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Protein

Myelin-associated oligodendrocyte basic protein

Gene

MOBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.By similarity

GO - Molecular functioni

GO - Biological processi

  • nervous system development Source: ProtInc
  • vesicle transport along actin filament Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin-associated oligodendrocyte basic protein
Gene namesi
Name:MOBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000168314.17.
HGNCiHGNC:7189. MOBP.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi4336.
OpenTargetsiENSG00000168314.
PharmGKBiPA30899.

Polymorphism and mutation databases

DMDMi134034171.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002810251 – 183Myelin-associated oligodendrocyte basic proteinAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99PhosphoserineBy similarity1
Modified residuei109PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PeptideAtlasiQ13875.
PRIDEiQ13875.

PTM databases

iPTMnetiQ13875.
PhosphoSitePlusiQ13875.

Expressioni

Gene expression databases

BgeeiENSG00000168314.
CleanExiHS_MOBP.
ExpressionAtlasiQ13875. baseline and differential.
GenevisibleiQ13875. HS.

Organism-specific databases

HPAiHPA035152.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110479. 6 interactors.
IntActiQ13875. 9 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ13875.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati97 – 106110
Repeati107 – 116210
Repeati117 – 126310
Repeati127 – 136410

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 1364 X 10 AA tandem repeats of P-R-S-P-P-R-S-E-R-QAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi77 – 168Pro-richAdd BLAST92

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000013933.
HOGENOMiHOG000054197.
HOVERGENiHBG081977.
InParanoidiQ13875.
OMAiCACQKTS.
OrthoDBiEOG091G14LC.
PhylomeDBiQ13875.

Family and domain databases

InterProiView protein in InterPro
IPR026666. Mobp.
IPR011011. Znf_FYVE_PHD.
PANTHERiPTHR14555:SF7. PTHR14555:SF7. 1 hit.
PfamiView protein in Pfam
PF02318. FYVE_2. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13875-1) [UniParc]FASTAAdd to basket
Also known as: OPRP2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQKPAKEGP RLSKNQKYSE HFSIHCCPPF TFLNSKKEIV DRKYSICKSG
60 70 80 90 100
CFYQKKEEDW ICCACQKTRT SRRAKSPQRP KQQPAAPPAV VRAPAKPRSP
110 120 130 140 150
PRSERQPRSP PRSERQPRSP PRSERQPRSP PRSERQPRPR PEVRPPPAKQ
160 170 180
RPPQKSKQQP RSSPLRGPGA SRGGSPVKAS RFW
Length:183
Mass (Da):20,959
Last modified:March 20, 2007 - v2
Checksum:i81831413BCC6A041
GO
Isoform 2 (identifier: Q13875-2) [UniParc]FASTAAdd to basket
Also known as: OPRP1

The sequence of this isoform differs from the canonical sequence as follows:
     183-183: Missing.

Show »
Length:182
Mass (Da):20,773
Checksum:iE31413BCC6A041B5
GO
Isoform 3 (identifier: Q13875-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-81: TSRRAKSPQRPK → LKRKIRPTPKKK
     82-183: Missing.

Note: No experimental confirmation available.
Show »
Length:81
Mass (Da):9,614
Checksum:i741E059219155AAF
GO
Isoform 4 (identifier: Q13875-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-68: T → TSSCQRRLSSRGEPWLPPPASFGPL
     183-183: Missing.

Note: No experimental confirmation available.
Show »
Length:206
Mass (Da):23,381
Checksum:i9B33699136F2E7D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28P → R in AAH75796 (PubMed:15489334).Curated1
Sequence conflicti40V → E in AK127034 (PubMed:14702039).Curated1
Sequence conflicti76S → P in BAA05660 (PubMed:7989345).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05515268T → TSSCQRRLSSRGEPWLPPPA SFGPL in isoform 4. 1 Publication1
Alternative sequenceiVSP_02393370 – 81TSRRA…PQRPK → LKRKIRPTPKKK in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_02393482 – 183Missing in isoform 3. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_023935183Missing in isoform 2 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28113 mRNA. Translation: BAA05659.1.
D28114 mRNA. Translation: BAA05660.1.
AK127034 mRNA. No translation available.
AK290187 mRNA. Translation: BAF82876.1.
AC092058 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64588.1.
CH471055 Genomic DNA. Translation: EAW64592.1.
BC022471 mRNA. Translation: AAH22471.1.
BC075796 mRNA. Translation: AAH75796.1.
BC119694 mRNA. Translation: AAI19695.1.
BC119695 mRNA. Translation: AAI19696.1.
CCDSiCCDS2687.1. [Q13875-3]
CCDS2688.1. [Q13875-1]
CCDS63598.1. [Q13875-4]
PIRiC55663.
RefSeqiNP_001265251.1. NM_001278322.1. [Q13875-4]
NP_001265252.1. NM_001278323.1. [Q13875-1]
NP_891980.1. NM_182935.3. [Q13875-3]
UniGeneiHs.121333.
Hs.594670.

Genome annotation databases

EnsembliENST00000311042; ENSP00000312293; ENSG00000168314. [Q13875-4]
ENST00000383754; ENSP00000373261; ENSG00000168314. [Q13875-3]
ENST00000415443; ENSP00000388148; ENSG00000168314. [Q13875-3]
ENST00000420739; ENSP00000400491; ENSG00000168314. [Q13875-1]
ENST00000424090; ENSP00000389055; ENSG00000168314. [Q13875-1]
ENST00000428261; ENSP00000401312; ENSG00000168314. [Q13875-3]
ENST00000441980; ENSP00000388827; ENSG00000168314. [Q13875-1]
ENST00000442631; ENSP00000413771; ENSG00000168314. [Q13875-2]
ENST00000447324; ENSP00000409730; ENSG00000168314. [Q13875-3]
ENST00000452959; ENSP00000405549; ENSG00000168314. [Q13875-3]
GeneIDi4336.
KEGGihsa:4336.
UCSCiuc003cju.5. human. [Q13875-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMOBP_HUMAN
AccessioniPrimary (citable) accession number: Q13875
Secondary accession number(s): A8K2C2
, G5E945, Q13874, Q6DHZ6, Q8TBJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: September 27, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot