
[1]"Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin."
Yamamoto Y., Mizuno R., Nishimura T., Ogawa Y., Yoshikawa H., Fujimura H., Adachi E., Kishimoto T., Yanagihara T., Sakoda S.
J. Biol. Chem. 269:31725-31730(1994) [PubMed: 7989345] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING.
Tissue: Spinal cord.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Thalamus.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D28113 mRNA. Translation: BAA05659.1.
D28114 mRNA. Translation: BAA05660.1.
AK290187 mRNA. Translation: BAF82876.1.
CH471055 Genomic DNA. Translation: EAW64588.1.
BC022471 mRNA. Translation: AAH22471.1.
BC075796 mRNA. Translation: AAH75796.1.
BC119694 mRNA. Translation: AAI19695.1.
BC119695 mRNA. Translation: AAI19696.1.
IPIIPI00337645.
IPI00456778.
IPI00789227.
PIRC55663.
RefSeqNP_891980.1. NM_182935.2.
UniGeneHs.121333.

3D structure databases

ProteinModelPortalQ13875.
SMRQ13875. Positions 1-75.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ13875.

PTM databases

PhosphoSiteQ13875.

Polymorphism databases

DMDM134034171.

Proteomic databases

PRIDEQ13875.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354668; ENSP00000346695; ENSG00000168314.
ENST00000420739; ENSP00000400491; ENSG00000168314.
ENST00000424090; ENSP00000389055; ENSG00000168314.
GeneID4336.
KEGGhsa:4336.
NMPDRfig|9606.3.peg.22330.
UCSCuc003cju.1. human.
uc003cjv.1. human.

Organism-specific databases

CTD4336.
GeneCardsGC03P039484.
HGNCHGNC:7189. MOBP.
HPAHPA035152.
MIM600948. gene.
neXtProtNX_Q13875.
PharmGKBPA30899.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG21071.
GeneTreeENSGT00390000013933.
HOVERGENHBG081977.
InParanoidQ13875.
PhylomeDBQ13875.

Gene expression databases

ArrayExpressQ13875.
BgeeQ13875.
CleanExHS_MOBP.
GenevestigatorQ13875.

Family and domain databases

ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameMOBP_HUMAN
AccessionPrimary (citable) accession number: Q13875
Secondary accession number(s): A8K2C2 expand/collapse secondary AC list , Q13874, Q6DHZ6, Q8TBJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: December 14, 2011
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents