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Protein

Myelin-associated oligodendrocyte basic protein

Gene

MOBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.By similarity

GO - Molecular functioni

GO - Biological processi

  • nervous system development Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin-associated oligodendrocyte basic protein
Gene namesi
Name:MOBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:7189. MOBP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30899.

Polymorphism and mutation databases

DMDMi134034171.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Myelin-associated oligodendrocyte basic proteinPRO_0000281025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991PhosphoserineBy similarity
Modified residuei109 – 1091PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ13875.

PTM databases

PhosphoSiteiQ13875.

Expressioni

Gene expression databases

BgeeiQ13875.
CleanExiHS_MOBP.
ExpressionAtlasiQ13875. baseline and differential.
GenevisibleiQ13875. HS.

Organism-specific databases

HPAiHPA035152.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-5P603703EBI-10230628,EBI-10172150
KRTAP10-7P604093EBI-10230628,EBI-10172290
KRTAP10-9P604113EBI-10230628,EBI-10172052

Protein-protein interaction databases

BioGridi110479. 6 interactions.
IntActiQ13875. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ13875.
SMRiQ13875. Positions 1-72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati97 – 106101
Repeati107 – 116102
Repeati117 – 126103
Repeati127 – 136104

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 136404 X 10 AA tandem repeats of P-R-S-P-P-R-S-E-R-QAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi77 – 16892Pro-richAdd
BLAST

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00750000117828.
HOGENOMiHOG000054197.
HOVERGENiHBG081977.
InParanoidiQ13875.
OMAiCACQKTS.
PhylomeDBiQ13875.

Family and domain databases

InterProiIPR026666. Mobp.
IPR011011. Znf_FYVE_PHD.
[Graphical view]
PANTHERiPTHR14555:SF5. PTHR14555:SF5. 1 hit.
PfamiPF02318. FYVE_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13875-1) [UniParc]FASTAAdd to basket

Also known as: OPRP2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQKPAKEGP RLSKNQKYSE HFSIHCCPPF TFLNSKKEIV DRKYSICKSG
60 70 80 90 100
CFYQKKEEDW ICCACQKTRT SRRAKSPQRP KQQPAAPPAV VRAPAKPRSP
110 120 130 140 150
PRSERQPRSP PRSERQPRSP PRSERQPRSP PRSERQPRPR PEVRPPPAKQ
160 170 180
RPPQKSKQQP RSSPLRGPGA SRGGSPVKAS RFW
Length:183
Mass (Da):20,959
Last modified:March 20, 2007 - v2
Checksum:i81831413BCC6A041
GO
Isoform 2 (identifier: Q13875-2) [UniParc]FASTAAdd to basket

Also known as: OPRP1

The sequence of this isoform differs from the canonical sequence as follows:
     183-183: Missing.

Show »
Length:182
Mass (Da):20,773
Checksum:iE31413BCC6A041B5
GO
Isoform 3 (identifier: Q13875-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-81: TSRRAKSPQRPK → LKRKIRPTPKKK
     82-183: Missing.

Note: No experimental confirmation available.
Show »
Length:81
Mass (Da):9,614
Checksum:i741E059219155AAF
GO
Isoform 4 (identifier: Q13875-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-68: T → TSSCQRRLSSRGEPWLPPPASFGPL
     183-183: Missing.

Note: No experimental confirmation available.
Show »
Length:206
Mass (Da):23,381
Checksum:i9B33699136F2E7D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281P → R in AAH75796 (PubMed:15489334).Curated
Sequence conflicti40 – 401V → E in AK127034 (PubMed:14702039).Curated
Sequence conflicti76 – 761S → P in BAA05660 (PubMed:7989345).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei68 – 681T → TSSCQRRLSSRGEPWLPPPA SFGPL in isoform 4. 1 PublicationVSP_055152
Alternative sequencei70 – 8112TSRRA…PQRPK → LKRKIRPTPKKK in isoform 3. 1 PublicationVSP_023933Add
BLAST
Alternative sequencei82 – 183102Missing in isoform 3. 1 PublicationVSP_023934Add
BLAST
Alternative sequencei183 – 1831Missing in isoform 2 and isoform 4. 2 PublicationsVSP_023935

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28113 mRNA. Translation: BAA05659.1.
D28114 mRNA. Translation: BAA05660.1.
AK127034 mRNA. No translation available.
AK290187 mRNA. Translation: BAF82876.1.
AC092058 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64588.1.
CH471055 Genomic DNA. Translation: EAW64592.1.
BC022471 mRNA. Translation: AAH22471.1.
BC075796 mRNA. Translation: AAH75796.1.
BC119694 mRNA. Translation: AAI19695.1.
BC119695 mRNA. Translation: AAI19696.1.
CCDSiCCDS2687.1. [Q13875-3]
CCDS2688.1. [Q13875-1]
CCDS63598.1. [Q13875-4]
PIRiC55663.
RefSeqiNP_001265251.1. NM_001278322.1. [Q13875-4]
NP_001265252.1. NM_001278323.1. [Q13875-1]
NP_891980.1. NM_182935.3. [Q13875-3]
UniGeneiHs.121333.
Hs.594670.

Genome annotation databases

EnsembliENST00000311042; ENSP00000312293; ENSG00000168314. [Q13875-4]
ENST00000383754; ENSP00000373261; ENSG00000168314. [Q13875-3]
ENST00000415443; ENSP00000388148; ENSG00000168314. [Q13875-3]
ENST00000420739; ENSP00000400491; ENSG00000168314. [Q13875-1]
ENST00000424090; ENSP00000389055; ENSG00000168314. [Q13875-1]
ENST00000428261; ENSP00000401312; ENSG00000168314. [Q13875-3]
ENST00000441980; ENSP00000388827; ENSG00000168314. [Q13875-1]
ENST00000442631; ENSP00000413771; ENSG00000168314. [Q13875-2]
ENST00000447324; ENSP00000409730; ENSG00000168314. [Q13875-3]
ENST00000452959; ENSP00000405549; ENSG00000168314. [Q13875-3]
GeneIDi4336.
KEGGihsa:4336.
UCSCiuc003cju.5. human. [Q13875-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28113 mRNA. Translation: BAA05659.1.
D28114 mRNA. Translation: BAA05660.1.
AK127034 mRNA. No translation available.
AK290187 mRNA. Translation: BAF82876.1.
AC092058 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64588.1.
CH471055 Genomic DNA. Translation: EAW64592.1.
BC022471 mRNA. Translation: AAH22471.1.
BC075796 mRNA. Translation: AAH75796.1.
BC119694 mRNA. Translation: AAI19695.1.
BC119695 mRNA. Translation: AAI19696.1.
CCDSiCCDS2687.1. [Q13875-3]
CCDS2688.1. [Q13875-1]
CCDS63598.1. [Q13875-4]
PIRiC55663.
RefSeqiNP_001265251.1. NM_001278322.1. [Q13875-4]
NP_001265252.1. NM_001278323.1. [Q13875-1]
NP_891980.1. NM_182935.3. [Q13875-3]
UniGeneiHs.121333.
Hs.594670.

3D structure databases

ProteinModelPortaliQ13875.
SMRiQ13875. Positions 1-72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110479. 6 interactions.
IntActiQ13875. 3 interactions.

PTM databases

PhosphoSiteiQ13875.

Polymorphism and mutation databases

DMDMi134034171.

Proteomic databases

PRIDEiQ13875.

Protocols and materials databases

DNASUi4336.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311042; ENSP00000312293; ENSG00000168314. [Q13875-4]
ENST00000383754; ENSP00000373261; ENSG00000168314. [Q13875-3]
ENST00000415443; ENSP00000388148; ENSG00000168314. [Q13875-3]
ENST00000420739; ENSP00000400491; ENSG00000168314. [Q13875-1]
ENST00000424090; ENSP00000389055; ENSG00000168314. [Q13875-1]
ENST00000428261; ENSP00000401312; ENSG00000168314. [Q13875-3]
ENST00000441980; ENSP00000388827; ENSG00000168314. [Q13875-1]
ENST00000442631; ENSP00000413771; ENSG00000168314. [Q13875-2]
ENST00000447324; ENSP00000409730; ENSG00000168314. [Q13875-3]
ENST00000452959; ENSP00000405549; ENSG00000168314. [Q13875-3]
GeneIDi4336.
KEGGihsa:4336.
UCSCiuc003cju.5. human. [Q13875-1]

Organism-specific databases

CTDi4336.
GeneCardsiMOBP.
H-InvDBHIX0018440.
HGNCiHGNC:7189. MOBP.
HPAiHPA035152.
MIMi600948. gene.
neXtProtiNX_Q13875.
PharmGKBiPA30899.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00750000117828.
HOGENOMiHOG000054197.
HOVERGENiHBG081977.
InParanoidiQ13875.
OMAiCACQKTS.
PhylomeDBiQ13875.

Miscellaneous databases

ChiTaRSiMOBP. human.
GenomeRNAii4336.
NextBioi17057.
PROiQ13875.
SOURCEiSearch...

Gene expression databases

BgeeiQ13875.
CleanExiHS_MOBP.
ExpressionAtlasiQ13875. baseline and differential.
GenevisibleiQ13875. HS.

Family and domain databases

InterProiIPR026666. Mobp.
IPR011011. Znf_FYVE_PHD.
[Graphical view]
PANTHERiPTHR14555:SF5. PTHR14555:SF5. 1 hit.
PfamiPF02318. FYVE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin."
    Yamamoto Y., Mizuno R., Nishimura T., Ogawa Y., Yoshikawa H., Fujimura H., Adachi E., Kishimoto T., Yanagihara T., Sakoda S.
    J. Biol. Chem. 269:31725-31730(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING.
    Tissue: Spinal cord.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Thalamus.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.

Entry informationi

Entry nameiMOBP_HUMAN
AccessioniPrimary (citable) accession number: Q13875
Secondary accession number(s): A8K2C2
, G5E945, Q13874, Q6DHZ6, Q8TBJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: March 16, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.